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New Modified Jacobi Elliptic function Expansion Method and Its Application to （3＋1）-Dimensional KP Equation

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Communications in Theoretical Physics 2006年第6期45卷 1063-1068页

作者： DOU fu-Quan SUN Jian-An DUAN Wen-shan SHI Yu-Ren Lü Ke-Pu HONG xue-Ren College of Physics and Electronics Engineering Northwest Normal University Lanzhou 730070 China

With the aid of computerized symbolic computation, the new modified Jacobi elliptic function expansion method for constructing exact periodic solutions of nonlinear mathematical physics equation is presented by a new general ansatz. The proposed method is more powerful than most of the existing methods. By use of the method, we not only can successfully recover the previously known formal solutions but also can construct new and more general formal solutions for some nonlinear evolution equations. We choose the （3＋1）-dimensional Kadomtsev-Petviashvili equation to illustrate our method. As a result, twenty families of periodic solutions are obtained. Of course, more solitary wave solutions, shock wave solutions or triangular function formal solutions can be obtained at their limit condition.

关键词： MJEFE method KP equation periodic solutions solitary wave solutions

Inner wall running state monitoring for the main pipe of nuclear power

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Science China(Technological Sciences) 2013年第10期56卷 2606-2614页

作者： ZHANG YuCun ZHOU shan fu XianBin Institute of Electrical Engineering Yanshan University

The heat conduction equation is solved in this paper under specific boundary *** coefficients of the obtained distribution equation are simplified with the piecewise integral *** the associated model for the cylindrical thermal equipment is *** relationship of the surface temperatures,the material properties and the inner wall state of the cylindrical thermal equipment is described in the associated *** model is applied to the inner wall running state monitoring of the main pipe.A multi-channel distributed optical fiber temperature measurement system is designed to acquire the external surface temperatures of the main *** the associated model can be used to analyze the surface temperature data of the main *** location and the physical dimension of the inner wall defect can be ***,the inner wall defect monitoring of the main pipe can be *** feasibility of this method is verified by *** method also provides a theoretical basis for the real-time monitoring of the main pipe’s internal state.

关键词： inner wall defect running state monitoring multi-channel distributed optical fiber temperature measurement mainpipe of nuclear power

Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog

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Chinese Journal of Cancer 2016年第2期35卷 61-68页

作者： shan Wang Yan fu Yongzhang Luo The National Engineering Laboratory for Anti-tumor Protein Therapeutics School of Life SciencesTsinghua University Beijing Key Laboratory for Protein Therapeutics School of Life SciencesTsinghua University Cancer Biology Laboratory School of Life SciencesTsinghua University

Background:Endostatin(ES) is a well-established potent endogenous antiangiogenic *** ES variant,called zinc-binding protein-ES(ZBP-ES),is clinically available;however,its use is limited by rapid renal clearance and short residence *** has been exploited to overcome these shortcomings,and mono-PEGylated ES(called M_2ES) as well as mono-PEGylated ZBP-ES(MZBP-ES) are developed in our *** study aimed to compare the biophysical properties and biological effects of M_2ES and MZBP-ES to evaluate their ***:Circular dichroism and tryptophan emission fluorescence were used to monitor the conformational changes of M_2ES and *** resistance to trypsin digestion and guanidinium chloride(GdmCl)-induced unfolding was examined by Coomassie staining and tryptophan emission fluorescence,*** biological effects of M_2ES and MZBP-ES on endothelial cell migration were evaluated using Transwell migration and wound healing assays,and the uptake of M_2ES and MZBP-ES in endothelial cells was also compared by Western blotting and ***:Structural analyses revealed that M_2ES has a more compact tertiary structure than ***,M_2ES was more resistant to trypsin digestion and GdmCI-induced unfolding compared with *** addition,although M_2ES and MZBP-ES showed comparable levels of inhibiting transwell migration and wound healing of endothelial cells,M_2ES displayed an increased ability to enter cells compared with MZBP-ES,possibly caused by the enhanced interaction with ***:M_2ES has a more compact tertiary structure,is more stable for trypsin digestion and GdmCI-induced unfolding,exhibits increased cellular uptake and shows equivalent inhibitory effects on cell migration relative to MZBP-ES,indicating that M_2ES is a more promising candidate for anticancer drug development compared with MZBP-ES.

