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转录诱导因子活化T细胞中人免疫缺陷病毒的表达

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微生物学免疫学译刊 1988年第1期 124-126页

作者： gary n. 杨宗模

使分泌淋巴激活素的细胞活化的成分可以诱导潜在感染的T淋巴细胞产生人免疫缺陷病病毒(HIV)。HIV中控制活化作用的基因组成分还不清楚,但是其表达必然是通过DnA的不同成分进行调节。HIV基因组的顺式显性( cis-acting)控制成分是增强子... 详细信息

使分泌淋巴激活素的细胞活化的成分可以诱导潜在感染的T淋巴细胞产生人免疫缺陷病病毒(HIV)。HIV中控制活化作用的基因组成分还不清楚,但是其表达必然是通过DnA的不同成分进行调节。HIV基因组的顺式显性( cis-acting)控制成分是增强子和启动子区,此病毒也编码tat-Ⅲ和art基因指定的反式显性(trans-acting)因子。我们检查了活化T细胞的特异产物是

关键词：细胞淋巴激活素 HIV CAT 转录因子增强子诱导因子 nF 结合位点

Kernel Projects for Linux

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丛书名：经典原版书库

2002年

作者： nutt gary

本丛书的内容不仅涵盖了程序设计，数据结构，操作系统，计算机体系结构，数据库，编译原理，软件工程，图形学，通信与网络，离散数学等国内大学计算机专业开设的核心课程。

ISBN: (纸本)7111100999

关键词： Operating systems (Computers)

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听:为什么听?怎样听?

外语教学理论与实践 1998年第2期 16-18页

作者： gary n Chambers 王绍梅复旦大学

引言: 老师们肯定有同榉的沮丧事:你尽心尽力向学生讲授一个独特的概念,他们呢,似乎也掌握了。然后你反反复复地用各种各样有针对性的能引起学生兴趣的方式进行训练。是的,他们确实掌握了。然而,一个星期以后,你会沮丧地发现,你所花的... 详细信息

引言: 老师们肯定有同榉的沮丧事:你尽心尽力向学生讲授一个独特的概念,他们呢,似乎也掌握了。然后你反反复复地用各种各样有针对性的能引起学生兴趣的方式进行训练。是的,他们确实掌握了。然而,一个星期以后,你会沮丧地发现,你所花的时间和一切努力全白费了,学生们所掌握的概念已经烟消云散。

关键词：学生兴趣听力训练听力过程老师学习过程练习饮料应试听音概念

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Solid-State nMR Spectroscopic Approaches to Investigate Dynamics, Secondary Structure and Topology of Membrane Proteins

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Open Journal of Biophysics 2012年第4期2卷 109-116页

作者： Shadi Abu-Baker gary A. Lorigan Miami University Department of Chemistry and Biochemistry Oxford USA

Solid-state nMR spectroscopy is routinely used to determine the structural and dynamic properties of both membrane proteins and peptides in phospholipid bilayers [1-26]. From the perspective of the perpetuated lipids, 2H solid-state nMR spectroscopy can be used to probe the effect of embedded proteins on the order and dynamics of the acyl chains of phospholipid bilayers [8-13]. Moreover, 31P solid-state nMR spectroscopy can be used to investigate the interaction of peptides, proteins and drugs with phospholipid head groups [11-14]. The secondary structure of 13C = O site-specific isotopically labeled peptides or proteins inserted into lipid bilayers can be probed utilizing 13C CPMAS solid-state nMR spectroscopy [15-18]. Also, solid-state nMR spectroscopic studies can be utilized to ascertain pertinent informa- tion on the backbone and side-chain dynamics of 2H- and 15n-labeled proteins, respectively, in phospholipid bilayers [19-26]. Finally, specific 15n-labeled amide sites on a protein embedded inside oriented bilayers can be used to probe the alignment of the helices with respect to the bilayer normal [2]. A brief summary of all these solid-state nMR ap- proaches are provided in this minireview.

关键词： Solid-State nMR Structure and Dynamics Membrane Proteins

论慈善投资资产管理人的信义责任——美国的法律规则和挑战

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温州大学学报（社会科学版） 2016年第1期29卷 19-30页

作者： Susan n.gary 占荔荔周贤日美国俄勒冈大学法学院美国尤金97403 华南师范大学

受托人或其董事管理和投资由慈善机构持有的资产必须符合两个重要的信义责任:忠实责任和谨慎或注意责任。本文阐述了这两种责任,重点在于论述有关谨慎投资者问题,探讨慈善信托是否可以或应该在进行投资决策时考虑该慈善组织的任务或目... 详细信息

