检索结果-南通市图书馆

3D printed grafts with gradient structures for organized vascular regeneration

International Journal of Extreme Manufacturing 2024年第3期6卷 505-520页

作者： Yuewei Chen Zhongfei Zou Tao fu Zhuang Li Zhaojie Zhang Meng Zhu Qing Gao Shaofei Wu guosheng fu Yong He Jiayin fu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016People’s Republic of China School of Mechanical Engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Department of Oral and Maxillofacial Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineSchool of Stomatologyand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhouZhejiang 310006People’s Republic of China

Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great ***,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis and stenosis after in vivo *** designing SDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(SML).To facilitate rapid SML regeneration,a high-resolution 3D printing method was used to create a novel bilayer SDVG with structures and mechanical properties mimicking natural *** by the collagen alignment of SML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate SML reconstruction for compliance restoration and spontaneous *** outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide SDVG with sufficient mechanical *** month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature *** study shows the importance of SML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly.

关键词： small-diameter vascular graft smooth muscle layer 3D printing endothelialization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

学科交叉教学研究模式在医学研究生创新能力培养中的应用效果

引用

全科医学临床与教育 2024年第2期22卷 155-157页

作者：肖云傅国胜浙江大学医学院附属邵逸夫医院心内科浙江杭州310016

目的探讨学科交叉教学研究模式在医学研究生创新能力培养中的应用效果。方法采用问卷调查的方式,对45名浙江大学临床医学院参与学科交叉教学研究的医学研究生进行了调查。问卷内容涵盖学生的年级分布、对学科交叉重要性的看法、学科... 详细信息

目的探讨学科交叉教学研究模式在医学研究生创新能力培养中的应用效果。方法采用问卷调查的方式,对45名浙江大学临床医学院参与学科交叉教学研究的医学研究生进行了调查。问卷内容涵盖学生的年级分布、对学科交叉重要性的看法、学科交叉在解决专业问题中的作用、以及对当前学科交叉教育与培训的满意度等方面。结果调查显示,42.22%的学生认为学科交叉在创新能力培养中非常重要,33.33%认为比重较大。44.44%的学生认为学科交叉对提升专业能力和创新思维非常有帮助,48.89%强烈认同它有助于开阔研究视野和增强团队合作与交流能力。此外,84.44%的学生认为有必要进行教育体制改革以促进学科交叉教学研究。结论学科交叉教学研究模式在医学研究生中得到了积极的评价,并能提升学生的专业能力和创新思维能力。尽管如此,一些学生对学科交叉的充分性及现有教育体制改革仍持保留态度。因此,未来的教育改革应更加关注实践机会的提供和跨学科教学内容的质量,以满足医学研究生对于高质量教育的需求,并促进他们在未来医疗领域的全面发展。

关键词：学科交叉创新能力医学教育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《国家心力衰竭指南2023》解读

引用

心脑血管病防治 2024年第4期24卷 1-5页

作者：杨莹傅国胜浙江大学医学院附属邵逸夫医院杭州310016

2023版国家心力衰竭指南是由国家心血管病中心发起,在国家心血管病专家委员会心力衰竭专业委员会的指导下,组织国内心力衰竭和心肌病领域的专家撰写[1]。新版指南是基于近年国内外在心力衰竭临床和基础研究,药物和非药物治疗上的诸多进... 详细信息

2023版国家心力衰竭指南是由国家心血管病中心发起,在国家心血管病专家委员会心力衰竭专业委员会的指导下,组织国内心力衰竭和心肌病领域的专家撰写[1]。新版指南是基于近年国内外在心力衰竭临床和基础研究,药物和非药物治疗上的诸多进步,继《中国心力衰竭诊断和治疗指南2018》发表时隔5年后的再次更新。

关键词：心血管病专家心力衰竭心肌病诊断和治疗指南药物和非药物治疗临床和基础研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrospun fiber membrane with asymmetric NO release for the differential regulation of cell growth

