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The exact theory of plane problems for piezoelectric media

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The exact theory of plane problems for piezoelectric media

Genetic variation in a heat shock transcription factor modulates cold tolerance in maize

201.年全国压电和声波理论及器件应用研讨会

作者： yang {1.~(1.*) Bao-Sheng ZHAO~2 1.college of science,china agricultural university,P.O.Box 74,beijing 100083 2 School of Mechanical Engineering,university of science and Technology Liaoning,Anshan 1.4044

＜正＞Without employing ad hoc assumptions,various equations and solutions for plane problems of piezoelectric media are deduced systematically.A method for the exact solution of three-dimensional equations is present... 详细信息

关键词： plane problems plate theory piezoelectric the exact theory

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Molecular Plant 2024年第9期17卷 1423-1438页

作者： Lei gao Lingling Pan Yiting Shi Rong Zeng Minze Li Zhuo{1. Li Xuan Zhang Xiaoming Zhao Xinru Gong Wei Huang Xiaohong {1. Jinsheng Lai Jianru Zuo Zhizhong Gong Xiqing wang Weiwei Jin Zhaobin Dong Shuhua {1. State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingDepartment of Plant Geneticsand BreedingChinaAgricultural UniversityBeijingChina State Key Laboratory of Plant Genomics and National Plant Gene Research Center Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China

Understanding how maize(Zea mays)responds to cold stress is crucial for facilitating breeding programs of cold-tolerant *** extensive utilization of the genome-wide association study(GWAs)approach for exploring favorable natural alleles associated with maize cold tolerance,few studies have successfully identified candidate genes that contribute to maize cold *** this study,we used a diverse panel of inbred maize lines collected from different germplasm sources to perform a GWAS on var-iations in the relative injured area of maize true leaves during cold stress-a trait very closely correlated with maize cold *** identified HsF21.which encodes a B-class heat shock transcription factor(HSF)that positively regulates cold tolerance at both the seedling and germination *** varia-tions in the promoter of the cold-tolerant HSF21.ap1.allele led to increased HSF21.expression under cold stress by inhibiting binding of the basic leucine zipper bziP68 transcription factor,a negative regulator of cold *** integrating transcriptome deep sequencing,DNA affinity purification sequencing,and targeted lipidomic analysis,we revealed the function of HsF21.in regulating lipid metabolism homeo-stasis to modulate cold tolerance in *** addition,we found that HsF21.confers maize cold tolerance without incurring yield ***,this study establishes HsF21.as a key regulator that en-hances cold tolerance in maize,providing valuable genetic resources for breeding of cold-tolerant maize varieties.

关键词： heat shock factor HSF21 cold tolerance natural variation bZiP68 lipid metabolism maize

Single nucleotide polymorphisms in chicken lmbr1.gene were associated with chicken growth and carcass traits

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science{1.(Life sciences) 2007年第1期50卷 62-69页

作者： HUANG YanQun1.2,3, DU XiaoHui2, DENG XueMei4, QIU XiangPin2, wang ChunKao4, CHEN Wen3, LI Ning1.& WU ChangXin4 1.State Key Laboratory for Agrobiotechnology,{1., beijing 1.0094, china 2 college of Animal science, Sichuan agricultural university, Ya’an 62501., china 3 college of Animal Husbandry and Veterinary, Henan agricultural university, Zhengzhou 450002, china 4 college of Animal science and Technology,{1., beijing 1.0094, china State Key Laboratory for Agrobiotechnology China Agricultural University Beijing 100094 China college of Animal {1. Sichuan Agricultural University Ya'an 625014 China college of Animal Husbandry and Veterinary Henan Agricultural University Zhengzhou 450002 China college of Animal {1. Sichuan Agricultural University Ya'an 625014 China college of Animal {1. and Technology China Agricultural University Beijing 100094 China college of Animal Husbandry and Veterinary Henan Agricultural University Zhengzhou 450002 China State Key Laboratory for Agrobiotechnology China Agricultural University Beijing 100094 China

