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COVID-19 mortality and Vaccine Coverage——Hong Kong Special Administrative Region,China,January 6,2022-march 21,2022

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China CDC weekly 2022年第14期4卷 288-292页

作者： Dallas J.Smith Avi J.Hakim gabriel m.leung Wenbo Xu WWilliam Schluter Ryan T.Novak Barbara marston Bradley S.Hersh CDC COVID-19 Response International Task Force Atlanta Epidemic Intelligence Service CDC Li Ka Shing Faculty of medicine University of Hong KongHong Kong Special Administrative RegionChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina CDC China BeijingChina

Summary What is already known about this topic?COVID-19 vaccines are important tools to protect populations from severe disease and *** is added by this report?Among persons aged≥60 years in Hong Kong,49%,had received≥2 doses of a COVID-19 vaccine,and vaccination coverage declined with *** January-march 2022,reported COVID-19-associated deaths rose rapidly in Hong *** these deaths,96%occurred in persons aged≥60 years;within this age group,the risk for death was 20 times lower among those who were fully vaccinated compared with those who were unvaccinated.

关键词： doses COV deaths

message from Deputy Editor-in-Chief gabriel m.leung—International Trade and Global Health Protection

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China CDC weekly 2019年第4期1卷 45-46页

作者： gabriel m.leung China CDC Weekly Dean of medicine The University of Hong KongHong Kong SARChina

It was external trade that first prompted the collection and reporting of surveillance data at the foreign ports from which the US imported *** established Bulletin of the Public Health—the first precursor to the US ... 详细信息

关键词： Trade prompt Health

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Innovating for Health in China’s Greater Bay Area

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China CDC weekly 2022年第1期4卷 1-3页

作者： Feichau Pang Puihong Chung gabriel m.leung School of Public Health LKS Faculty of MedicineThe University of Hong KongHong KongChina

The Success of World metropolitan and Bay Areas The Tokyo Bay Area,the New York metropolitan Area,and the San Francisco Bay Area are leading regions for science and *** share an economic transformation from industrial or manufacturing bases to predominantly service-based economies with this sector contributing 75%of their gross domestic product(GDP)in *** companies in these locations accounted for 60%of the revenue of the top 100 global tech companies in 2018(1).The success of these locations stems from the convergence of academia,technology giants,government support,and a high density of investors,as well as innovative entrepreneurs(2).

关键词： companies revenue bases

Charge balance materials for homojunction and heterojunction OLED applications

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Frontiers of Optoelectronics 2009年第4期2卷 435-441页

作者： Louis m.leung Yik-Chung LAW michael Y.WONG Tik-Ho LEE Kin ming LAI Lok-Yee TANG Department of Chemistry and Centre for Advanced Luminescence materials Hong Kong Baptist University

In a homojunction device, a single organic layer assumes the multiple roles of hole, electron transportation, and emitter. Its ease in processing is highly desirable from the manufacturing point of view. In this paper, we shall describe the synthesis of a range of bipolar small molecules and conductive vinyl polymers for application in homojunction and heterojunction organic light emitting diodes（OLEDs）. The bipolar materials, in general, consist of three basic building blocks: an arylamine, a 1,3,4-oxadiazole, and a polycyclic aromatic moiety. The achievement of charge balance can be validated either by direct measurement of electron/hole mobility or indirectly via optimization of device properties.A series of conductive vinyl copolymers containing hole transporting N-（4-methoxyphenyl）-N-（4-vinylphenyl）naphthalen-1-amine（4meONPA） and electron transporting 2-phenyl-5-（4-vinylphenyl）-1,3,4-oxadiazole（OXA）at different compositions was applied for heterojunction and homojunction OLEDs. For heterojunction devices employed the copolymers as the hole transporting layer and Alq3as the electron transporting and emitting layer,a maximum luminance and current efficiency of over 23000 cd/m2and 4.2 cd/A（PL of Alq3）, respectively, were achieved at the charge balance composition. Homojunction devices for the copolymers were demonstrated by the addition of rubrene as a dopant. The single layer devices at the optimal copolymer composition has ca 1500 cd/m2and 0.74 cd/A.

