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Prospective, randomized comparison of two supplemental oxygen methods during gastro-scopy with propofol mono-sedation in obese patients

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World Journal of Clinical Cases 2021年第20期9卷 5479-5489页

作者： Liu-Jia-Zi Shao Fang-Xiao Hong fu-Kun Liu Lei Wan fu-shan xue Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Hypoxemia is a common complication in obese patients during gastroscopy with *** Wei nasal jet tube(WNJT)is a new special nasopharyngeal airway with the ability to provide supraglottic jet ventilation and oxygen insufflation via its built-in wall *** aim of this study was to compare the efficacy and safety of the WNJT vs a nasal cannula for supplemental oxygen during gastroscopy with propofol mono-sedation in obese *** To compare the efficacy and safety of the WNJT vs a nasal cannula for supplemental oxygen during gastroscopy with propofol mono-sedation in obese *** A total of 103 obese patients with a body mass index of 30 kg/m2 or more undergoing elective gastroscopy under propofol mono-sedation were randomly assigned to receive supplemental oxygen at 5 L/min through either a WNJT(WNJT group,n=51)or a nasal cannula(nasal cannula group,n=52).The lowest pulse oxygen saturation(SpO2)and mild and severe hypoxemia during gastroscopy were *** primary outcome was the incidence of *** The lowest SpO2 during gastroscopy with propofol mono-sedation was significantly increased in the WNJT group compared with the nasal cannula *** incidence of mild hypoxemia and total incidence of hypoxemia were significantly lower in the WNJT group than in the nasal cannula *** than a higher incidence of epistaxis in the WNJT group,the occurrence of adverse events was similar between the *** neither device demonstrated a statistically significant difference in satisfaction among patients,the WNJT did result in improved satisfaction among anesthetists and *** During gastroscopy with propofol mono-sedation in obese patients,the WNJT,when compared with a nasal cannula for supplemental oxygen,can significantly reduce the occurrence of hypoxemia and improve both arterial oxygenation and satisfaction among anesthetists and *** use of the WNJT may,however,lead to epistaxis

关键词： Supplemental oxygen Gastroscopy Sedation Obese patients

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Perioperative transcutaneous electrical acupoint stimulation for improving postoperative gastrointestinal function:A randomized controlled trial

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Journal of Integrative Medicine 2021年第3期19卷 211-218页

作者： Wen-jing Li Chao Gao Li-xin An Yu-wei Ji fu-shan xue Yi Du Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Anesthesiology Beijing Hui-Min HospitalBeijing 100053China Department of Traditional Chinese Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Background:Postoperative gastrointestinal dysfunction(PGD)is one of the most common complications in patients undergoing major abdominal *** has been used widely in gastrointestinal diseases due to its effectiveness and minimally invasive ***:This study evaluated the efficacy of using transcutaneous electrical acupoint stimulation(TEAS)during the surgery and postoperative recovery in patients with gastric and colorectal surgery for improving postoperative gastrointestinal ***,setting,participants and interventions:A total of 280 patients undergoing abdominal surgery were stratified by type of surgery(i.e.,gastric or colorectal surgery)and randomly allocated into the TEAS group(group T)or the sham group(group S).Patients in group T received TEAS at LI4,PC6,ST36 and *** in group S received pseudo-TEAS at sham *** stimulation was given from 30 min before anesthesia until the end of *** same treatment was performed at 9 am on the 1st,2nd and 3rd days after surgery,until the recovery of flatus in *** outcome measures:The primary outcome was the time to the first bowel motion,as detected by *** secondary outcomes included the first flatus and ambulation time,changes of perioperative substance P(SP),incidence of PGD,postoperative pain,postoperative nausea and vomiting(PONV)and some economic ***:The time to first bowel motion,first flatus and first ambulation in group T was much shorter than that in group S(P<0.01).In patients undergoing colorectal surgery,the concentration of SP was lower in group T than in group S on the third day after the operation(P<0.05).The average incidence of PGD in all patients was 25%,and the frequency of PGD was significantly lower in group T than in group S(18.6%vs.31.4%,respectively;P<0.05).TEAS treatment(odds ratio=0.498;95%confidence interval:0.232–0.786)and type of surgery were relevant factors for the development of ***

关键词： Transcutaneous electrical acupoint stimulation Postoperative period Gastrointestinal disorders Substance P

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Is low postoperative cholesterol level really an independent risk factor of adverse outcomes after living donor liver transplantation?

