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Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates

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Asian j.urnal of Andrology 2019年第2期21卷 201-207页

作者： Fabiana A de Oliveira Waldemar S Costa francisco j.B Sampaio Bianca M Gregorio Urogenital Research Unit Biomedical CenterState University of Rio de JaneiroRio de Janeiro 20551-030Brazil

High-fat diets affect male reproduction and sexual ***,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria *** Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)*** 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 *** were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further *** were analyzed by one-way ANOVA,and P<0.05 was considered statistically *** CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C ***,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis.

关键词： cafeteria diet morphology resveratrol spermatozoa testicle

The extractable hydrokinetic power from an oscillating membrane-based harvester

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Theoretical & Applied Mechanics Letters 2019年第2期9卷 66-70页

作者： francisco j.Arias Salvador De Las Heras Department of Fluid Mechanics University of Catalonia

The extractable hydrokinetic power from an oscillating membrane in standing motion and induced by a water flow and its possible significance with regard energy harvesting is *** main attractiveness of such an energy harvester lies in the possibility of an inexpensive technology able to be used in those water flows which either because limitation of space(narrow channels) or a limited differential pressure drop with the surrounding but yet with a non negligible velocity are not well suited to be turbined. Utilizing a simplified geometrical model, an estimate of the extractable output density power per area of membrane was derived. Preliminary experiments were performed using a rectangular thin rubber membrane and for a typical domestic water intake as source. The experimental data quantitatively agree very well with the theoretical prediction where it was found that for water flows around 2 m/s the output power density from the membrane may be around 30 mW/cm^2 of membrane. Additional research and development is required in order to arrive at a reliable practical and commercial design.

关键词： Energy harvesting Residual waters Waste waters

Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study

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j.urnal of Sport and Health Science 2021年第3期10卷 360-367页

作者： Carlos Cristi-Montero j.vier Courel-Ibanez francisco B.Ortega j.se Castro-Pinero Alba Santaliestra-Pasias Angela Polito j.remy Vanhelst Ascension Marcos Luis M.Moreno j.natan R.ruiz IRyS Group Physical Education SchoolPontificia Universidad Catolicade ValparaisoValparaisso 2530388Chile Department of Physical Activity and Sport Faculty of Sport SciencesUniversity of MurciaMurcia 30071Spain PROmoting FITness and Health through Physical Activity Research Group(PROFITH) Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18001Spain Department of Physical Education Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Department of Health and Human Performance School of Health SciencesUniversity of ZaragozaZaragoza 50001Spain Growth ExerciseNutrition and Development(GENUD)Research GroupZaragoza 50001Spain National Institute for Food and Nutrition Research Rome 80070Italy Lille Inflammation Research International Center University of LilleLille 59000France Immunonutrition Research Group Department Metabolism and NutritionInstitute of Food Science and Technology and Nutrition(ICTAN)Spanish National Research Council(CSIC)Madrid E-28040 Spain

Purpose:This study was aimed to analyze the mediation role of cardiorespiratory fitness(CRF)on the association between fatness and cardiometabolic risk scores(CMRs)in European ***:A cross-sectional study was conducted in adolescents(n=525;46%boys;14.1±1.1 years old,mean ±SD)from 10 European cities involved in the Healthy Lifestyle in Europe by Nutrition in Adolescence *** was measured by means of the shuttle run test,while fatness measures included body mass index(BMI),waist to height ratio,and fat mass index estimated from skinfold thicknesses.A clustered CMRs was computed by summing the standardized values of homeostasis model assessment,systolic blood pressure,triglycerides,total cholesterol/highdensity lipoprotein cholesterol ratio,and ***:Linear regression models indicated that CRF acted as an important and partial mediator in the association between fatness and CMRs in 1217-year-old adolescents(for BMI:coefficients of the indirect role b=0.058(95%confidence interval(95%CI):0.023-0.101),Sobel test z=3.11(10.0%mediation);for waist to height ratio:b=4.279(95%CI:2.242-7.059),z=3.86(11.5%mediation);and for fat mass index:b=0.060(95%CI:0.020-0.106),z=2.85(9.4%mediation);all p<0.01).Conclusion:In adolescents,the association between fatness and CMRs could be partially decreased with improvements to fitness levels;therefore,CRF contribution both in the clinical field and public health could be important to consider and promote in adolescents independently of their fatness levels.

