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Integration of multiple flexible electrodes for realtime detection of barrier formation with spatial resolution in a gut-on-chip system

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Microsystems & Nanoengineering 2024年第1期10卷 105-114页

作者： Mara Lucchetti gabriel werr Sofia Johansson Laurent Barbe Léa Grandmougin Paul Wilmes Maria Tenje Luxembourg Centre for Systems Biomedicine(LCSB) University of LuxembourgEsch-sur-Alzette L-4362Luxembourg Division of Biomedical Engineering Department of Materials Science and EngineeringScience for Life LaboratoryUppsala University75121 UppsalaSweden Department of Life Sciences and Medicine Faculty of ScienceTechnology and MedicineUniversity of LuxembourgEsch-sur-Alzette L-4362Luxembourg

In healthy individuals,the intestinal epithelium forms a tight barrier to prevent gut bacteria from reaching blood *** study the effect of probiotics,dietary compounds and drugs on gut barrier formation and disruption,human gut epithelial and bacterial cells can be cocultured in an in vitro model called the human microbial crosstalk(HuMiX)gut-on-a-chip ***,we present the design,fabrication and integration of thin-film electrodes into the HuMiX platform to measure transepithelial electrical resistance(TEER)as a direct readout on barrier tightness in *** various aspects of the HuMiX platform have already been set in their design,such as multiple compressible layers,uneven surfaces and nontransparent materials,a novel fabrication method was developed whereby thin-film metal electrodes were first deposited on flexible substrates and sequentially integrated with the HuMiX system via a transfer-tape ***,to measure localized TEER along the cell culture chamber,we integrated multiple electrodes that were connected to an impedance analyzer via a *** further developed a dynamic normalization method because the active measurement area depends on the measured TEER *** fabrication process and system setup can be applicable to other barrier-on-chip *** a proof-of-concept,we measured the barrier formation of a cancerous Caco-2 cell line in real-time,which was mapped at four spatially separated positions along the HuMiX culture area.

关键词： barrier system multiple

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Human health risks associated to trace elements and metals in commercial fish from the Brazilian Amazon

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Journal of Environmental Sciences 2025年第2期148卷 230-242页

作者： Andrea V.Waichman gabriel Silva de Souza Nunes Rhaul de Oliveira Isabel López-Heras Andreu Rico Federal University of the Amazon Institute of Biological SciencesAv.Rodrigo Ramos 3000Manaus 69077-000Brazil Federal University of Pernambuco Department of ZoologyAv.Prof Moraes Rego 1235Cidade UniversitáriaRecife 50670-901Brazil University of Campinas School of TechnologyRua Paschoal Marmo 1888-Jd.Nova ItáliaLimeira 13484-332Brazil IMDEA Water Institute Science and Technology Campus of the University of AlcaláAv.Punto Com 2Alcaláde Henares 28805MadridSpain Cavanilles Institute of Biodiversity and Evolutionary Biology University of Valenciac/Catedrático JoséBeltrán 246980PaternaValenciaSpain

Fish constitutes the main protein source for the Amazonian ***,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely *** we assessed exposure levels of 10 trace elements andmetals(Cr,Mn,Fe,Ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 samples belonging to 11 different species of fish from the Brazilian *** studied the relationship between exposure levels,fish origin,and fish feeding habits,and assessed toxicological and carcinogenic risks for the Amazonian *** significant correlation was found between sampling site and exposure levels to the studied elements,but a significant difference was found between the accumulation of some metals and the position of the fish species in the food *** concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human *** study shows that current fish consumption patterns can lead to estimated daily intakes of Hg,As and Cr that exceed the oral reference dose,thus posing a toxicological ***,carcinogenic risks may be expected due to the continued exposure to Cr and *** results of this study show that the consumption of wild caught fish in the Amazon region should be ***,continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended,particularly for riverine and indigenous communities.

