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有显式解的养老金动态资产负债管理模型

统计与信息论坛 2008年第3期23卷 38-42页

作者：谢远涛高晓斐杨娟中国人民大学统计学院中国人民大学出版社北京100872 中盈达科技发展有限公司北京100022

人口快速老龄化所带来的养老金支付缺口问题亟待解决,对养老金进行管理以兑现其偿付能力的承诺意义重大。通过建立动态优化模型以求得资金运用约束、清偿力约束和资产增值公式约束下给定养老金保险成本的最小化。尝试建立一个有显式解... 详细信息

人口快速老龄化所带来的养老金支付缺口问题亟待解决,对养老金进行管理以兑现其偿付能力的承诺意义重大。通过建立动态优化模型以求得资金运用约束、清偿力约束和资产增值公式约束下给定养老金保险成本的最小化。尝试建立一个有显式解的动态规划模型,找出显式解并分析其均衡解的动态特征。该模型把许多诸如投资组合的不确定性变量拿到模型外面建模实现,回避了封闭性的要求,抛弃了有限状态的假定,避免了转化为线性规划问题所产生的巨大计算量,甚至还存在均衡解,利用这个均衡解可以轻易调整资产配置额来实现长期稳定均衡。

关键词：资产负债管理 ALM动态规划养老金精算

Molecular mechanism of a coastal cyanobacterium Synechococcus *** 7002 adapting to changing phosphate concentrations

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Marine Life Science & Technology 2024年第3期6卷 562-575页

作者： Qiao-Wei Sun Yu gao Jordan Wang fei-xue Fu Cheng-Wen Yong Shuang-Qing Li Hai-Long Huang Wei-Zhong Chen Xin-Wei Wang Hai-Bo Jiang School of Marine Sciences Ningbo UniversityNingbo 315211China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China School of Life Sciences Central China Normal UniversityWuhan 430079China Department of Biological Sciences University of Southern CaliforniaLos AngelesCA 90089USA

Phosphorus concentration on the surface of seawater varies greatly with different environments,especially in *** molecular mechanism by which cyanobacteria adapt to fluctuating phosphorus bioavailability is still *** this study,transcriptomes and gene knockouts were used to investigate the adaptive molecular mechanism of a model coastal cyanobacterium Synechococcus *** 7002 during periods of phosphorus starvation and phosphorus recovery(adding sufficient phosphorus after phosphorus starvation).The findings indicated that phosphorus deficiency affected the photosynthesis,ribosome synthesis,and bacterial motility pathways,which recommenced after phosphorus was *** more,most of the metabolic pathways of cyanobacteria were enhanced after phosphorus recovery compared to the control which was kept in continuous phosphorus replete *** on transcriptome,54 genes potentially related to phosphorusdeficiency adaptation were selected and knocked out individually or in *** was found that five mutants showed weak growth phenotype under phosphorus deficiency,indicating the importance of the genes(A0076,A0549-50,A1094,A1320,A1895)in the adaptation of phosphorus *** mutants were found to grow better than the wild type under phosphorus deficiency,suggesting that the products of these genes(A0079,A0340,A2284–86)might influence the adaptation to phosphorus *** analysis revealed that cyanobacteria exposed to highly fluctuating phosphorus concentrations have more sophisticated phosphorus acquisition *** results elucidated that Synechococcus *** 7002 have variable phosphorus response mechanisms to adapt to fluctuating phosphorus concentration,providing a novel perspective of how cyanobacteria may respond to the complex and dynamic environments.

