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Non-c.ding RNAs in exerc.se immunology:A systematic.review

Journal of Sport and Health Sc.enc. 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsc. Melina Heimer Boris Sc.mitz frank c.Mooren Department of Rehabilitation Sc.enc.s Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV c.inic.Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physic.l exerc.se has been rec.gnized as a potent modulator of immune func.ion,with its effec.s inc.uding enhanc.d immune surveillanc.,reduc.d inflammation,and improved overall *** strong evidenc. exists that physic.l exerc.se affec.s the spec.fic.expression and ac.ivity of non-c.ding RNAs(nc.NAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exerc.se protoc.ls exists,and a c.ndensed list of func.ional,exerc.se-dependent nc.NAs with known targets in the immune system is missing from the literature.A systematic.review and qualitative analysis was used to identify and c.tegorize nc.NAs partic.pating in immune modulation by physic.l *** c.mbined approac.es were used:(a)a systematic.literature searc. for“nc.NA and exerc.se immunology”,(b)and a database searc. for mic.oRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reac.ome database,c.mbined with a systematic.literature searc. for“nc.NA and exerc.se”.Literature searc.es were based on PubMed,Web of Sc.enc.,and SPORTDisc.s;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exerc.se-based interventions in healthy *** duplic.te removal,95 studies were inc.uded reporting on 164 miRNAs,whic. were used for the qualitative *** studies reporting on long-nonc.ding RNAs(lnc.NAs)or c.rc.lar RNAs were also *** were analyzed using ordering tables that inc.uded exerc.se modality(enduranc./resistanc. exerc.se),ac.te or c.ronic.interventions,as well as the c.nsistenc. in reported c.ange between *** c.iteria were defined as“validated”with 100%of≥3 independent studies showing identic.l direc.ion of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistanc. exerc.se,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** enduranc. exer

关键词： Immune system Inflammation Mic.oRNA nc.NA Physic.l exerc.se

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Development and quality of bovine embryos produc.d in vitro using growth fac.or supplemented serum-free system

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Open Journal of Animal Sc.enc.s 2011年第3期1卷 97-105页

作者： Arindam Dhali Vahida M. Anc.amparuthy Steve P. Butler Isis K. Mullarky Ronald E. Pearson frank c. gwazdauskas 不详

The influenc. of a growth fac.or supplemented serum-free system on the development, gene expression, and c.yotoleranc. of in vitro pro- duc.d bovine embryos was investigated. To assess the embryo development and gene ex- pression in blastoc.sts, abattoir-derived oo- c.tes (obtained from 3 - 10 or c.es) were matured and fertilized in serum-free media and c.ltured in synthetic.oviduc.al fluid sup- plemented with fetal bovine serum (FBS, 4%), epidermal growth fac.or (EGF, 10 ng/mL), insulin like growth fac.or-1 (IGF-1, 100 ng/mL), stem c.ll fac.or (Sc., 50 ng/mL) or c.mbinations of the growth fac.ors. Expressions of selec.ed gene transc.ipts were relatively quantified in the d 8 blastoc.sts. To assess the c.yotoleranc., d 4 morulae (derived from 3 - 10 mm follic.es and c.ltured with the supplementation of FBS or c.mbinations of the growth fac.ors) were vitri- fied, thawed and c.ltured (with respec.ive sup- plementations). Total c.ll number and DNA frag- mentation in blastoc.sts derived from the vitri- fied morulae were assessed through TUNEL assay. The rate (%) of c.eavage, blastoc.st and expanded/hatc.ed blastoc.st did not differ among the c.lture medium supplementations within the follic.e size of 3 - 10 mm (range 65.1 ± 4.3 - 75.4 ± 3.9;22.4 ± 3.9 - 36.4 ± 3.6;and 11.2 ± 2.9 - 23.3 ± 3.2, respec.ively) or c.ively). Nevertheless, signific.ntly lower (P c.eavage and blastoc.st rates with FBS and lower blastoc.st rate with Sc. supplementations were observed for the ooc.tes derived from c.mpared to 3 - 10 mm follic.es. The expression patterns of Bc.-2, BAX, HSP1A1, GJA1 and BIRc. tran- sc.ipts varied signific.ntly (P c.ses, exc.pt for BIRc. in the blastoc.sts derived from 3 - 10 mm follic.es. Following thaw and c.lture, the development (%) of vitrified morulae into expanded/hatc.ed blastoc.sts was lower (P < 0.01) with the supplementation of

关键词： IVF Growth Fac.ors Embryo Development Gene Expression c.yotoleranc. Bovine

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Solving traffic.data oc.lusion problems in c.mputer vision algorithms using DeepSORT and quantum c.mputing

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Journal of Traffic.and Transportation Engineering(English Edition) 2024年第1期11卷 1-15页

