Could quantitative liver function tests gain wide acceptance among hepatologists?
Could quantitative liver function tests gain wide acceptance among hepatologists?作者机构：Department of Clinical and Experimental Medicine Federico II University Medical School of Naples
出 版 物：《世界胃肠病学杂志：英文版》 (WORLD JOURNAL OF GASTROENTEROLOGY)
年 卷 期：2009年第15卷第28期
页 面：3457-3461页
核心收录：
主 题：肝脏疾病 功能试验 定量评估 抗病毒治疗 严重程度 长期预测 安替比林 临床实践
摘 要：It has been emphasized that the assessment of residual liver function is of paramount importance to determine the following: severity of acute or chronic liver diseases independent of etiology; long-term prognosis; step-by- step disease progression; surgical risk; and efflcacy of antiviral treatment. The most frequently used tools are the galactose elimination capacity to asses hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, and antipyrine clearance to estimate microsomal activity. However, a widely accepted liver test (not necessarily a laboratory one) to assess quantitative functional hepatic reserve still needs to be established, although there have been various proposals. Furthermore, who are the operators that should order these tests? Advances in analytic methods are expected to allow quantitative liver function tests to be used in clinical practice.
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