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A Study of Extratropical Transition and Re-Intensification of Typhoon Mindulle(2004)

Journal of Ocean University of China 2011年第3期10卷 197-209页

作者： ZHU Xiande WANG qi fu Gang LIU Yulong TIAN Ying College of Physical and Environmental Oceanography Ocean University of ChinaQingdao 266100 P. R.China

In this study,the fifth-generation Pennsylvania State University-National Center for Atmospheric Research (PSU-NCAR) Mesoscale Model (MM5) is used to simulate Typhoon Mindulle (2004) at high resolution (3-km grid size).The data from measurements show that in the upper atmosphere the existence of an upper jet is important to the transition *** Mindulle moved to the area of the upper jet entrance,where high-altitude divergence existed, the pumping of the high-altitude divergence would enhance the vertical motion and low-level cyclone convergence. The enhanced vertical motion was confirmed by the simulation results and indicated that the existence of upper divergence enhanced the vertical motion which was favorable for the maintenance of Typhoon *** process of extratropical transition (ET) and re-intensification always accompanies the process of cold air invasion. This process enhances the baroclinicity of the atmosphere and the formation of front at high altitudes, which converts baroclinic potential energy into kinetic energy and strengthens the cyclone *** distributions of equivalent potential temperature (θe) and temperature anomalies show that the warm-core of the typhoon at the tropopause aids the re-intensification of the system. As the typhoon reenters the ocean, latent heat flux (LHF) increases in the north and west and the strong reflectivity and vertical motion occur in the east and southeast,and the *** the re-intensification of the typhoon the wind field evolves from an oval to a circle at the lower atmosphere, the area coverage by high winds increases, and the distribution of the tangential wind shows an asymmetric pattern.

关键词： typhoon landfalling extratropical transition re-intensification westerly trough upper level jet

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Detailed study of RF properties of cold models for CW window-type RFQ

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Nuclear Science and Techniques 2018年第11期29卷 194-200页

作者： qi fu Kun Zhu Yuan-Rong Lu Zhi Wang Shu-Li Gao Fang-Jian Jia Yuan He State Key Laboratory of Nuclear Physics and Technology Peking University Institute of Modern Physics China Academy of Science

A 50 mA CW deuteron RFQ is being built for a joint 973 project between Peking University and the Institute of Modern Physics. This RFQ adopts a high-frequency window-type structure. To study its RF properties and to validate the reliability of an electromagnetic simulation, two full-length aluminum models with tuners were built in succession. RF measurements were obtained from the test bench and compared to the simulations, including frequencies, quality factors, and electric fields of different modes and the field in aperture. Through field tuning, the maximal field unflatness for a single quadrant and the average asymmetry of four quadrants were reduced from 8.7% and ± 3.6% to 5.8% and ± 1.7%, ***, a tuning method of adjusting the gap distance between the endplates and the vanes was also studied in this paper.

关键词： CW RFQ Cold model RF measurement Magnetic coupling window

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Plant-derived nanovesicles: further exploration of biomedical function and application potential

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3300-3320页

作者： Aixue Li Dan Li Yongwei Gu Rongmei Liu Xiaomeng Tang Yunan Zhao fu qi Jifu Wei Jiyong Liu College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmacy Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pharmacy Jiangsu Cancer HospitalNanjing 210009China Jiangsu Institute of Cancer Research Nanjing 210009China The Affiliated Cancer Hospital of Nanjing Medical University Nanjing 210009China Department of Pharmacy Shanghai Proton and Heavy Ion CenterShanghai 201315China

Extracellular vesicles(EVs)are phospholipid bilayer vesicles actively secreted by cells,that contain a variety of functional nucleic acids,proteins,and lipids,and are important mediums of intercellular *** on their natural properties,EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery *** them,plant-derived nanovesicles(PNVs)are characterized as natural disease therapeutics with many advantages such as simplicity,safety,eco-friendliness,low cost,and low toxicity due to their abundant resources,large yield,and low risk of immunogenicity in *** review systematically introduces the biogenesis,isolation methods,physical characterization,and components of PNVs,and describes their administration and cellular uptake as therapeutic *** highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers,including anti-inflammatory,anticancer,wound healing,regeneration,and antiaging properties as well as their potential use in the treatment of liver disease and ***,the toxicity and immunogenicity,the current clinical application,and the possible challenges in the future development of PNVs were *** expect the functions of PNVs to be further explored to promote clinical translation,thereby facilitating the development of a new framework for the treatment of human diseases.

