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Identifying specific RGC types may shed light on their idiosyncratic responses to neuroprotection

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Neural Regeneration Research 2015年第8期10卷 1228-1230页

作者： Manuel Vidal-Sanz francisco M.Nadal-Nicolás francisco j.Valiente-Soriano Marta Agudo-Barriuso Maria P.Villegas-Pérez Departamento de Oftalmología Facultad de Medicina Universidad de Murcia and Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca) Campus de Ciencias de la Salud Carretera Buenavista s/n 30120 El Palmar Murcia Spain

Retinal ganglion cells（RGCs）are located in the innermost layer of the retina and are the only retinal output neurons,conveying light information to the main retinorecipient target regions of the brain responsible for the image-and non-image-forming visual *** are well over twenty RGC types,each with its own dendritic morphology and physiological characteristics,

关键词： RGCs retina physiological conveying ganglion glaucoma suppression neurotrophin pigmented reflex

A plasmonic route for the integrated wireless communication of subdiffraction-limited signals

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Light(Science & Applications) 2020年第1期9卷 930-938页

作者： Hao Chi Zhang Le Peng Zhang Pei Hang He jie Xu Cheng Qian francisco j.Garcia-Vidal Tie jun Cui State Key Laboratory of Millimeter Waves Southeast University210096 NanjingChina Departamento de Fisica Teorica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autonoma de MadridMadridSpain Donostia International Physics Center(DIPC) Donostia/San SebastianSpain

Perfect lenses,superlenses and time-reversal mirrors can support and spatially separate evanescent waves,which is the basis for detecting subwavelength information in the far ***,the inherent limitations of these methods have prevented the development of systems to dynamically distinguish subdiffraction-limited *** the physical merits of spoof surface plasmon polaritons(SPPs),we demonstrate that subdiffraction-limited signals can be transmitted on planar integrated SPP channels with low loss,low channel interference,and high gain and can be radiated with a very low environmental ***,we show how deep subdiffraction-limited signals that are spatially coupled can be distinguished after line-of-sight wireless *** a visualized demonstration,we realize the high-quality wireless communication of two movies on subwavelength channels over the line of sight in real time using our plasmonic scheme,showing significant advantages over the conventional methods.

关键词： communication spatially diffraction

Simulating FAS-induced apoptosis by using P systems

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Progress in Natural Science:Materials International 2007年第4期17卷 424-431页

作者： Smitha Cheruku Andrei Pǎun francisco j. Romero-Campero Mario j. Pérez-jiménez Oscar H. Ibarra Department of Computer Science/IfM Louisiana Tech UniversityP.O. Box 10348RustonLA 71272USA Department of Computer Science and Artificial Intelligence University of SevilleAvda. Reina Mercedes s/n 41012SevillaSpain Department of Computer Science University of California-Santa BarbaraSanta BarbaraCA 93106USA

In contrast to differential equations, P systems are an unconventional model of computation which takes into consideration the discrete character of the quantity of components and the inherent randomness that exists in biological phenomena. The key feature of P systems is their compartmentalised structure which represents the heterogeneity of the structural organisation of the cells, and where one can take into account the role played by membranes in the functioning of the system, for example signalling at the cell surface, selective uptake of substances from the media, diffusion across different compartments, etc. We show here that P systems can be a reliable tool for Systems Biology and could even outperform in some cases the current simulation techniques based on differential equations. We will also use a strategy based on the well known Gillespie algorithm but running on more than one compartment called Multi-compartmental Gillespie Algorithm.

关键词： FAS-induced apoptosis P systems deterministic waiting times algorithm multi-compartmental Gillespie algorithm.

