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Hybrid coronary revascularization vs. percutaneous coronary interventions for multivessel coronary artery disease

Journal of Geriatric Cardiology 2021年第3期18卷 159-167页

作者： Edward L.Hannan Yi-Feng WU Kimberly Cozzens Jacqueline Tamis-Holland Frederick S.K.Ling Alice K.Jacobs Ferdinand J.Venditti Peter B.Berger gary Walford Spencer B.kingⅢ University at Albany State University of New YorkAlbanyNYUSA Mount Sinai St.Luke’s Hospital New YorkNYUSA University of Rochester Medical Center RochesterNYUSA Boston Medical Center BostonMAUSA Albany Medical Center AlbanyNYUSA Unaffiliated Johns Hopkins Medical Center Emory Health System AtlantaGAUSA

OBJECTIVE Hybrid coronary revascularization(HCR)combines a minimally invasive surgical approach to the left anterior descending(LAD)artery with percutaneous coronary intervention(PCI)for non-LAD diseased coronary *** is associated with shorter hospital lengths of stay and recovery times than conventional coronary artery bypass surgery,but there is little information comparing it to isolated PCI for multivessel *** objective is to compare long-term outcomes of HCR and PCI for patients with multivessel *** This cohort study used data from New York’s cardiac surgery and PCI registries in 2010−2016 to examine mortality and repeat revascularization rates for patients with multivessel coronary artery disease who underwent HCR and *** proportional hazards methods were used to reduce selection *** were followed for a median of four *** There was a total of 335 HCR patients(1.2%)and 25,557 PCI patients(98.8%)after *** was no difference in 6-year risk adjusted survival between HCR and PCI patients 83.17%vs.81.65%,adjusted hazard ratio(aHR)=0.90(95%CI:0.67−1.20).However,HCR patients were more likely to be free from repeat revascularization in the LAD artery(91.13%vs.83.59%,aHR=0.51(95%CI:0.34−0.77)).CONCLUSIONS For patients with multi-vessel coronary artery disease,HCR is rarely *** are no differences in mortality rates after four years,but HCR is associated with lower repeat revascularization rates in the LAD artery,presumably due to better longevity in left arterial mammary grafts.

关键词： coronary revascularization mortality

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Nitric oxide: promoter or suppressor of programmed cell death?

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Protein & Cell 2010年第2期1卷 133-142页

作者： Yiqin Wang Chen Chen gary J.Loake Chengcai Chu National Key Laboratory of Plant Genomics and National Centre for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Beijing Forestry University Beijing 100083China Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghKing’s BuildingsEdinburgh EH93JRUnited Kingdom

Nitric oxide(NO)is a short-lived gaseous free radical that predominantly functions as a messenger and effector *** affects a variety of physiological processes,including programmed cell death(PCD)through cyclic guanosine monophosphate(cGMP)-dependent and-independent *** this field,dominant discoveries are the diverse apoptosis networks in mammalian cells,which involve signals primarily via death receptors(extrinsic pathway)or the mitochondria(intrinsic pathway)that recruit caspases as effector *** plants,PCD shares some similarities with animal cells,but NO is involved in PCD induction via interacting with pathways of *** has both promoting and suppressing effects on cell death,depending on a variety of factors,such as cell type,cellular redox status,and the flux and dose of local *** this article,we focus on how NO regulates the apoptotic signal cascade through protein S-nitrosylation and review the recent progress on mechanisms of PCD in both mammalian and plant cells.

关键词： nitric oxide S-nitrosylation programmed cell death

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Structural insights of mechanically induced aluminum-doped hydroxyapatite nanoparticles by Rietveld refinement

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Chinese Journal of Chemical Engineering 2017年第2期25卷 238-247页

作者： Abbas Fahami Bahman Nasiri-Tabrizi gary W. Beall Wan Jefrey Basirun Materials Science Engineering and Commercialization Program Texas State University San Marcos 78666 TX USA Advanced Materials Research Center Materials Engineering Department Najafabad Branch Islamic Azad University Najafabad lsfahan lran Department of Chemistry and Biochemistry Texas State University San Marcos 78666 TX USA Physics Department Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia Department of Chemistry Faculty of Science University of Malaya150603 Kuala Lumpur Malaysia

