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Efficacy and safety of pharmacotherapeutic interventions used in visceral leishmaniasis clinical trials:A systematic review and network meta-analysis

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Asian Pacific Journal of Tropical Medicine 2022年第8期15卷 343-353,I0001-I0010页

作者： Aamir Bashir gautam sahu Ishfaq Rashid Pramil Tiwari Department of Pharmacy Practice National Institute of Pharmaceutical Education and ResearchS.A.S.Nagar Mohali160062PunjabIndia

Objective:To compare the efficacy and safety outcomes of different antileishmanial agents used in visceral leishmaniasis clinical ***:A systematic literature search in PubMed/MEDLINE,EMBASE,Cochrane,and Google Scholar was done using keywords“randomized controlled trials”,“antileishmanial”and“visceral leishmaniasis”.The outcomes included were cure rate,overall withdrawals,relapse rate,and treatment-emergent adverse *** estimates through the frequentist network meta-analysis approach were presented as OR with 95%*** plots were used for identifying the“best intervention”based on p-scores obtained using the surface under the cumulative *** risk of bias was evaluated by using Pedro ***:Seventeen randomized controlled trials with 5143 visceral leishmaniasis patients who received different antileishmanial agents(amphotericin B,miltefosine,paromomycin,meglumine antimoniate,sodium stibogluconate,sitamaquine,and pentavalent antimonials)and met the inclusion criteria were *** efficacy outcomes of the treatments,the rankogram of the network meta-analysis revealed that paromomycin(p-score=0.8148)has the highest probability of being best in the pool,followed by sodium stibogluconate(OR 0.82,95%CI 0.24-2.79,p-score=0.7580),amphotericin B+miltefosine(OR 0.66,95%CI 0.02-19.04,p-score=0.7329)as compared to the remaining treatments;however,the most of the treatment-emergent adverse events were reported with ***:Paromomycin reported the highest cure rates,while the maximum treatment-emergent adverse events were seen with sitamaquine.

关键词： Visceral leishmaniasis Treatment Efficacy Safety Network meta-analysis

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Post Millennium Development Goals Prospect on Child Mortality in India: An Analysis Using Autoregressive Integrated Moving Averages (ARIMA) Model

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Health 2016年第15期8卷 1845-1872页

作者： Partha De Damodar sahu Arvind Pandey B. K. Gulati Nomita Chandhiok Arvind Kumar Shukla Pavitra Mohan Raj gautam Mitra Indian Statistical Institute Kolkata India National Institute of Medical Statistics ICMR Ansari Nagar New Delhi India Indian Council of Medical Research New Delhi India Subharti Medical College Meerut India UNICEF New Delhi India

Background & Objectives: Sustainable Development Goals (SDGs) are set up as a part of the Post Millennium Development Goals (MDGs). Then it becomes essential to review the achievement of the MDGs in India and lessons learned to incorporate into the SDGs. The present study reviews and predicts different components of under-five mortality rate beyond 2015 to assess the present situation and to determine the future possibilities of achieving the new targets for SDGs in India. Data and Methods: It uses available time series data on different components of U5MR from the India’s Sample Registration System (SRS). Autoregressive Integrated Moving Averages (ARIMA) model has been taken as the method of time series analysis to forecast the mortality rates beyond 2015. Results: There is a consistent pattern of faster decline in the under-five mortality compared with the neonatal mortality rate across all major states in India although neonatal mortality contributes largest share in under-five mortality. Again, share of neonatal death among under-five death is increasing steadily over the future projected years. This indicates very slow progress of reduction in neonatal mortality. Stimulating efforts with new intervention programmes will be needed to focus more on lowering neonatal mortality particularly in rural India.

关键词： Under-Five Mortality Infant Mortality Neonatal Mortality Sustainable Development Goals Post-2015 Development Agenda ARIMA Model Mortality Projection

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