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Engineered Regeneration 2024年第2期5卷 269-281页

作者： greg sacks Vincent DeStefano Claire Parker Ryan Lebens Harry Mushlin Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA

Nucleus Pulposus(NP)Replacement is a developing surgical methodology for the treatment of pathology related to degeneration of intervertebral discs(IVDs).This article provides necessary context regarding the patholo-gies treated with this technology,the biomechanical structure and function of the IVD,and the procedures this technology aims to ***,it provides an overview and discussion of commercial and experimental preformed and in situ curing prosthesis designs reported in the scientific literature and summarizes the results of biomechanical and clinical studies evaluating their *** and updated information on the most recent research into NP replacement with novel hydrogel and tissue engineering(TE)strategies is *** of the NP allows for potential improvement in the treatment of degenerative spinal pathologies through minimally invasive surgical techniques.

关键词： Nucleus Pulposus Intradiscal Prosthesis Hydrogel Artificial Disc Implant Spine Surgery

PETg:Applications in Modern Medicine

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Engineered Regeneration 2024年第1期5卷 45-55页

作者： Catherine Yan Corinne Kleiner Aaron Tabigue Veer Shah gregory sacks Darshi Shah Vincent DeStefano Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA Department of Biology Niagara UniversityLewistonNYUSA Stony Brook University Stony BrookNYUSA Department of Mechanical and Industrial Engineering Northeastern UniversityBostonMAUSA

Polyethylene terephthalate glycol,PETg,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical *** may be manufactured in several ways,most notably 3D printing *** such,PETg has emerged as a viable biomaterial for a variety of medical applications such as tissue engineering,dentistry,optometry,vascular health,cardiology,orthopedics,neurology,gynecology,and *** also serves a valuable role in biomedical research and engineering by offering improvements in cell studies,drug carriers,and anti-bacterial *** medical research and innovation utilizing PETg will better characterize its value as an inexpensive and versatile biomaterial.

关键词： Polyethylene terephthalate glycol Tissue Engineering 3D Printing Clinical Applications Biomedical Research

营养素度量法的应用:慢性疾病预防饮食中的潜在角色以及核心营养素度量体系的可行性

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营养健康新观察 2014年第1期 37-38页

作者： g sacks M Rayner L Stockley P Scarborough W Snowdon B Swinburn 刘轶群 Deakin Population Health Deakin University British Heart Foundation Health Promotion Research group Department of Public HealthUniversity of Oxford Pacific Research Centre for the Prevention of Obesity and Non-communicable Diseases(C-POND) Fiji School of Medicine

背景/目的:大量不同的营养素度量模型被提出但只有少量营养素度量法的应用被评估验证。本论文旨在描述营养素度量法的应用在慢性疾病饮食(DRCD)中的潜在角色,以及考虑核心营养素度量体系的可行性,哪一个可以被改进从而加强特定国家中多... 详细信息

背景/目的:大量不同的营养素度量模型被提出但只有少量营养素度量法的应用被评估验证。本论文旨在描述营养素度量法的应用在慢性疾病饮食(DRCD)中的潜在角色,以及考虑核心营养素度量体系的可行性,哪一个可以被改进从而加强特定国家中多重潜在应用的基础。方法:市场营销中的4‘P'(产品、促销、地点和价格)被作为一个框架去识别和区分营养素度量法的潜在应用。逻辑通路的提出可被适用于评估营养素度量干预对行为改变、饮食改变以及慢病饮食效果改变的潜在影响。核心营养素度量体系的可行性可用于评估不同模型设计策略的影响以及不同目的的适宜性。结果和结论:使用营养素度量法作为干预慢病饮食策略的一部分具有巨大的空间。核心营养素度量体系作为各种应用的基础是可以减少差异以及缩小监管机构、制造商和消费者的混乱。并且它作为公共元素并被合并为核心体系的一部分也是可行的,例如,标准评分法、营养素的核心体系、食物成分和清晰的食物分类,以及额外的专用标准应用。无论如何,在一个系统的发展和实施过程中需要与几个特定国家的背景和技术性因素相协调。

关键词：营养素度量法慢性疾病饮食应用

营养素度量法的应用:慢性疾病预防饮食中的潜在角色以及核心营养素度量体系的可行性

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营养素度量法的应用:慢性疾病预防饮食中的潜在角色以及核心营养...