Aluminum doped hydroxyapatite （HA：AI3 ＋） nanopowders were successfully prepared via a simple and efficient one-pot mechanochemical route. The effects of dopant loading on phase compositions and structural features were assessed by Rietveld analysis. The XRD-Rietveld refinement revealed the stabilization of HA in hexagonal structure for all the samples. The sharpness and intensity of the apatite-derived XRD peaks decreased as the dopant content increased to 10% due to the increase in lattice imperfections and mechanically induced amorphization. The incorpo- ration of A13 ＋ into the HA lattice decreased the unit cell parameters. From the FfiR measurements, the representing bands of apatite were identified in all cases. The mechanosynthesized nanopowders consisted of nanospheroids with an average size of 44 - 20 nm and therefore are promising for bone tissue regeneration.

关键词： SynthesisIon exchangeMechanochemicalRietveld refinement

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A meta-analysis of soluble suppression of tumorigenicity 2 （sST2） and clinical outcomes in pulmonary hypertension

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Journal of Geriatric Cardiology 2017年第12期14卷 766-771页

作者： king Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui gary Tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li Ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Department of Cardiology Qilu Hospital Shandong University Jinan China Research Center of Ion Channelopathy Institute of Cardiology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan China JC School of Public Health and Primary Care The Chinese University ofHong Kong Hong Kong China State Key Laboratory of Digestive Disease LKS Institute of Health Sciences Chinese University ofHong Kong Hong Kong China

Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.

关键词： Mortality Poor outcomes Pulmonary hypertension Soluble suppression of tumorigenicity 2 SST2

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Imaging assessment after SBRT for hepatocellular carcinoma

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Hepatoma Research 2020年第7期6卷 78-85页

作者： Connie Yip Tiffany Priyanthi Hennedige gary JRCook Vicky Goh Radiation Oncology National Cancer Centre SingaporeSingapore 169610Singapore Oncologic Imaging National Cancer Centre SingaporeSingapore 169610Singapore Cancer Imaging King’s College LondonLondon WC2R 2LSUnited Kingdom

The use of stereotactic body radiotherapy(SBRT)in hepatocellular carcinoma(HCC)has increased over the past few ***,accurate evaluation of post-SBRT treatment response is essential to avoid over-treatment of responders as well as missing the opportunity to salvage *** are some intricate imaging differences after liver SBRT compared to those observed after conventional fractionated radiotherapy and other locoregional *** aim to review the imaging changes that occur following SBRT for HCC and their potential clinical implications.

关键词： Imaging liver stereotactic body radiotherapy hepatocellular carcinoma

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Making rainfed agriculture sustainable through environmental friendly technologies in Pakistan:A review

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International Soil and Water Conservation Research 2013年第2期1卷 36-52页

作者： Mirza B.Baig Shabbir A.Shahid gary S.Straquadine Department of Agricultural Extension and Rural Society College of Food and Agricultural SciencesKing Saud UniversityKingdom of Saudi Arabia International Centre for Biosaline Agriculture DubaiUnited Arab Emirates Ohio State University ColumbusOHUSA 43210

Pakistan is an agricultural country spreading over an area of about 79.6 million hectares(Mha)with an arid and semi arid *** 79.6 Mha,about 23 Mha is suitable for crop production and nearly 25 percent of the total cultivated area is designated for rainfed ***,rain-fed agriculture is constrained with multifarious problems such as moisture stress,soil erosion and crusting,nutrient deficiency,depletion and poor nutrient use efficiency,and weed infestation limiting the yield potential of these *** addition,deforestation and poor crop husbandry techniques are commonly noticed *** meet the food requirements,farmers bring all the available pieces of lands under plough including steep *** on steep slopes if not managed on scientific lines,results in severe *** problems faced by the farmers are due to the unsustainable practices they adopt to practice dryland agriculture,limiting the productive potential of these important ***,their potential can be improved by adopting suitable rainwater harvesting techniques;employing scientific soil and water conservation methods and using sustainable agricultural *** paper highlights some important issues associated with the rainfed agriculture of *** strategies for realizing optimum and sustainable yields have been outlined while conserving both land and water resources.

