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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl Lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. in this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. in the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年

作者： Xiang WANg guang-Hui YU Yakov KUZYAKOV Bo-Hao YiN andreas KAPPLER Cong-Qiang LiU Bohai Coastal critical Zone National Observation and Research Station Institute of Surface-Earth System Science School of Earth System Science Tianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai Rim Tianjin University Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil Science University of G?ttingen Agro-Technological institute Peoples Friendship University of Russia (RUDN University) geomicrobiology Center for Applied Geosciences University of Tübingen Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infection University of Tübingen

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues (necromass). Yet, it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across biomes. Here, this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes. A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global level. High spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered nanoparticles. We propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i) fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces, and (ii) fungi stabilize their residues on mineral surfaces, leading to millennial scale persistence of soil C. Concluding, fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent carbon. They are crucial in stabilizing carbon on mineral surfaces, thereby facilitating the long-term removal of carbon from rapid biotic cycling.

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Molecular changes in hepatic metabolism and transport incirrhosis and their functional importance

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World Journal of gastroenterology 2016年第1期22卷 72-88页

作者： Christoph g Dietrich Oliver götze andreas geier Bethlehem Center of Health Department of Internal MedicineD-52222 Stolberg(Rhineland)Germany University of Würzburg Division of HepatologyDepartment of Internal Medicine IID-97080 WürzburgGermany

Liver cirrhosis is the common endpoint of many hepatic diseases and represents a relevant risk for liver failure and hepatocellular *** progress of liver fibrosis and cirrhosis is accompanied by deteriorating liver *** review summarizes the regulatory and functional changes in phase Ⅰ and phaseⅡmetabolic enzymes as well as transport proteins and provides an overview regarding lipid and glucose metabolism in cirrhotic ***,phase Ⅰ enzymes are generally down regulated transcriptionally,while phaseⅡenzymes are mostly preserved transcriptionally but are reduced in their *** proteins are regulated in a specific way that resembles the molecular changes observed in obstructive *** and glucose metabolism are characterized by insulin resistance and catabolism,leading to the disturbance of energy expenditure and *** non-invasive tests,especially breath tests,for components of liver metabolism are *** heterogeneity and complexity of changes in hepatic metabolism complicate the assessment of liver function in individual ***,studies in humans are rare,and species differences preclude the transferability of data from rodents to *** clinical practice,some established global scores or criteria form the basis for the functional evaluation of patients with liver cirrhosis,but difficult treatment decisions such as selection for transplantation or resection require further research regarding the application of existing non-invasive tests and the development of more specific tests.

关键词： liver cirrhosis drug metabolism transport breath tests lipid metabolism glucose metabolism

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Liver transplantation for severe hepatic trauma:Experience from a single center

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World Journal of gastroenterology 2009年第13期15卷 1641-1644页

作者： Spiros g Delis andreas Bakoyiannis gennaro Selvaggi Debbie Weppler David Levi andreas g Tzakis Department of Surgery Division of TransplantationUniversity of Miami Miller School of Medicine

Liver transplantation has been reported in the literature as an extreme intervention in cases of severe and complicated hepatic *** main indications for liver transplant in such cases were uncontrollable bleeding and postoperative hepatic *** here describe four cases of orthotopic liver transplantation after penetrating or blunt liver *** indications were liver failure,extended liver necrosis,liver gangrene and multiple episodes of gastrointestinal bleeding related to portal hypertension,*** patient died due to postoperative cerebral *** other three patients recovered well and remain on *** transplantation should be considered as a saving procedure in severe hepatic trauma,when all other treatment modalities fail.

