Electrospun fiber membrane with asymmetric NO release for the differential regulation of cell growth

作     者：Shengyu Chen Fan Jia Luying Zhao Fuyu Qiu Shaohua Jiang Jian Ji Guosheng Fu Shengyu Chen;Fan Jia;Luying Zhao;Fuyu Qiu;Shaohua Jiang;Jian Ji;Guosheng Fu

作者机构：Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China MOE Key Laboratory of Macromolecule Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang ProvinceHangzhou 310016China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第3期

页      面：469-478页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the Natural Key Research and Development Project of Zhejiang Province,China(No.2018C03015) the National Key Research and Development Program of China(No.2016YFC1102203) the Medical Health Science and Technology Projects of Zhejiang Province(No.2019KY426) 

主　　题：Nitric oxide Asymmetric drug release Electrospun fiber membrane Artificial blood vessel 

摘      要：The high incidence of cardiovascular disease has led to significant demand for synthetic vascular grafts in clinical ***-proliferation drugs are usually loaded into devices to achieve desirable anti-thrombosis effects after ***,the non-selectiveness of these conventional drugs can lead to the failure of blood vessel reconstruction,leading to potential complications in the long *** address this issue,an asymmetric membrane was constructed through electro-spinning *** bilayer membrane loaded and effectively released nitric oxide(NO),as hoped,from only one *** to the short diffusion distance of NO,it exerted negligible effects on the other side of the membrane,thus allowing selective regulation of different cells on both *** released NO boosted the growth of endothelial cells(ECs)over smooth muscle cells(SMCs)-while on the side where NO was absent,SMCs grew into *** overall structure resembled a native blood vessel,with confluent ECs as the inner layer and layers of SMCs to support *** addition,the membrane preserved the normal function of ECs,and at the same time did not exacerbate inflammatory *** preparing this material type that regulates cell behavior differentially,we describe a new method for its application in the cardiovascular field such as for artificial blood vessels.