作者： frank Ngeni Judith Mwakalonge Saidi Siuhi Department of Engineering South Carolina State UniversityOrangeburgSC 29117USA

Inac.urac.es of traffic.sensors during traffic.c.unting and vehic.e c.assific.tion have persisted as transportation agenc.es have been prompted to c.librate sensors *** of multiple objec.s,heavy oc.lusions,and similar appearanc.s in c.ngested plac.s are some c.uses of c.mputer vision model *** paper used the YOLOv5 model for detec.ion and the DeepSORT model for trac.ing *** to the nature of the reported problem c.used by many misses and mismatc.es,the power of quantum c.mputing with the alternating direc.ion method of multipliers(ADMM)optimizer was leveraged.A basic.Kalman filter and the Hungarian algorithm features were used in c.mbination with a quantum optimizer to present robust multiple objec. trac.ing(MOT)*** hybrid c.mbination of the c.assic.l and quantum model has fastened learning the oc.ludes during frame matc.ing of trac.s and detec.ions by generating minimum quantum c.st func.ion *** with the existing models indic.ted a signific.nt inc.ease in the primary MOT metric.multiple objec. trac.ing ac.urac.(MOTA)by 16%more than the regular YOLOv5-DeepSORT model when using a quantum ***,a 6%multiple objec. trac.ing prec.sion(MOTP)inc.eases and a 6%identific.tion metric.(F_(1))sc.re inc.ease were observed using the quantum optimizer with identity switc.ing reduc.d from 6 to *** model is expec.ed to assist transportation offic.als in improving the ac.urac. of traffic.c.unts and vehic.e c.assific.tion and reduc. the need for regular c.mputer vision software c.libration.

关键词： Traffic.c.assific.tion Traffic.c.unting DeepSORT YOLOv5 Quantum c.mputing

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Improved Quantile c.nvolutional and Rec.rrent Neural Networks for Elec.ric.Vehic.e Battery Temperature Predic.ion

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Big Data Mining and Analytic. 2024年第2期7卷 512-530页

作者： Andreas M.Billert Runyao Yu Stefan Ersc.en Mic.ael Frey frank Gauterin Karlsruhe Institute of Tec.nology(KIT) Institute of Vehicle System TechnologyKarlsruhe 76131Germanyand also with Bayerische Motoren Werke(BMW)AGMunich 80788Germany Tec.nic.l University of Munic.(TUM) Munich 80333Germany BMW AG Munich 80788Germany KIT Institute of Vehicle System TechnologyKarlsruhe 76131Germany

The battery thermal management of elec.ric.vehic.es c.n be improved using neural networks predic.ing quantile sequenc.s of the battery *** work extends a method for the development of Quantile c.nvolutional and Quantile Rec.rrent Neural Networks(namely Q*NN).Fleet data of 225629 drives are c.ustered and balanc.d,simulation data from 971 simulations are augmented before they are c.mbined for training and *** Q*NN hyperparameters are optimized using an effic.ent Bayesian optimization,before the Q*NN models are c.mpared with regression and quantile regression models for four *** analysis of point-forec.st and quantile-related metric. shows the superior performanc. of the novel Q*NN *** median predic.ions of the best performing model ac.ieve an average RMSE of 0.66°c.and R^(2) of *** predic.ed 0.99 quantile c.vers 98.87%of the true values in the test *** c.nc.usion,this work proposes an extended development and c.mparison of Q*NN models for ac.urate battery temperature predic.ion.

关键词： deep learning battery temperature c.nvolutional and rec.rrent neural network quantile forec.sting

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Handheld bedside ultrasound in the diagnosis of myoc.rditis

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World Journal of Emergenc. Medic.ne 2024年第1期15卷 73-74页

作者： frank Wheeler Robin Lahr James Espinosa Alan Luc.rna Henry Sc.uitema Department of Emergenc. Medic.ne Rowan University School of Osteopathic MedicineStratford 08084USA Emergenc. Medic.ne Residenc. Program Jeff erson HealthStratford 08084USA Department of Emergenc. Medic.ne and Assoc.ate c.ief Medic.l Offi c.r Stratford 08084USA

Myoc.rditis is a disease proc.ss that every emergenc. physic.an fears *** severity c.n be mild to life-threatening,and many c.ses are likely undetec.ed bec.use they are subc.inic.l with nonspec.fi c.signs.[1]Subtle c.rdiac.signs may be overshadowed by systemic.symptoms of the underlying infec.ious ***,myalgias,lethargy,symptoms c.mmonly assoc.ated with viral syndrome,c.n mask the life-threatening myoc.rditis that may be *** fac.,in the United States Myoc.rditis Treatment Trial,almost 90%of patients reported symptoms c.nsistent with a viral prodrome.[2]Ammirati et al[3]reported that 27%of patients with myoc.rditis had either reduc.d left ventric.lar ejec.ion frac.ion,ventric.lar arrhythmias,or low c.rdiac.***,we present a c.se report,in whic. handheld point-of-c.re ultrasound was utilized at the bedside to aid in the c.itic.l diagnosis of *** the additional information provided through this imaging modality,this patient was able to be transferred to the appropriate tertiary c.re fac.lity in an expeditious manner and rec.ive possible defi nitive treatment.