受托人或其董事管理和投资由慈善机构持有的资产必须符合两个重要的信义责任:忠实责任和谨慎或注意责任。本文阐述了这两种责任,重点在于论述有关谨慎投资者问题,探讨慈善信托是否可以或应该在进行投资决策时考虑该慈善组织的任务或目的的问题;在分析由受托人提供指导的投资方面的法律发展近况后,指出这些规则允许慈善机构作为谨慎的投资者考虑的众多因素中的一个,指出考虑环境、社会和治理因素也可能是谨慎的投资者作出投资决策应该做的一些事情。信托管理人也面对着涉及捐赠人限制捐赠物的问题,文章的第二部分探讨了当经过一段时间,周围情况发生了变化,限制捐赠物的用途是可以拓宽的问题。本文介绍了允许修改限制的法律规则,并指出通过在慈善机构和捐助者之间将灵活机制融入捐赠物协议的一些策略,从而可以保护捐赠人的意愿。

关键词：慈善信义谨慎附条件捐赠物

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Higher Child-Reported Internalizing and Parent-Reported Externalizing Behaviors were Associated with Decreased Quality of Life among Pediatric Cardiac Patients Independent of Diagnosis:A Cross-Sectional Mixed-Methods Assessment

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Congenital Heart Disease 2021年第3期16卷 255-267页

作者： Jacqueline S.Lee Angelica Blais Julia Jackson Bhavika J.Patel Lillian Lai gary Goldfield Renee Sananes Patricia E.Longmuir Children’s Hospital of Eastern Ontario Research Institute OttawaCanada Faculty of Health Science University of OttawaOttawaCanada Faculty of Medicine University of OttawaOttawaCanada Children’s Hospital of Eastern Ontario OttawaCanada The Hospital for Sick Children TorontoCanada

Background:Pediatric cardiology patients often experience decreased quality of life(QoL)and higher rates of mental illness,particularly with severe disease,but the relationship between them and comparisons across diagnostic groups are *** mixed-methods cross-sectional study assessed the association between QoL anxiety and behavior problems among children with structural heart disease,arrhythmia,or other cardiac ***:Children(6–14 years,n=76,50%female)and their parents completed measures of QoL(PedsQL),behavior(BASC-2,subset of 19 children)and anxiety(MASC-2,children 8+years).Pearson correlations/regression models examined associations between QoL,behavior and anxiety,controlling for age,sex,diagnosis and condition *** t-tests compared results to published normative ***-structured interviews(15 children,13 parents)examined self-and parent-reported perceptions of the patient’s emotional ***:Child reported social QoL(95%CI difference:−11.0,−2.1),emotional well-being(95%CI difference:−12.5,−3.8)and adjustment skills(95%CI difference:−13.9,−3.0)were significantly below published norms(pneither age,sex,nor diagnosis were significantly related to questionnaire *** to children with mild conditions,child and parent-reported QoL was significantly lower in children with complex conditions(np2≥0.14,pngly associated with more internalizing problems based on both child(r=−0.78,pnd parent(r=−0.67,pnses suggested emotional distress was attributed to“normal”child problems rather than the child’s cardiac ***:Children with complex cardiac conditions,regardless of diagnosis,had diminished *** the PedsQL in clinical settings may help identify pediatric cardiology patients experiencing emotional distress(i.e.,anxiety and depression).

关键词： Anxiety emotional well-being internalizing behaviors congenital heart defects arrhythmia cardiomyopathy

Handbook of Statistical Analysis and Data Mining Applications 1st ed.

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Prevalence and intensity of soil-transmitted helminth infections among school-age children in the Cagayan Valley, the Philippines

丛书名： Handbook of Statistics 29, Part B

2009年

作者： Robert nisbet John Elder gary Miner

ISBN: (数字)9780080912035

ISBN: (纸本)9780123747655

The Handbook of Statistical Analysis and Data Mining Applications is a comprehensive professional reference book that guides business analysts, scientists, engineers and researchers (both academic and industrial) through all stages of data analysis, model building and implementation. The Handbook helps one discern the technical and business problem, understand the strengths and weaknesses of modern data mining algorithms, and employ the right statistical methods for practical application. Use this book to address massive and complex datasets with novel statistical approaches and be able to objectively evaluate analyses and solutions. It has clear, intuitive explanations of the principles and tools for solving problems using modern analytic techniques, and discusses their application to real problems, in ways accessible and beneficial to practitioners across industries - from science and engineering, to medicine, academia and commerce. This handbook brings together, in a single resource, all the information a beginner will need to understand the tools and issues in data mining to build successful data mining solutions.

