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Modifying the progression of Parkinson's disease through movement interventions:multimodal quantification of underlying mechanisms

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Neural Regeneration Research 2024年第8期19卷 1651-1652页

作者： Manuel Bange Damian Marc Herz Dumitru Ciolac gabriel gonzalez-Escamilla Sergiu Groppa Section of Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational Neuroscience(FTN)University Medical Center of the Johannes Gutenberg-University MainzMainzGermany

Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is accompanied by widespread alterations in the structu re and function of distributed brain networks.Togethe r,these processes cause a variety of motor symptoms such as bradykinesia,rigidity,tremor,gait disorders,or difficulties in fine motor control(Bange et al.,2022).

关键词： alterations movement

Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet gabriel Capellá Heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

Brain network correlates of epilepsy occurrence in multiple sclerosis and neuroinflammation

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Neural Regeneration Research 2023年第8期18卷 1717-1718页

作者： Dumitru Ciolac gabriel gonzalez-Escamilla Yaroslav Winter Vinzenz Fleischer Matthias Grothe Sergiu Groppa Department of Neurology Focus Program Translational NeuroscienceRhine Main Neuroscience Network(rmn2)University Medical Center of the Johannes Gutenberg University MainzMainzGermany State University of Medicine and Pharmacy“Nicolae Testemitanu” ChisinauRepublic of Moldova Department of Neurology Institute of Emergency MedicineChisinauRepublic of Moldova Mainz Comprehensive Epilepsy and Sleep Medicine Center Department of NeurologyJohannes Gutenberg University MainzMainzGermany Department of Neurology Philipps-UniversityMarburgGermany Department of Neurology Heinrich Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS),the most common inflammatory condition of the central nervous system in young adults,is characterized by immunemediated demyelination and neurodegeneration that translate into heterogeneous clin... 详细信息

关键词： epilepsy inflammation sclerosis

A Finite Element Model for the Instability Analysis of Flexible Pipes Tensile Armor Wires

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Journal of Mechanics Engineering and Automation 2017年第3期7卷 165-170页

作者： gabriel gonzalez Jose Renato Mendes de Sousa Luis Volnei Sudati Sagrilo Civil Engineering Program COPPE Federal University of Rio de Janeiro Rio de Janeiro 21941-596 Brazil

Choroid plexus imaging to track neuroinflammation—a translational model for mouse and human studies

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Neural Regeneration Research 2023年第3期18卷 521-522页

作者： Muthuraman Muthuraman Mohammadsaleh Oshaghi Vinzenz Fleischer Dumitru Ciolac Ahmed Othman Sven G.Meuth gabriel gonzalez-Escamilla Sergiu Groppa Department of Neurology Focus Program Translational NeuroscienceRhine Main Neuroscience Network(rmn2)University Medical Center of the Johannes Gutenberg University MainzMainzGermany Department of Neuroradiology University Medical Center of the Johannes Gutenberg University MainzMainzGermany Department of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

The choroid plexus(ChP)is a highly vascularized and secretory tissue in each of the brain ventricles that represents the key structure between the blood and the cerebrospinal fluid(CSF).Besides its essential role in CSF production and brain waste clearance pathways,the ChP also contributes to the regulation of central nervous system(CNS)immunosurveillance(Ghersi-Egea et al.,2018).Indeed,the ChP forming the blood-CSF barrier(BCSFB)regulates the entry of immune cells and solute molecules into the brain and vice versa.When antigen-specific,autoreactive immune activation occurs in the periphery,inflammatory cells migrate through the brain barriers towards the CNS(Strominger et al.,2018),initiating neuroinflammatory diseases such as multiple sclerosis(MS).

关键词： al. plexus inflammation

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.Garcia-Lopez Jose M.Olano gabriel Sanguesa-Barreda Miguel Garcia-Hidalgo Susana Gomez-gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio Garcia-gonzalez Laura Lozano-Lopez Paula Garcia-gonzalez Ana I.Garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human activities.In the past,Canary laurel forests have been greatly altered by logging,livestock and agriculture.The remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic disturbances.Using dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife Island.Wood cores were collected from over 80 trees per stand at three stands per forest.We used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed growth.Twelve tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common species.Although some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism economy.Some trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past decades.Strong growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： Jose A.Vega Stefano Arellano-Perez Juan gabriel Alvarez-gonzalez Cristina Fernandez Enrique Jimenez Pedro Cuinas Jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(P.pinaster;P.radiata and P.sylvestris):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor fuels.Additive systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as regressors.The systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological differences.In general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel fractions.The best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability explained.To reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential regressors.Only relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor relationships.Nevertheless,these models explained around 52%of the observed variability.Finally,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were fitted.These models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowing for landscape-scale estimates of total fuel lo