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 378-379页

作者： Qing Liu fu-shan xue Gui-Zhen Yang Ya-Yang Liu Department of Anesthesiology Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Anesthesiology Beijing Friendship HospitalCapital Medical University

To the Editor:We read with great interest the article by Yang et al.[1]evaluating the effects of postoperative serum total cholesterol(s TC)changes on early allograft dysfunction and survival after living donor liver transplantation(LDLT).By the multivariate regression analysis,they showed that patients with s TC<1.42 mmol/L on postoperative day 3 had 4.08-fold and 2.72-fold greater risks of

关键词： Is low postoperative cholesterol level really an independent risk factor of adverse outcomes after living donor liver transplantation TC AUC

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Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography

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World Journal of Clinical Cases 2022年第9期10卷 2773-2782页

作者： Yi Zou Na Li Liu-Jia-Zi Shao fu-Kun Liu fu-shan xue Xing Tao Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Sedation during endoscopic ultrasonography(EUS)poses many challenges and moderate-to-deep sedation are often *** conventional method to preform moderate-to-deep sedation is generally intravenous benzodiazepine alone or in combination with ***,this combination has some *** medication delivery may be an alternative to this sedation *** To determine,by continual reassessment method(CRM),the minimal effective dose of intranasal sufentanil(SUF)when combined with intranasal dexmedetomidine(DEX)for moderate sedation of EUS in at least 95%of patients(ED95).METHODS Thirty patients aged 18-65 and scheduled for EUS were recruited in this *** received intranasal DEX and SUF for *** dose of DEX(1μg/kg)was fixed,while the dose of SUF was assigned sequentially to the subjects using CRM to determine *** sedation status was assessed by modified observer’s assessment of alertness/sedation(MOAA/S)*** adverse events and the satisfaction scores of patients and endoscopists were *** The ED95 was intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,with an estimated probability of successful moderate sedation for EUS of 94.9%(95%confidence interval:88.1%-98.9%).When combined with intranasal 1μg/kg DEX,probabilities of successful moderate sedation at each dose level of intranasal SUF were as follows:0μg/kg SUF,52.8%;0.1μg/kg SUF,75.4%;0.2μg/kg SUF,89.9%;0.3μg/kg SUF,94.9%;0.4μg/kg SUF,98.0%;0.5μg/kg SUF,99.0%.CONCLUSION The ED95 needed for moderate sedation for EUS is intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,based on CRM.

关键词： Moderate sedation Intranasal administration Dexmedetomidine Sufentanil Continual reassessment method Endoscopic ultrasonography

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Comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in patients with a normal body mass index

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World Journal of Gastroenterology 2020年第43期26卷 6867-6879页

作者： Liu-Jia-Zi Shao Yi Zou fu-Kun Liu Lei Wan Shao-Hua Liu Fang-Xiao Hong fu-shan xue Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Hypoxemia due to respiratory depression and airway obstruction during upper gastrointestinal endoscopy with sedation is a common *** Wei nasal jet tube(WNJT)is a new nasopharyngeal airway with the ability to provide supraglottic jet ventilation and oxygen insufflation via its built-in wall *** available evidence indicates that with a low oxygen flow,compared with nasal cannula,the WNJT does not decrease the occurrence of hypoxemia during upper gastrointestinal endoscopy with propofol *** date,there has been no study assessing the performance of WNJT for supplemental oxygen during upper gastrointestinal endoscopy with sedation when a moderate oxygen flow is *** To determine whether the WNJT performs better than the nasal prongs for the prevention of hypoxemia during gastroscopy with propofol mono-sedation when a moderate oxygen flow is provided in patients with a normal body mass *** This study was performed in 291 patients undergoing elective gastroscopy with propofol *** were randomized into one of two groups to receive either the WNJT(WNJT group,n=147)or the nasal cannula(nasal cannula group,n=144)for supplemental oxygen at a 5-L/min flow during *** lowest SpO2 during gastroscopy was *** primary endpoint was the incidence of hypoxemia or severe hypoxemia during *** The total incidence of hypoxemia and severe hypoxemia during gastroscopy was significantly decreased in the WNJT group compared with the nasal cannula group(P=0.000).The lowest median SpO2 during gastroscopy was significantly higher(98%;interquartile range,97-99)in the WNJT group than in the nasal cannula group(96%;interquartile range,93-98).Epistaxis by device insertion in the WNJT group occurred in 7 patients but stopped naturally without any *** two groups were comparable in terms of the satisfaction of physicians,anesthetists and *** With a moderate oxygen flow,the WNJT

关键词： Gastroscopy Hypoxemia Wei nasal jet tube Nasal cannula Supplemental oxygen Adverse outcomes

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Prokaryotic Expression and Polyclonal Antibody Preparation of PRL3