关键词： Cardiovascular disease Children Fat mass Fitness Health Physical activity

The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso j.ão Vitor Mahler Pedro Henrique Fonseca-Castro francisco j.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

Prey availability, prey selection, and trophic niche width in the lizard Psammodromus algirus along an elevational gradient

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Current Zoology 2018年第5期64卷 603-613页

作者： Gregorio MORENO-RUEDA Elena MELERO Senda REGUERA francisco j. ZAMORA-CAMACHO Ines ALVAREZ-BENITO Departamento de Zoologla Facultad de Ciencias Universidad de Granada Granada E-18071 Spain Departamento de Biogeografia y Carnbio Global Museo Nacional de Ciencias Naturales-CSIC C/Jose Gutierrez Abascal 2 E-28006 Madrid Spain

Mountains imply enormous environmental variation, with alpine habitats entailing harsh environ- ments, especially for ectotherms such as lizards. This environmental variability also may imply variation in prey availability. However, little is known about how lizard trophic ecology varies with elevation. In this study, we analyze diet, prey availability, prey selection, and trophic niche width in the lacertid lizard Psammodromus algirus along a 2,200-m elevational gradient in the Sierra Nevada （SE Spain）. The analysis of fecal samples has shown that Orthoptera, Formicidae, Hemiptera, Coleoptera, and Araneae are the main prey, although, according to their abundance in pitfall traps, Formicidae and Coleoptera are rej.cted by the lizard whereas Orthoptera, Hemiptera, and Araneae are preferred. Prey abundance and diversity increase with elevation and diet subtly varies along with the elevational gradient. The consumption of Coleoptera increases with elevation probably as a consequence of the lizard foraging more in open areas while basking. The electivity for Araneae increases with elevation. Araneae are rej.cted in the lowlands--where they are rela- tively abundant--whereas, at high elevation, this lizard positively selects them, despite they being less abundant. The lizard trophic niche width expands with elevation due to concomitant greater prey diversity and hence this lizard feeds on more prey types in highlands. Although no sex difference in diet has been found, the trophic niche is broader in females than males. As a whole, alpine lizards show a trophic niche simitar to that found at lower elevat（ons, suggesting that P. algirus is well adapted to the harsh environment found in alpine areas.

关键词： alpine habitats arthropods mountain ecology niche variation hypothesis trophic ecology

Migration from an SQL to a hybrid SQL/NoSQL data model

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j.urnal of Management Analytics 2020年第1期7卷 1-11页

作者： Marina V.Sokolova francisco j.Gomez Larisa N.Borisoglebskaya Orel State University OrelRussia Department of Computing Systems University of Castilla-La ManchaAlbaceteSpain

The paper presents a redesign of a database management system for a retail business ***,based on a traditional data model,it is migrated to a hybrid model which combines both SQL and NoSQL *** approach adds flexibility,mobility,and efficiency to the data management *** NoSQL database uses an ontology as a data schema,which we describe in this *** NoSQL database is consulted using the SPARQL query language,and some examples of the queries are detailed in the *** architecture of the system and its functionality are discussed.

关键词： NoSQL ontology digitalization RDF

Age structure of a lizard along an elevational gradient reveals nonlinear lifespan patterns with altitude

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Current Zoology 2020年第4期66卷 373-382页

作者： Mar Comas Senda Reguera francisco j.amora-Camacho Gregorio Moreno-Rueda Departamento de Zoologia Facultad de CienciasUniversidad de GranadaGranadaE-18071Spain Estacion Biologica de Donana(EBD-CSIC) Americo Vespucio 26SevillaE-41092Spain Department of Biological Sciences Dartmouth CollegeHanoverNHUSA

Lifespan is one of the main components of life *** lifespans can be expected in marginal ***,in the case of ectotherms,lifespan typically increases with altitude,even though temperature-one of the main factors to determine ectotherms'life history-declines with *** pattern can be explained by the fact that a shorter activity time favors *** this study,we analyzed how lifespan and other life-history traits of the lizard Psammodromus algirus vary along a 2,200 m elevational gradient in Sierra Nevada(SE Spain).Populations at inter-mediate altitudes(1,200-1,700 m),corresponding to the optimal habitat for this species,had the shortest lifespans,whereas populations inhabiting marginal habitats(at both low and at high altitudes)lived ***,this lizard did not follow the typical pattern of ectotherms,as it also lived longer at the lower limit of its distribution,nor did it show a longer lifespan in areas with optimal *** results might be explained by a complex combination of different gradients along the mountain,namely that activity time decreases with altitude whereas food availability *** could explain why lifespan was maximum at both high(limited activity time)and low(limited food availability)altitudes,resulting in similar lifespans in areas with contrasting environmental *** findings also indicated that reproductive investment and body condition increase with elevation,suggesting that alpine populations are locally adapted.

