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Dietary g.een Tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： g.lande Sheethal Ranjeet K. Tokala Pavan Pondug.la Krishna Vemula Vijayalakshmi venkatesan Pothani Suresh Surya Satyanarayana Sing. g.duru venkat rao Duvvur Nag.shwar Reddy Mitnala Sasikala Basic Science and Translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biolog. National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surg.cal g.stroenterolog. Asian Institute of Gastroenterology Hyderabad India Department of g.stroenterolog. Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (CP) is a prog.essive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normog.ycemia with conventional treatment requiring.multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arg.nine respectively with an intent to study islet dysfunction and develop therapeutic strateg. in animal models of CP. Dietary intervention of epig.llocatechin-3-g.llate (Eg.g. was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morpholog. of pancreatic parenchyma and inflammation by staining.with H&E and fibrotic chang.s by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal g.ucose tolerance test was performed to monitor the g.ucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arg.nine model. 2-fold improvement in g.ucose-stimulated insulin secretory functions of islets was observed with 0.5% Eg.g.dietary intervention in cerulein model of CP and 1.6-fold in L-arg.nine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with Eg.g. Our results thus demonstrate and hig.lig.t the therapeutic potential of dietary g.een tea (Eg.g. supplementation in reversing.islet dysfunction and improving.g.ucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/J Mice Epig.llocatechin-3-g.llate N-Acetyl Cysteine Curcumin Chronic Pancreatitis Islets g.ucose Stimulated Insulin Secretion

Seismic safety evaluation methodolog. for masonry building.and retrofitting.using.splint and bandag. technique with wire mesh

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Frontiers of Structural and Civil Eng.neering 2022年第4期16卷 478-505页

作者： Pravin Kumar venkat rao PADALU Yog.ndra SINg. Earthquake Eng.neering.Research Center International Institute of Information Technology Hyderabad(IIIT-H)Telangana 500032India Department of Earthquake Eng.neering Indian Institute of Technology Roorkee(IITR)Uttarakhand 247667India

The paper presents a seismic safety assessment of unreinforced masonry(URM)building.using.two *** first approach uses the‘Pier Analysis’method,based on the concept of equivalent lateral stiffness,where in-plane and out-of-plane actions are considered *** second approach is developed with the prog.am SAP2000,where the linear response is evaluated using.continuum‘finite element modelling.(FEM).Both methods are compared to evaluate the safety of wall piers and the differences in the outcomes under combined g.avitational and lateral seismic *** analysis results showed that few wall elements are unsafe in in-plane and out-of-plane *** is also observed that the pier analysis method is conservative compared to FEM,but can be used as a simplified and quick tool in desig. offices for safety assessment,with reasonable *** safeg.ard the URM wall piers under lateral loads,a retrofitting.technique is adopted by providing.vertical and horizontal belts called splints and bandag.s,respectively,using.welded wire mesh(WWM)*** study using.the‘Pier Analysis’shows that the lateral load capacity of unsafe URM piers can be enhanced up to 3.67 times and made safe using.the applied retrofitting.***,the retrofitting.desig. methodolog. and recommendations for application procedures to on-site URM building. are discussed in detail.

关键词： unreinforced masonry seismic in-plane and out-of-plane forces pier analysis finite element modelling splint and bandag. technique with wire mesh

g.netic mechanisms underlying.the pathog.nesis of tropical calcific pancreatitis

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World Journal of g.stroenterolog. 2009年第3期15卷 264-269页

作者： Swapna Mahurkar D Nag.shwar Reddy g.venkat rao g.riraj Ratan Chandak Asian Institute of g.stroenterolog. 6-3-661SomajigudaHyderabad 500082India g.nome Research g.oup Centre for Cellular and Molecular BiologyUppal RoadHyderabad 500007India

Chronic pancreatitis is known to be a heterog.neous disease with varied *** calcific pancreatitis(TCP) is a severe form of chronic pancreatitis unique to developing.*** g.owing.evidence of g.netic factors contributing.to the pathog.nesis of TCP,this review is aimed at compiling.the available information in this *** also propose a two hit model to explain the sequence of events in the pathog.nesis of TCP.

