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Zoological Research 2018年第1期39卷 3-14页

作者： gary wong Xiang-Guo Qiu Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen Guangzhou 518020China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Special Pathogens Program National Microbiology LaboratoryPublic Health Agency of CanadaWinnipegManitoba R3E 3R2Canada Department of Medical Microbiology and Infectious Diseases University of ManitobaWinnipegManitoba R3E 0J9Canada

Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the Flaviviridae, Filoviridae, Arenaviridae, Bunyaviridae, Henipaviridae, and Togaviridae. In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

关键词： Ifnar Mice Animal model Flavivirus Filovirus Arenavirus Bunyavirus Henipavirus Togavirus

Did ZIKV evolve to be more dangerous? A new clue towards neurovirulence

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National Science Review 2018年第2期5卷 121-122页

作者： gary wong George F.Gao Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Third People's Hospital CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Before 2015,Zika virus(ZIKV)was a little-known flavivirus that caused sporadic symptomatic infections in humans(under 20 reported cases,but likely manymore unreported asymptomatic cases)in the decades following its di... 详细信息

关键词： ZIKA virus FLAVIVIRUSES EPIDEMICS

Animal models for filovirus infections

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Zoological Research 2018年第1期39卷 15-24页

作者： Vinayakumar Siragam gary wong Xiang-Guo Qiu Special Pathogens Program Public Health Agency of CanadaWinnipegManitoba R3E 3R2Canada Department of Medical Microbiology University of ManitobaWinnipegManitoba R3E 0J9Canada Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen Guangzhou 51 8020China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates （NHPs）, causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

关键词： Filovirus Ebola virus Marburg virus Marburg virus disease Ebola virus disease Mouse-adapted ebolavirus Guinea-pig-adapted ebolavirus Sudan virus Plaque-forming units

Can Ebola virus become endemic in the human population？

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Protein & Cell 2016年第1期7卷 4-6页

作者： gary wong George F. Gao Xiangguo Qiu Special Pathogens Program National Microbiology Laboratory Public Health Agency of Canada Winnipeg MB CanadaDepartment of Medical Microbiology University of Manitoba Winnipeg MB Canada Department of Medical Microbiology University of Manitoba Winnipeg MB Canada CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of SciencesBeijing 100101 China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100052 China Officeof Director-General Chinese Center for Disease Control and Prevention Beijing 102206 China

The 2014-15 Ebola virus reported during March 2014 Guinea. has shown itself to （EBOV） outbreak, originally n the Western African nation of be resistant to traditional con- tainment methods, with over 28,000 infections and 11,000 deaths over 18 months. Recently, news that a Scottish nurse had relapsed to EBOV disease with neurological symptoms at 10 months after recovery have astonished experts. The prolonged nature of the outbreak has led to questions whether EBOV can become endemic in the human popula- tion, an undesirable outcome due to the large amount of resources required to keep this virus under control. In this commentary, we discuss aspects EBOV disease with those caused by pathogens considered endemic in humans, as well as factors which may contribute to sustained EBOV transmission in humans.

关键词： Can Ebola virus become endemic

Bat origin of a new human coronavirus:there and back again

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Science China(Life Sciences) 2020年第3期63卷 461-462页

作者： Xiang Li Yuhe Song gary wong Jie Cui CAS Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Center for Biosafety Mega-Science Chinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Shanghai UniversityShanghai 200444China

A novel coronavirus reported to cause pneumonia in 41 people during December 2019 in Wuhan,the capital of Hubei province,China,was identified and designated as the 2019 novel coronavirus(2019-nCoV)(Zhu et al.,2020;Li et al.,2020).Infection with 2019-nCoV results in clusters of severe respiratory illness similar to that caused by severe acute respiratory syndrome coronavirus(SARS-CoV)and is associated with high mortality(Chen et al.,2020;Huang et al.,2020).This new coronavirus belongs to genus Betacoronavirus,family Coronaviridae,with a single-stranded,positive-sense RNA genome,but genetically distinct from SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV).

关键词： Middle origin belongs

Zika virus in the testes： should we be worried？

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Protein & Cell 2017年第3期8卷 162-164页

作者： gary wong Shihua Li Lei Liu Yingxia Liu Yuhai Bi Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious Disease Shenzhen Third People's_ Hospital Shenzhen 518112 China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Center for Influenza Research and Early-warning (CASCIRE) Chinese Academy of Sciences Beijing 100101 China

Zika virus （ZIKV） is a mosquito-borne pathogen from the family Flaviviridae, and infection of humans with ZIKV through mosquito bites may result in a disease known as Zika fever. Most Zika fever cases are asymptomatic and thus go unreported, but if symptoms do appear, they are usually mild in nature （fever, joint pain, headache and macu- Iopapular rash）, and self-resolve within one week （Chen and Hamer 2016）. No deaths have ever been attributed to Zika fever; however, when a woman is infected with ZIKV during pregnancy, vertical transmission of the virus may result in microcephaly in the offspring （Rasmussen, Jamieson et al., 2016）. ZIKV infections in adults are associated with episodes of Guillain-Barr6 syndrome, an autoimmune disorder of the peripheral nervous system, resulting in rapid-onset muscle weakness （Cao-Lormeau, Blake et al. 2016）.

