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Spread of Zika virus:The key role of mosquito vector control

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 468-471页

作者： giovanni Benelli Insect Behaviour Group Department of AgricultureFood and EnvironmentUniversity of Pisa

Mosquitoes(Diptera: Culicidae) represent a key threat for millions of humans and animals worldwide, since they act as vectors for important parasites and pathogens,including malaria, filariasis and a wide number of arboviruses. The recent outbreaks of Zika virus infections occurring in South America, Central America, and the Caribbean,represent the most recent four arrivals of important arboviruses in the western hemisphere, over the last 20 years, namely dengue, West Nile virus, and chikungunya. Since there are no specific treatments for Zika virus and the other arboviruses mentioned above,it should be highlighted that the eco-friendly and effective control of mosquito vectors is of pivotal importance. Besides radiation, transgenic and symbiont-based mosquito control approaches, an effective option may be the employ of biological control agents of mosquito young instars, in presence of ultra-low quantities of green-synthesized nanoparticles, which magnify their predation efficiency. Furthermore, behaviour-based control tools relying on the employ of swarming behaviour manipulation(i.e. the "lure and kill"approach), pheromone traps, sound traps need further research attention. In particular,detailed basic information on the physical and chemical cues routing mosquito swarming and mating dynamics is urgently required.

关键词： Anopheles Aedes Culex Arbovirus Chikungunya Dengue Guillain–Barre syndrome Microcephaly Natural product research Nanoparticles

Should nonalcoholic fatty liver disease be regarded as a hepatic illness only?

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World Journal of Gastroenterology 2007年第35期13卷 4669-4672页

作者： giovanni Tarantino Section of Hepatology in Internal Medicine Department of Clinical and Experimental MedicineFederico Ⅱ University Medical School of NaplesItaly

The highly increasing prevalence of obesity and type 2 diabetes mellitus in the general population makes nonalcoholic fatty liver disease the most common diagnosis in every-day practices. Lifestyle changes （mainly exercise withdrawal and weight gain） have probably heightened the prevalence of nonalcoholic fatty liver disease. Mortality in patients with Nonalcoholic Fatty Liver Disease is significantly higher when compared with that of the same age-gender general population. Hepatologists claim to bear a new burden, being Nonalcoholic Fatty Liver Disease strongly linked to systemic diseases.

关键词： Nonalcoholic fatty liver disease Metabolic syndrome Diabetes mellitus Obesity Polycystic ovary sindrome Obstructive sleep apnea Cardiovascular disease

Compact Differential Evolution Light: High Performance Despite Limited Memory Requirement and Modest Computational Overhead

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Journal of Computer Science & Technology 2012年第5期27卷 1056-1076页

作者： giovanni Iacca Fabio Caraffini Ferrante Neri EDepartment of Mathematical Information Technology University of JyvskylP.O.Box 35(Agora) Department of Mathematical Information Technology University of JyvskylP.O.Box 35(Agora)

Compact algorithms are Estimation of Distribution Algorithms which mimic the behavior of population-based algorithms by means of a probabilistic representation of the population of candidate solutions. These algorithms have a similar behaviour with respect to population-based algorithms but require a much smaller memory. This feature is crucially important in some engineering applications, especially in robotics. A high performance compact algorithm is the compact Differential Evolution （cDE） algorithm. This paper proposes a novel implementation of cDE, namely compact Differential Evolution light （cDElight）, to address not only the memory saving necessities but also real-time requirements, cDElight employs two novel algorithmic modifications for employing a smaller computational overhead without a performance loss, with respect to cDE. Numerical results, carried out on a broad set of test problems, show that cDElight, despite its minimal hardware requirements, does not deteriorate the performance of cDE and thus is competitive with other memory saving and population-based algorithms. An application in the field of mobile robotics highlights the usability and advantages of the proposed approach.

关键词： differential evolution compact optimization real-time optimization

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重新评估当前货币体系的合理性

清华金融评论 2024年第8期 44-45页

作者：乔瓦尼·特里亚罗马第二大学

自布雷顿森林体系80年前建立以来,国际货币体系经历了巨大的变化,有必要重新评估当前货币体系的合理性。本文先回顾了布雷顿森林体系的历程与困境,接着对有关重建布雷顿森林体系的话题进行探讨,并在此基础上指出以美元为中心的国际货币... 详细信息

自布雷顿森林体系80年前建立以来,国际货币体系经历了巨大的变化,有必要重新评估当前货币体系的合理性。本文先回顾了布雷顿森林体系的历程与困境,接着对有关重建布雷顿森林体系的话题进行探讨,并在此基础上指出以美元为中心的国际货币体系越来越受到质疑的原因。

关键词：国际货币体系布雷顿森林体系重新评估合理性美元

Automated mixing of maximally localized Wannier functions into target manifolds

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npj Computational Materials 2023年第1期9卷 229-237页