关键词： Endostatin, PEGylation, Antiangiogenic therapy, Drug design, Zinc-binding protein-endostatin

Existence and Uniqueness of Positive Solutions for Some Singular Boundary Value Problems with Linear functional Boundary Conditions

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Acta Mathematica Sinica,English Series 2011年第10期27卷 2073-2084页

作者： Zeng Qin ZHAO fu shan LI School of Mathematical Sciences Qufu Normal University Qufu 273165 P. R. China

By using the upper and lower solution method and fixed point theory, we investigate some nonlinear singular second-order differential equations with linear functional boundary conditions. The nonlinear term f（t, u） is nonincreasing with respect to u, and only possesses some integrability. We obtain the existence and uniqueness of the C[0, 1] positive solutions as well as the C1 [0, 1] positive solutions.

关键词： Linear functional boundary condition decreasing function positive solution upper and lower solution method fixed point theorem

Earth Pressure Distribution and Sand Deformation Around Modified Suction Caissons(MSCs) Under Monotonic Lateral Loading

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China Ocean Engineering 2019年第2期33卷 198-206页

作者： LI Da-yong LI shan-shan ZHANG Yu-kun CHEN fu-quan College of Civil Engineering Fuzhou University Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and Technology

The modified suction caisson(MSC) is a novel type of foundation for ocean engineering, consisting of a short external closed-top cylinder-shaped structure surrounding the upper part of the regular suction caisson(RSC). The MSC can provide larger lateral bearing capacity and limit the deflection compared with the RSC. Therefore, the MSC can be much more appropriate to use as an offshore wind turbine foundation. Model tests on the MSC in saturated sand subjected to monotonic lateral loading were carried out to investigate the effects of external structure sizes on the sand surface deformation and the earth pressure distribution along the embedded depth. Test results show that the deformation range of the sand surface increases with the increasing width and length of the external structure. The magnitude of sand upheaval around the MSC is smaller than that of the RSC and the sand upheaval value around the MSC in the loading direction decreases with the increasing external structure dimensions. The net earth pressure in the loading direction acting on the internal compartment of the MSC is smaller than that of the RSC at the same embedded depth. The maximum net earth pressure acting on the external structure outer wall in the loading direction is larger than that of the internal compartment, indicating that a considerable amount of the lateral load and moment is resisted by the external skirt structure.

关键词： MSC (modified suction caisson) RSC (regular suction caisson) model tests monotonic lateral loading deformation of sand surface earth pressure distribution

PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells

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Chemical Research in Chinese Universities 2006年第1期22卷 68-72页

作者： LI Zhao-fa XU xue-song SHEN Xing-gui LI Qing-shan ZHAO Zhi-zhuang fu xue-qi LI Yu-lin LI Yi-lei Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changchun 130021 P. R. China China-Japan Union Hospital Jilin University Changchun 130031 P. R. China The Key Laboratory of Pathobiology Ministry of Education Jilin University Changchun 130023 P. R. China

Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions.

关键词： PRL Metastasis Proliferation Expression SW480 cell SW620 cell

Performance evaluation and optimization design of photoelectric pyrometer detection optical system

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Defence Technology（防务技术） 2020年第2期16卷 401-407页

作者： xue-yan Han Ke-wei Huan shan-ju Sheng School of Science Changchun University of Science and TechnologyChangchun 130022China