关键词： should virus Zika

Zoonotic origins of human coronavirus 2019(HCoV-19/SARS-CoV-2):why is this work important?

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Zoological Research 2020年第3期41卷 213-219页

作者： gary wong Yu-Hai Bi Qi-Hui Wang Xin-Wen Chen Zhi-Gang Zhang Yong-Gang Yao CAS Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Department of Microbiology-Infectiology and Immunology Laval UniversityQuebec G1V 4G2Canada CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China State key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life SciencesYunnan UniversityKunmingYunnan 650091China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic.

关键词： origin why is this work important HCoV-19/SARS-CoV-2 Zoonotic origins of human coronavirus 2019

Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection

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Virologica Sinica 2017年第6期32卷 545-547页

作者： gary wong shihua he vinayakumar siragam yuhai bi majambu mbikay michel chretien xiangguo qiu Special Pathogens Program Public Health Agency of CanadaWinnipeg R3E 3R2Canada Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People’s Hospita1.Shenzhen 5l1700China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100l01China Department of Medical Microbiology University of ManitobaWinnipeg R3E 0J9Canada FunctionaI EndoprOteOlVsis Laboratory ClinicaI Research Institute of Montrea1Montreal H2W 1R7Canada Chronic Disease Program Ottawa Hospital Research Institute0ttawa K1H 8L6Canada

Dear Editor, The 2015-2016 outbreak of Zika virus （ZIKV） fever, first reported in Brazil during early 2015 （Zanluca et al., 2015）, has infected millions of people and is a global public health concern. ZIKV infections are associated with fetal microcephaly, as well as neurological complications in humans. The virus can be shed in the semen and vaginal secretions of humans, leading to sexual transmission, and unexpectedly ZIKV infections cause severe damage to the male reproductive organs in male mice （Govero et al., 2016; Ma et al., 2016）.

关键词： Antiviral activity quercetin-3-β-O-D-glucoside against Zika virus infection

Ribavirin is effective against drug-resistant H7N9 influenza virus infections

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Protein & Cell 2016年第8期7卷 611-614页

作者： Bi, Yuhai wong, gary Liu, Yingxia Liu, Lei Gao, George F. Shi, Yi Chinese Acad Sci Inst Microbiol CAS Key Lab Pathogen Microbiol & Immunol Beijing 100101 Peoples R China Shenzhen Third Peoples Hosp Shenzhen Key Lab Pathogen & Immun State Key Discipline Infect Dis Shenzhen 518112 Peoples R China Chinese Acad Sci Ctr Influenza Res & Early Warning CASCIRE Beijing 100101 Peoples R China Chinese Acad Sci Beijing Inst Life Sci RNIH Beijing 100101 Peoples R China Zhejiang Univ Collaborat Innovat Ctr Diag & Treatment Infect Di Hangzhou 310003 Zhejiang Peoples R China

Dear Editor, In February and March 2013, a novel influenza A （H7N9） virus emerged in China, causing an acute respiratory distress syndrome and occasionally multiple organ failure with high fatality rates in humans （Li et al., 2014）. A total of 681 laboratory-confirmed cases and 275 deaths have been reported as of November 13th,

关键词：

Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges

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The Innovation 2022年第5期3卷 38-47页

作者： Jing Yang Yuhuan Gong Chunge Zhang Ju Sun gary wong Weifeng Shi Wenjun Liu George FGao Yuhai Bi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271016China

Since the 20th century,humans have lived through five pandemics caused by influenza A viruses(IAVs)(H1N1/1918,H2N2/1957,H3N2/1968,and H1N1/2009)and the coronavirus(CoV)severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).IAVs and CoVs both have broad host ranges and share multiple *** co-circulation and even co-infections facilitate genetic reassortment among IAVs and recombination among CoVs,further altering virus evolution dynamics and generating novel variants with increased cross-species transmission ***,SARS-CoV-2 may maintain longterm circulation in humans as seasonal ***-existence and co-infection of both viruses in humans could alter disease transmission patterns and aggravate disease ***,we demonstrate how virus-host ecology correlates with the co-existence and co-infection of IAVs and/or CoVs,further affecting virus evolution and disease dynamics and burden,calling for active virus surveillance and countermeasures for future public health challenges.

关键词： infection maintain generating