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

Assessing a novel modelling approach with high resolution UAV imagery for monitoring health status in priority riparian forests

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Forest Ecosystems 2021年第4期8卷 810-830页

作者： Juan Guerra-Hernandez Ramon A.Diaz-Varela Juan gabriel Avarez-gonzalez Patricia Maria Rodriguez-gonzalez edata Centro de iniciativas empresariaisFundacion CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonInstituto Superior de Agronomia(ISA)Tapada da Ajuda1349-017 LisbonPortugal Biodiversity and Applied Botany Unit(GI BIOAPLIC 1809) Department of BotanyEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus Universitario27002 LugoSpain Sustainable Forest Management Unit(UXFS) Department of Agroforestry EngineeringEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus UniversitarioE-27002 LugoSpain

Background:Black alder(Alnus glutinosa)forests are in severe decline across their area of distribution due to a disease caused by the soil-borne pathogenic Phytophthora alni species complex(class Oomycetes),“alder Phytopththora”.Mapping of the different types of damages caused by the disease is challenging in high density ecosystems in which spectral variability is high due to canopy heterogeneity.Data obtained by unmanned aerial vehicles(UAVs)may be particularly useful for such tasks due to the high resolution,flexibility of acquisition and cost efficiency of this type of data.In this study,A.glutinosa decline was assessed by considering four categories of tree health status in the field:asymptomatic,dead and defoliation above and below a 50% threshold.A combination of multispectral Parrot Sequoia and UAV unmanned aerial vehicles-red green blue(RGB)data were analysed using classical random forest(RF)and a simple and robust three-step logistic modelling approaches to identify the most important forest health indicators while adhering to the principle of parsimony.A total of 34 remote sensing variables were considered,including a set of vegetation indices,texture features from the normalized difference vegetation index(NDVI)and a digital surface model(DSM),topographic and digital aerial photogrammetry-derived structural data from the DSM at crown level.Results:The four categories identified by the RF yielded an overall accuracy of 67%,while aggregation of the legend to three classes(asymptomatic,defoliated,dead)and to two classes(alive,dead)improved the overall accuracy to 72% and 91% respectively.On the other hand,the confusion matrix,computed from the three logistic models by using the leave-out cross-validation method yielded overall accuracies of 75%,80% and 94% for four-,three-and two-level classifications,respectively.Discussion:The study findings provide forest managers with an alternative robust classification method for the rapid,effective assessment of areas affected and non-affected by the disease,thus

关键词： Alder RPAS Multi-spectral Defoliation Texture variables 3D point cloud Tree health monitoring

Clinical features,histology,and histogenesis of combined hepatocellular-cholangiocarcinoma

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World Journal of Hepatology 2017年第6期9卷 300-309页

作者： Shweta Gera Mark Ettel gabriel Acosta-gonzalez Ruliang Xu Department of Pathology Montefiore Medical Center Department of Pathology NYU Langone Medical Center

Combined hepatocellular-cholangiocarcinoma(CHC) is a rare tumor with poor prognosis,with incidence ranging from 1.0%-4.7% of all primary hepatic tumors.This entity will be soon renamed as hepato-cholangiocarcinoma.The known risk factors for hepatocellular carcinoma(HCC) have been implicated for CHC including viral hepatitis and cirrhosis.It is difficult to diagnose this tumor pre-operatively.The predominant histologic component within the tumor largely determines the predominant radiographic features making it a difficult distinction.Heterogeneous and overlapping imaging features of HCC and cholangiocarcinoma should raise the suspicion for CHC and multiple core biopsies(from different areas of tumor) are recommended before administering treatment.Serum tumor markers CA19-9 and alpha-fetoprotein can aid in the diagnosis,but it remains a challenging diagnosis prior to resection.There is sufficient data to support bipotent hepatic progenitor cells as the cell of origin for CHC.The current World Health Organization classification categorizes two main types of CHC based on histo-morphological features:Classical type and CHC with stem cell features.Liver transplant is one of the available treatment modalities with other management options including transarterial chemoembolization,radiofrequency ablation,and percutaneous ethanol injection.We present a review paper on CHC highlighting the risk factors,origin,histological classification and therapeutic modalities.

关键词：联合 hepatocellular-cholangiocellular 癌 Hepatocellular 癌 Cholangiocellular 癌肝的祖先房间 Histogenesis 分类