关键词： Liver injury Orthotopic liver transplantation Severe liver trauma Hepatic coma Hepatic trauma

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green Composite Material Made from Typha latifolia Fibres Bonded with an Epoxidized Linseed Oil/Tall Oil-Based Polyamide Binder System

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Journal of Renewable Materials 2020年第5期8卷 499-512页

作者： günter Wuzella Arunjunai Raj Mahendran andreas Kandelbauer Kompetenzzentrum Holz(Wood K Plus) LinzA-4040Austria Reutlingen University Lehr-und Forschungszentrum Process Analysis&TechnologySchool of Applied ChemistryReutlingenD-72762Germany

Here,we report the mechanical and water sorption properties of a green composite based on Typha latifolia *** composite was prepared either completely binder-less or bonded with 10%(w/w)of a bio-based resin which was a mixture of an epoxidized linseed oil and a tall-oil based *** flexural modulus of elasticity,the flexural strength and the water absorption of hot pressed Typha panels were measured and the influence of pressing time and panel density on these properties was *** cure kinetics of the biobased resin was analyzed by differential scanning calorimetry(DSC)in combination with the iso-conversional kinetic analysis method of Vyazovkin to derive the curing conditions required for achieving completely cured *** the binderless Typha panels the best technological properties were achieved for panels with high *** adding 10%of the binder resin the flexural strength and especially the water absorption were improved significantly.

关键词： Natural fibre composite Cattails Typha latifolia epoxidized linseed oil cure kinetics iso-conversional kinetic analysis

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Periodicities in the emplacement of large igneous provinces through the Phanerozoic:Relations to ocean chemistry and marine biodiversity evolution

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geoscience Frontiers 2013年第3期4卷 263-276页

作者： andreas Prokoph Hafida E1 Bilali Richard Ernst Speedstat 19 Langstrom CrescentOttawaON K1G 5J5Canada Carleton University Department of Earth SciencesHerzberg BuildingOttawaON KIS 5B6Canada Carleton University Department of Earth SciencesHerzberg BuildingOttawaON K1S 5B6Canada Ernstgeosciences 43 Margrave AvenueOttawaON K1T 3Y2Canada

Large igneous provinces （LiPs） are considered a relevant cause for mass extinctions of marine life throughout Earth＇s history. Their flood basalts and associated intrusions can cause significant release of SO4 and CO2 and consequently, cause major environmental disruptions. Here, we reconstruct the long-term periodic pattern of LiP emplacement and its impact on ocean chemistry and biodiversity from δ34Ssulfate of the last 520 Ma under particular consideration of the preservation limits of LiP records. A combination of cross-wavelet and other time-series analysis methods has been applied to quantify a potential chain of linkage between LiP emplacement periodicity, geochemical changes and the Phanerozoic marine genera record. We suggest a mantle plume cyclicity represented by LiP volumes （V） of V= （350-770） × 103km3sin（27πt/ 170 Ma）＋（300-650）× 103 km3 sin（2πt/64.5 Ma ＋ 2.3） for t= time in Ma. A shift from the 64.5 Ma to a weaker -28-35 Ma LiP cyclicity during the Jurassic contributes together with probably independent changes in the marine sulfur cycle to less ocean anoxia, and a general stabilization of ocean chemistry and increasing marine biodiversity throughout the last -135 Ma. The LiP cycle pattern is coherent with marine biodiversity fluctuations corresponding to a reduction of marine biodiversity of -120 genera/Ma at 600 x 103 km3 LiP eruption volume. The 62-65 Ma LiP cycle pattern as well as excursion in -34Ssulfate and marine genera reduction suggest a not-vet identified found LiP event at - 440-450 Ma.

关键词： Large igneous provinces Wavelet transform Sulfur isotope Mantle plume Marine biodiversity Periodicity

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Recent advances in the treatment of opioid use disorders–focus on long-acting buprenorphine formulations

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World Journal of Psychiatry 2021年第9期11卷 543-552页

作者： Michael Soyka andreas g Franke Psychiatric Hospital University of MunichMünchen 80336Germany University of Applied Labour Studies Mannheim 68163Germany

Oral methadone or sublingual buprenorphine are first-line medications for pharmacotherapy of opioid use disorders(OUDs).Three long-acting buprenorphine depot or implant formulations are currently available for the treatment of OUDs:(1)CAM 2038(Buvidal)for subcutaneous weekly and monthly application;(2)RBP-6000(Sublocade^(TM))as a monthly depot formulation;and(3)A six-month buprenorphine implant[Probuphine^(TM)].The pharmacology,clinical efficacy and prospects of these medications are discussed.