关键词： homojunction devices charge balance bipolar small molecules conductive vinyl copolymers

Social Determinants,Data Science,and Decision making:The 3-D Approach to Achieving Health Equity in Asia

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Health Data Science 2022年第1期2022卷 39-40页

作者： Luxia Zhang Sabina Faiz Rashid gabriel leung National Institute of Health Data Science Peking UniversityBeijingChina Advanced Institute of Information Technology Peking UniversityHangzhouZhejiang ProvinceChina Renal Division Department of MedicinePeking University First HospitalBeijingChina BRAC James P Grant School of Public Health BRAC UniversityDhakaBangladesh WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of Data Discovery for Health Hong Kong Science and Technology ParkHong Kong Special Administrative RegionChina

Improving population health by creating more equitable health systems is a major focus of health policy and planning ***,before we can achieve equity in health,we must first begin by leveraging all we have learned,and are continuing to discover,about the many social,structural,and environmental determinants of *** must fully consider the conditions in which people are born,grow,learn,work,play,and *** study of social determinants of health has made tremendous strides in recent *** the same time,we have seen huge advances in how health data are collected,analyzed,and used to inform action in the health *** is time to merge these two fields,to harness the best from both and to improve decision-making to accelerate evidence-based action toward greater health equity.

关键词： action today equity

Interaction between gut microbiota and COVID-19 and its vaccines

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World Journal of Gastroenterology 2022年第40期28卷 5801-5806页

作者： John S m.leung Cardiothoracic Unit St.Paul’s HospitalHong KongChina

The whole world has been continuously afflicted by the coronavirus disease 2019(COVID-19)pandemic for the past 3 *** countries have tried many methods to control this virus infection with varying successes and *** gut microbiota is a biosystem spanning the entire length of the digestive tract and playing important roles in health and *** is much affected by *** return it also substantially impacts *** particular,the gut microbiota has established a bidirectional interaction with the COVID-19 vaccines,enhancing or reducing vaccine efficacy by virtue of its varying ***,COVID-19 vaccines also make a substantial impact on the gut microbiota,reducing its overall population and *** is hoped that by exploring and harnessing this bidirectional interaction we may break new ground and develop new methods to prevent and treat this formidable virus infection.

关键词： Gut microbiota COVID-19 vaccines Vaccine interactions Gut microbiota alterations

Conserved RB functions in development and tumor suppression

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Protein & Cell 2011年第11期2卷 864-878页

作者： gabriel m.Gordon Wei Du Ben may Department for Cancer Research University of ChicagoChicagoIL 60637USA

The variety of human cancers in which the retinoblastoma protein pRb is inactivated reflects both its broad importance for tumor suppression and its multitude of cellular *** evidence indicates that pRb contributes to a diversity of cellular functions,including cell proliferation,differentiation,cell death,and genome *** performs these diverse functions through the formation of large complexes that include E2F transcription factors and chromatin *** this review we will discuss some of the recent advances made in understanding the structure and function of pRb as they relate to tumor suppression,and highlight research using Drosophila melanogaster that reveals important,evolutionarily conserved functions of the RB family.

关键词： RB E2F Drosophila Rbf cell cycle chromatin modification

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Biased activity of soluble guanylyl cyclase:the Janus face of thymoquinone

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Acta Pharmaceutica Sinica B 2017年第4期7卷 401-408页

作者： Charlotte Detremmerie Paul m.Vanhoutte Susan leung Department of Pharmacology and Pharmacy and State Key Laboratory for Pharmaceutical Biotechnology Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

The natural compound thymoquinone, extracted from Nigella sativa(black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endotheliumindependent vasodilator effects in isolated rat aortae and pulmonary arteries, depending in part on activation of adenosine triphosphate-sensitive potassium channels and inhibition of voltage-dependent calcium channels. The compound also improves endothelial dysfunction in mesenteric arteries of ageing rodents and in aortae of rabbits treated with pyrogallol, by inhibiting oxidative stress. Serendipitously,thymoquinone was found to augment contractions in isolated arteries with endothelium of both rats and pigs. The endothelium-dependent augmentation it causes counterintuitively depends on biased activation of soluble guanylyl cyclase(sGC) producing inosine 3',5'-cyclic monophosphate(cyclic ImP) rather than guanosine 3',5'-cyclic monophosphate. This phenomenon shows a striking mechanistic similarity to the hypoxic augmentation previously observed in porcine coronary arteries. The cyclic ImP preferentially produced under thymoquinone exposure causes an increased contractility of arterial smooth muscle by interfering with calcium homeostasis. This brief review summarizes the vascular pharmacology of thymoquinone, focussing in particular on how the compound causes endothelium-dependent contractions by biasing the activity of sGC.

关键词： Thymoquinone Endothelium-dependentcontraction Nitric oxide Soluble guanylyl cyclase Cyclic ImP NADPH:quinone oxidoreductase

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