Prenatal administration of heparin-binding epidermal growth factor-like growth factor in an experimental model of necrotizing enterocolitis decreased both incidence and severity of the disease

背景/目的:大量不同的营养素度量模型被提出但只有少量营养素度量法的应用被评估验证。本论文旨在描述营养素度量法的应用在慢性疾病饮食(DRCD)中的潜在角色,以及考虑核心营养素度量体系的可行性,哪一个可以被改进从而加强特定国家中多重潜在应用的基础。方法:市场营销中的4‘P’(产品、促销、地点和价格)被作为一个框架去识别和区分营养素度量法的潜在应用。逻辑通路的提出可被适用于评估营养素度量干预对行为改变、饮食改变以及慢病饮食效果改变的潜在影响。核心营养素度量体系的可行性可用于评估不同模型设计策略的影响以及不同目的的适宜性。结果和结论:使用营养素度量法作为干预慢病饮食策略的一部分具有巨大的空间。核心营养素度量体系作为各种应用的基础是可以减少差异以及缩小监管机构、制造商和消费者的混乱。并且它作为公共元素并被合并为核心体系的一部分也是可行的,例如,标准评分法、营养素的核心体系、食物成分和清晰的食物分类,以及额外的专用标准应用。无论如何,在一个系统的发展和实施过程中需要与几个特定国家的背景和技术性因素相协调。

关键词：营养素度量法慢性疾病饮食应用

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World Journal of Pediatric Surgery 2022年第1期5卷 18-24页

作者： Marla Ashley sacks Yomara Stephanie Mendez Faraz A Khan Robert Propst Craig W Zuppan Christopher g Wilson Andrei Radulescu Division of Pediatric Surgery Department of SurgeryLoma Linda University Children's HospitalLoma LindaCaliforniaUSA Department of Pathology Loma Linda University Children's HospitalLoma LindaCaliforniaUSA Department of Neonatology Loma Linda University Children's HospitalLoma LindaCaliforniaUSA

background Necrotizing enterocolitis(NEC)is the leading gastrointestinal cause of death in premature infants and causes long-term ***,enteral heparin-binding epidermal growth factor-like growth factor(HB-EgF)administered after birth demonstrated decreased incidence and severity of NEC in a neonatal animal model of *** investigated the potential prophylactic strategy of preventing NEC using prenatally administered *** An HB-EgF(800μg/kg/dose)dose was injected into pregnant rats via tail vein or intraperitoneal route 2 hours prior to *** cesarean section(C-section)at 21 days’gestation,the rat pups were subjected to the NEC protocol by inducing stressors:hypoxia,hypothermia,hypertonic feeds,and orogastric gavage of lipopolysaccharide(2 mg/kg).Postnatally,pups were monitored for 96 hours and assessed for the development of clinical and postmortem histological *** The experimental NEC incidence in untreated,stressed rat pups was 66%.Compared with untreated pups,the maternal administration of HB-EgF correlated with a significant NEC incidence and severity decrease in rat *** strongest decrease was seen when HB-EgF was administered via the intraperitoneal route 2 hours prior to C-section(66%vs 31%,*pgF administration significantly increased pups’survival after NEC protocol exposure,with the greatest benefit observed in the group that received HB-EgF intraperitoneally 2 hours before *** Prenatal administration of HB-EgF decreases the incidence and severity of NEC,preserves gut barrier function and increases *** may represent a novel prophylactic clinical strategy for NEC offered to mothers at risk of delivering a premature infant.

关键词： severity heparin incidence

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膳食脂肪与血压

国外医学（卫生学分册） 1991年第4期18卷 234-237页

作者： sacks FM 王庆国

30多年的人群研究提供了充分的证据表明高血压对心血管疾病有不利影响。某一人群的平均血压水平同该人群心脑血管病的流行有关。由于观察到平均血压不同的人群其膳食存在着差别,因此对营养素与血压间关系进行直接研究。降低钠盐摄入虽... 详细信息

30多年的人群研究提供了充分的证据表明高血压对心血管疾病有不利影响。某一人群的平均血压水平同该人群心脑血管病的流行有关。由于观察到平均血压不同的人群其膳食存在着差别,因此对营养素与血压间关系进行直接研究。降低钠盐摄入虽可降低血压,特别是对于已确诊的高血压病人,但目前已知,在一个社会团体内或几个社会团体间钠摄入量的差异只会引起血压的很小变异。许多平均血压低的人群其膳食总脂肪和饱和脂肪酸含量也低。本文评述了膳食脂肪和血压之间可能存在的关系及有关的回顾性。

关键词：膳食脂肪血压高血压

Radio Frequency-Microchannels for Transdermal Delivery: Characterization of Skin Recovery and Delivery Window

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Pharmacology & Pharmacy 2012年第1期3卷 20-28页

