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Chinese Chemical Letters 2003年第4期14卷 401-403页

作者： Bao Hai shao Xiu Zhu XU Jian De LU li ZOU Xiao Yun fu Department of Chemistry Zhejiang UniversityHangzhou 310027

The influence of different alcohol modifiers in mobile phase on the chiral separation of 4-methoxyl flavanone, 5-methoxyl flavanone and 6-methoxyl flavanone on cellulose tris (3, 5-dimethylphenylcarbamate) (CDMPC) column was studied and the chiral recognition mechanism was discussed. Using hexane-tert-butanol (1.31 mol L-1) as the mobile phase, those three methoxyl flavanones were excellently separated on CDMPC chiral column.

关键词： Cellulose tris (3,5-dimethylphenylcarbamate) methoxyl flavanone chiral stationary phase enantioseparation.

Bilateral liver resection for bilateral intrahepatic stones

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World Journal of Gastroenterology 2009年第29期15卷 3660-3663页

作者： shao-Qiang li li-Jian liang Yun-Peng Hua Bao-Gang Peng Dong Chen Shun-Jun fu Department of Hepatobiliary Surgery the First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080 Guangdong Province China

AIM: To evaluate the shortand long-term outcomes of bilateral liver resection for bilateral intrahepatic stones. METHODS: We reviewed retrospectively 101 consecutive patients with bilateral intrahepatic stones who underwent bilateral liver resection in the past 10 years. The shortand long-term outcomes of the patients were analyzed. The Cox proportional hazards model was used to identify the risk factors related to stone recurrence. RESULTS: There was no surgical mortality in this group of patients. The surgical morbidity was 28.7%. Stone clearance rate after hepatectomy was 84.2% and final clearance rate was 95.0% following postoperative choledochoscopic lithotripsy. The stone recurrence rate was 7.9% and the occurrence of postoperative cholangitis was 6.5% in a median follow-up period of 54 mo. The Cox proportional hazards model indicated that liver resection range, less than the range of stone distribution (P = 0.015, OR = 2.152) was an independent risk factor linked to stone recurrence. CONCLUSION: Bilateral liver resection is safe and its shortand long-term outcomes are satisfactory for bilateral intrahepatic stones.

关键词： Intrahepatic stone Hepatectomy Riskfactor Outcome Bilateral

Phenolic extract of Morchella angusticeps peck inhibited the proliferation of HepG2 cells in vitro by inducing the signal transduction pathway of p38/MAPK

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Journal of Integrative Agriculture 2020年第11期19卷 2829-2838页

作者： li fu-hua ZHENG shao-jie ZHAO Ji-chun liAO Xia WU Su-rui MING Jian College of Food Science Southwest UniversityChongqing 400715P.R.China Research Center of Food Storage&Logistics Southwest UniversityChongqing 400715P.R.China Kunming Edible fungi Institute All China Federation of Supply and Marketing CooperativesKunming 650223P.R.China

Morchella angusticeps Peck,one of the most popular edible mushrooms,has attracted great attention due to its delicious taste and healthy ***,both its biological effects and the possible mechanism of action have not yet been *** investigated the anti-proliferative activity of the phenolic extract derived from Morchella angusticeps Peck(MPE)against HepG2 human hepatocellular carcinoma *** showed that MPE at non-cytotoxicity doses significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner with inhibitory rates ranging from 18 to 90%(Plin D1,cyclin-dependent kinases-4(CDK4)and proliferating cell nuclear antigen(PCNA).Additionally,MPE downregulated TRAF-2 and p-p53,while upregulated p-ASK1 and ***,it could be inferred that MPE might induce the anti-proliferative function to HepG2 cells through the p38/MAPK signal transduction pathway.

关键词： Morchella angusticeps Peck phenolic extract cell cycle apoptosis anti-proliferation

Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome:A Narrative Review

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Chinese Journal of Integrative Medicine 2022年第8期28卷 753-761页

作者： YUAN Jia-yao fu Yu FENG Zhi-hai SANG Feng shao Ming-yi li Lei-lei School of First Clinical Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Gastroenterology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 *** of the NLRP3 inflammasome leads to the secretion of the proinflammatory cytokines interleutkin(IL)-1β and IL-18 and induces *** studies have shown that the NLRP3 inflammasome participates in the initiation and progression of diabetic atherosclerosis through pathological mechanisms such as β-cell dysfunction,insulin resistance,endothelial cell dysfunction,monocyte adhesion and infiltration,and smooth muscle cell proliferation and *** diabetic atherosclerosis,Chinese medicine has been proven effective for the inflammatory response mediated by the NLRP3 *** review summarizes the latest progress on the NLRP3 inflammasome in the pathogenesis and potential Chinese medicine treatment of diabetic atherosclerosis.

