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Evolving technologies for growing,imaging and analyzing 3D root system architecture of crop plants

Journal of Integrative Plant Biology 2016年第3期58卷 230-241页

作者： miguel A.Pieros Brandon G.Larson Jon E.Shaff David J.Schneider Alexandre Xavier Falcao Lixing Yuan Randy T.Clark Eric J.Craft Tyler W.Davis Pierre-Luc Pradier Nathanael m.shaw Ithipong Assaranurak Susan R.mc Couch Craig Sturrock malcolm Bennett Leon V.Kochian USDA-ARS Robert Holley Center for Agriculture and Health538 Tower RoadIthacaNY 14580USA Department of Information Systems Institute of ComputingUniversity of CampinasAv.Albert Einstein1251CEP 13083-852CampinasSPBrazil Department of Plant Nutrition China Agricultural UniversityBeijing 100193China Department of Plant Breeding and Genetics Cornell UniversityIthacaNY 14853USA Centre for Plant Integrative Biology School of BiosciencesUniversity of NottinghamSutton BoningtonLE12 5RDUK College of Science King Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

A plant＇s ability to maintain or improve its yield under limiting conditions,such as nutrient de ficiency or drought,can be strongly in fluenced by root system architecture（RSA）,the three-dimensional distribution of the different root types in the soil. The ability to image,track and quantify these root system attributes in a dynamic fashion is a useful tool in assessing desirable genetic and physiological root traits. Recent advances in imaging technology and phenotyping software have resulted in substantive progress in describing and quantifying RSA. We have designed a hydroponic growth system which retains the three-dimensional RSA of the plant root system,while allowing for aeration,solution replenishment and the imposition of nutrient treatments,as well as high-quality imaging of the root system. The simplicity and flexibility of the system allows for modi fications tailored to the RSA of different crop species and improved throughput. This paper details the recent improvements and innovations in our root growth and imaging system which allows for greater image sensitivity（detection of fine roots and other root details）,higher ef ficiency,and a broad array of growing conditions for plants that more closely mimic those found under field conditions.

关键词： Abiotic stress digital root phenotyping mineral nutrition root system architecture

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The effect of EmG magnitude on the masseter vestibular evoked myogenic potential(mVEmP)

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Journal of Otology 2022年第4期17卷 203-210页

作者： Daniel J.Romero gary P.Jacobson Richard A.Roberts Department of Hearing and Speech Sciences Division of Vestibular SciencesVanderbilt University Medical Center121521st Ave.South6308 Medical Center EastNashvilleTN37232-8718USA

Introduction:The masseter vestibular evoked myogenic potential(mVEmP)is a bilaterally generated,electromyographically(EmG)-mediated response innervated by the trigeminal *** purpose of the present investigation was to 1)determine whether subjects could accurately achieve and maintain a range of EmG target levels,2)to examine the effects of varied EmG levels on the latencies and amplitudes of the mVEmP,and 3)to investigate the degree of side-to-side asymmetry and any effects of EmG ***:Subjects were nine neurologically and otologically normal young adults.A high-intensity tone burst was presented monaurally while subjects were seated upright and asked to match a range of EmG target levels by clenching their *** were made from the ipsilateral and contralateral masseter muscles referenced to the ear being monaurally ***:We found that the tonic EmG target had no effect on mVEmP ***,although mVEmP amplitudes“scaled”to the EmG target,there was a tendency for the subjects’EmG level to“undershoot”the EmG target levels greater than 50 *** some individuals did generate differences in EmG activation between sides,there were no significant differences on average EmG activation between ***,while average corrected amplitude asymmetry was similar across EmG targets,some individuals demonstrated large,corrected amplitude asymmetry ***:The results of this investigation suggest that,as with cVEmP recordings,the underlying EmG activation may vary between subjects and could impact mVEmP amplitudes,yet could be mitigated by amplitude correction *** it is important to be aware that even young normal subjects have difficulty maintaining large,tonic EmG activity during the mVEmP recording.

关键词： Vestibular evoked myogenic potentials (VEmPs) masseter VEmPs Electromyography(EmG) Vestibulomasseteric reflex(VmR) EmG target Level

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Vascular disease in the older adult

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Journal of Geriatric Cardiology 2016年第9期13卷 727-732页

作者： Andrew P miller Christopher m Huff gary S Roubin Cardio Vascular Associates Birmingham Alabama USA

Among older adults, incidence and prevalence of aortic disease, peripheral arterial disease (PAD), and venous thromboembolism (VTE) increase as age-related alterations in vascular structure and function are compounded by longer exposure to cardiovascular disease (CVD) risk factors. This review highlights the unique presentations and treatment strategies for aortic dissection, abdominal aortic aneurysm (AAA), PAD, and VTE in older adults.

关键词：大动脉的疾病心血管的疾病外部动脉的疾病老

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modern Electronic Communication 7th ed.

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丛书名：国外高校电子信息类优秀教材

2004年

作者： miller gary m.

来源：畅想之星图书光盘版（南... 评论

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Cardiovascular care for older adults： hypertension and stroke in the older adult

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Journal of Geriatric Cardiology 2016年第5期13卷 373-379页

作者： Andrew P miller Ann m Navar gary S Roubin Suzanne Oparil CardioVascular Associates Birmingham Alabama USA Duke Clinical Research Institute Durham North Carolina USA Vascular Biology & Hypertension Program Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham Alabama USA

Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiovascular risk factors. This chapter is aimed at connecting age-related alterations in vascular function and structure to the resultant target organ damage, and to raise awareness of unique presentations and treatment strategies for hypertension and stroke in older adults.