作者： Yossi Kam Hagit sacks Keren Mevorat Kaplan Meir Stern galit Levin 不详

Transdermal delivery through Radio-Frequency-MicroChannels (RF-MCs) was proven to be a promising delivery method for hydrophilic drugs and macromolecules that must be injected. An important issue in assessing this technology is the life span of the microchannels (MCs). The time window in which the MCs remain open affects the delivery rate and determine the effective delivery duration. The present work focused on the characterization of the ViaDor-MCs recovery and closure process by measurements of transepidermal water loss (TEWL) before and after the formation of MCs, evaluation of the delivery window, and assessment of skin histology. Testosterone-cyclodextrin complex was used as the model drug for evaluation of the transdermal delivery. In-vitro permeation system and in-vivo guinea pig animal model were used in the delivery studies. Our findings demonstrate the recovery process of MCs created by the RF ablation technology. The observed gradual skin recovery affected the transdermal delivery rate. A significant transdermal delivery was shown up to 24 hrs post device application suggesting that an extended delivery of water soluble drugs, including macromolecules, is possible. The histology assessments demonstrated repair and healing of the induced MCs indicating that the RF micro-channeling technology is minimally invasive, transient in nature with no resulting skin trauma.

关键词： Microporation Microchannels RF ablation testosterone Transdermal Delivery

gaAs/Al_(0.23)ga_(0.77)As双量子阱的带边不连续性和阱间耦合

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物理学报 1992年第8期41卷 1322-1329页

作者：潘士宏黄晖张存洲 R.N.sacks 南开大学物理系天津300071 United Technologies Research Center East HartfordConnectioutU.S.A.

本文报道在300和77K对一组具有不同垒宽Lb的gaAs/Al_(0.23)ga_(0.77)As双量子阱样品的光调制反射谱(PR)的研究结果。除观察到11H,11L和22H等容许跃迁外,同时还识别一个从Al_(0.23)ga_(0.77)As价带顶至量子阱第一电子束缚能级的跃迁,另... 详细信息

本文报道在300和77K对一组具有不同垒宽Lb的gaAs/Al_(0.23)ga_(0.77)As双量子阱样品的光调制反射谱(PR)的研究结果。除观察到11H,11L和22H等容许跃迁外,同时还识别一个从Al_(0.23)ga_(0.77)As价带顶至量子阱第一电子束缚能级的跃迁,另一个从量子阱第一轻空穴束缚能级至Al_(0.23)ga_(0.77)As导带底的跃迁。利用这些跃迁确定导带边不连续性为0.63。对Lb≤40实验观察到11H和11L跃迁都明显地分裂成对称和反对称分量,对分裂大小的实验值与理论计算作了比较。在77K的11H的PR谱中在高能端明显地出现一个肩形峰,其形状不能用PR标准线形来拟合。如认为它对应于带间跃迁,并由此估计激子的束缚能约为8meV。

关键词：双量子阱带边不连续性阱间耦合

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糖尿病孕妇的血糖水平对婴儿出生体重的影响

世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 22-23页

作者： sacks D.A. Wolde-Tsadik g. 吕涛 Department of Obstetrics and gynecology Kaiser Foundation Hospital Bellflower CA United States Dr.

Objective: This study was undertaken to determine the proportion of birth weight attributable to glucose concentrations of diabetic mothers. Study design: Data of diabetic women who used insulin were eligible for analysis if the women had been treated during pregnancy for at least 12 weeks, and had recorded at least 50% of 4 daily glucose checks (fasting and 1- hour postprandial) until the last office visit before delivery. The independent association between maternal glucose values and demographics and birth weight percentiles for gestational age and gender were analyzed by multiple regression methods. Results: Data of 90 diabetic women were analyzed. Only third-trimester glucose concentrations were associated with birth weight. Prepregnancy body mass index was also selected in the models, including second-and/or third-trimester glucose. Together, these variables explained 18% of the variance in birth weight percentiles. Conclusion: Maternal glycemia during third-trimester and prepregnancy body mass index are independent predictors of birth weight in pregnancies complicated by insulin-requiring gestational or type 2 diabetes.

关键词：糖尿病孕妇婴儿出生体重妊娠晚期孕前体重指数变异情况多元回归方法人口统计学最后一次周和

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超越精度的顶峰

现代制造 2007年第3期 76-78页

作者： Terry sacks 海克斯康测量技术(青岛)有限公司

无需赘述在飞机组装过程中测量不精确所带来的消极影响,这样．使得质量保证和测量技术在空间飞行领域具有着非常重要的作用。这也是空中客车公司在不来梅工厂采用七台Leica激光跟踪仪的意义所在。通过使用Leica激光跟踪仪,并配备新型的T... 详细信息

无需赘述在飞机组装过程中测量不精确所带来的消极影响,这样．使得质量保证和测量技术在空间飞行领域具有着非常重要的作用。这也是空中客车公司在不来梅工厂采用七台Leica激光跟踪仪的意义所在。通过使用Leica激光跟踪仪,并配备新型的T-Probe测量系统,不来梅的员工显著节省了生产成本和时间。

关键词：激光跟踪仪 Leica 精度空中客车公司测量技术组装过程空间飞行质量保证