关键词： Arid agriculture Sustainable technologies Rainwater harvesting Agronomic practices Extension Education

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商王朝恐怖主义策略起源与兴衰背景——同中美洲阿兹特克帝国恐怖主义策略比较分析

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江汉考古 2005年第1期 55-59,41页

作者：何驽 gary W.Pahl 中国社会科学院考古研究所北京100027

文章分析了商王朝恐怖主义策略在商代政治领域的兴衰及背景,结合同中美洲阿兹特克帝国恐怖主义策略及其历史背景的对比观察,认识到恐怖主义在国策中作用的兴衰,同有关统治者的统治自信心强弱程度以及周围政治环境对他压力的大小息息相... 详细信息

文章分析了商王朝恐怖主义策略在商代政治领域的兴衰及背景,结合同中美洲阿兹特克帝国恐怖主义策略及其历史背景的对比观察,认识到恐怖主义在国策中作用的兴衰,同有关统治者的统治自信心强弱程度以及周围政治环境对他压力的大小息息相关。当一个原本弱小的文化在短期内拥有和控制广大疆域和众多民族的国家时,恐怖主义策略是常被采用的统治方法之一。

关键词：恐怖主义文化背景商朝阿兹特克

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Electrospinning nanofiber scaffolds for soft and hard tissue regeneration

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Journal of Materials Science & Technology 2020年第24期59卷 243-261页

作者： Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz gary L.Bowlin Mohamed El-Newehy Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Biomedical Engineering University of MemphisMemphisTN38152USA

Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and *** three fundamental pillars of tissue engineering are scaffolds,cells,and *** nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected *** this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue *** first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial ***,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament ***,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas.

关键词： Nanofibers Electrospinning Tissue engineering Regeneration Biomedical application

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早期乳腺癌最佳辅助化疗方案与人类表皮生长因子受体2阳性乳腺癌辅助靶向治疗选择：依据 ASCO 对 CCO临床实践指南的改编

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中国全科医学 2016年第18期19卷 2113-2114页

作者： Neelima Denduluri Mark R Somerfield Andrea Eisen Jamie N Holloway Arti Hurria Tari A king gary H Lyman Ann H Partridge Melinda L Telli Maureen E Trudeau Antonio C Wolff 本刊编辑部 US Oncology Network Virginia Cancer Specialists American Society of Clinical Oncology Sunnybrook Health Sciences Centre and Cancer Care Ontario City of Hope Dana-Farber/Brigham and Women' s Cancer Center Fred Hutchinson Cancer Research Center Dana-Farber Cancer Institute Stanford University The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO... 详细信息

目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO临床实践指南的严谨性与内容适用性进行回顾。结果基于对CCO临床实践指南内容的回顾,ASCO小组认为,CCO临床实践指南在整体上清晰全面,以最确切的科学证据为基础,为患者提供可接受的治疗选项。推荐关于辅助化疗方案的决定,应考虑到基线复发风险、毒性、利益可能性和宿主因素(如合并症)。对于高风险HER2阴性的身体状况良好的人群,蒽环类和紫杉烷治疗方案是标准治疗方案。4个周期的多西他赛和环磷酰胺治疗方案是可接受的非蒽环类治疗方案。对于高风险HER2阳性患者,推荐蒽环类与紫杉烷序贯疗法联合曲妥单抗或多西他赛、卡铂、曲妥单抗进行6个周期的治疗。对于低风险、非淋巴结转移、HER2阳性人群,推荐每周一次的紫杉醇和曲妥单抗连续进行12个周期的替代治疗。曲妥单抗应持续使用1年。不应采用铂复合盐对三阴性人群进行常规的辅助管理,除非出现有效的生存数据加以支持。

关键词：乳腺肿瘤抗肿瘤联合化疗方案受体,表皮生长因子指南

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[货架]合理利用货架改善配送效率

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现代制造 2010年第5期 44-45页

作者： Lorie king Rogers

对货架等基本物流设备的合理利用可以对配送中心的操作过程和效率产生有利影响。毫无疑问,对货架的革新是非常罕见的。Unarco MaterialHandling公司兼货架制造业协会(RMI)总裁gary Slater认为,货架行业发展较为成熟,几乎没有机会进行革... 详细信息

对货架等基本物流设备的合理利用可以对配送中心的操作过程和效率产生有利影响。毫无疑问,对货架的革新是非常罕见的。Unarco MaterialHandling公司兼货架制造业协会(RMI)总裁gary Slater认为,货架行业发展较为成熟,几乎没有机会进行革命性的技术创新和突破。而且。

关键词：配送中心高货架合理利用有利影响解决方案仓库技术创新操作过程制造业行业发展

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