关键词：高血压老年人心血管中风护理年龄相关血管功能脑血管疾病

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低剂量CT对肾结石的评估:从2011—2012年至2015—2016年尚无进展

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国际医学放射学杂志 2018年第2期 228-229页

作者： K.Weisenthal P.Karthik m.shaw D.Sengupta m.Bhargavan-Chatfeld J.Burleson 孔庆倩 Department of Emergency medicine Yale School of Medicine

摘要目的为确定与2011—2012年相比,2015—2016年使用低剂量CT对肾结石的评估是否增加,根据该适应证的设备确定辐射暴露的变异性,并且通过查询国家剂量注册

关键词：肾结石低剂量 CT

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RNA binding proteins in spermatogenesis： an in depth focus on the musashi family

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Asian Journal of Andrology 2015年第4期17卷 529-536页

作者： Jessie m Sutherland Nicole A Siddall gary R Hime Eileen A mcLaughlin School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Neuroscience University of Melbourne ParkvilleVIC 3010 Australia

Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy translational requirements for continued growth and differentiation. Hence, spermatogenesis is highly reliant on mechanisms of posttranscriptional regulation of gene expression, facilitated by RNA binding proteins （RBPs）, which remain abundantly expressed throughout this process. One such group of proteins is the musashi family, previously identified as critical regulators of testis germ cell development and meiosis in Drosophila, and also shown to be vital to sperm development and reproductive potential in the mouse. This review describes the role and function of RBPs our recent knowledge of the musashi proteins in spermatogenesis. within the scope of male germ cell development, focusing on The functional mechanisms utilized by RBPs within the cell are outlined in depth, and the significance of sub-cellular localization and stage-specific expression in relation to the mode and impact of posttranscriptional regulation is also highlighted. We emphasize the historical role of the musashi family of RBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian musashi proteins, musashi-1 and musashi-2, with a primary focus on our findings in spermatogenesis. This review highlights both the essential contribution of RBPs to posttranscriptional regulation and the importance of the musashi family as master regulators of male gamete development.

关键词： gene regulation musashi musashi-1 musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation

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macrophages in immunoregulation and therapeutics

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Signal Transduction and Targeted Therapy 2023年第6期8卷 I0002-I0002,2821-2854页

作者： Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang Haizhao Xu gary Guishan Xiao Lang Rao Yanhong Duo Department of Respiratory Diseases and Critic Care Unit Shenzhen Institute of Respiratory DiseaseShenzhen Key Laboratory of Respiratory DiseaseShenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen518020China Department of Cancer Biology Beckman Research Institute of City of Hope National Medical CenterLos AngelesCA91010USA Department of Laboratory medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen UniversityShenzhen518052China Department of Respiratory The First Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518055China State Key Laboratory of Fine Chemicals Department of Pharmaceutical SciencesSchool of Chemical EngineeringDalian University of TechnologyDalianChina Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen518132China Department of microbiology Tumor and Cell Biology(MTC)Karolinska InstitutetStockholmSweden

macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and *** possess binary m1/m2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely *** crucial questions about macrophage signaling and immune modulation are yet to be *** addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their ***,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade ***,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic ***,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage ***,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and ***,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

关键词： becoming polarization macrophages

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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An Ecological Evaluation of Vinyl Chloride Exposure and Liver Cancer Incidence and mortality in Texas

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 99-105页

作者： Kevin m.Towle Stacey m.Benson Natalie S.Egnot gary m.marsh Cardno ChemRisk San FranciscoCAUSA Cardno ChemRisk PittsburghPAUSA

The goal of this analysis was to evaluate the association between county-level ambient vinyl chloride(VC)and county-level liver cancer incidence and mortality rates in *** county-level ambient VC data were obtained from the National Air Toxics ***-adjusted county-level liver cancer incidence rates were abstracted from the Texas Cancer Registry and age-standardized county-level liver cancer mortality rates were obtained from the peer-reviewed *** imputation was utilized to impute incidence rates in counties with suppressed liver cancer incidence *** binomial and Poisson regression models were utilized to evaluate the association between county-level ambient VC and county-level liver cancer incidence and mortality rates,respectively,adjusted for county-level heavy drinking prevalence,hepatitis mortality rates,median income,and race(percent Hispanic).County-level ambient VC was not associated with county-level liver cancer incidence or mortality ***,when compared to the lowest tertile of ambient VC,the middle(relative risk[RR]:1.06,95%confidence interval[CI]:0.95-1.19)and highest(RR:1.03,95%CI:0.90-1.17)tertiles of ambient VC were not associated with liver cancer ***,county-level ambient VC in the middle(RR:0.95,95%CI:0.85-1.05)and highest(RR:0.93,95%CI:0.82-1.05)tertiles were not associated with liver cancer *** analysis suggests that county-level ambient VC is not associated with liver cancer incidence or mortality in *** study provides novel results regarding liver cancer risk from low-level non-occupational exposure to ambient VC.

关键词： Vinyl chloride Liver cancer Epidemiology Incidence

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