关键词： age structure elevation lite history longevity marginal habitats relative clutch mass

Morphological determinants of j.mping performance in the Iberian green frog

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Current Zoology 2020年第4期66卷 417-424页

作者： Gregorio Moreno-Rueda Abelardo Requeinia-Blaimco francisco j.Zamora-Camacho Mar Comas Guillem Pascual Departamento de Zoologia Facultad de CienciasUniversidad de GranadaGranadaE-18071Spain Department of Biological Sciences Dartmouth CollegeHanoverNH03055USA Galanthus/Ctra.de j.ia 46.17460 CelraSpain

Predation is one of the main selective forces in nature, frequently selecting potential prey for developing escape strategies. Escape ability is typically influenced by several morphological parameters, such as morphology of the locomotor appendices, muscular capacity, body mass, or fluctuating asymmetry, and may differ between sexes and age classes. In this study, we tested the relationship among these variables and j.mping performance in 712 Iberian green frogs Pelophylax perezi from an urban population. The results suggest that the main determinant of j.mping capacity was body size (explaining 48% of variance). Larger frogs j.mped farther, but j.mping performance reached an asymptote for the largest frogs. Once controlled by structural body size, the heaviest frogs j.mped shorter distances, suggesting a trade-off between fat storage and j.mping performance. Relative hind limb length also determined a small but significant percentage of variance (2.4%) in j.mping performance-that is, the longer the hind limbs, the greater the j.mping capacity. j.veniles had relatively shorter and less muscular hind limbs than adults (for a given body size), and their j.mping performance was poorer. In our study population, the hind limbs of the frogs were very symmetrical, and we found no effect of fluctuating asymmetry on j.mping performance. Therefore, our study provides evidence that j.mping performance in frogs is not only affected by body size, but also by body mass and hind limb length, and differ between age classes.

关键词： body mass fluctuating asymmetry hind limb length hind limb width locomotor performance morphometry

Porcine Respiratory Pathogens in Swine Farms Environment in Mexico

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Open j.urnal of Animal Sciences 2014年第4期4卷 196-205页

作者： Victor M. Loera-Muro Abraham Loera-Muro Marcela Morfín-Mata Mario j.cques francisco j. Avelar-gonzález Flor Ramírez-Castillo Elsa M. Ramírez-López Alma L. Guerrero-Barrera Centro de Ciencias Básicas Universidad Autónoma de Aguascalientes Aguascalientes México Groupe de Recherche sur la Maladies Infectieuses du Porc Faculté de Médecine Vétérinaire Université de Montréal St-Hyacinthe Québec Canada Keken Jefatura Sitio 2 y WTF Mérida México Laboratorio de Biología Celular y Tisular Departamento de Morfología Centro de Ciencias Básicas Universidad Autónoma de Aguascalientes Aguascalientes México

Respiratory pathogens are the main health problem in the swine industry worldwide. These pathogens are transmitted by direct contact between animals or by aerosols and however are not well known yet, if the environment works as its reservoir, inoculum and/or dispersion medium. The obj.ctive of this study was to determine the presence of respiratory pathogens in environmental samples from swine farms in Aguascalientes, Mexico, through of PCR and RT-PCR techniques. The bacteria Actinobacillus pleuropneumoniae and Pasteurella multocida were found viable in samples from water, food, soil and air. Streptococcus suis was found in a viable state in water samples. Haemophilus parasuis, Porcine Reproductive and Respiratory Syndrome virus and Swine Influenza virus (H1N1 and H3N2) were detected in drinking water samples. Mycoplasma hyopneumoniae and Porcine Circovirus type 2 (PCV2) were not detected in environmental samples. These results suggest that the environment of the farms acts as a reservoir, inoculum and/or vehicle of dispersion for these pathogens except for M. hyopneumoniae and PCV2.

关键词： Environment Respiratory Pathogen Porcine Respiratory Disease Complex PCR and RT-PCR