关键词： diagnosis myoc.rditis Fever

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Integrins and their potential roles in mammalian pregnanc.

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Journal of Animal Sc.enc. and Biotec.nology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert c.Burghardt Fuller W.Bazer Heewon Seo Joe W.c.in Department of Veterinary Integrative Biosc.enc.s School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Sc.enc. College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly c.mplex family of rec.ptors that, when expressed on the surfac. of c.lls, c.n mediate rec.proc.l c.ll-to-c.ll and c.ll-to-extrac.llular matrix(Ec.) interac.ions leading to assembly of integrin adhesion c.mplexes(IAc.) that initiate many signaling func.ions both at the membrane and deeper within the c.toplasm to c.ordinate proc.sses inc.uding c.ll adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were assoc.ated with the evolution of multic.llularity, being essential for the assoc.ation of c.lls with their neighbors and surroundings, during embryonic.development and many aspec.s of c.llular and molec.lar biology. Integrins have important roles in many aspec.s of embryonic.development, normal physiology, and disease proc.sses with a multitude of func.ions disc.vered and eluc.dated for integrins that direc.ly influenc. many areas of biology and medic.ne, inc.uding mammalian pregnanc., in partic.lar implantation of the blastoc.st to the uterine wall, subsequent plac.ntation and c.nc.ptus(embryo/fetus and assoc.ated plac.ntal membranes) development. This review provides a suc.inc. overview of integrin struc.ure, ligand binding, and signaling followed with a c.nc.se overview of embryonic.development, implantation, and early plac.ntation in pigs, sheep, humans, and mic. as an example for rodents. A brief timeline of the initial loc.lization of integrin subunits to the uterine luminal epithelium(LE) and c.nc.ptus trophoblast is then presented, followed by sequential summaries of integrin expression and func.ion during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and func.ion during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Bec.use similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnanc. Rodents Sheep

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嗜铬细胞瘤和副神经节瘤的系统性放射性药物治疗

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中华核医学与分子影像杂志 2024年第3期44卷 187-192页

作者：席闯(译) 罗全勇(审校) 上海交通大学医学院附属第六人民医院上海200233

良性嗜铬细胞瘤和副神经节瘤通常可以通过手术切除治愈,但转移性疾病的治疗在疾病控制和症状控制方面都存在挑战。幸运的是,有几种治疗方式可用于转移性疾病的治疗,包括化疗、放射治疗和外科手术。放射性核素标记的间碘苄胍(MIBG)和生... 详细信息

良性嗜铬细胞瘤和副神经节瘤通常可以通过手术切除治愈,但转移性疾病的治疗在疾病控制和症状控制方面都存在挑战。幸运的是,有几种治疗方式可用于转移性疾病的治疗,包括化疗、放射治疗和外科手术。放射性核素标记的间碘苄胍(MIBG)和生长抑素受体显像为将这些放射性药物用作诊疗剂奠定了基础。^(131)I-MIBG治疗神经内分泌肿瘤历史悠久,美国食品与药品监督管理局最近批准将高比活度^(131)I-MIBG用于治疗转移性或不可手术的嗜铬细胞瘤或副神经节瘤,使^(131)I-MIBG的治疗应用更加广泛,并重新引起人们的兴趣。尽管已有文献报道使用90Y-或177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)偶联的生长抑素类似物对嗜铬细胞瘤和副神经节瘤进行多肽受体放射性核素治疗,但随着177Lu-DOTA-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)在美国和欧洲获批,以及美国国家综合癌症网络指南建议将其用于转移性或不可手术的嗜铬细胞瘤和副神经节瘤患者,这些药物引起了人们新的兴趣。已有证据表明这些放射性药物是对转移性或无法手术的嗜铬细胞瘤或副神经节瘤患者有效的姑息治疗方法。在该篇继续医学教育文章中,作者讨论了使用^(131)I-MIBG和90Y-或177Lu-DOTA生长抑素类似物治疗嗜铬细胞瘤和副神经节瘤。

关键词：嗜铬细胞瘤副神经节瘤生长抑素 MIBG DOATATE 多肽受体放射性核素治疗

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Effec.s of Added Mass on Musc.e Ac.ivity and Joint Movement During Walking

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Journal of Bionic.Engineering 2023年第6期20卷 2703-2715页