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Chemical Research in Chinese Universities 2007年第6期23卷 697-700页

作者： SHEN Xing-gui LI Wan-nan WANG Jing JIANG Yi-qun LI Qing-shan fu xue-qi Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changchun 130021 P. R. China

Phosphatase of regenerating liver 3 （ PRL3 ）, which belongs to the superfamily of protein tyrosine phosphatases （PTPs）, represents a group of low molecular weight PTPs that participate in tumorigenesis and metastasis processes. Presented here are the results of cloning, prokaryotic expression, purification, and polyclonal antibody preparation of PRL3. To obtain a specific polyclonal antibody against PRL3, the authors have prepared GST-PRL3 to immunize rabbits and purify an anti-PRL3 polyclonal antibody by negative selection affinity columns. Western blot analysis shows that the anti-PRL3 polyclonal antibody has a specific binding ability with PRL3 protein. The anti-PRL3 polyclonal antibody provides a good tool to further study the function of PRL3.

关键词： PRL3 Prokaryotic expression Polyclonal antibody

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Assessing Influences of Perioperative Transfusion on Early- and Late-Term Outcomes after Living Donor Liver Transplantation： Methodological Issues

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Chinese Medical Journal 2018年第10期131卷 1259-1260页

作者： fu-shan xue Ming Tian Department of Anesthesiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

To the Editor：In a retrospective study by Zheng et al. assessing the influences of perioperative single-donor platelet apheresis and red blood cell transfusion on 90-day and overall survival in 126 recipients who underwent their first adult-to-adult living donor liver transplantation （LDLT）,multivariate regression analysis showed that platelet transfusion was only associated with postoperative early-term mortality,but had no significant impact on postoperative overall long-term ***,units of red blood cell transfusion were independent predictors of postoperative long-term *** that perioperative blood transfusion has been associated with postoperative outcomes of LDLT patients,their findings have potential ***,this is a retrospective study,which can introduce a number of potential *** they have done a valuable job,some methodological issues seem important to avoid any optimistic interpretation or misinterpretation of their results.

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Fracheal Intubation Awake or Under Anesthesia for Potential Difficult Airway： Look Before You Leap

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Chinese Medical Journal 2018年第6期131卷 753-756页

作者： fu-shan xue Qian-Jin Liu Department of Anesthesiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Anesthesiology Washington University School of Medicine St. Louis Missouri USA

Securing a patent airway remains a pivotal point in clinical anesthesia, while failure to establish airway in anesthetized patients can cause severe outcomes in a few minutes. According to the closed claims analysis conducted by the American Society of Anesthesiologists, a leading cause of anesthesia-related patient injury is the inability to intubate the trachea and secure the airway. As consequences, 85% of those are either death or brain damage.

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Perioperative anaphylaxis:a potential hazard to the safety of surgical patients

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Chinese Medical Journal 2020年第5期133卷 609-612页

作者： Yi Zou Liu-Jia-Zi Shao fu-shan xue Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Anaphylaxis is a rare,but severe,potentially lifethreatening allergic reaction,which most commonly presents with multi-system involvements,such as cutaneous,cardiovascular,respiratory,gastrointestinal and central nervous system signs and *** can hardly be recognized when occurring in the perioperative period due to the many influencing factors,for example,the cutaneous changes concealed by sterile drapes,inability to describe their symptoms when patients are sedated or anesthetized,and the application of anesthetics leading to sympathetic blockade which presents with blood pressure *** of the above reasons make the identification and immediate treatment of perioperative anaphylaxis difficult and are partially attributable to high mortality.

关键词： patients involvement hazard

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New nomenclature of peri-operative cognitive impairments: possible impacts on further practice and research

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Chinese Medical Journal 2019年第15期132卷 1859-1861页

作者： Yi ZOU Liu-Jia-Zi Shao fu-shan xue Department of Anesthesiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Peri-operative neurocognitive disorders (PND) is a new term recommended by an international,multidisciplinary group named as Nomenclature Consensus Working Group including experts from multiple disciplines such as anesthesiology,neurology,geriatrics,psychiatry,neuropsychology,surgery,and *** is a comprehensive term for cognitive impairments identified in the perioperative *** recommendation of this new nomenclature has been published in several influential journals simultaneously in November 2018.[1-6] It is a tremendous change in the field of peri-operative cognitive ***,it is necessary to know the reasons and purposes of this new nomenclature,differences between old and new nomenclatures,and the possible impacts of new nomenclature on clinical and basic researches of peri-operative cognitive impairments in the future.

关键词： cognitive impairments practice research

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