引用

Bio-Design and Manufacturing 2021年第3期4卷 469-478页

作者： Shengyu Chen Fan Jia Luying Zhao fuyu Qiu Shaohua Jiang Jian Ji guosheng fu Department of Cardiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China MOE Key Laboratory of Macromolecule Synthesis and functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Hangzhou 310016China

The high incidence of cardiovascular disease has led to significant demand for synthetic vascular grafts in clinical ***-proliferation drugs are usually loaded into devices to achieve desirable anti-thrombosis effects after ***,the non-selectiveness of these conventional drugs can lead to the failure of blood vessel reconstruction,leading to potential complications in the long *** address this issue,an asymmetric membrane was constructed through electro-spinning *** bilayer membrane loaded and effectively released nitric oxide(NO),as hoped,from only one *** to the short diffusion distance of NO,it exerted negligible effects on the other side of the membrane,thus allowing selective regulation of different cells on both *** released NO boosted the growth of endothelial cells(ECs)over smooth muscle cells(SMCs)-while on the side where NO was absent,SMCs grew into *** overall structure resembled a native blood vessel,with confluent ECs as the inner layer and layers of SMCs to support *** addition,the membrane preserved the normal function of ECs,and at the same time did not exacerbate inflammatory *** preparing this material type that regulates cell behavior differentially,we describe a new method for its application in the cardiovascular field such as for artificial blood vessels.

关键词： Nitric oxide Asymmetric drug release Electrospun fiber membrane Artificial blood vessel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

QT DISPERSION: A RISK INDICATOR FOR SEVERE VENTRICULAR ARRHYTHMIA IN PATIENTS WITH ISCHEMIC AND IDIOPATHIC CARDIOMYOPATHY

引用

Chinese Medical Journal 1995年第3期 69-70页

作者： fu guosheng Achim MeiBner Rudiger Simon Departmenr of Cardiology Christian-Albrechts- University Hospital. Kid GermanyDepartmenr of Cardiology Christian-Albrechts- University Hospital. Kid GermanyDepartmenr of Cardiology Christian-Albrechts- University Hospital. Kid Germany

Increased QT dispersion in the surface ECG (QTd = QTmax minus QTmin) is considered as an indicator of electrical inhomogeneitv and a useful predictor for severe ventricular arrhythmia and sudden cardiac death in patients with different heart diseases. Patients with ischemic and idiopathic cardiomyopathy have a very high incidence of severe ventricular arrhythmia and sudden cardiac death. We compared QT, QTc. JT and JTc dispersion in ischemic (ICMP) and idopathic (CCMP) cardiomyopathy patients with and without severe ventricular arrhythmia and normal controls.

关键词： QT DISPERSION CMP A RISK INDICATOR FOR SEVERE VENTRICULAR ARRHYTHMIA IN PATIENTS WITH ISCHEMIC AND IDIOPATHIC CARDIOMYOPATHY

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults≤45 Years of Age with Acute Coronary Syndrome

引用

Cardiovascular Innovations and Applications 2022年第3期7卷 36-45页

作者： Xulin Hong Duanbin Li Xinrui Yang guosheng fu Chenyang Jiang Wenbin Zhang Department of Cardiology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Department of Cardiology The Hangzhou Lin’an People’s HospitalHangzhouChina

Background:A non-invasive predictive model has not been established to identify the severity of coronary lesions in young adults with acute coronary syndrome(ACS).Methods:In this retrospective study,1088 young adults(≤45 years of age)first diagnosed with ACS who underwent coronary angiography were enrolled and randomized 7:3 into training or testing *** build the nomogram,we determined optimal predictors of coronary lesion severity with the Least Absolute Shrinkage and Selection Operator and Random Forest *** predictive accuracy of the nomogram was assessed with calibration plots,and performance was assessed with the receiver operating characteristic curve,decision curve analysis and the clinical impact ***:Seven predictors were identified and integrated into the nomogram:age,hypertension,diabetes,body mass index,low-density lipoprotein cholesterol,mean platelet volume and C-reactive *** operating characteristic analyses demonstrated the nomogram’s good discriminatory performance in predicting severe coronary artery disease in young patients with ACS in the training(area under the curve 0.683,95%confidence interval[0.645–0.721])and testing(area under the curve 0.670,95%confidence interval[0.611–0.729])*** nomogram was also well-calibrated in both the training(P=0.961)and testing(P=0.302)*** curve analysis and the clinical impact curve indicated the model’s good clinical ***:A simple and practical nomogram for predicting coronary artery disease severity in young adults≤45 years of age with ACS was established and validated.

