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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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当代医学科学（英文） 2024年第4期44卷 741-747页

作者： Su-guo WANG Yong-gang WANG Guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN gao-zhong huang Hong-tao LI Department of General Medicine Shenzhen Third People's Hospital Shenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Department of VIP Clinic Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Objective:To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant ***:After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage Ⅱ disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein Al,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant ***:The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16％,38％,and 20％,respectively,*** values;P＜0.01).The mean levels of LDL-C and ApoE were also 19％and 16％higher,respectively(P＜0.05).No correlation was found between the pretreatment lipid profile and the histologic response to *** increase in Lp(a)was strongly correlated with the Ki-67 index(R=0.31,P=0.023).Moreover,a trend toward longer disease-free survival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion:Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： neoadjuvant chemotherapy osteosarcoma serum lipids

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High-temperature wetting behavior between slag and refractory

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Journal of Iron and Steel Research International 2024年第6期31卷 1304-1319页

作者： Yong-xin Wang Ya-ge Li Ya-bo gao zhong huang Hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Slag corrosion is one of the main factors of the damage of refractory,and its primary manifestations involve the melting of refractory in slag and the slag penetration into refractory,both of which are highly related to the wetting behavior between slag and *** high-temperature wettability could be characterized by parameters including the surface tension,adhesion work,and spreading coefficient of the slag on refractory surface,and it could be suppressed by altering the slag/refractory interface,thus resulting in an improved anti-corrosion *** this,the key knowledges of the slag corrosion,theory of wetting behavior and test of high-temperature contact angle were firstly ***,the major factors influencing the high-temperature slag wetting behavior were discussed based on the aspects of slag composition,refractory composition,and surface ***,the future research direction was proposed in this field.

关键词： High-temperature wetting Refractory Slag corrosion Surface tension

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APFA:Ameliorated Pathfinder Algorithm for Engineering Applications

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Journal of Bionic Engineering 2024年第3期21卷 1592-1616页

作者： Keyu zhong Fen Xiao Xieping gao Key Laboratory of Computing and Stochastic Mathematics of Ministry of Education Hunan Normal UniversityChangsha410081China School of Mathematics and Statistics Hunan Normal UniversityChangsha410081China School of Computer Science Xiangtan UniversityXiangtan411105China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha410081China

Pathfinder algorithm(PFA)is a swarm intelligent optimization algorithm inspired by the collective activity behavior of swarm animals,imitating the leader in the population to guide followers in finding the best food *** algorithm has the characteristics of a simple structure and high ***,PFA faces challenges such as insufficient population diversity and susceptibility to local optima due to its inability to effectively balance the exploration and exploitation *** paper proposes an Ameliorated Pathfinder Algorithm called APFA to solve complex engineering optimization ***,a guidance mechanism based on multiple elite individuals is presented to enhance the global search capability of the ***,to improve the exploration efficiency of the algorithm,the Logistic chaos mapping is introduced to help the algorithm find more high-quality potential solutions while avoiding the worst ***,a comprehensive following strategy is designed to avoid the algorithm falling into local optima and further improve the convergence *** three strategies achieve an effective balance between exploration and exploitation overall,thus improving the optimization performance of the *** performance evaluation,APFA is validated by the CEC2022 benchmark test set and five engineering optimization problems,and compared with the state-of-the-art metaheuristic *** numerical experimental results demonstrated the superiority of APFA.

关键词： Pathfinder algorithm Swarm intelligent Metaheuristic Engineering problems

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An Efficient Multi-objective Approach Based on Golden Jackal Search for Dynamic Economic Emission Dispatch

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Journal of Bionic Engineering 2024年第3期21卷 1541-1566页