Experimental study on the wear evolution of different PVD coated tools under milling operations of LDX2101 duplex stainless steel

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Advances in Manufacturing 2023年第1期11卷 158-179页

作者： Vitor F.C.Sousa francisco j.G.Silva Ricardo Alexandre jose S.Fecheira Gustavo Pinto Andresa Baptista ISEP-School of Engineering Polytechnic of PortoRua Dr.António Bernardino de Almeida4314200–072PortoPortugal INEGI-Driving Science and Innovation Rua Dr.Roberto Frias4004200–465PortoPortugal TEandM-Technology Engineering and MaterialsS.A.Parque Industrial do TaveiroLotes 41-423045–504TaveiroPortugal

Duplex stainless steels are being used on applications that require,especially,high corrosion resistance and overall good mechanical properties,such as the naval and oil-gas exploration *** components employed in these industries are usually obtained by machining,however,these alloys have low machinability when compared to conventional stainless *** this work,a study of the wear developed when milling duplex stainless-steel,LDX 2101,is going to be presented and evaluated,employing four types of milling tools with different geometries and coatings,while studying the influence of feed rate and cutting length in the wear of these *** used have been provided with two and four flutes,as well as three different coatings,namely:TiAlN,TiAlSiN and *** cutting behavior of these tools was analyzed;data relative to the cutting forces developed during the process were obtained;and roughness measurements of the machined surfaces were *** tools were then submitted to scanning electron microscope(SEM)analysis,enabling the identification of the wear mechanisms that tools were subjected to when machining this material,furthermore,the early stages of these mechanisms were also *** this work was done with the goal of relating the machining parameters and cutting force values obtained,identifying,and discussing the wear patterns that were observed in the coating and tools after the milling tests,providing further information on the machining of these alloys.

关键词： Duplex stainless-steel Milling Tool coatings Surface roughness Wear mechanisms

Immediate and late effects of chronic stress in the testes of prepubertal and adult rats

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Asian journal of Andrology 2018年第4期20卷 385-390页

作者： Carina T Ribeiro Diogo B De Souza Waldemar S Costa francisco j B Sampaio Marco A Pereira-Sampaio Urogenital Research Unit State University of Rio de Janeiro Rio de Janeiro RJ 20551-030 Brazil Department of Morphology Fluminense Federal University Niteroi RJ 24210-150 Brazil

The objective of this study was to investigate the effects of chronic stress on the testes of prepubertal and adult rats and to evaluate whether any alterations could be reversed when stress induction is ended. Seventy-six male rats were assigned to eight groups depending on the type of treatment （control or stressed）, the age at which stress was initiated （prepubertal or adult）, and the time of evaluation （immediate or late）. Stress stimuli were applied for 6 weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimulus were included in SP-I and SA-I groups, respectively. The late prepubertal （SP-L） and adult （SA-L） groups of stressed rats were evaluated 6 weeks after the last stress stimulus. Age-matched rats were used as controls （CP-I, CA-I, CP-L, and CA-L groups）. Application of stress stimuli to rats in the SP-I group resulted in body weight and seminiferous tubule diameter reduction. The rats in the SA-I group also showed several functional （testosterone level and sperm parameter） and morphological （testicular weight and seminiferous tubule diameter） reductions. The rats in the SP-L group showed increased body weight and intertubular compartment volumetric and absolute densities and reduced tubular compartment volumetric density. The rats in the SA-L group presented only reduced sperm viability. Stress stimuli promoted changes in the rats in all the study groups. The testes of the adult rats were the most affected by chronic stress. However, the stressed adult rats recovered well from the testicular alterations.

关键词： chronic stress morphometry rat testis

How to express tumours using membrane systems

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Progress in Natural Science:Materials International 2007年第4期17卷 449-457页

作者： Miguel A. Gutiérrez-Naranjo Mario j. Pérez-jiménez Agustín Riscos-Núez francisco j. Romero-Campero Department of Computer Science and Artificial Intelligence University of Seville Avda. Reina Mercedes s/n41012SevillaSpain

In this paper we discuss the potential usefulness of membrane systems as tools for modelling tumours. The approach is followed both from a macroscopic and a microscopic point of view. In the first case, one considers the tumour as a growing mass of cells, focusing on its external shape. In the second case, one descends to the microscopic level, studying molecular signalling pathways that are crucial to determine if a cell is cancerous or not. In each of these approaches we work with appropriate variants of membrane systems.

关键词： tumour membrane system modeling.