关键词： Plant-derived nanovesicles Extracellular vesicles Therapeutic agents Drugdelivery systems Clinical application

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Activity and Tissue Expression of Tyrosine Phosphatase PTP-MEG2

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Chemical Research in Chinese Universities 2011年第2期27卷 287-290页

作者： DONG Hong-bo LI Guo-dong WANG Shao-feng fu Xue-qi ZHAO Zhi-zhuang Joe Edmond H. Fischer Signal Transduction Laboratory College of Life Science Jilin University Changchun 130012 P. R. China School of Pharmaceutical Science Jilin University Changchun 130021 P. R. China The Second Hospital of Jilin University. Changchun 130041 P. R. China Department of Pathology University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA

Protein tyrosine phosphatases（PTPs） are crucial regulators of signal transduction. Among them, PTP-MEG2 is an intracellular enzyme of 593 amino acid residues with a putative lipid-binding domain at the N-terminus. In the present study, we cloned the full-length form of the enzyme and expressed it in E. coli cells as a 6xHis-tagged protein. The majority of the expressed enzyme was found in the inclusion body of E. coli cell extracts. Upon extraction with a buffer containing urea, the recombinant enzyme was purified to near homogeneity on a single Ni-NTA-agarose column. This procedure resulted in the production of over 100 mg of purified recombinant PTP-MEG2 from 1 L E. coli cell culture. The purified protein displayed a single polypeptide band with expected molecular size on SDS-polyacrylamide gel electrophoresis under reducing conditions. Isolated under denatured conditions in urea, the purified enzyme was re-natured by dialyzing against a refolding buffer. The re-natured enzyme effectively dephosphorylated the common PTP substrate para-nitrophenylphosphate with a specific activity of 2000 units/mg. Meanwhile, the denatured enzyme was used to immunize a rabbit to produce antibodies. The resulting anti- serum had extremely high sensitivity and specificity. When used for Western blot analysis, the anti-serum revealed a wide expression of PTP-MEG2 in many tissues of mice. Together, we developed a highly effective way to purify a large amount of PTP-MEG2 and generated highly sensitive antibodies that can specifically detect endogenous expression of the enzyme in tissues.

关键词： Protein tyrosine phosphatase Expression Antibody production Enzyme assay Tissue expression

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Polymerization of Phenyl Isocyanate by Divalent Samarium Complex (ArO)_2Sm(THF)_4 (ArO=2,6-di-tert-butyl-4-methylphenoxo)

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Chinese Chemical Letters 1997年第7期8卷 639-640页

作者： fu Gen YUAN and qi SHEN(School of Chemistry and Chemical Engineering. Suzhou University. Suzhou. 215006) SUZHOU UNIV SCH CHEM & CHEM ENGNSUZHOU 215006PEOPLES R CHINA

Phenyl isocyanate was for the first time successfully polymerized by divalent samarium complex (ArO)2Sm(THF)4. The monomer concentration and temperatur affected the polymerization greatly.

关键词： Sm ArO=2,6-di-tert-butyl-4-methylphenoxo Polymerization of Phenyl Isocyanate by Divalent Samarium Complex ArO THF

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Factors controlling organic-rich shale development in the Liushagang Formation,Weixinan Sag,Beibu Gulf Basin:Implications of structural activity and the depositional environment

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Petroleum Science 2021年第4期18卷 1011-1020页

作者： Jin-Jun Xu qiang Jin Xin-De Xu fu-qi Cheng Chen-Hui Hu Bin Wang Tao Chen Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China CNOOC China Limited Zhanjiang BranchGuangdong524057China Research Institute of Petroleum Exploration and Development Shengli Oilfield CompanySinopecDongying257015China

The mechanisms of lacustrine organic-rich shale formation have attracted attention due to its association with global shale oil and shale gas *** of general-quality and excellent-quality source rocks,and oil shale from the Beibu Gulf Basin were analyzed to investigate their organic geochemistry,palynofacies,and trace *** potential was higher in the oil shale(29.79 mg/g)than in the general-quality source rock(3.82 mg/g),and its kerogen type wasⅠ-Ⅱ***-rich liptinite(cutinite and sporinite)components derived from terrigenous higher plants provided most of the hydrocarbon potential of excellent-quality source rock and oil *** the influence of depressioncontrolling fault activity,a deeper subsidence center promotes the deposition of excellent-quality source rock and oil shale in brackish-hypoxic bottom water.A shallower subsidence center,due to subsag-controlling fault activity,promotes the formation of excellent-quality source rock under freshbrackish and weak oxidation-weak reducing *** local uplift and shallow-slope led to the formation of general-quality source rock,under freshwater weak-oxidation conditions.A model was established for organic matter(OM)accumulation in organic-rich shales,accounting for fault activity,terrigenous hydrogen-rich OM,and the preservation conditions,to predict the development of excellent-quality source rock from areas with low levels of exploration.