关键词： Metals Deforestation Mining Freshwater ecosystems Carcinogenic risks Amazon

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Strategies for the Airline Industry on the African Continent

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Journal of Transportation Technologies 2025年第1期15卷 17-49页

作者： Tilmann gabriel African Aviation & Aerospace University Abuja Nigeria

African Aviation continues to fall short of serving the demands of the fast-growing African population. For major air transport in and out of the African continent, African travellers rely mainly on non-African Airlines. There is, however, one successful airline on the continent at the writing of this paper: Ethiopian Airlines and the Ethiopian Aviation Group. Why are no further successful airlines possible on a continent of 1.4 billion people (25% of the world’s population) and only a 2%-share of global air transport? At the introduction of SAATM, which is anticipated as the start of the domestic African aviation boom, most African countries seem unprepared to build a success story like Ethiopia. Transportation infrastructure in sub-Saharan Africa does not start with roads and rail but with runways and airlines. This research investigates the basic requirements needed to equip Africa with a competitive aviation industry that would contribute some 5% to the continent’s GDP and create hundreds of thousands of workplaces. Interviews with African SAATM leaders signal a slowdown in the effort to succeed. The research is also concerned about the lack of inclusion in the implementation of a NetZero CO2 emission scheme in Africa.

关键词： African Aviation SAATM African Air Transport Industry African Airlines NetZero

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Large-scale laboratory investigation of pillar-support interaction

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 71-93页

作者： Akash Chaurasia gabriel Walton Sankhaneel Sinha Timothy J.Batchler Kieran Moore Nicholas Vlachopoulos Bradley Forbes Colorado School of Mines GoldenCOUSA Equilibrium Mining KolkataWest BengalIndia National Institute of Occupational and Safety Hazard(NIOSH) PittsburghPAUSA Royal Military College of Canada(RMC) KingstonOntarioCanada BGC Engineering Inc. KingstonOntarioCanada

Underground mine pillars provide natural stability to the mine area,allowing safe operations for workers and *** prior research has been conducted to understand pillar failure mechanics and design safe pillar ***,limited studies(mostly based on empirical field observation and small-scale laboratory tests)have considered pillar-support interactions under monotonic loading conditions for the design of pillar-support *** study used a series of large-scale laboratory compression tests on porous limestone blocks to analyze rock and support behavior at a sufficiently large scale(specimens with edge length of 0.5 m)for incorporation of actual support elements,with consideration of different w/h *** unsupported and supported(grouted rebar rockbolt and wire mesh)tests were conducted,and the surface deformations of the specimens were monitored using three-dimensional(3D)digital image correlation(DIC).Rockbolts instrumented with distributed fiber optic strain sensors were used to study rockbolt strain distribution,load mobilization,and localized deformation at different w/h *** axial and bending strains were observed in the rockbolts,which became more prominent in the post-peak region of the stress-strain curve.

关键词： Grouted rockbolt Welded wire mesh Porous limestone Digital image correlation Distributed fiber optic sensing Large-scale laboratory tests

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Assessing Joint Simulation and Estimation Approaches in Geometallurgical Modeling

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Journal of Geoscience and Environment Protection 2025年第1期13卷 316-330页

作者： Farzaneh Khorram gabriel Pais Manuel Reyes Facultad de Ingeniera Universidad Andres Bello Santiago Chile

Given that energy costs are a significant component of overall processing costs in mineral plants, reducing these costs through process optimization or technology adoption enhances the technical and financial feasibility of a deposit. Geometallurgical modeling plays a key role in understanding the relationship between material characteristics, mine planning, and processing stages, ultimately contributing to more efficient resource management and cost reduction in mineral processing. This study aims to develop a block model for evaluating comminution energy consumption (CEC) and identifying blocks with the highest energy usage potential during the grinding process in a specified region. Therefore, by applying advanced geostatistical techniques, including joint estimation and simulation based on geometallurgical data from multiple mineral processing stages, we predict CEC across the study area. The dataset encompasses 2.754 drill samples and a block model with 4.680 blocks. In this effort, imulation techniques, such as Plurigaussian and Turning Bands, provided more realistic outcomes than cokriging, considering the unique characteristics of geometallurgical data and the limitations of kriging methods.