关键词： Synechococcus sp PCC 7002 Phosphorus fluctuation Cyanobacteria ・Gene knockout Molecular mechanism

Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 564-576页

作者： Yujia Shen Yiwei Gong xiaoli Da Shajing gao Shuo Zhang Minjuan Sun Yuanzhi Yang xiaoyun Qiu Menghan Li Yang Zheng Fan fei Yi Wang Zhong Chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology NHC and CAMS Key Laboratory of Medical NeurobiologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Department of Neurology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China

Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary *** is one of the major resultants of pharmacoresistance and failure of surgical outcomes in epilepsy,but still lacks effective ***,we aimed to test the effects of low-frequency stimulation(LFS)at the subiculum for secondary epileptogenesis in a mouse ***,secondary epileptogenesis was simulated at regions both contralateral and ipsilateral to the primary focus by applying successive kindling *** kindled at the right CA3 showed higher seizure susceptibilities at both the contralateral CA3 and the ipsilateral entorhinal cortex and had accelerated kindling processes compared with naive *** at the ipsilateral subiculum during the primary kindling progress at the right CA3 effectively prevented secondary epileptogenesis at both the contralateral CA3 and the ipsilateral entorhinal cortex,characterized by decreased seizure susceptibilities and a retarded kindling process at those secondary *** application along with the primary epileptogenesis was ***,the effects of LFS on secondary epileptogenesis were associated with its inhibitory effect at the secondary focus through interfering with the enhancement of synaptic connections between the primary and secondary *** results imply that LFS at the subiculum is an effective preventive strategy for extensive secondary epileptogenesis in temporal lobe epilepsy and present the subiculum as a target with potential translational importance.

关键词： Secondary epileptogenesis Low-frequency stimulation Subiculum Temporal lobe epilepsy

中国共产党百年来对“党的领导”的表述与定位

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五邑大学学报（社会科学版） 2022年第2期24卷 1-5,92页

作者：胡沫高晓菲武汉轻工大学马克思主义学院湖北武汉430023

党的领导是中国特色社会主义的最本质特征。中国共产党在百年历史进程中对“党的领导”有着不同表述,大致经历四个阶段:新民主主义革命时期强调要把握领导权,明确“党的领导”是革命成功的关键;社会主义革命和建设时期指出,“领导我们... 详细信息

党的领导是中国特色社会主义的最本质特征。中国共产党在百年历史进程中对“党的领导”有着不同表述,大致经历四个阶段:新民主主义革命时期强调要把握领导权,明确“党的领导”是革命成功的关键;社会主义革命和建设时期指出,“领导我们事业的核心力量是中国共产党”;改革开放和社会主义现代化建设新时期要求“坚持党的领导,必须改善党的领导”;中国特色社会主义新时代则提出坚持党的全面领导,即坚持党对一切工作的统领。就意义形塑而言,不同表述有着特定的时代背景,蕴含着丰富的内涵和意义,引领着各个历史时期的中心工作和历史使命的完成。

关键词：中国共产党党的领导表述

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ALMANAC模型对大豆产量的模拟

资源科学 2005年第4期27卷 100-105页

作者：温美丽高晓飞谢云刘宝元北京师范大学地理学与遥感科学学院环境演变与自然灾害教育部重点实验室

本文使用ALMANAC作物生长模型对黑龙江省嫩江县鹤山农场的大豆产量进行了模拟,并探讨了影响大豆模拟产量与实际产量差异的原因。研究结果发现,1991年~2003年鹤山农场大豆的平均实际产量和模拟产量分别为2·75t/hm2和3·00t/hm2左右,误差... 详细信息

本文使用ALMANAC作物生长模型对黑龙江省嫩江县鹤山农场的大豆产量进行了模拟,并探讨了影响大豆模拟产量与实际产量差异的原因。研究结果发现,1991年~2003年鹤山农场大豆的平均实际产量和模拟产量分别为2·75t/hm2和3·00t/hm2左右,误差为8·9%左右;大豆的实际产量与模拟产量趋势一致,均呈降低的趋势,说明模型能够用于模拟大豆的生产。造成差异的主要原因可能是某些突发的自然灾害。模拟得到的温度和水分的胁迫日数与该地区的气候变化有较一致的关系,即温度胁迫有减少的趋势,水分胁迫有增加的趋势。模拟结果还发现,提高大豆的出苗密度可以增加大豆的产量,但增加值与生长季的降水量有一定的关系。

关键词： ALMANAC模型大豆产量作物生长模型 2003年 1991年黑龙江省产量差异研究结果产量趋势自然灾害气候变化温度胁迫水分胁迫模拟结果嫩江县降水量生长季增加值农场鹤山原因出苗

