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Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer:A systematic review of observational studies

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World Journal of gastroenterology 2023年第7期29卷 1219-1234页

作者： Lourdes Pilar chávez-Hidalgo Silvia martín-Fernández-de-Labastida marian m de Pancorbo marta Arroyo-Izaga Department of Pharmacy and Food Sciences Faculty of PharmacyUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain Department of Z.and Cellular Biology A. University of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain BIOmICs Research group MICROFLUIDICs and BIOMICs Cluster UPV/EHULascaray Research CenterUniversity of the Basque Country UPV/EHUVitoria-Gasteiz 01006Araba/ÁlavaSpain

BACKgROUND Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer(CRC).However,whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still *** To improve the current understanding of the molecular basis of *** A literature search in the medline database,Reference Citation Analysis(https://***/),and manual reference screening were performed to identify observational studies published from inception to may *** A total of fourteen case-control studies and five cohort studies were *** studies included information on dietary methyl donors,dietary components that potentially modulate the bioavailability of methyl groups,genetic variants of methyl metabolizing enzymes,and/or markers of Cpg island methylator phenotype and/or microsatellite instability,and their possible interactions on CRC *** Several studies have suggested interactions between methylenetetrahydrofolate reductase polymorphisms,methyl donor nutrients(such as folate)and alcohol on CRC ***,vitamin B6,niacin,and alcohol may affect CRC risk through not only genetic but also epigenetic *** of specific mechanisms in these interactions associated with CRC may assist in developing targeted prevention strategies for individuals at the highest risk of developing CRC.

关键词： Colorectal cancer DNA methylation Epigenetics methyl donors microsatellite instability Nutrients

Tolerance of chrysantemum maximum to heavy metals:The potential for its use in the revegetation of tailings heaps

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Journal of Environmental Sciences 2013年第2期25卷 367-375页

作者： ma.del Carmen A.gonzlez-chvez Rogelio Carrillo-gonzlez Colegio de Postgraduados Programa de EdafologíaCarr.Mxico-Texcocokm 36.5MontecilloTexcoco estado de Mxico 56230Mxico

To find if ornamental plants are applicable to the remediation of metal-polluted areas, the tolerance of chrysanthemum plants （chysanthemum maximum） var. shasta to different metals under hydroponic conditions was studied. Their responses as influenced by the mycorrhizal fungus glomus mosseae （Nicol. ＆ gerd.） gerdemann ＆ Trappe BEg25 on substrates containing mine residues were also investigated. Our results showed that chrysanthemum is a metal-tolerant plant under hydroponic conditions, plants behaving as Pb-excluders, whereas Cd, Cu and Ni were accumulated in roots. Low accumulation in flowers was observed for Cd and Cu but it was concentration-dependent. Ni and Pb were not translocated to flowers. shoot biomass was not significantly affected by the different rates of mine residue addition for both mycorrhizal and non-mycorrhizal plants. mycorrhizal plants accumulated less Pb and Cu in both shoots and roots than non-mycorrhizal plants. chysanthemum could be a prospective plant for revegetation of tailings and the use of inoculation may decrease plant metal accumulation in polluted soils.

关键词： mine residues ornamental plants phytostabilization urban remediation

Surface-modified Ag@Ru-P25 for photocatalytic CO_(2) conversion with high selectivity over ch_(4) formation at the solid–gas interface

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Carbon Energy 2024年第1期6卷 182-196页

作者： chaitanya B.Hiragond Sohag Biswas Niket SPowar Junho Lee Eunhee gong Hwapyong Kim Hong Soo Kim Jin-Woo Jung chang-Hee cho Bryan m.Wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience Corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of CO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with H_(2)O_(2) treatment was designed in this study to convert CO_(2) and H_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas H_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–OH)groups and promotes CO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,CO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of H_(2)O_(2) treatment in increasing CO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent CO_(2) reduction activity into CO,ch4,and C2H6 with a~95%selectivity of ch4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of H_(2)O_(2) treatment on the photocatalyst that dramatically increases CO_(2) reduction activity.

关键词： gas-phase CO_(2) reduction H_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

Kinetic Study on CO_2 Reforming of methane

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chinese Journal of chemical Engineering 2001年第2期9卷 190-195页

作者： C.E.Quincoces m.g.gonzález Centro de Investigacion y Desarrollo en Procesos Cataliticos (CINDECA) 阿根廷

The kinetics of CO2 reforming of methane has been studied at 976－1033K on a commercial NiO/CaO/Al2O3 catalyst in a packed-bed continuous reactor. The reaction was carried out at atmospheric pressure and CO2/ch4 ratio ＞ 2. The Hougen-Watson rate models were fitted to experimental data assuming the disso ciative adsorption of methane as the rate-determining step. The reaction rate showed an effective reaction order of about unity for ch4. The apparent activity energy was found to be 104 kJ·mol-1. Therefore the kinetic reaction parameters were determined and a possible reaction mechanism was proposed.