关键词： Acute coronary syndrome risk factor nomogram Gensini score Youth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The study of active fixation electrodes in different parts of the right ventricular pacing and current of injury

The study of active fixation electrodes in different parts o...

引用

2013年浙江省心电生理与起搏学术年会

作者： Jifeng Zheng guosheng fu Zhejiang University School of Medicine Vasculocardiology Deparment

Objective:To explore the feasibility and safety of right ventricular pacing with active fixed leads,and to investigate the physiological pacing site by observing body-surface electrocardiogram QRS duration during diferent pacing *** study was to determine whether current of injury can guide adequate placement of active-fixation pacing leads through the observation of pacing parameters and current of injury. Methods:Sixty-eight patients were implanted active fixed leads for permanent *** magnitude of ST-segment elevation of current of injury and pacing parameters were measured up to 15 min after *** time was measuredby recording pacing electrocardiogram(ECG).Some parameters were measured and observed during the follow-up time. Results:All the cases came through the operation successfully with no serious ***-eight active fixed leads were *** patients were followed up in one,three an d six months after being *** case of wire dislocation happened and the parameters showed no significant difference in the follow up *** QRS duration during pacing in the RVOT ventricular septum and right ventricular middle septum was shorter than that in the right ventricular apical and in the RVOT ventricular free wall(P0.05). 53 active-fixation leads had a current of *** baseline to the time of fixation,the magnitude of the ST-segment increased from7.07±0.11 mV tol.50±0.23mV(p<0.001),with subsequent improvement in pacing thresholds from 1.19±0.40 V to 0.69±0.12 V(p<0.001) at 15 *** the 15 leads without a COI,6 dislodged acutely and 9 had high pacing thresholds at 15 min,requiring repositioning. Conclusions:The special cardiac site pacing by the active fixation lead is feasible and *** pacing site of RVOT ventricular septum or right ventricular middle septum should be suggested to gain narrower QRS *** i

关键词： Active fixed lead The right ventricular outflow tract(RVOT) Injury current Pacing parameter Safety

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Shexiang Tongxin dropping pill(麝香通心滴丸)protects against sodium laurate-induced coronary microcirculatory dysfunction in rats

引用

Journal of Traditional Chinese Medicine 2021年第1期41卷 89-97页

作者： LIU Huahua ZHAO Jingjing ZHU Yeke TANG Weiliang PENG Fang PAN Sunlei fu guosheng Department of Cardiology Shaoxing HospitalZhejiang University school of medicineShaoxing 312000China Department of Cardiology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325000China Department of Cardiology Shaoyifu Hospitalschool of medicineZhejiang UniversityHangzhou 310003China

OBJECTIVE:To investigate the protective effects of Shexiang Tongxin dropping pill(麝香通心滴丸,STDP)in a rat model of coronary microcirculatory dysfunction(CMD).METHODS:Sprague-Dawley rats were allocated randomly into four groups:sham,CMD model,STDP,and *** 4 weeks of treatment,CMD was induced by injection of sodium laurate(0.2 m L,2 g/L)into the left ventricle while obstructing the ascending *** in the sham group underwent an identical surgical procedure but were administered physiological(0.9%)saline(0.2 m L).Twenty-four hours after surgery,blood samples were collected for biochemical analyses and enzyme-linked immunosorbent *** tissues were removed for histopathology staining;apoptosis and inflammatory cytokines were examined by Western ***:The STDP group had a lower level of creatine kinase-myocardial band,lactate dehydrogenase,and cardiac troponin-I than that in the CMD model *** of inflammatory cells,myocardial ischaemia,and microthrombosis were relieved in the STDP group compared with CMD model *** of endothelin-1,nuclear factor-kappa B,tumour necrosis factor-α,interleukin-6,interleukin-1β,malondialdehyde,B-cell lymphoma(Bcl)-2-associated X protein,and caspase-3 were lower,and levels of nitric oxide,Bcl-2,and superoxide dismutase were higher,in the STDP group in comparison with the CMD model ***:STDP pretreatment improved the CMD induced by sodium laurate via anti-inflammatory,anti-apoptosis,and anti-oxidant mechanisms.