Hydrogen sulfide:A novel component in Arabidopsis peroxisomes which triggers catalase inhibition

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journal of Integrative Plant Biology 2019年第7期61卷 871-883页

作者： francisco j.Corpas juan B.Barroso Salvador Gonzalez-Gordo Maria A.Munoz-Vargas jose M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstacion Experimental del ZaidfnCSICC/Profesor Albareda 1E-18008 GranadaSpain Group of Biochemistry and Cell Signaling in Nitric oxide Department of Biochemistry and Molecular BiologyCampus"Las Lagunillas"E-23071University of JaenJaenSpain

Plant peroxisomes have the capacity to gen erate different reactive oxygen and nitrogen species(ROS and RNS),such as H2O2,superoxide radical(O2^·-),nitric oxide and peroxynitrite(ONOO^-).These organelles have an active nitrooxidative metabolism which can be exacerbated by adverse stress *** sulfide(H2S)is a new signaling gasotransmitter which can mediate the posttranslational modification(PTM)*** used Arabidopsis thaliana transgenic seedlings expressing cyan fluorescent protein(CFP)fused to a canonical peroxisome targeting signal 1(PTS1)to visualize peroxisomes in living cells,as well as a specific fluorescent probe which showed that peroxisomes contain H2S.H2S was also detected in chloroplasts under glyphosate-induced oxidative stress *** enzyme activities,including catalase,photorespiratory H2O2-generating glycolate oxidase(GOX)and hydroxypyruvate reductase(HPR),were assayed in vitro with a H2S *** line with the persulfidation of this enzyme,catalase activity declined significantly in the presence of the H2S *** corroborate the inhibitory effect of H2S on catalase activity,we also assayed pure catalase from bovine liver and pepper fruit-enriched samples,in which catalase activity was *** together,these data provide evidenee of the presence of H2S in plant peroxisomes which appears to regulate catalase activity and,consequently,the peroxisomal H2O2 metabolism.

关键词： Hydrogen sulfide triggers catalase inhibition

Biliary-colonic fistula caused by cholecystectomy bile duct injury

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 443-445页

作者： francisco Igor B Macedo Victor j Casillas james S Davis joe U Levi Danny Sleeman Dewitt Daughtry Family Department of Surgery University of Miami Miller School of Medicine and Ryder Trauma Center/Jackson Memorial HospitalMiami Florida USA Department of Radiology University of Miami Miller School of Medicine and Ryder Trauma Center/Jackson Memorial HospitalMiami Florida USA

Biliary-colonic fistula is a rare complication after laparoscopic cholecystectomy. We present a case of post-cholecystectomy iatrogenic biliary injury that resulted in a fistula between the common hepatic duct and large bowel. Magnetic resonance cholangiopancreatography provided good visualization of injury even with concurrent normal level of alkaline phosphatase. Radiologic findings and surgical management of this condition are discussed in detail.

关键词： cholecystectomy magnetic resonance imaging biliary tract disease

Post-transcriptional regulation of seed dormancy and germination: Current understanding and future directions

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Plant Communications 2021年第4期2卷 1-22页

作者： Rocío Soledad Tognacca javier francisco Botto Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de FisiologíaBiología Molecular y Neurociencias(IFIBYNE)Facultad de Ciencias Exactas y NaturalesCP1428 Buenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Investigaciones Fisiològicas y Ecològicas Vinculadas a la Agricultura(IFEVA)Facultad de AgronomíaCP1417 Buenos AiresArgentina

Seed dormancy is a developmental checkpoint that prevents mature seeds from germinating under conditions that are otherwise favorable for *** and light are themost relevant environmental factors that regulate seed dormancy and *** environmental cues can trigger molecular and physiological responses including hormone signaling,particularly that of abscisic acid and *** balance between the content and sensitivity of these hormones is the key to the regulation of seed *** and light tightly regulate the transcription of thousands of genes,as well as other aspects of gene expression such asmRNAsplicing,translation,and *** remodeling determines specific transcriptional outputs,and alternative splicing leads to different outcomes and produces transcripts that encode proteins with altered or lost *** regulation of chromatin remodeling and alternative splicing may be highly relevant to seed ***,microRNAs are also critical for the control of gene expression in *** review aims to discuss recent updates on post-transcriptional regulation during seed maturation,dormancy,germination,and post-germination *** propose future prospects for understanding howdifferent post-transcriptional processes in crop seeds can contribute to the design of genotypes with better performance and higher productivity.

关键词： alternative splicing chromatin remodeling dormancy germination microRNA(miRNA) seeds