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Safety and Efficacy of Physical Thermal Ablation Combined Sorafenib for Hepatocellular Carcinoma:A Meta-analysis

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 149-159页

作者： Mengdi Jin Qiong Yu Yahui Liu Weiling Xu xueqi fu Bai Ji Department of Hepatobiliary and Pancreatic Surgery the First Hospital of Jilin UniversityChangchunJilinChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchunJilinChina Edmond H.Fischer Signal Transduction Laboratory College of Life SciencesJilin UniversityChangchunJilinChina

Background and Aims:To compare the efficacy and safety of physical thermal ablation(PTA),including radiofrequency ablation(RFA)and microwave ablation(MWA),combined with sorafenib and physical thermal ablation alone for the control and treatment of hepatocellular carcinoma(HCC)according to the available ***:Comprehensive searches were performed on PubMed,Embase,CNKI,the Cochrane Library,China Biomedical Literature Database(known as CBM),Weipu Journal,and Wanfang ***-analysis was performed using Revman 5.3 ***:A total of 15 studies,consisting of 2,227 HCC patients,were selected and included in this *** with the RFA-alone group,the patients in the RFA+sorafenib group had longer 1-,2-,and 3-year overall survival(all p<0.05),better overall efficacy(p<0.0001),longer radiofrequency interval(p<0.001),and lower 2-year recurrence rate(p=0.02).The 1-year overall survival(p=0.003)and overall efficacy(p=0.002)of the MWA+sorafenib group were also higher than those of the MWA-alone *** incidences of adverse reactions in the RFA+sorafenib group,such as hand-foot skin reactions(p<0.001),diarrhea and constipation(p=0.0001),hypertension(p=0.009),and alopecia(p<0.001),were significantly higher than those in the RFA-alone ***:RFA or MWA combined with sorafenib has produced a better therapeutic effect on HCC than physical thermal ablation alone;however,adverse reactions have been *** is necessary to evaluate the safety of combination therapy,and pay close attention to the adverse reactions that develop in patients.

关键词： Physical thermal ablation Radiofrequency ablation Microwave ablation Sorafenib Hepatocellular carcinoma Meta-analysis

Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease

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BIOCELL 2023年第10期47卷 2163-2176页

作者： XIANGYU QUAN XUETING MA GUODONG LI xueqi fu JIANGTAO LI LINLIN ZENG Edmond H.Fischer Signal Transduction Laboratory School of Life SciencesJilin UniversityChangchun130012China Department of General Surgery The Second Hospital of Jilin UniversityChangchun130041China

Exosomes are extracellular vesicles with a 30–150 nm diameter originating from *** recent years,scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease(AD)across the blood-brain barrier due to their nanoscale size and low immunogenicity.A large amount of evidence shows that exosomes are rich in biomarkers,and it has been found that the changes in biomarker content in blood,cerebrospinal fluid,and urine are often associated with the onset of AD *** this paper,some recent advances in the use of exosomes in the treatment of AD are reviewed,and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes.

关键词： Exosome Alzheimer’s disease Biomarker Medical treatment Medical forecast

Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1756-1758页

作者： Xin Chen xueqi fu Wanke Zhao Wan-Ting Tina Ho Shu Xing Zhizhuang Joe Zhao Edmond H.Fischer Signal Transduction Laboratory College of Life SciencesJilin UniversityChangchunChina Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA

Dear Editor,Tyrosine phosphatase SHP2/PTPN11 plays an important role in cell *** mutation of SHP2 causes cancer,which makes the enzyme an anti-cancer drug *** selective and potent SHP2 inhibitors have been ***099,the best known SHP2 inhibitor currently in clinical trials,has been shown to be effective for receptor tyrosine kinase-driven and oncogenic KRAS-driven cancers1,*** employed a colorectal cancer cell line HCT-116 that carries a KRAS-G13D mutation in this ***,SHP2 inhibitors failed to inhibit HCT-116 growth and ERK1/2 activation but in contrast had the opposite *** then generated SHP2 knockout cells by using the CRISPR technique and provided further evidence that loss of SHP2 activity promotes growth of HCT-116 cells in vitro and in *** study suggests that targeting SHP2 may have adverse effects on certain cancers,which may have major implications for further development of anti-cancer drugs targeting SHP2.