关键词： Organic-rich shale Geochemical characteristics Palynofacies Structural activity Depositional environment Accumulation model Beibu gulf basin

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Altered profiles of nuclear matrix proteins during the differentiation of human gastric mucous adenocarcinoma MGc80-3 cells

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World Journal of Gastroenterology 2005年第30期11卷 4628-4633页

作者： Chun-Hong Zhao qi-fu Li Laboratory of Cell Biology the Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 Fujian Province China

AIM： To find and identify specific nuclear matrix proteins associated with proliferation and differentiation of carcinoma cells, which will be potential markers for cancer diagnosis and targets in cancer therapy. METHODS： Nuclear matrix proteins were selectively extracted from MGcS0-3 cells treated with or without hexamethylamine bisacetamide （HMBA）, and subjected to 2-D gel electrophoresis. The resulted protein patterns were analyzed by Melanie software. Spots of nuclear matrix proteins differentially expressed were excised and subjected to in situ digestion with trypsin. Peptide masses were obtained by matrix-assisted laser-desorption/ ionization time of flight mass spectrometry （MALDI-TOFMS） analysis and submitted for database searching using Mascot tool. RESULTS： The MGc80-3 cells were induced into differentiation by HMBA. There were 22 protein spots which changed remarkably in the nuclear matrix, from differentiation of MGcS0-3 cells compared to control. Eleven of which were identified. Seven proteinsactin, prohibitin, porin 31HL, heterogeneous nuclear dbonucleoprotein A2/B1, vimentin, ATP synthase, and heat shock protein 60 were downregulated, whereas three proteins - heat shock protein gp96, heat shock protein 90-beta, and valosin-containing protein were upregulated, and the oxygen-regulated protein was only found in the differentiated MGc80-3 cells. CONCLUSION： The induced differentiation of carcinoma cells is accompanied by the changes of nuclear matrix proteins. further characterization of those proteins will show the mechanism of cellular proliferation and differentiation, as well as cancer differentiation.

关键词： Nuclear matrix proteins Cell differentiation Human gastric mucous adenocarcinoma MGc80-3 Hexamethylamine bisacetamide

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Family Planning among Ethnic Minorities:a Review

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The Journal of Human Rights 2009年第1期8卷 15-17页

作者： fu qi

It is known to all that China, the world＇s most populous country with 1.3 billion people, has been practicing a stringent family planning policy as part of an endeavor to ensure a sustainable development. Does this policy of allowing most couples to have only one child apply to China＇s 55 ethnic minority groups？ To put it another way, what is exactly the government policy toward family planning among ethnic minorities,

关键词： Family Planning among Ethnic Minorities than Zhang

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Day surgery in strabismus operation under general anesthesia

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Annals of Eye Science 2018年第1期3卷 382-386页

作者： qi fu Ling-Bo He Xue-Ru Yang Jing Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China

Background:The purpose of this study is to summarize the application of day surgery combined with fast track program in strabismus operation under general ***:The clinical data of 2,000 cases of strabismus patients who had underwent surgery in day surgery or traditional hospitalization in the duration from 2015 to 2016 was retrospectively *** safety and efficacy were assessed by comparing the average length of stay in hospitals,anesthesia recovery time,patient satisfaction and number of adverse ***:Compared with the traditional group,the average length of stay in hospital and recovery time in day surgery group were significantly lower(P<0.001)and the satisfaction of patient was improved(P<0.05),which were statistically significant ***,no adverse events occurred among these ***:The application of day surgery in strabismus operation under general anesthesia is feasible,which can reduce the recovery time and shorten the hospital stay of patients safely and effectively,and their satisfaction was improved at the same time.

关键词： Day surgery general anesthesia fast track surgery nursing

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Influence of Oxide Morphologies on Galvanizability of Third Generation Automotive Steel

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Journal of Iron and Steel Research International 2014年第11期21卷 1059-1064页

作者： She-ming JIANG Shi-jie FENG Xun-hua YUAN Yuan-peng LI Zhen-hua LI qi-fu ZHANG National Engineering Laboratory of Advanced Coating Technology for Metal Materials Central Iron and Steel Research Institute Faculty of Material Science and Engineering Kunming University of Science and Technology

Focusing on improving the galvanizability of the third generation automotive steel, the effect of surface ox ide morphologies on the galvanizability was studied. The results show that the surface oxide types of sample steels by X ray photoelectron spectroscopy （XPS） analysis after annealing in different conditions are the same. Only MnO, MnO2 and Cr2O3 were detected and no complex oxide exists on the surface. Morphologies of surface oxides can greatly influence the galvanizability of the third generation automotive steel. Nodule-like oxide surface can contribute to better wettability and inhibition layer than vitreous film like oxide surface. Galvanized panels of nodule-like oxide surface steels only show pinhole sized bare spots, while panels galvanized from vitreous film-like oxide surface steels reveal larger areas of bare spots and uncoated areas. Inhibition layer observed in galvanized panels of nodule-like oxide surface steels is compact but not homogeneous; some inhibition layer grains are fine, and others are coarse, while the inhibition layer grains of panels galvanized from vitreous film-like oxide surface steels have a non-compact morphology with some particularly fine equiaxed crystals which developed deficiently.

关键词： galvanizing third generation automotive steel oxide morphology galvanizability

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