Dynamic Economic Emission Dispatch(DEED)aims to optimize control over fuel cost and pollution emission,two conflicting objectives,by scheduling the output power of various units at specific *** many methods well-performed on the DEED problem,most of them fail to achieve expected results in practice due to a lack of effective trade-off mechanisms between the convergence and diversity of non-dominated optimal dispatching *** address this issue,a new multi-objective solver called Multi-Objective Golden Jackal Optimization(MOGJO)algorithm is proposed to cope with the DEED *** proposed algorithm first stores non-dominated optimal solutions found so far into an ***,it chooses the best dispatching solution from the archive as the leader through a selection mechanism designed based on elite selection strategy and Euclidean distance index *** mechanism can guide the algorithm to search for better dispatching solutions in the direction of reducing fuel costs and pollutant ***,the basic golden jackal optimization algorithm has the drawback of insufficient search,which hinders its ability to effectively discover more Pareto *** this end,a non-linear control parameter based on the cosine function is introduced to enhance global exploration of the dispatching space,thus improving the efficiency of finding the optimal dispatching *** proposed MOGJO is evaluated on the latest CEC benchmark test functions,and its superiority over the state-of-the-art multi-objective optimizers is highlighted by performance ***,empirical results on 5-unit,10-unit,IEEE 30-bus,and 30-unit systems show that the MOGJO can provide competitive compromise scheduling solutions compared to published DEED ***,in the analysis of the Pareto dominance relationship and the Euclidean distance index,the optimal dispatching solutions provided by MOGJO are the closest to the ideal solutions for minimizing fuel costs

关键词： Dynamic economic emission dispatch Multi-objective optimization Golden jackal Euclidean distance index

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Simulation of gas-solid flow characteristics of the circulating fluidized bed boiler under pure-oxygen combustion conditions

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Chinese Journal of Chemical Engineering 2024年第6期70卷 9-19页

作者： Kaixuan gao Xiwei Ke Bingjun Du Zhenchuan Wang Yan Jin zhong huang Yanhong Li Xuemin Liu Key Laboratory of Special Equipment Safety and Energy-Saving for State Market Regulation China Special Equipment Inspection&Research InstituteBeijing 100029China Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China School of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China

Under the pressure of carbon neutrality,many carbon capture,utilization and storage technologies have witnessed rapid development in the recent years,including oxy-fuel combustion(OFC)***,the conventional OFC technology usually depends on the flue gas recirculation system,which faces significant investment,high energy consumption,and potential low-temperature corrosion *** these deficiencies,the direct utilization of pure oxygen to achieve particle fluidization and fuel combustion may reduce the overall energy consumption and CO_(2)-capture *** this paper,the fundamental structure of a self-designed 130 t·h^(-1) pure-oxygen combustion circulating fluidized bed(CFB)boiler was provided,and the computational particle fluid dynamics method was used to analyze the gas-solid flow characteristics of this new-concept boiler under different working *** results indicate that through the careful selection of design or operational parameters,such as average bed-material size and fluidization velocity,the pure-oxygen combustion CFB system can maintain the ideal fluidization state,namely significant internal and external particle ***,the contraction section of the boiler leads to the particle backflow in the lower furnace,resulting in the particle suspension concentration near the wall region being higher than that in the center ***,the upper furnace still retains the classic core-annulus flow *** addition to increasing solid circulation rate by reducing the average bed-material size,altering primary gas ratio and bed inventory can also exert varying degrees of influence on the gas-solid flow characteristics of the pure-oxygen combustion CFB boiler.

关键词： Circulating fluidized bed Pure-oxygen combustion Gas-solid flow characteristics Simulation CO_(2)capture

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New Results in Cooperative Adaptive Optimal Output Regulation

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Journal of Systems Science & Complexity 2024年第1期37卷 253-272页

作者： DONG Yuchen gao Weinan JIANG zhong-Ping State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China Department of Electrical and Computer Engineering Tandon School of EngineeringNew York UniversityBrooklynNY 11201USA

This paper investigates the cooperative adaptive optimal output regulation problem of continuous-time linear multi-agent *** the multi-agent system dynamics are uncertain,solving regulator equations and the corresponding algebraic Riccati equations is challenging,especially for high-order *** this paper,a novel method is proposed to approximate the solution of regulator equations,i.e.,gradient descent *** is worth noting that this method obtains gradients through online data rather than model information.A data-driven distributed adaptive suboptimal controller is developed by adaptive dynamic programming,so that each follower can achieve asymptotic tracking and disturbance ***,the effectiveness of the proposed control method is validated by simulations.

关键词： Adaptive dynamic programming cooperative output regulation gradient descent method multi-agent systems.