关键词： Chinese medicine diabetic atherosclerosis NLRP3 inflammasome interleukin-1β TXNIP pyroptosis

脂肪间充质干细胞来源外泌体改善放射性口腔黏膜炎

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中国组织工程研究 2025年第1期29卷 31-37页

作者：李杨付丽丽杨建堂遵义医科大学附属口腔医院贵州省遵义市563000

背景:头颈肿瘤放疗极易引起放射性口腔黏膜炎,严重影响患者的健康及肿瘤的治疗计划。间充质干细胞在多种疾病中表现出治疗潜力,外泌体是其发挥功能的重要因素之一。目前尚无脂肪间充质干细胞来源外泌体应用于放射性口腔黏膜炎的相关研... 详细信息

背景:头颈肿瘤放疗极易引起放射性口腔黏膜炎,严重影响患者的健康及肿瘤的治疗计划。间充质干细胞在多种疾病中表现出治疗潜力,外泌体是其发挥功能的重要因素之一。目前尚无脂肪间充质干细胞来源外泌体应用于放射性口腔黏膜炎的相关研究。目的:探讨脂肪间充质干细胞来源外泌体在放射性口腔黏膜炎中的作用。方法:提取脂肪间充质干细胞及脂肪间充质干细胞来源外泌体并进行鉴定。通过3 Gy X射线辐射口腔黏膜上皮细胞诱导放射性口腔黏膜炎体外模型,在造模前给予脂肪间充质干细胞或脂肪间充质干细胞来源外泌体预处理48 h,EdU实验和克隆形成实验检测口腔黏膜上皮细胞的增殖能力。通过3 Gy X射线辐射构建放射性口腔黏膜炎小鼠模型,将脂肪间充质干细胞和脂肪间充质干细胞来源外泌体分别注入放射性口腔黏膜炎小鼠尾静脉,采用苏木精-伊红染色和免疫组化评估口腔黏膜上皮组织的炎症变化。结果与结论:(1)与对照组相比,脂肪间充质干细胞及脂肪间充质干细胞来源外泌体均可促进口腔黏膜上皮细胞克隆形成,增加口腔黏膜上皮细胞EdU阳性率;(2)脂肪间充质干细胞及脂肪间充质干细胞来源外泌体均能够缓解辐射处理小鼠口腔黏膜上皮组织的炎症;口腔黏膜上皮组织中CD45阳性细胞均减少,PCNA阳性细胞均增加。结果表明,脂肪间充质干细胞来源外泌体可促进口腔黏膜上皮细胞增殖,对放射性口腔黏膜炎小鼠口腔黏膜炎症具有缓解作用。

关键词：放射性口腔黏膜炎脂肪间充质干细胞外泌体头颈部肿瘤放疗口腔黏膜炎症恶性肿瘤

Priori knowledge based a bathymetry assessment method using the sun glitter imagery:a case study of sand waves on the Taiwan Banks

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Acta Oceanologica Sinica 2014年第1期33卷 120-126页

作者： shao Hao li Yan li li State Key Laboratory of Marine Environmental Science Xiamen University Troops 91039 the Chinese People's Liberation Army Third Institute of Oceanography State Oceanic Administration

High resolution optical satellite imageries containing the sun glitter,similar to synthetic aperture radar（SAR） imageries,are useful in identifying and mapping of bottom topography in shallow *** errors in the previous studies are corrected,and a method for mapping submarine bottom topography is developed using the sun glitter satellite *** method is established on the basis of empirical description of a sand wave using an equation with two unknowns named r and *** order to determine r and k,a ＂trial and error＂ approach is introduced and testified by a case study on the Taiwan Banks using an ASTER *** results show that the inversed water depths match well with the sounding water *** agreement between the inversed results and the in situ measurements is about 78% by comparing 371 ***,this method has the advantage in keeping the original appearance of a sand wave,especially in positions around the sand wave *** fine agreement indicates that the imaging model is flexible and the approach developed is feasible.

关键词： sun glitter submarine topography sand wave Taiwan Banks

Pregnancy complicated by juxtaglomerular cell tumor of the kidney:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2541-2548页

作者： Xian fu Gang Deng Kai Wang Chang shao li-Ping Xie Department of Urology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Juxtaglomerular cell tumor(JGCT)of the kidney,also known as reninoma,is a rare renal tumor that typically clinically manifests as hypertension,hypokalemia,high renin,and high *** is a cause of secondary *** with JGCT is rarer and easily misdiagnosed as pregnancy-induced hypertension,thus affecting *** SUMMARY A 28-year-old woman presented in early pregnancy with hypertension(blood pressure of 229/159 mmHg),nausea,and occasional dizziness and *** patient was diagnosed with pregnancy-induced hypertension,and no relief was found after symptomatic treatment;hence,the pregnancy was terminated by artificial *** blood pressure remained high following termination of *** tests suggested hypokalemia(2.997 mmol/L),blood aldo-sterone measured 613 ng/L,and computed tomography urography showed a tumor in the right ***,laparoscopic partial nephrectomy was *** surgery,the patient’s blood pressure returned to normal,and blood potassium,aldosterone,and renin *** pathological examination revealed *** long-term follow-up,the patient became pregnant again 6 mo after *** hypertension occurred during pregnancy,and the patient delivered a healthy female *** Patients with pregnancy complicated by JGCT are difficult to ***,we advise surgeons on proper handling of such situations.