作者： Junfeng Qiao giovanni Pizzi Nicola Marzari Theory and Simulations of Materials(THEOS) and National Centre for Computational Design and Discovery of Novel Materials(MARVEL)École Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland Laboratory for Materials Simulations(LMS) Paul Scherrer Institut(PSI)CH-5232 Villigen PSISwitzerland

Maximally localized Wannier functions(MLWFs)are widely used in electronic-structure *** have recently developed automated approaches to generate MLWFs that represent natural tight-binding sets of atomic-like orbitals;these describe accurately both the occupied states and the complementary unoccupied *** many applications,it is required to use MLWFs that describe instead certain target groups of bands:the valence or the conduction bands,or correlated ***,we start from these tight-binding sets of MLWFs,and mix them using a combination of parallel transport and maximal localization to construct manifold-remixed Wannier functions(MRWFs):these are orthogonal sets of MLWFs that fully and only span desired target *** algorithm is simple and robust,and is showcased here in reference applications(silicon,MoS_(2),and SrVO_(3))and in a mid-throughput study of 77 insulators.

关键词： maximal bands occupied

giovanni Battista Piranesi

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Gastric cancer: Current status of lymph node dissection

作者： giovanni Battista Piranesi [introduction by] Luigi Ficacci.

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World Journal of Gastroenterology 2016年第10期22卷 2875-2893页

作者： Maurizio Degiuli giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom franco Roviello Francesco Santullo Mario Morino Department of Surgery University of TurinCitta della Salute e della Scienza Department of Surgery University of VeronaOspedale Borgo Trento Division of Surgery Ospedale di Arco Department of Surgery University "Cattolica del Sacro Cuore""A.Gemelli" University Hospital Department of Surgery University of Siena Department of Oncology University of Siena Department of Surgery Wielkopolskie Centrum Onkologii

D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC.

关键词： Gastric cancer Lymph node dissection Lymphadenectomy D2 gastrectomy D1 gastrectomy D1 plus gastrectomy Robot assisted lymphadenectomy Laparoscopic lymphadenectomy

Chronic hepatitis B： role of anti-platelet therapy in inflammation control

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Cellular & Molecular Immunology 2015年第3期12卷 264-268页

作者： Roberto Aiolfi giovanni Sitia Division of Immunology Transplantation and Infectious Diseases IRCCS San Raffaele Scientific Institute Milan Italy

Platelets play a known role in the maintenance of vascular homeostasis, but these cells are emerging as important cellular mediators of acute and chronic inflammatory diseases. Platelets are key elements in the pathogenesis of acute and chronic liver disease associated with hepatitis B virus （HBV） infection by promoting the accumulation of virus-specific CD8＋ T cells and nonspecific inflammatory cells into the liver parenchyma. This review discusses major platelet functions in immune and inflammatory responses, with an emphasis on recent pre-clinical studies that suggest that the inhibition of platelet activation pathways represent an alternative therapeutic strategy with potential use in the reduction of virus-specific T cell-mediated chronic inflammation, liver fibrosis and hepatocellular carcinoma in patients who are chronically infected with HBV.

关键词： anti-platelet drugs CD8+ T cells chronic hepatitis B hepatocellular carcinoma platelets

Gut microbiota and nutrient interactions with skin in psoriasis:A comprehensive review of animal and human studies

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World Journal of Clinical Cases 2020年第6期8卷 1002-1012页

作者： giovanni Damiani Nicola Luigi Bragazzi Thomas S McCormick Paolo Daniele Maria Pigatto Sebastiano Leone Alessia Pacifico Danica Tiodorovic Sveva Di franco Aniello Alfieri Marco Fiore Department of Dermatology Case Western Reserve UniversityClevelandOH 44106United States Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoa 16132Italy Department of Medicine Division of Infectious diseases“San Giuseppe Moscati”HospitalAvellino 83100Italy San Gallicano Dermatological Institute IRCCSRome 00144Italy Dermatology Clinic Medical FacultyNis UniversityNis 18000Serbia Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy

The intestinal tract(i.e.,the gut),is where the body’s nutrients are absorbed,and is simultaneously inhabited by numerous *** increasing body of literature suggests a crucial role for the gut microbiome in modulating systemic inflammatory *** is a chronic systemic inflammatory disease and its pathogenesis is related to the interaction between genetic susceptibility,immune response and environmental *** omics era has allowed physicians to assess different aspects of psoriasis pathogenesis such as the microbiome,infectome,and ***,diet appears to play an important role in modulating disease activity,perhaps by influencing gut *** these observations,we aimed to summarize the current knowledge regarding skin-microbiome-gut-nutrients and psoriasis.

关键词： Gut Microbiota Nutrients Endotypes Exposome Psoriasis