Lmbr1.is the key candidate gene controlling vertebrate limb development, but its effects on animal growth and carcass traits have never been reported. In this experiment, lmbr1.was taken as the candi-date gene affecting chicken growth and carcass traits. T/C and G/A mutations located in exon 1. and one A/C mutation located in intron 5 of chicken lmbr1.were detected from Silky, White Plymouth Rock broilers and their F2 crossing chickens by PCR-SSCP and sequencing methods. The analysis of vari-ance (ANOVA) results suggests that T/C polymorphism of exon 1. had significant association with eviscerated yield rate (EYR), gizzard rate (GR), shank and claw rate (SCR) and shank girth (SG); A/C polymorphism of intron 5 was significantly associated with SCR, liver rate and head-neck weight (HNW), while both sites had no significant association with other growth and carcass traits. These results demonstrate that lmbr1.gene could be a genetic locus or linked to a major gene significantly affecting these growth and carcass traits in chicken.

关键词： chicken lmbr1 SNPs shank and claw rate carcass traits

Pathogen-induced methylglyoxal negatively regulates rice bacterial blight resistance by inhibiting OsCDR1.protease activity

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Molecular Plant 2024年第2期17卷 325-341页

作者： Zheng-Wei Fu Jian-Hui Li Xiang gao Shi-Jia {1. Ting-Ting Yuan Ying-Tang Lu State Key Laboratory of Hybrid Rice College of Life SciencesRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Key Laboratory of Biology and Genetic Improvement of OilCrops Ministry of Agriculture and Rural AffairsOilCrops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Xanthomonas oryzae ***(Xoo)causes bacterial blight(BB),a globally devastating disease of rice(Oryza sativa)that is responsible for significant crop *** and sugar metabolites are important for pathogen infection,providing energy and regulating events associated with defense responses;howev-er,the mechanisms by which they regulate such events in BB are *** an inevitable sugar metabolite,methylglyoxal(MG)is involved in plant growth and responses to various abiotic stresses,but the underlying mechanisms remain *** and how MG functions in plant biotic stress responses is almost completely ***,we report that the Xoo strain PXO99 induces OsWRKY62.1.to repress transcrip-tion of OsGLY Il genes by directly binding to their promoters,resulting in overaccumulation of *** negatively regulates rice resistance against Pxo99:osglyll2 mutants with higher MG levels are more sus-ceptible to the pathogen,whereas OsGLYIl2-overexpressing plants with lower MG content show greater resistance than the wild *** of OsGLYll2 to prevent excessive MG accumulation confers broad-spectrum resistance against the biotrophic bacterial pathogens Xoo and Xanthomonas oryzae *** and the necrotrophic fungal pathogen Rhizoctonia solani,which causes rice sheath *** evidence shows that MG reduces rice resistance against PXO99 through CONSTITUTIVE DISEASE RESISTANCE 1.OsCDR1..MGmodifies the Arg97 residue of OsCDR1.o inhibit its aspartic protease activ-ity,which is essential for OsCDR1.enhanced *** together,these findings illustrate how Xoo promotes infection by hijacking a sugar metabolite in the host plant.

关键词： Oryza sativa bacterial blight OsWRKY62.1 methylglyoxal OsCDR1

Efficient inhibition of SARS-CoV-2 emerging EG.5,EG.5.1.and BA.2.86 variants by fusion inhibitor HY3000 peptide

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hLife 2024年第1期2卷 43-46页

作者： Lili Wu Anqi Zheng yangming Tang Xiaoyun {1. Yue gao Wenwen Lei Guizhen Wu Qihui {1. George Fu gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina university of the Chinese Academy of {1.s BeijingChina Hybio Pharmaceutical Co. Ltd.GuangdongChina college of Life {1. Hebei UniversityHebeiChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and ***,the Omicron EG.5 linage,which was first detected in Indonesia on 1. February 2023,has raised concerns due to its increased prevalence and extended immune escape properties,according to the risk analysis by the World Health Organization(WHO)[1..As of 3 October 2023,EG.5 and its sub-linages have been reported in 83 countries with shared 49,008 genome sequences in GISAID database(https://***/hcov1.-variants/).EG.5 has become the dominant strain in the United States according to Centers for Disease Control and Prevention(CDC),accounting for 29.4%of SARS-CoV-2 infections(https://***/covid-data-tracker/#variant-proportions).