关键词： Inflammation Oxidative stress Apoptosis Coronary microcirculatory dysfunction Shexiang Tongxin dropping pill

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advanced Glycation End Products Upregulates The Expression Of Connexin 43 Via ERK MAPK And PI3K/Akt Pathways In Human Endothelial Cells

Advanced Glycation End Products Upregulates The Expression O...

引用

第五届钱江国际心血管病会议暨2011浙江省心血管病年会

作者： Yanbo Zhao Shengjie Xu Chongying Jin guosheng fu Shaoxiang Weng

＜正＞Intercellular communication through gap junctions plays an essential role in maintaining the functional integrity of vascular *** emerging evidence suggests that advanced glycation end products（AGEs） may impair endothelial ***,its effect on connexin43 （Cx43） gap junction in endothelial cells remains *** we investigated the effect Of AGEbovine serum albumin（AGE-BSA） on Cx43 gap junction in endothelial *** levels of Cx43 protein in human umbilical vein endothelial cells（HUVECs） was significantly increased by AGE-BSA treatment, accompanied by RAGE *** augmentation can be reversed by RAGE *** addition,AGE-BSA activated ERK,P38,and JNK mitogen-activated protein kinases（MAPKs）,which were supposed to participate in the regulation of Cx43.A MEK inhibitor PD98059,but not SB203580（a p38 kinase inhibitor） or SP600125（a JNK kinase inhibitor）,abolished the effects of AGE-BSA on Cx43 ***,both Akt and PKC phosphorylation were time-dependently augmented by AGEBSA, PI3K inhibitor LY294002（but not GF109203X,a PKC inhibitor） blocked the effects of AGE-BSA on Cx43 gap *** together,AGE-BSA upregulated Cx43 expression via AGE-RAGE signaling, ERK MAPK and PI3K/Akt Signal transduction pathways appear to be involved in these processes.

关键词： advanced glycation end products endothelial cells connexin43 gap junction

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

心房颤动的抗栓与抗血小板治疗

引用

临床心血管病杂志 2006年第5期22卷 311-312页

作者：周方傅国胜松阳县人民医院心内科浙江松阳323400 浙江大学医学院附属第二医院

目的:了解临床实践中心房颤动(房颤)患者抗栓治疗的现状及分析。方法:调查2003年(225例) -2004年(280例)年间有血栓栓塞高危因素的房颤患者接受抗栓治疗的情况。结果:发现2年间高危因素有明显增加(由平均1．4个增加到1．8个),但接受抗... 详细信息

目的:了解临床实践中心房颤动(房颤)患者抗栓治疗的现状及分析。方法:调查2003年(225例) -2004年(280例)年间有血栓栓塞高危因素的房颤患者接受抗栓治疗的情况。结果:发现2年间高危因素有明显增加(由平均1．4个增加到1．8个),但接受抗栓治疗均以阿司匹林为主(64．8％与72．5％),服用华法林的比例很低(4．0％与6．25％),且剂量均偏低。结论:临床实践中房颤接受抗栓治疗达到标准的比例很低,接受阿司匹林治疗者较多,但剂量偏少,接受华法林治疗者很少,房颤的抗栓治疗尚需进一步规范。

关键词：心房颤动抗凝治疗华法林

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：