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使用微型蒸发器测定土壤蒸发的研究进展

水利水电科技进展 2010年第1期30卷 85-90页

作者：高晓飞史海珍杨洁王晓岚北京师范大学地理学与遥感科学学院北京100875

对微型蒸发器相关的文献进行综合与分析,并对其应用进行了综述。认为微型蒸发器的材料以热容量高、导热性差的非金属材料为宜;蒸发器口径一般应大于56mm,小于150mm;深度以150～200mm为宜;安装方法还可以进一步改进。合理运用微型蒸发器... 详细信息

对微型蒸发器相关的文献进行综合与分析,并对其应用进行了综述。认为微型蒸发器的材料以热容量高、导热性差的非金属材料为宜;蒸发器口径一般应大于56mm,小于150mm;深度以150～200mm为宜;安装方法还可以进一步改进。合理运用微型蒸发器可以得到更精确的观测结果。

关键词：微型蒸发器裸土蒸发冠层下蒸发研究进展

TIP-6通过诱导细胞自噬抑制培养的HepG2细胞和正常肝细胞增殖

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细胞与分子免疫学杂志 2009年第10期25卷 883-886页

作者：高笑菲海军杜宇平王勤惠新平兰州大学生命科学学院兰州大学化学化工学院应用有机国家重点实验室甘肃兰州730000

目的:研究7-(4-甲氧基苯基)-5,8a-二苯基-1,2,3,7,8,8a-六氢咪唑[1,2-a]吡啶(TIP-6)对培养的人肝癌HepG2细胞和人正常肝细胞L02增殖的影响。方法:用MTT法和台盼蓝染色法检测TIP-6对细胞增殖的影响;相差显微镜观察细胞形态学的变化;流式... 详细信息

目的:研究7-(4-甲氧基苯基)-5,8a-二苯基-1,2,3,7,8,8a-六氢咪唑[1,2-a]吡啶(TIP-6)对培养的人肝癌HepG2细胞和人正常肝细胞L02增殖的影响。方法:用MTT法和台盼蓝染色法检测TIP-6对细胞增殖的影响;相差显微镜观察细胞形态学的变化;流式细胞术(FCM)分析细胞周期改变;吖啶橙荧光染色观察自噬泡的变化;Annexin V/7-AAD和DAPI染色检测细胞凋亡;DNA电泳检测凋亡梯形带的产生。细胞免疫化学法测定NF-κB的表达。结果:TIP-6浓度为90～200μmol/L时,细胞增殖受到抑制,且与浓度、时间有关;当浓度为200μmol/L、处理72h时,两种细胞增殖数分别只有对照的12.10%和18.75%,空泡化也随剂量和时间的增加而加剧,空泡数目越来越多、体积越来越大;FCM结果显示,细胞被阻滞在G2/M期,且HepG2比L02细胞敏感。吖啶橙荧光染色证实自噬及自噬性细胞死亡会随着化合物浓度和时间增加而增多;AnnexinV/7-AAD、DAPI染色及DNA电泳均证实凋亡并非TIP-6诱导HepG2及L02细胞增殖抑制的主要形式;细胞免疫化学法的结果显示,随着核转录因子NF-κB表达量的上调,自噬泡会随之增加,细胞增殖却相应减少。结论:TIP-6可能诱导自噬抑制培养的肝癌细胞和肝细胞增殖。自噬性细胞死亡可能与NF-κB蛋白的活化有关。

关键词： TIP-6 HepG2 L02 自噬 NF—κB

Development and Diagnosis Performance of IgM-Based Rapid Antigen Test for Early Detection of SARS-CoV-2 Infection in a Large Cohort of Suspected COVID-19 Cases—USA,Poland,and Sweden,2021-2022

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China CDC weekly 2024年第37期6卷 953-961,I0009,I0010页