关键词： ch4 reforming Ni catalysts syngas

genesis and Distribution of Ultra-alkaline magmatism within the East Antarctic Associated with the Kerguelen Plume Activity

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Acta geologica Sinica(English Edition) 2016年第S1期90卷 198-199页

作者： Nadezhda m.Sushchevskaya Boris V.Belyatsky Robert sh.Krymsky Vernadsky Institute of geochemistry RAS Karpinsky geological Institute (VSEgEI)

Alkaline magmatism is often associated with the initial or final stages of huge plume *** alkaline bodies are most often found within the boundary area of plume impact upon the *** initial stages of the

关键词： genesis and Distribution of Ultra-alkaline magmatism within the East Antarctic Associated with the Kerguelen Plume Activity Jetty

Effect of Partial Substitution of Ni by Cu in LaNiO_3 Perovskite Catalyst for Dry methane Reforming

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催化学报 2012年第5期33卷 797-801页

作者： g.R.mORADI F.KHOSRAVIAN m.RAHmANZADEH Catalyst Research Center Chemical Engineering DepartmentFaculty of EngineeringRazi UniversityKermanshah 67149-67346Iran

A series of ternary perovskite type oxides LaNi1-xCuxO3(x = 0.2,0.4,0.6,0.8,and 1.0) were synthesized via the sol-gel method in propionic *** substitution of Ni by Cu showed higher activities and selectivities towards syngas ***0.8Cu0.2O3 was the most active toward the ch4 and CO2 conversions,and was selective for syngas ***-programmed reduction results showed that the addition of Cu facilitates the reduction of Ni3+ to Ni0,which is the main reason for the higher performance of this catalyst.

关键词： dry reforming of methane perovskite lanthanun nickel sol-gel method

Subcellular localization and functional analyses of structural domains of COP1 in transgenic tobacco

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chinese Science Bulletin 2002年第15期47卷 1250-1257,1321-1322页

作者： Wang, CX Huang, ch Wu, gY Wu, XY Zhao, JD Peking Univ Coll Life Sci Beijing 100871 Peoples R China

Plants have evolved an extremely exquisite light signal regulatory network to adapt to the changing ambient light conditions, in which COP1 plays a critical role of the light signal transduction. Based on the cloned pea COP1 cDNA sequence and its protein structure, four individual gene fragments encoding different structural domains of the COP1 were designed to fuse to the gFP gene. The plant expression vectors containing these fusion genes as well as the COPIgFP fusion gene were constructed and used to transform tobacco by Agribacterium as confirmed by South-]ern analyses. Antibodies were raised against the recombi-nant gFP-COP1 overproduced in Escherichia coli. 1m-munoblotting results demonstrated that all of the fusion genes were constitutively expressed in transgenic tobacco plants. We systematically investigated the different subcell-ular localization of these fusion proteins and the resulting phenotypic characteristics of these transgenic plants under light and dark conditions. Our data show that (

关键词： photomorphogenesis COP1 tobacco gFP subcellular localization.

Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro

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World Journal of gastroenterology 2000年第4期6卷 532-539页

作者： Tu SP Zhong J Tan JH Jiang XH Qiao mm Wu YX Jiang sh shanghai Second med Univ Ruijin Hosp Dept Gastroenterol Shanghai 200025 Peoples R China

AIm To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells（SgC-7901,mKN-45,mKN-28）withrespect to both cytotoxicity and induction ofapoptosis in *** The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by *** changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron *** and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow *** As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer *** IC50ofAs2O3 on well differentiated gastric cancer cellmKN-28,moderately differentiated gastric cancercell SgC-7901,and poorly differentiated gastriccancer cell mKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,*** IC50of HCPT on mKN-28,SgC-7901,and mKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h *** 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before g0/g1 phase was observedby flow *** apoptotic rates of SgC-7901,mKN-45,and mKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SgC-7901,mKN-45,and mKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L *** apoptotic indicewere 7%-15% as assessed by TUNEL *** effect of As2O3 on SgC-7901 showedremarkable cell cycle specificity,which inducedcell death in g1 phase,and blocked g2/m *** also showed a remarkable cell cyclespecificity,by inducing cell death and a

关键词： gastric cancer apoptosis arsenic trioxide hydroxycamptothecin

Effect of laser shock processing on erosive resistance of 6061-T6 aluminum

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Transactions of Nonferrous metals Society of china 2016年第6期26卷 1522-1530页

作者： J.IBARRA E.RODRígUEZ O.JIméNEZ g.gómEZ-ROSAS m.FLORES J.VERDUZCO J.cháVEZ Universidad de guadalajara Departamento de Ingeniería de Proyectos Universidad de guadalajara Departamento de Física Centro Universitario de Ciencias Exactas e Ingenierías

Application of laser shock processing （LSP） on 6061-T6 aluminum was made in order to evaluate its response to the erosive wear by silica sand. Impact angles of 15° , 30° , 60° and 90° were tested, two particle speeds （37 and 58 m/s） and two LSP irradiation conditions were used. Erosion marks were characterized by 3D profilometry and SEm analysis was conducted to identify the erosion mechanisms for each tested angle. The results showed a maximum erosive wear at low impact angles （ductile type behavior）. Erosion strength and the erosion mechanisms were not affected by the application of LSP and they were attributed to the high strain rate of the erosion phenomena. A few differences encountered on the erosion plots were explained on the basis of the surface roughness left by the LSP process. The maximum mass loss and the maximum erosion penetration happened in different impact angles （15° and 30° , respectively）. Finally, a well-defined erosion mechanism transition was observed, from cutting action at low impact angle, to crater formation at 90° of incidence.

关键词： 6061-T6 aluminum erosive wear laser shock processing