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regulation of cell adhesion in the testis： a new role for p73

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Asian Journal of Andrology 2014年第6期16卷 799-800页

作者： Helen E Abud gary r hime Department of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia Department of Anatomy and Neuroscience University of Melbourne Parkville VIC 3010Australia.

The dramatic changes that male germ cells in the adult testis undergo in gene expression profile and morphology as they transition from spermatogonial stem cells through to mature spermatozoa is dependent upon their association with Sertoli cells. Sertoli cells are crucial for survival and maturation of male germ cells. Two recent papers, Holembowski et al？ and Inoue et a13 have described a surprising role for the p53 family member, p73, in regulation of germ cell-Sertoli cell adhesion.

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rNA binding proteins in spermatogenesis： an in depth focus on the Musashi family

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Asian Journal of Andrology 2015年第4期17卷 529-536页

作者： Jessie M Sutherland Nicole A Siddall gary r hime Eileen A McLaughlin School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Neuroscience University of Melbourne ParkvilleVIC 3010 Australia

Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy translational requirements for continued growth and differentiation. Hence, spermatogenesis is highly reliant on mechanisms of posttranscriptional regulation of gene expression, facilitated by rNA binding proteins （rBPs）, which remain abundantly expressed throughout this process. One such group of proteins is the Musashi family, previously identified as critical regulators of testis germ cell development and meiosis in Drosophila, and also shown to be vital to sperm development and reproductive potential in the mouse. This review describes the role and function of rBPs our recent knowledge of the Musashi proteins in spermatogenesis. within the scope of male germ cell development, focusing on The functional mechanisms utilized by rBPs within the cell are outlined in depth, and the significance of sub-cellular localization and stage-specific expression in relation to the mode and impact of posttranscriptional regulation is also highlighted. We emphasize the historical role of the Musashi family of rBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian Musashi proteins, Musashi-1 and Musashi-2, with a primary focus on our findings in spermatogenesis. This review highlights both the essential contribution of rBPs to posttranscriptional regulation and the importance of the Musashi family as master regulators of male gamete development.

关键词： gene regulation Musashi Musashi-1 Musashi-2 posttranscriptional control rNA binding proteins spermatogenesis splicing testis translation

Alternative models for transgenerational epigenetic inheritance:Molecular psychiatry beyond mice and man

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World Journal of Psychiatry 2021年第10期11卷 711-735页

作者： gary r hime Sophie LA Stonehouse Terence Y Pang Department of Anatomy and Physiology The University of MelbourneParkville 3010VICAustralia Mental Health Theme The Florey Institute of Neuroscience and Mental HealthParkville 3052VICAustralia

Mental illness remains the greatest chronic health burden globally with few inroads having been made despite significant advances in genomic knowledge in recent *** field of psychiatry is constantly challenged to bring new approaches and tools to address and treat the needs of vulnerable individuals and subpopulations,and that has to be supported by a continuous growth in *** majority of neuropsychiatric symptoms reflect complex geneenvironment interactions,with epigenetics bridging the gap between genetic susceptibility and environmental stressors that trigger disease onset and drive the advancement of *** has more recently been demonstrated in preclinical models that epigenetics underpins the transgenerational inheritance of stressrelated behavioural phenotypes in both paternal and maternal lineages,providing further supporting evidence for heritability in ***,unbiased prospective studies of this nature are practically impossible to conduct in humans so preclinical models remain our best option for researching the molecular pathophysiologies underlying many neuropsychiatric *** rodents will remain the dominant model system for preclinical studies(especially for addressing complex behavioural phenotypes),there is scope to expand current research of the molecular and epigenetic pathologies by using invertebrate ***,we will discuss the utility and advantages of two alternative model organisms–Caenorhabditis elegans and Drosophila melanogaster-and summarise the compelling insights of the epigenetic regulation of transgenerational inheritance that are potentially relevant to human psychiatry.

关键词： Transgenerational inheritance Epigenetics Invertebrate models Caenorhabditis elegans Drosophila melanogaster Environmental stress

Analyzing stem cell dynamics： use of cutting edge genetic approaches in model organisms

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Frontiers in Biology 2015年第1期10卷 1-10页

作者： gary r. hime Nicole SIDDALL Katja HOrVAY Helen E. ABUD Department of Anatomy and Neuroseienee University of Melbourne VIC 3010 Australia Department of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia

regeneration of many cell types found in adult organs relies upon the presence of relatively small pools of undifferentiated stem cells. Initial studies that attempted to isolate stem cells and propagate them in vitro have been complemented by analysis of stem cells in their endogenous tissues where they are subject to a variety of regulatory cues. This has been facilitated by the advent of new methods for lineage tracing and genetic manipulation of stem cells and their associated niche cells. The picture that is emerging is that different stem cell populations utilize diverse processes to ensure maintenance of the stem cell pool accompanied by production of cells committed to regenerate differentiated cells.

关键词： stem cells Drosophila mouse testis intestine lineage tracing