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Analytical Solution for the Reissner-Sagoci Problem of a Piezoelectric Half-Space

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Acta Mechanica Solida Sinica 2024年第3期37卷 363-370页

作者： Keqiang Hu Cun-Fa gao Zengtao Chen Zheng zhong State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Department of Mechanical Engineering University of AlbertaEdmontonABT6G 1H9Canada School of Science Harbin Institute of TechnologyShenzhen518055China

In this paper,a transversely isotropic piezoelectric half-space with the isotropy axis parallel to the z-axis is considered under rotation on a rigid circular disk bonded to the surface of the piezoelectric *** is a type of Reissner-Sagoci mixed boundary value *** utilizing the Hankel transform,the mixed boundary value problem is simplified into solving a pair of dual integral ***-field analytical expressions for displacement,stresses,and electric displacement inside the half-space are *** shear stresses and electric displacement on the surface are found to be singular at the edge of the rigid circular disk,and the stress intensity factors and electric displacement intensity factor are *** results show that material properties and geometric size have significant effects on displacement,shear stresses,and electric displacement.

关键词： Piezoelectric half-space Circular disk Reissner-Sagoci problem Stress intensity factor Electric displacement intensity factor

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Dendritic Learning and Miss Region Detection-Based Deep Network for Multi-scale Medical Segmentation

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Journal of Bionic Engineering 2024年第4期21卷 2073-2085页

作者： Lin zhong Zhipeng Liu Houtian He Zhenyu Lei Shangce gao Faculty of Engineering University of ToyamaToyama9300887Japan

Automatic identification and segmentation of lesions in medical images has become a focus area for *** for medical image provides professionals with a clearer and more detailed view by accurately identifying and isolating specific tissues,organs,or lesions from complex medical images,which is crucial for early diagnosis of diseases,treatment planning,and efficacy *** paper introduces a deep network based on dendritic learning and missing region detection(DMNet),a new approach to medical image *** combines a dendritic neuron model(DNM)with an improved SegNet framework to improve segmentation accuracy,especially in challenging tasks such as breast lesion and COVID-19 CT scan *** work provides a new approach to medical image segmentation and confirms its *** have demonstrated that DMNet outperforms classic and latest methods in various performance metrics,proving its effectiveness and stability in medical image segmentation tasks.

关键词： Medical image segmentation Dendritic learning Deep supervision Dynamic focal loss

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A simple photochemical method for surface fluorination using perfluoroketones

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Chinese Chemical Letters 2024年第5期35卷 254-258页

作者： Zhiwei zhong Yanbin huang Wantai Yang Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Surface fluorination of conventional polymers can give them desirable surface properties similar to the expensive and difficult-to-process ***,traditional surface fluorination techniques often require toxic reagents and special ***,we report a simple and effective polymer surface fluorination method by using safe and inexpensive perfluoro-2-methyl-3-pentanone(PFMP,C_(2)F_(5)C(=O)CF(CF_(3))_(2))and UV *** method is applicable to various polymer materials,and generates nanometer-thick fluorinated layer on the outermost surface,significantly changing their surface properties without changing the surface morphology.

关键词： Surface fluorination Perfluoroketone UV irradiation Photochemistry Surface free energy

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Hole cleaning evaluation and installation spacing optimization of cuttings bed remover in extended-reach drilling

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Petroleum Science 2024年第3期21卷 2005-2022页

作者： Shuo Peng Wen-Jun huang De-Li gao MOE Key Laboratory of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing102249China

In extended-reach or long-horizontal drilling,cuttings usually deposit at the bottom of the *** cuttings accumulate to a certain thickness,complex problems such as excessive torque and drag,tubing buckling,and pipe stuck probably occur,which results in a lot of non-productive time and remedial *** bed remover can efficiently destroy deposited cuttings in time through hydraulic and mechanical stirring *** paper aims to build a method for hole cleaning evaluation and installation spacing optimization of cuttings bed remover to improve the wellbore cleaning ***,a Computational Fluid Dynamics approach with Eulerian—Eulerian multiphase model was utilized to investigate the mechanism of cuttings transportation,and a new type of cuttings bed remover was ***,an evaluation method of hole cleaning effect of remover was *** that,the effects of several drilling parameters on hole cleaning including flow rate of drilling fluid,rotational speed of drillpipe,rate of penetration,wellbore size,rheological property of drilling fluid,and remover eccentricity on the performance of cuttings bed remover were *** results demonstrate that the new type of remover with streamline blade performs better than conventional *** efficiency of hole cleaning is greatly improved by increasing the rotational speed of drillpipe,flow rate of drilling fluid,remover eccentricity,and 6 rpm Fann dial reading for drilling *** higher rate of penetration and large wellbore size result in worse hole *** findings can serve as an important guide for the structure optimization design of cuttings bed remover and installation spacing of removers.

关键词： Extended-reach drlling Drilling hydraulics Cuttings transport Hole cleaning Cuttings bed remover

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