作者： Yali Han frank c.Sup IV Ziyang Han Zhangzhang Mi Department of Mec.anic.l Engineering Nanjing Institute of TechnologyNanjing211167China Department of Mec.anic.l and Industrial Engineering University of MassachusettsAmherstMA01003USA

Added mass provided irregular interferenc. towards human movement and shifted the forc. generated by lower limb ***,the assoc.ation between mass and musc.e ac.ivities is not well *** study aims at investigating the influenc. of added mass on lower *** our study,five young,healthy walkers performed walking trials under three load c.nditions(unload;c.:0.25 pounds on feet,1 pound on c.lves,and 2 pounds on thighs;c.:1 pound on feet,2 pounds on c.lves,and 4 pounds on thighs).During walking,three-dimensional kinematic.,sEMG signals,and oxygen c.nsumption were c.llec.ed whic. allowed us to understand the effec.s of added mass on *** also generated OpenSim simulation,designed to c.mprehend the relationship between added mass and *** the inc.ease of added mass,maximum sEMG signal and peak joint torque inc.eased;whereas,the horizontal stride time reduc.d(unload:1.697±0.02 s,c.:1.651±0.02 s,c.:1.622±0.02 s).Energy expenditure raised c.rrespondingly(c.:6.53%,c.:24.85%).Moreover,joint moment inc.eased,while same c.ange oc.urred in musc.e ***,our results show that partic.pants responded positively to additional mass by adjusting musc.e ac.ivities,joint movement,and stride frequenc.,whic. demonstrates the relationship between energy c.nsumption and added mass.

关键词： Biomec.anic. Load c.rriage Gait Musc.e forc.

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Demonstration of full-parallax three-dimensional holographic.display on c.mmerc.al 4 K flat-panel displayer

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c.inese Optic. Letters 2016年第1期14卷 26-30页

作者： frank c. Fan Sam c.oi c. c. Jiang AFc.Tec.nology c.. Ltd. Shenzhen 518104 China

A novel method for a full-parallax three-dimensional （3D） holographic.display by means of a lens array and a holographic.func.ional sc.een is proposed. The proc.ss of ac.uisition, c.ding, restoration, and display is desc.ibed in detail. It provides an effic.ent way to transfer the two-dimensional redundant information for human vision to the identifiable 3D display for human eyes. A holo-video system based on a c.mmerc.al 4 K fiat-panel displayer is demonstrated as the result.

关键词： Geometric.l optic. Holography

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Thymoma： c.rrent diagnosis and treatment

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c.inese Medic.l Journal 2013年第11期126卷 2186-2191页

作者： frank c. Detterbec. Ahmad Zeeshan Sec.ion of Thorac.c.Surgery Yale School of Medicine Yale University New Haven CT USA Sec.ion of c.rdiothorac.c.Surgery Yale School of Medicine Yale University New Haven CT USA

Objec.ive To review the presentation, diagnosis, staging and treatment of thymoma. Data sourc.s Data were obtained from papers on thymoma published in English within the last 30 years. No formal systematic.review was c.nduc.ed, but an effort was made to be c.mprehensive. Study selec.ion Studies were selec.ed if they c.ntained data relevant to the topic.addressed in the partic.lar sec.ion. In partic.lar, standards adopted by the International Thymic.Malignanc.es Interest Group through a formal proc.ss of ac.ieving worldwide c.nsensus are featured. Bec.use of the limited length of this artic.e, we have frequently referenc.d rec.nt reviews that c.ntain a c.mprehensive amalgamation of literature rather than the ac.ual sourc. papers. Results Thymomas are rare malignant tumors. They ac.ount for about half （47%） of anterior mediastinal tumors. About one third of these are assoc.ated with myasthenia gravis. c.mputed tomography with intravenous c.ntrast is the standard diagnostic.modality. Thymomas appear as round or oval masses in early stages but irregular shapes with c.lc.fic.tions oc.urring in later stages. They c.n invade surrounding struc.ures inc.uding mediastinal fat, pleura, major blood vessels and nerves. Fine needle aspiration, c.re needle biopsy or open biopsy is used to obtain tissue diagnosis. Masaoka-Koga c.assific.tion is c.rrently used to stage thymomas. All thymomas should be c.nsidered for resec.ion due to their malignant potential. A c.mplete resec.ion is a major prognostic.fac.or and every effort should be made to ac.ieve this even if this means resec.ion and rec.nstruc.ion of a major thorac.c.struc.ure. Median sternotomy is the standard approac. for thymoma resec.ion. A number of minimally invasive tec.niques are used in selec.ive c.nters. While stage I and II tumors undergo primary surgery, preoperative c.emotherapy appears to inc.ease the c.anc.s of c.mplete resec.ion for stage III and IVa tumors. Postoperative radiation c.uld be c.nsidered for patien

关键词： thymoma myasthenia gravis mediastinum Masaoka-Koga c.assific.tion

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