关键词： Juxtaglomerular cell tumor Pregnancy Hypertension Hypokalemia Partial nephrectomy Case report

AN INSIGHT ON DRIVERS OF LAND USE CHANGE AT REGIONAL SCALE

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Chinese Geographical Science 2006年第2期16卷 176-182页

作者： shao Jing-an WEI Chao-fu XIE De-ti College of Resource and Environment Southwest University Chongqing 400716 P. R. China Chongqing Key Laboratory of Digital Agriculture Chongqing 400716 P. R. China

The studies of driving forces of regional land use change (LUC) are to reveal the real motivation behind the LUC and its interacting mechanism, so as to simulate and predict the process of LUC. Presently, studies rooting from different natural and socio-economic backgrounds and from different scales have deepened the people’s understanding and cognition to driving forces of regional LUC. Biophysical driving forces are relatively stable, and have the cumulating effects. Human driving forces are relatively active, and are main driving forces of short-term regional LUC. Existing regional LUC models can answer the three main problems: which contribution (why), which location (where) and what rate (when). But, regional land use system is defined as the self-organized system, usually affected by the cri- tical value area and sudden change, and controlled by different stages. To reduce the impact of critical threshold and break on land use system, the studies of LUC driving forces will aim at following priority areas: data linkage between remote sensing and no-remote sensing data; underlying driving force identification; driving factor quantification; driving factor scale dependence; and driving process integration simulation.

关键词： land use change driving forces driving mechanism process simulation regional scale

Fabrication of a flexible microwave absorber sheet based on a composite filler with fly ash as the core filled silicone rubber

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International Journal of Minerals,Metallurgy and Materials 2023年第3期30卷 548-558页

作者： Qiuying li Yiheng Lu Zhuoyan shao Polymer Processing Laboratory School of Material Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

A new type of composite filler was designed by a modified sol-gel method using fly ash(FA),Fe(NO_(3))_(3)·9H_(2)O,and Ni(NO_(3))_(2)·6H_(2)O as raw *** composite filler was a spherical core-shell structure composed of FA as the core and NiFe_(2)O_(4)as the ***,the composite filler was added into the silicone rubber to fabricate the high temperature vulcanized microwave absorption materials;X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,and scanning electron microscope confirmed that NiFe_(2)O_(4)was successfully coated on the surface of FA and formed a uniform and continuous coating *** expected,silicone rubber filled with the composite filler had a minimum reflection loss of-23.8 dB at 17.5 GHz with the thickness of 1.8 mm,while the effective absorption bandwidth was as high as 12 *** addition of the composite filler greatly enhanced the microwave absorption properties of the system,which was resulted from multiple losses mechanism:interface polarization losses,magnetic losses,and multiple reflection ***,silicone rubber filled with the composite filler exhibited excellent thermal stability,flexibility,environmental resistance,and hydrophobicity compared with traditional silicone ***,this work not only responds to the green chemistry to achieve efficient FA recovery,but also devises a new strategy to prepare microwave absorption materials with strong potential for civilian applications.

关键词： fly ash microwave absorption silicone rubber multiple losses mechanism

Cell membrane-covered nanoparticles as biomaterials

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National Science Review 2019年第3期6卷 551-561页

作者： Mingjun Xuan Jingxin shao Junbai li Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of Sciences (ICCAS)

Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in ***, exogenous properties make synthetic nanosystems invaders that easily trigger the passive immune clearance mechanism, increasing the retention effect caused by the reticuloendothelial systems and bioadhesion, finally leading to low therapeutic efficacy and toxic effects. Recently, a cell membrane cloaking technique has been reported as a novel interfacing approach from the biological/immunological perspective, and has proved useful for improving the performance of synthetic nanocarriers in vivo. After cell membrane cloaking, nanoparticles not only acquire the physiochemical properties of natural cell membranes but also inherit unique biological functions due to the presence of membrane-anchored proteins, antigens, and immunological moieties. The derived biological properties and functions, such as immunosuppressive capability, long circulation time, and targeted recognition integrated in synthetic nanosystems, have enhanced their potential in biomedicine in the future. Here, we review the cell membrane-covered nanosystems, highlight their novelty, introduce relevant biomedical applications, and describe the future prospects for the use of this novel biomimetic system constructed from a combination of cell membranes and synthetic nanomaterials.

关键词： cell membranes synthetic nanosystem bio-stealth long circulation time biomedical applications