关键词：慢性胰腺炎钙化胰腺炎胰腺糖尿病综合疾病

Pancreatic stellate cell: Pandora's box for pancreatic disease biolog.

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World Journal of g.stroenterolog. 2017年第3期23卷 382-405页

作者： Ratnakar R Bynig.ri Aparna Jakkampudi Ramaiah Jang.la Chivukula Subramanyam Mitnala Sasikala g.venkat rao D Nag.shwar Reddy Rupjyoti Talukdar Institute of Basic Sciences Asian Healthcare FoundationHyderabad 500082India Department of Medical g.stroenterolog. Asian Institute of GastroenterologyHyderabad 500082India Department of Surg.cal g.stroenterolog. Asian Institute of GastroenterologyHyderabad 500082India

Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiolog.cal condition, but are essential for maintaining.the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving.different cytokines and contribute to prog.essive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt sig.aling. Hedg.hog.etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrog.nic function of PSCs. The role of PSCs g.es much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in sig.ificant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour prog.ession, metastasis, tumour hypoxia, immune evasion and drug.resistance. This is the rationale for therapeutic preclinical and clinical trials that have targ.ted PSCs and the cancer stroma.

关键词： Pancreatic stellate cells Pancreatic fibrosis Pancreatic cancer stroma Physiolog.cal functions Pancreatic stellate cells-cancer-stromal interactions Therapeutic targ.ts

Innovative Applications of Post-Tension for Restoration and Rehabilitation of Bridg.s and Structures--Case Studies in India

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Journal of Civil Eng.neering.and Architecture 2014年第7期8卷 869-880页

作者： Ramesh Kommajosyula Narapraju venkat Ramana rao Varshitha Concrete Technolog.es Pvt. Ltd. Hyderabad 500 033 India Department of Civil Jawaharlal Nehru Technological University Hyderabad 500085 India

This paper deals with new and innovative case studies of application of post-tensioning.for restoration of structures for building., bridg.s and rock stabilization in India. In earlier situations for these types of cases conventional method of repair and rehabilitation has been used. These innovative approaches for restoration have led to enormous saving.of cost and time. The advantag.s of post tensioning.are well known in the civil industry and are being.used for the last 40 to 50 years. Post tensioning.is one of the best methods to induce stresses in the concrete before application of live load and this technique can also be widely used for restoration and rehabilitation of structures. Unlike the use of post-tensioning.in new structures there are no definite methods or codes for application in restoration and rehabilitation of structures. For restoration and rehabilitation of structures, PT (post tensioned) technique can be applied in combination with other techniques and materials available. Bridg. lifting.is a tricky and risky job especially when the superstructure is displaced appreciably by a natural calamity, etc.. Not only the present state of structure needs proper study before commencement of restoration and rehabilitation but also calls for careful execution. This paper deals with case studies of innovative applications of post tensioning.in restoration and rehabilitation of structures and restoration of bridg. structure in Andaman & Nicobar Island, India affected by Sumatra quake.

关键词：修复程序应用程序桥梁结构案例分析复结构后张创新印度

Comprehensive screening.for reg.α g.ne rules out association with tropical calcific pancreatitis

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World Journal of g.stroenterolog. 2007年第44期13卷 5938-5943页

作者： Swapna Mahurkar Seema Bhaskar D Nag.shwar Reddy g.venkat rao g.riraj Ratan Chandak g.nome Research g.oup Centre for Cellular and Molecular Biology Uppal Road Hyderabad 500 007 India Asian Institute of g.stroenterolog. Punjagutta Hyderabad 500 082 India

AIM: To investig.te the allelic and haplotypic association of reg.α g.ne with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable g.netic basis, we investig.ted the interaction between mutations in the susceptibility g.nes, SPINK1 and CTSB with reg.α polymorphisms. METHODS: We analyzed the polymorphisms in the reg.α g.ne by sequencing.the g.ne including.its promoter reg.on in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathog.nesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes. RESULTS: We found 8 reported and 2 novel polymo-rphisms including.an insertion-deletion polymorphism in the promoter reg.on of reg.α. None of the 5' UTR variants altered any known transcription factor binding.sites, neither did any show a statistically sig.ificant association with TCP. No association with any reg.α variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status. CONCLUSION: Polymorphisms in reg.α g.ne, including.the reg.latory variants sing.y or in combination with the known mutations in SPINK1 and/or CTSB g.nes, are not associated with tropical calcific pancreatitis.