关键词： Geometallurgy Multivariate Analysis Plurigaussian Turning Band Method Cokriging

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Overcoming antibiotic-resistant Helicobacter pylori infection:Current challenges and emerging approaches

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World Journal of Gastroenterology 2025年第10期31卷 7-29页

作者： gabriel Reis Rocha Fabian Fellipe Bueno Lemos Luis Guilherme de Oliveira Silva Marcel Silva Luz gabriel Lima Correa Santos Samuel Luca Rocha Pinheiro Mariana Santos Calmon Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Recent studies have shown a noticeable increase in global Helicobacter pylori(***)resistance,with clarithromycin resistance surpassing 15%in various ***,inadequate epidemiological monitoring,especially in developing countries,and the absence of uniform testing methods lead to discrepancies between regions and a possible underestimation of resistance *** complexity of treating *** is driven by its highly dynamic genome,which is prone to frequent mutations contributing to phenotypical *** usual course of action in empirical treatment involves using a combination of various drugs simultaneously,leading to significant resistance selection pressure and potential side *** emergence of *** strains resistant to multiple drugs is closely tied to failures in first-line treatment,highlighting the need to prevent further resistance by using optimal initial empirical therapy or regimens guided by antibiotic susceptibility testing,requiring a collection of mixed samples and multiple isolates for accurate *** emergence of new treatments like potassium-competitive acid blockers offers a hopeful approach to decrease antimicrobial usage while still ensuring effectiveness in comparison to traditional therapies with proton pump ***,the use of probiotics is under investigation to identify specific strains and formulations that may mitigate therapy-associated adverse effects.

关键词： Helicobacter pylori Antibiotic resistance Multidrug resistance Heteroresistance Empirical treatment Antimicrobial susceptibility testing

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Valued gabriel quiver of a wedge product and semiprime coalgebras

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Frontiers of Mathematics in China 2013年第5期8卷 1157-1183页

作者： gabriel NAVARR0 Department of Computer Sciences and AI University of Granada E1 Greco s/n E-51002Ceuta Spain

We describe the valued gabriel quiver of a wedge product of coalgebras and study the category of comodules of a semiprime coalgebra. In particular, we prove that any monomial semiprime k-tame fc-tame coalgebra is string. We also prove a version of Eisenbud-Griffith theorem for coalgebras, namely, any hereditary semiprime strictly quasi-finite coalgebra is serial.

关键词： Wedge product semiprime coalgebras representation theory,valued gabriel quiver

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Message from Deputy Editor-in-Chief gabriel M Leung—International Trade and Global Health Protection

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China CDC weekly 2019年第4期1卷 45-46页

作者： gabriel M Leung China CDC Weekly Dean of Medicine The University of Hong KongHong Kong SARChina

It was external trade that first prompted the collection and reporting of surveillance data at the foreign ports from which the US imported *** established Bulletin of the Public Health—the first precursor to the US ... 详细信息

关键词： Trade prompt Health

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A case study on the efficacy of different roof bolting schemes in Lhoist North America’s Crab Orchard Mine

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International Journal of Mining Science and Technology 2020年第1期30卷 99-104页

作者： Reece Kurre gabriel Walton Stantec Consulting Services Inc. Walnut CreekCA 94597USA Department of Geology and Geological Engineering Colorado School of MinesGoldenCO 80401USA

Roof bolting has long been used in underground mines across the world to provide ground *** roof bolts are cheap and easy to install with the use of specialized machines as a part of the production cycle. Lhoist North America’s Crab Orchard Mine is an underground room and pillar limestone mine that uses mechanically anchored roof bolts for ground support. The mine currently employs two different roof bolting patterns: a standard 1.5 × 1.5 m pattern, and another 0.8 × 0.8 m pattern for use in areas with particularly hazardous roof conditions. The purpose of this study is to evaluate the relative effectiveness of each bolting pattern. A series of numerical models were created using Roc Science’s RS2. The models were based on a symmetrical section of the mine at its deepest point, and were modeled using generalized Hoek-Brown failure criterion along with a discrete fracture network. A series of sensitivity analyses were performed on the models by varying parameters such as joint friction angle, crack persistence, joint randomization, and tensile strength of the limestone. Based on the results of the original models and sensitivity analyses, it appeared that the standard bolting pattern provided sufficient roof support capacity under almost all the expected conditions at the mine, since safety factors below the design value of 1.5 were only found for individual bolts in a few of the worst test cases *** results can help improve the mine’s productivity and reduce operating costs without compromising safety.

关键词： Numerical modeling Mining Roof bolting Roof stability Analysis RocScience’s RS2 Underground stone

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