关键词： Data mining

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Asian Pacific Journal of Tropical Medicine 2021年第3期14卷 113-121页

作者： Ryan V.Labana Vimar A.Romero Analette M.Guinto Alvin n.Caril Kimberly D.Untalan Alejandro Jose C.Reboa Khristine L.Sandoval Kristel Joy S.Cada gary Antonio C.Lirio Iris Rowena A.Bernardo Lanieleen Jerah Mae Arocha Julieta Z.Dungca Department of Biology College of SciencePolytechnic University of the PhilippinesSta.MesaManilathe Philippines Graduate School Centro Escolar UniversityManilathe Philippines Center for Life Sciences Research Institute of Science and Technology ResearchPolytechnic University of the PhilippinesSta.MesaManilathe Philippines Department of nutrition and Dietetics College of SciencePolytechnic University of the PhilippinesSta.MesaManilathe Philippines School of Science and Technology Centro Escolar UniversityManilathe Philippines

Objective:To identify the prevalence of soil-transmitted helminthiasis(STH)among school-age children in the Cagayan Valley,the Philippines,assess their level of awareness on the disease,and determine predisposing factors of the ***:A total of 478 GradesⅢ-Ⅴschool-age children in Pamplona and Sanchez-Mira School Districts in the Cagayan Valley answered the questionnaire assessing their knowledge,attitude,and practices on STH,subjected to anthropometric measurements,and provided faecal samples for parasitologic assessment(direct smear,Kato-Katz,and formol-ether concentration techniques).Results:The participants of the study,with 55.86%females,were 8 to 14 years *** nutritional status was assessed‘normal’(84.31%),‘severely wasted’(6.49%),‘wasted’(5.23%),‘overweight’(2.72%),and‘obese’(1.26%).The prevalence of infection with at least 1 STH species was 25.99%in Pamplona and 19.40%in ***,the prevalence of heavy intensity was 7.11%for Ascaris lumbricoides and 1.67%for Trichuris *** hookworm infections had light *** majority of the school-age children had a low score in the KAP *** knowledge of STH,‘stunted growth as a symptom of infection’was associated with a lower risk of Ascaris lumbricoides infection(OR 0.448;95%CI 0.212,0.945;P=0.035)while‘playing with soil as a mode of transmission’was associated with an increased risk of Ascaris lumbricoides infection(OR 2.067;95%CI 1.014,4.212;P=0.046).In attitude towards STH,‘I think I have intestinal worm now’was associated with a higher risk of Ascaris lumbricoides infection(OR 1.681;95%CI 1.061,2.662;P=0.027).Conclusions:The prevalence rate of Ascaris lumbricoides among the school-age children in the Cagayan Valley shows the need to further intensify intervention in the area to meet the threshold set by the World Health *** identified predictors of infection,which concerns the school-age children’s knowledge and attitude toward STH,can be used in augmenting

关键词： Intestinal worms War on worms Infectious disease neglected tropical diseases

neonatal pneumothorax in congenital diaphragmatic hernia:Be wary of high ventilatory pressures

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World Journal of Pediatric Surgery 2022年第3期5卷 154-161页

作者： nathan Rubalcava Gabriella A norwitz Aimee G Kim gary Weiner niki Matusko Meghan A Arnold George B Mychaliska Erin E Perrone Pediatric Surgery University of MichiganAnn ArborMichiganUSA Section of neonatology Department of PediatricsUniversity of MichiganAnn ArborMichiganUSA Department of Surgery University of MichiganAnn ArborMichiganUSA

Background Patients with congenital diaphragmatic hernia(CDH)require invasive respiratory support and higher ventilator pressures may be associated with *** sought to evaluate the risk factors associated with pneumothorax in CDH neonates prior to *** Weretrospectivelyreviewednewborns born withCDHbetween 2014and 2019who developeda pneumothorax,and we matched these cases to patients with CDH without *** Twenty-sixpatientswere included(n=13per group).The pneumothorax group required extracorporeal life support(ECLS)more frequently(85%vs 54%,p=0.04),particularly among type A/B defects(31%vs 7%,p=0.01).The pneumothorax group had higher positive end-expiratory pressure(PEEP)within 1 hour of birth(p=0.02),at pneumothorax diagnosis(p=0.003),and at ECLS(p=0.02).The pneumothorax group had a higher mean airway pressure(Paw)at birth(p=0.01),within 1 hour of birth(p=0.01),and at pneumothorax diagnosis(p=0.04).Using multiple logistic regression with cluster robust SEs,higher Paw(OR 2.2,95%Cl 1.08 to 3.72,p=0.03)and PEEP(OR 1.8,95%CI 1.15 to 3.14,p=0.007)were associated with an increased risk of developing *** was no difference in survival(p=0.09).Conclusions Development of a pneumothorax in CDH neonates is independently associated with higher Paw and higher PEEP.A pneumothorax increases the likelihood of treated with ECLS,even with smaller defect.

关键词： PEEP pneumothorax diagnosis