Conserved RB functions in development and tumor suppression

作     者：Gabriel M.Gordon Wei Du 

作者机构：Ben May Department for Cancer ResearchUniversity of ChicagoChicagoIL 60637USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2011年第2卷第11期

页      面：864-878页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：by grants from the National Institutes of Health(RO1CA149275,RO1GM074197,PO1AT004418) a grant from DOD(W81XWH-10-1-0077)to WD 

主　　题：RB E2F Drosophila Rbf cell cycle chromatin modification 

摘      要：The variety of human cancers in which the retinoblastoma protein pRb is inactivated reflects both its broad importance for tumor suppression and its multitude of cellular *** evidence indicates that pRb contributes to a diversity of cellular functions,including cell proliferation,differentiation,cell death,and genome *** performs these diverse functions through the formation of large complexes that include E2F transcription factors and chromatin *** this review we will discuss some of the recent advances made in understanding the structure and function of pRb as they relate to tumor suppression,and highlight research using Drosophila melanogaster that reveals important,evolutionarily conserved functions of the RB family.