Molecular changes in hepatic metabolism and transport incirrhosis and their functional importance

作     者：Christoph G Dietrich Oliver Götze Andreas Geier 

作者机构：Bethlehem Center of HealthDepartment of Internal MedicineD-52222 Stolberg(Rhineland)Germany University of WürzburgDivision of HepatologyDepartment of Internal Medicine IID-97080 WürzburgGermany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第1期

页      面：72-88页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：liver cirrhosis drug metabolism transport breath tests lipid metabolism glucose metabolism 

摘      要：Liver cirrhosis is the common endpoint of many hepatic diseases and represents a relevant risk for liver failure and hepatocellular *** progress of liver fibrosis and cirrhosis is accompanied by deteriorating liver *** review summarizes the regulatory and functional changes in phase Ⅰ and phaseⅡmetabolic enzymes as well as transport proteins and provides an overview regarding lipid and glucose metabolism in cirrhotic ***,phase Ⅰ enzymes are generally down regulated transcriptionally,while phaseⅡenzymes are mostly preserved transcriptionally but are reduced in their *** proteins are regulated in a specific way that resembles the molecular changes observed in obstructive *** and glucose metabolism are characterized by insulin resistance and catabolism,leading to the disturbance of energy expenditure and *** non-invasive tests,especially breath tests,for components of liver metabolism are *** heterogeneity and complexity of changes in hepatic metabolism complicate the assessment of liver function in individual ***,studies in humans are rare,and species differences preclude the transferability of data from rodents to *** clinical practice,some established global scores or criteria form the basis for the functional evaluation of patients with liver cirrhosis,but difficult treatment decisions such as selection for transplantation or resection require further research regarding the application of existing non-invasive tests and the development of more specific tests.