关键词： acute respiratory variants

SARS-CoV-2 ORF1. hijacking ubiquitination machinery reveals potential unique drug targeting sites

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4164-4173页

作者： Kaixiang Zhu Lili Song Linyue wang Lei Hua Ziyu Luo Tongyun wang Bo Qin Shuofeng Yuan Xiaopan gao Wenyi Mi Sheng Cui NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical college) Ministry of EducationBeijing 100730China The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Tianjin Medical University General HospitalDepartment of ImmunologyTianjin Medical UniversityTianjin 300070China Medical School Yan’an UniversityShaanxi ProvinceYan’an 716000China State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina Department of Microbiology Li Ka ShingFaculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina

Viruses often manipulate ubiquitination pathways to facilitate their replication and ***2ZYG1.B known as the substrate receptor of cullin-2 RING E3 ligase,is bound by SARS-CoV-2 ORF1. to increase its E3 ligase activity,leading to degradation of IFT46,a protein component of the intraflagellar transport(IFT)complex *** results in dysfunctional cilia,which explains certain symptoms that are specific to ***,the precise molecular mechanism of how ORF1. recognizes CUL2ZYG1.B remains ***,we determined the crystal structure of CUL2ZYG1.B complexed with the N-terminal extension(NTE)of SARS-CoV-2 ORF1.(2.9 A°).The structure reveals that the ORF1. N-terminal heptapeptide(NTH)mimics the Gly/N-degron to bind *** studies identified key residues within ORF1. that are key players in its interaction with CUL2ZYG1.B both in ITC assay and in vivo *** addition,we prove that enhancement of CUL2ZYG1.B activity for IFT46 degradation by which ORF1.-mediated correlates with the binding affinity between ORF1. and ***,we used a Global Protein Stability system to show that the NTH of ORF1. mimics the Gly/N-degron motif,thereby binding competitively to CUL2ZYG1.B and inhibiting the degradation of target substrates bearing the Gly/N-degron ***,this study sheds light on how SARS-CoV-2 ORF1. exploits the ubiquitination machinery for proteasomal degradation,and offers valuable insights for optimizing PROTAC-based drug design based on NTH CUL2ZYG1.B interaction,while pinpointing a promising target for the development of treatments for COVID-1..

关键词： SARS-CoV-2 ORF1. Crystal structure cullin-2 RING E3 ligase Drug design

Enzymatic properties and identification of a fibrinolytic serine protease purified from Bacillus subtilis DC33

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Enzymatic properties and identification of a fibrinolytic se...

Inhomogeneity problem with a sliding interface under remote shearing stress

中国食品科学技术学会第五届年会暨第四届东西方食品业高层论坛

作者： Chengtao wang~(1,2) Baoping Ji~(2*) Yanping Cao~1 Baoguo Sun~1 Xudong Li~3 (1.The college of Chemistry and Environment Engineering,beijing Technology and Business university,beijing 100037.china 2.college of Food science and Nutritional Engineering,china agricultural university,beijing 100083,china 3.Laizhou Entry-exit Inspection and Quarantine Bureau)