作者： Yihua Huang Yiyi Pu Youhong Weng Yahan Wu Qing He Sofia Litchev Longyou Zhao Haojie Ding Yunru Lai Jie Li xiaojun Zheng Jinshu Chen XianqinXiong Shaohong Lu fei gao Meng gao Qingming Kong Department of Laboratory Medicine Lishui Second People's Hospital Affiliated to Wenzhou Medical UniversityLishui CityZhejiang ProvinceChina Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province School of Laboratory Medicine and BioengineeringHangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Basic Medicine and Forensics Key Laboratory of Bio-tech Vaccine of Zhejiang ProvinceEngineering Research Center of Novel Vaccine of Zhejiang ProvinceHangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina The Fifth Affiliated Hospital of Wenzhou Medical University Lishui CityZhejiang ProvinceChina Baylor College of Medicine HoustonTXUSA Department of Research and Development Hangzhou AllTest Biotech Co.LtdHangzhou CityZhejiang ProvinceChina

Introduction:Antigen testing has been crucial in effectively managing the coronavirus disease 2019(COVID-19)*** study evaluated the clinical performance of a nasopharyngeal swab(NPS)-based antigen rapid diagnostic test(Ag-RDT)compared to the gold standard real-time reverse transcription-polymerase chain reaction(RT-PCR)for early detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods:We developed an IgM-based rapid antigen test for early detection of SARS-CoV-2 *** July 2021 and January 2022,we analyzed 1,030 NPS samples from participants at three centers in different countries,using both antigen rapid diagnostic tests(Ag-RDT)and ***:The Ag-RDT demonstrated minimal detection limits as low as 0.1 ng/mL for recombinant N antigen and 100 TCID50/mL for heat-inactivated SARS-CoV-2 *** assessments involving four human coronaviruses and 13 other respiratory viruses showed no *** Ag-RDT assay(ALLtest)exhibited high sensitivity(93.18%-100%)and specificity(99.67%-100%)across all *** such as cycle threshold(Ct)values and the timing of symptoms since onset were influential,with sensitivity increasing at lower Ct values(<30)and within the first week of ***:The ALLtest Ag-RDT demonstrated high reliability and significant potential for diagnosing suspected COVID-19 cases.

关键词： Antigen specificity centers

钒基催化剂同步去除燃煤烟气中甲苯与NO_(x)研究

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中国环境科学 2021年第8期41卷 3546-3554页

作者：张益兰肖高飞李剑晗杜玥莹付名利胡芸华南理工大学环境与能源学院广东广州510006 广东省大气环境与污染控制重点实验室广东广州510006 广东省环境风险防范与应急处置工程技术研究中心广东广州510006

采用不同工艺制备V_(2)O_(5)-WO_(3)-MoO_(x)/TiO_(2)堇青石整体式催化剂,以甲苯和NO为探针分子,考察了Mo的负载量、涂覆方法、粘结剂的种类等制备工艺对整体式催化剂性能的影响,用XRD、SEM-EDS、FT-IR、BET等技术对催化剂进行了表征分... 详细信息

采用不同工艺制备V_(2)O_(5)-WO_(3)-MoO_(x)/TiO_(2)堇青石整体式催化剂,以甲苯和NO为探针分子,考察了Mo的负载量、涂覆方法、粘结剂的种类等制备工艺对整体式催化剂性能的影响,用XRD、SEM-EDS、FT-IR、BET等技术对催化剂进行了表征分析.结果表明,采用涂敷法,以添加量为1%的甲基纤维素为粘结剂所制备的V1W6Mo3/TiO_(2)堇青石蜂窝陶瓷整体式催化剂具有最优活性和稳定性(T_(90)为307℃,负载率为28.26%,脱落率为6.81%),在燃煤烟气中具有优异的同步去除VOCs与NO性能,甲苯去除率可达99%,NO去除率为100%,N_(2)选择性为99%.XRD、SEM-EDS表明V、W、Mo活性组分分布均匀且高度分散.FT-IR证明添加甲基纤维素的整体式催化剂具有优异的抗硫性能.

关键词：燃煤烟气催化氧化整体式催化剂 VOCs与NO_(x)同步去除