关键词： Opioids Opioid dependence Maintenance treatment Methadone Buprenorphine Depot implant

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Screening for nonalcoholic fatty liver disease-when,who and how?

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World Journal of gastroenterology 2021年第35期27卷 5803-5821页

作者： Christoph g Dietrich Monika Rau andreas geier Department of internal Medicine Bethlehem Health CenterStolberg 52222Germany Department of internal Medicine ii University Hospital WürzburgWürzburg 97080Germany Department of Medicine ii University Hospital WürzburgWürzburg 97080Germany

Nonalcoholic fatty liver disease(NAFLD)is becoming a frequent liver disease,especially in patients with metabolic syndrome and especially in Western *** of NAFLD comprise progressive fibrosis,cirrhosis and hepatocellular *** also represents an independent risk factor for cardiovascular disease,extrahepatic neoplasia and other organ damage,such as renal *** the epidemiological importance of the disease,new developments in specific treatment of the disease and the wide availability of noninvasive techniques in estimating steatosis and fibrosis,NAFLD should be subject to screening programs,at least in countries with a high prevalence of the *** review discusses prerequisites for screening,cost-effectiveness,current guideline recommendations,suitability of techniques for screening and propositions for the following questions:Who should be screened?Who should perform screening?How should screening be performed?it is time for a screening program in patients at risk for NAFLD.

关键词： Screening Nonalcoholic fatty liver disease Diabetes Liver fibrosis Cirrhosis

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Non-alcoholic fatty liver disease and COViD-19: Harmless companions or disease intensifier?

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World Journal of gastroenterology 2023年第2期29卷 367-377页

作者： Christoph g Dietrich andreas geier Uta Merle gastro-Praxis Wiesbaden Leberzentrum WiesbadenWiesbaden 65189Germany Division of Hepatology Department of Medicine IIUniversity Hospital WuerzburgWuerzburg 97080Germany Department of gastroenterology and Hepatology University Hospital HeidelbergHeidelberg 69120Germany

The pandemics of coronavirus disease 2019(COViD-19)and non-alcoholic fatty liver disease(NAFLD)*** liver function tests are frequent in COViD-19 and may influence liver damage in NAFLD,while preexisting liver damage from NAFLD may influence the course of ***,the prognostic relevance of this interaction,though,is *** is a risk factor for the presence of NAFLD as well as a severe course of *** studies reveal conflicting results regarding the influence of NAFLD presence on COViD-19 illness *** molecular similarities of cytokine pathways in both diseases,including postacute sequelae of COViD-19,suggest common pathways for chronic low-activity *** review will summarize existing data regarding the interaction of both diseases and discuss possible mechanisms of the influence of one disease on the other.

关键词： COViD-19 Postacute sequelae of COViD-19 Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis inflammation Fatty liver

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Chatter prediction for uncertain parameters

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Advances in Manufacturing 2018年第3期6卷 319-333页

作者： Michael Loser andreas Otto Steffen ihlenfeidt günter Radons institute of Machine Tools and Control Engineering TU Dresden 01069 Dresden Germany institute of Physics Chemnitz University of Technology09107 Chemnitz Germany

The occurrence of chatter in milling processeswas investigated in this study. The prediction of the sta-bility lobes of metal cutting processes requires a model ofthe cutting force and a model of the dynamic machine toolbehavior. Parameter uncertainties in the models may leadto significant differences between the predicted and mea-sured stability behavior. One approach towards robuststability consists of running a large number of simulationswith a random sample of uncertain parameters and deter-mining the confidence levels for the chatter vibrations,which is a time-consuming task. in this paper, an efficientimplementation of the multi frequency solution and theconstruction of an approximate solution is presented. Theapproximate solution requires the explicit calculation of themulti frequency solution only at a few parameter points,and the approximation error can be kept small. This studyfound that the calculation of the robust stability lobe dia-gram, which is based on the approximate solution, is sig-nificantly more efficient than an explicit calculation at allrandom parameter points. The numerically determinedrobust stability diagrams were in good agreement with theexperimentally determined stability lobes.

关键词： Milling Chatter Uncertainties Vibration Stability

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