Plant-derived nanovesicles: Further exploration of biomedical function and application potential

作     者：Aixue Li Dan Li Yongwei Gu Rongmei Liu Xiaomeng Tang Yunan Zhao Fu Qi Jifu Wei Jiyong Liu Aixue Li;Dan Li;Yongwei Gu;Rongmei Liu;Xiaomeng Tang;Yunan Zhao;Fu Qi;Jifu Wei;Jiyong Liu

作者机构：College of PharmacyShandong University of Traditional Chinese MedicineJinan 250355China Department of PharmacyFudan University Shanghai Cancer CenterShanghai 200032China Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of PharmacyJiangsu Cancer HospitalNanjing 210009China Jiangsu Institute of Cancer ResearchNanjing 210009China The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of PharmacyShanghai Proton and Heavy Ion CenterShanghai 201315China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第8期

页      面：3300-3320页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(82274103,82074272,China) Program of Shanghai Academic Research Leader(21XD1403400,China) the Science and Technology Commission of Shanghai Municipality(20S21900300,China) Shanghai Sailing Program(20YF1412100,China) 

主　　题：Plant-derived nanovesicles Extracellular vesicles Therapeutic agents Drugdelivery systems Clinical application 

摘      要：Extracellular vesicles(EVs)are phospholipid bilayer vesicles actively secreted by cells,that contain a variety of functional nucleic acids,proteins,and lipids,and are important mediums of intercellular *** on their natural properties,EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery *** them,plant-derived nanovesicles(PNVs)are characterized as natural disease therapeutics with many advantages such as simplicity,safety,eco-friendliness,low cost,and low toxicity due to their abundant resources,large yield,and low risk of immunogenicity in *** review systematically introduces the biogenesis,isolation methods,physical characterization,and components of PNVs,and describes their administration and cellular uptake as therapeutic *** highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers,including anti-inflammatory,anticancer,wound healing,regeneration,and antiaging properties as well as their potential use in the treatment of liver disease and ***,the toxicity and immunogenicity,the current clinical application,and the possible challenges in the future development of PNVs were *** expect the functions of PNVs to be further explored to promote clinical translation,thereby facilitating the development of a new framework for the treatment of human diseases.