A novel fibrinolytic enzyme subtilisin FS33 was purified from Bacillus subtilis DC33, isolated from a traditional flavour-rich food in *** purified subtilisin FS33 was a single chain protein with *** of 30 kDa measured by *** activated SDS-PAGE,the enzyme band exhibited strong fibrinolytic activity on the fibrin *** FS33 was stable at below 60℃ over a wide range ofpH 5-1.,with a maximum activity at pH 8.0,but the activity completely disappeared at＞65℃ for 1. *** NH-terminal amino acid sequence of the enzyme was different from that of other known fibrinolytic enzymes,such as NK,CK,SMCE, KA38,subtilisin E,subtilisin DFE and *** amidolytic activities of subtilisin FS33 were inhibited completely by phenylmethanesulfonyl fluoride(PMSF)and soybean trypsin inhibitor(SBT1..EDTA did not affect the enzyme activity,and none of tested ions activated the ***,the enzyme was thought to be a subtilisin-like serine *** enzyme degraded the Bβ-chains of fibrin(ogen)very rapidly and then degraded the Aα-chain,at least five fragments from fibrin(ogen)were obtained after *** subtilisin FS33 was able to cleave blood clots in the absence of endogenous fibrinolytic factors.

关键词： fibrinolytic subtilisin homology inhibitor purification serine protease substrate specificity thrombolytic agent

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science{1.(Physics,Mechanics & Astronomy) 2012年第11期55卷 2122-2127页

作者： ZHAO YingTao gao {1. wang minzhong Department of Mechanics School of Aerospace EngineeringBeijing Institute of TechnologyBeijing 100081China college of {1. China Agricultural UniversityP.O.Box 74Beijing 100083China State Key Laboratory for Turbulence and Complex Systems and Department of Mechanics and Aerospace Engineering College of EngineeringPeking UniversityBeijing 100871China

The problem of an ellipsoidal inhomogeneity embedded in an infinitely extended elastic medium with sliding interfaces is investigated. An exact solution is presented for such an inhomogeneous system that is subject to remote uniform shearing stress. Both the elastic inclusion and matrix are considered isotropic with a separate elastic modulus. Based on Lur’e’s approach to solving ellipsoidal cavity problems through Lamé functions, several harmonic functions are introduced for Papkovich-Neuber displacement potentials. The displacement fields inside and outside the ellipsoidal inclusion are obtained explicitly, and the stress field in the whole domain is consequently determined.

关键词： inhomogeneity sliding interface Lamé’s function Eshelby problem

Response of warm season secondary pollutants to emissions and meteorology in the North china Plain region during 201.-2022

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Atmospheric and Oceanic science Letters 2024年第4期17卷 58-64页

作者： Yueqi gao Siyu {1. Zhaolei Zhang Wenxuan Yu Shuai {1. Shengqiang Zhu Peng {1. Yan Li Yele Sun Hongliang Zhang Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science&EngineeringFudan UniversityShanghaiChina Department of Atmospheric and Oceanic sciences Fudan UniversityShanghaiChina Shanghai Key Laboratory of Ocean-land-atmosphere Boundary Dynamics and Climate Change ShanghaiChina IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghaiChina State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina college of Earth and Planetary {1.s University of Chinese Academy of SciencesBeijingChina Institute of Eco-Chongming ShanghaiChina

自201.年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用201.-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在201.-2022年间,PM_(2.5)浓度显著下降31.-37%,O_(3)和NO_... 详细信息

自201.年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用201.-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在201.-2022年间,PM_(2.5)浓度显著下降31.-37%,O_(3)和NO_(2)的年下降速率分别为1.和0.5%SIA和SOA也显著减少,每年分别减少9%和6%PM_(2.5)主要因排放减少而下降,而O_(3)则受气象影响而波动.硫酸盐和铵下降的主因是减排,而硝酸盐对气象变化敏感排放和气象变化对SOA的总体减少同样重要,但人为SOA对排放控制敏感生物SOA易受气象变化影响.研究强调了控制人为排放对缓解NCP地区夏季二次污染的重要性.

关键词： PM_(2.5) 二次污染物人为排放气象华北平原