关键词： colorectal drugs KRAS

Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment

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Science China Materials 2017年第10期60卷 995-1007页

作者： Guanyi Wang Wantong Song Na Shen Haiyang Yu Mingxiao Deng Zhaohui Tang xueqi fu Xuesi Chen Edmond H. Fischer Signal Transduction Laboratory School of Life Sciences Jilin University Changchun 130012 China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China College of Chemistry Northeast Normal University Changchun 130024 China

Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic ***（Cur） has shown its potential for the treatment of many cancers; however,the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study,a mixed system of monomethoxy（polyethylene glycol）-poly（d,l-lactide-co-glycolide）/poly（ε-caprolactone）（m PEGPLGA/PCL） was used to build a formulation of curcuminencapsulated nanoparticles（Cur-NPs）,which significantly improved the solubility,stability and cellular uptake of curcumin. Moreover,the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation,migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein,which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment.

关键词： curcumin drug delivery PLGA metastatic osteo-sarcoma

SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction

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BIOCELL 2021年第4期45卷 963-970页

作者： HAN NIU XIN CHEN xueqi fu JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU fuQIANG ZHANG LINLIN ZENG Edmond H.Fischer Signal Transduction Laboratory College of Life SciencesJilin UniversityChangchun130012China Scientific Research Centre of China-Japan Union Hospital Jilin UniversityChangchun130033China Department of Biology College of Arts and SciencesUniversity of Texas of the Permian BasinOdessaTX 79762USA Department of General Surgery The Second Hospital of Jilin UniversityChangchun130041China School of Life Sciences and Technology Tongji UniversityShanghai200092China

Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon *** dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly *** B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS *** death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking *** studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced *** this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in *** data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax ***,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction.

关键词： ALS Bax Mitochondria PSAP SOD1^(G93A)

Application of membrane technology for water treatment: Ultrasound-associated cleaning of fouled microfiltration membranes

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Chinese Journal Of Geochemistry 2006年第B8期25卷 128-129页

作者： Rui CHEN Xiaoli WANG Yonggang ZHANG xueqi fu College of Environmental Science and Engineering Nankai University Tianjin 300071 China College of Environmental Science and Safety Engineering Tianjin University of Technology Tianjin 300071 China

Simultaneous nitrification and denitrification by aerobic granular sludge membrane bioreactor for high concentration ammonium nitrogen wastewater

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Chinese Journal Of Geochemistry 2006年第B8期25卷 130-131页

作者： Rui CHEN Xiaoli WANG Yonggang ZHANG xueqi fu College of Environmental Science and Engtneering Nankai University Tianjin 300071 China College of Environmental Science and Safety Engineering Tianjin University of Technology Tianjin 300071 China

用电去离子过程从稀溶液中回收镍离子并制备纯水(英文)

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化工学报 2007年第5期58卷 1259-1261页

作者：卢会霞闫博王建友傅学起 College of Environmental Science and Engineering Nankai University

The recovery of nickel ions and pure water production from dilute nickel-containing solution was achieved simultaneously only within one process by using electrodeionization(EDI)*** a 55 mg·L-1 nickel ions feed solution,the outlet concentration of dilute product was below 0.05 mg·L-1,therefore the nickel rejection was higher than 99.9%,and the dilute product resistivity was in the range of 2.02—2.59 MΩ·cm while the concentration of nickel ions in the concentrate stream could reach as high as 1263 mg·*** feasibility of the EDI operation for the recovery of heavy metal ions together with pure water production from dilute industrial heavy metal wastewater was demonstrated in this study,cleaner production and closed circuit circulation can be realized in some industries such as electroplating.

关键词：镍离子废水利用金属分离法

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pH值响应分离膜研究进展

化工进展 2005年第9期24卷 951-955页

作者：刘燕军傅学起南开大学环境科学与工程学院

介绍了pH值响应分离膜的主要类型及其制备,评述了制备两性型pH值响应分离膜的新型聚合物膜材料、接枝膜的种类、天然膜材料改性以及pH值响应分离膜的表面电荷分布特征;综述了pH值响应膜在选择性分离有机离子化合物、分离无机离子和药物... 详细信息

介绍了pH值响应分离膜的主要类型及其制备,评述了制备两性型pH值响应分离膜的新型聚合物膜材料、接枝膜的种类、天然膜材料改性以及pH值响应分离膜的表面电荷分布特征;综述了pH值响应膜在选择性分离有机离子化合物、分离无机离子和药物释控技术中的应用研究进展。

关键词： pH值响应性(pH敏感性) 膜选择性分离药物释控