The measurement and control of high temperature play very important roles in national defense,military,scientific experiments,industrial and agricultural *** pyrometer is one of the important radiation thermometers for non-contact temperature *** has an important application in the field of high temperature measurement,and its performance directly affects the accuracy of temperature *** improving the design of the detection optical system of the photoelectric pyrometer,the imaging performance of the photoelectric pyrometer can be improved effectively,and the temperature measurement accuracy can be *** this paper,the temperature measurement principle of photoelectric pyrometer,the wo rking principle of the detection optical system and the composition of the system are *** optical components that affect the imaging of the optical system of the photoelectric pyrometer are *** optical pyrometer detection optical system is simulated by ZEMAX software,based on the analysis results,the Modulation Transfer function(MTF)and the spot Diagram are used as the main evaluation criteria to optimize the design of the objective lens of the photoelectric pyrometer detection optical *** imaging performance of the photoelectric pyrometer detection optical system and the accuracy of temperature measurement of the photoelectric pyrometer are improved by optimization design of the detection optical system.

关键词： Photoelectric pyrometer Detection optical system ZEMAX MTF Spot diagram

Phosphorus sorption capacities in a headstream landscape—The pond chain structure

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Journal of Environmental Sciences 2006年第5期18卷 1004-1011页

作者： fu Qiang YIN Cheng-qing shan Bao-qing State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Understanding phosphorus sorption phenomena in different wetland sediments is important in controlling the P output in headstream watersheds. The pond chain structure （PCS） is widespread in the headstream agricultural watersheds in the southeast of China. Phosphorus sorption characteristics were determined for pond surface sediments （0-12 cm） along a pond chain structure in Liuchahe watershed of Chaohu Lake. Results showed that P sorption capacities （expressed by P sorption index （PSI）） varied both with the landscape position of the ponds and sediment depth. From foothill ponds to riverside ponds the P sorption capacities indicated a significant gradient variability. The higher elevation ponds showed greater sorption capacities, and with the pond elevation decline, P sorption capacities gradually decreased. Some physico-chemical properties, such as pH, oxalate-extractable Fe （Feox）, organic matter （TOC） and Mehlich l-extractable Ca, Mg of pond sediments also indicated significant gradient variability from high elevation ponds to low elevation ponds. Feox was the sediment parameters most highly positively correlated with PSI and was the key factor in controlling P sorption capacity in the pond chain structure （r=0.92, p〈0.001）. Long-term hydrologic and sediment inputs can affect the distribution of sediment constituents and further affect the P sorption capacity. Making the best of the spatial difference of sorption capacities of ponds in watersheds to control nonpoint source P pollutant is necessary.

关键词： pond sediment adsorption spatial variability nonpoint source

Efficient reinforcement learning in continuous state and action spaces with Dyna and policy approximation

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Frontiers of Computer Science 2019年第1期13卷 106-126页

作者： shan ZHONG Quan LIU Zongzhang ZHANG Qiming fu School of Computer Science and Technology Soochow UniversitySuzhou 215000China School of Computer Science and Engineering Changshu Institute of TechnologyChangshu 215500China Jiangsu Province Key Laboratory of Intelligent Building Energy Efficiency Suzhou University of Science and TechnologySuzhou 215006China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210000China College of Electronic &Information Engineering Suzhou University of Science and TechnologySuzhou 215000China

Dyna is an effective reinforcement learning (RL) approach that combines value function evaluation with model ***,existing works on Dyna mostly discuss only its efficiency in RL problems with discrete action *** paper proposes a novel Dyna variant,called Dyna-LSTD-PA,aiming to handle problems with continuous action ***-LSTD-PA stands for Dyna based on least-squares temporal difference (LSTD)and policy ***-LSTD-PA consists of two simultaneous,interacting *** learning process determines the probability distribution over action spaces using the Gaussian distribution;estimates the underlying value function,policy,and model by linear representation;and updates their parameter vectors online by LSTD(,t).The planning process updates the parameter vector of the value function again by using ofttine LSTD(2).Dyna-LSTD-PA also uses the Sherman-Morrison formula to improve the efficiency of LSTD(,t),and weights the parameter vector of the value function to bring the two processes ***,the global error bound is derived by considering approximation,estimation,and model ***,Dyna-LSTD-PA outperforms two representative methods in terms of convergence rate,success rate,and stability performance on four benchmark RL problems.

关键词： problem solving control methods heuristic search methods dynamic programming