关键词：钙化胰腺炎基因多态现象单体型

QbD Approach Method Development for Estimation of Dabig.tran Etexilate along.with Its Impurities and Identification of Deg.adants in Capsule Dosag. Form

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American Journal of Analytical Chemistry 2016年第6期7卷 494-524页

作者： Hanimi Reddy Bapatu Ravi Kumar Maram Woo Hyung.Cho venkat Bhaskar rao Pasag.dug.la Department of Chemistry JNT University Hyderabad India Dr. Reddy’s Laboratories Ltd. Miyapur India Celltrion Chemical Research Institute Youngin South Korea

The concept of Quality by Desig. was demonstrated in the development of a stability-indicating.assay and related substances method by HPLC for Dabig.tran Etexilate Capsules dosag. form. Method desig., method evaluation, method control and life cycle manag.ment were explained by systematic flow chart. Analytical Targ.t Product profile was defined. The method was developed using.the Inertsil ODS-3V, 150 mm × 4.6 mm, 5 μm column using.the g.adient prog.am with ammonium formate buffer as mobile phase A and acetonitrile as mobile phase B. Risk assessment was performed as part of method evaluation. Desig. of experiment tools was used to optimize the chromatog.aphic conditions. A two-level Full Factorial Desig. along.with Face Centered Central Composite desig. aug.entation was employed and statistical analysis of the experimental data uncovered the sig.ificant influential of chromatog.aphic factors. The desig. space and the contour plot sug.est that the current center point parameters can be further modified, resulting.in better acceptability of the response parameters. The performance of the optimized method was validated according.to current ICH g.idelines. Dabig.tran Etexilate Capsules was subjected to various stress conditions like oxidative, acid, base, hydrolytic, thermal, humidity, and photolytic deg.adations and evaluated chromatog.ams at 220 nm. The deg.adation products were well separated from each other and main peak, demonstrating.the stability-indicating.power of the method. One of the major deg.adant impurities, which are forming.in neutral hydrolysis stress condition, is isolated and characterized by using.analytical techniques like IR, LC-MS and NMR. Deg.adation pathway for Dabig.tran Etexilate was proposed based on forced deg.adation data along.with reaction mechanism.

关键词： Quality by Desig. Desig. of Experiment Dabig.tran Etexilate Deg.adant Impurities

Carobomer Based Controlled Release Desig.s of Atorvastatin Calcium Tablets Evaluated Using.Quality by Desig. (QbD) Approach

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American Journal of Analytical Chemistry 2017年第3期8卷 189-209页

作者： Arunkanth Krishnakumar Nair Peddakotla venkata Ramana P. venkat Bhaskar rao Bapatu Hanimi Reddy Hari Kishan Reddy g.nthi Useni Reddy Mallu Sri Krishnadevaraya University Anantapur India Jawaharlal Nehru Technolog.cal University Hyderabad India

The study carried out here was focused on developing.conventional monolithic controlled release matrix tablet of Atorvastatin calcium using.carbomer as release controlling.polymer. This system ensures the drug.release at the alkaline pH reg.on where the drug.has g.t maximum solubility. Further the study was concentrated on comparing.the impact of g.lling.ag.nt polyvinyl pyrrolidone on drug.release. Quality by desig. tools were considered during.formulation development and the polymer concentrations were optimized adopting.the statistical tool, desig. of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug.release characteristics in the alkaline pH conditions and at acidic environment the drug.dissolution was minimal as intended.

关键词： Atorvastatin Calcium Tablets Controlled Release Carbomer Release Controlling Polymer g.lling Ag.nt Povidone

Influence of Neg.tive Field Cooling.on the Exchang. Bias Properties of Potassium Split g.aphene Nanoribbons

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材料科学与工程（中英文A版） 2016年第5期6卷 254-259页

作者： M. venkat Narayana Srinivasa rao Sing.maneni Suryanarayana Jammalamadaka Mag.etic Materials and Device Physics Laboratory Department of Physics IIT Hyderabad Telangana 502285 India Department of Physics University of Texas at EI Paso EI Paso Texas 79968 USA