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Computers, Materials & Continua 2019年第8期61卷 481-502页

作者： S.Kshrisagar A.francis j.j.Yee S.Natarajan C.K.Lee Integrated Modelling and Simulation Lab Department of Mechanical EngineeringIndian Institute of Technology MadrasChennai600036India The Department of Architectural Engineering Dong-A UniversityS04-0302Engineering 237Nakdongdaero 550beon-gilSaha-guBusan49315Korea National Research Center for Disaster-free&Safe Ocean City Dong-A UniversityS04-0311-3Engineering 237Nakdong-daero 550beon-gilSaha-guBusan49315Korea

In this paper,the node based smoothed-strain Abaqus user element(UEL)in the framework of finite element method is *** basic idea behind of the node based smoothed finite element(NSFEM)is that finite element cells are divided into subcells and subcells construct the smoothing domain associated with each node of a finite element cell[Liu,Dai and Nguyen-Thoi(2007)].Therefore,the numerical integration is globally performed over smoothing *** is demonstrated that the proposed UEL retains all the advantages of the NSFEM,i.e.,upper bound solution,overly soft stiffness and free from locking in compressible and nearly-incompressible *** this work,the constant strain triangular(CST)elements are used to construct node based smoothing domains,since any complex two dimensional domains can be discretized using CST *** additional challenge is successfully addressed in this *** efficacy and robustness of the proposed work is obtained by several benchmark problems in both linear and nonlinear *** developed UEL and the associated files can be downloaded from https://***/nsundar/NSFEM.

关键词： Smoothed finite element method(SFEM) node based SFEM(NSFEM) linear and nonlinear elasticity Abaqus UEL(user elements) compressible and nearlyincompressible materials

Conservative Discontinuous Galerkin/Hermite Spectral Method for the Vlasov-Poisson System

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Communications on Applied Mathematics and Computation 2022年第1期4卷 34-59页

作者： francis Filbet Tao Xiong Institut de Mathématiques de Toulouse UniversitéPaul SabatierToulouse 31062France School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen UniversityXiamen 361005Fujian ProvinceChina

We propose a class of conservative discontinuous Galerkin methods for the Vlasov-Pois-son system written as a hyperbolic system using Hermite polynomials in the velocity *** schemes are designed to be systematically as accurate as one wants with prov-able conservation of mass and possibly total *** properties in general are hard to achieve within other numerical method frameworks for simulating the Vlasov-Poisson *** proposed scheme employs the discontinuous Galerkin discretization for both the Vlasov and the Poisson equations,resulting in a consistent description of the distribu-tion function and the electric *** simulations are performed to verify the order of the accuracy and conservation properties.

关键词： Energy conserving Discontinuous Galerkin method Hermite spectral method Vlasov-Poisson

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用于PjMIF的超快气阀性能表征

应用物理 2024年第6期14卷 508-521页

作者：景原通刘延斌 Y. C. francis Thio 张德雨袁东方张晓兵上海科技大学终极能源中心上海

上海科技大学正在研发第三代用于PjMIF的同轴等离子体枪STG1以及配套超快气阀。STG1的超快气阀需要在百微秒(~100 μs)的开关时间内注入0~30 mg的均匀气体。超快气阀利用j × B电磁力驱动金属飞盘控制气路开关,检测气阀结构中金属飞盘... 详细信息

上海科技大学正在研发第三代用于PjMIF的同轴等离子体枪STG1以及配套超快气阀。STG1的超快气阀需要在百微秒(~100 μs)的开关时间内注入0~30 mg的均匀气体。超快气阀利用j × B电磁力驱动金属飞盘控制气路开关,检测气阀结构中金属飞盘弹射时的运动轨迹可以直接体现气阀的稳定性和开关性能。针对两种结构的超快气阀搭建实验平台,采用激光三角测距法对气阀的金属飞盘的位移进行检测,获得金属飞盘在两种结构下的位移曲线,以及新型结构的气阀在不同电压下的开关时间,并通过有限元分析法对飞盘弹射过程中的振动现象进行验证。研究结果表明,金属飞盘在弹射过程中会产生中心振动,新型弹簧和短翼无孔飞盘组合下的新型结构相比于传统结构具有更高的重复性,可以通过改变电压的方式可以有效的将气阀的开关时间控制在0~300 μs。

关键词： PjMIF 超快气阀三角激光测距法飞盘

Kidney Tubular-Cell Secretion of Osteoblast Growth Factor Is Increased by Kaempferol:A Scientific Basis for "The Kidney Controlling the Bone" Theory of Chinese Medicine

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Chinese journal of Integrative Medicine 2014年第9期20卷 675-681页

作者：龙勉李顺祥肖江峰王健 Lozanoff Scott 张志光 Luft Benjamin j johnson francis Department of Complementary and Alternative Medicine University of Hawai'i at Manoa.John ABurns School of Medicine 9681 3USA Department of Phytochemistry of Institute of Chinese Medica Matria.Hunan Academy of Traditional Chinese Medicine Department of Research Jiangsu Jiangshan PharmaceuticalCompany Department of Anatomy Biochemistry and Physiology University of Hawai'i at ManoaJohn ABurns School of Medicine Honolulu96813USA Department of Botany School of Life ScienceHunan Normal University Department of Medicine State University of New York at Stony BrookHonolulu11794-8160USA Departments of Pharmacological Sciences and Chemistry State University of New York at Stony BrookHonolulu11794-3400USA

Objective： To study, at the cytological level, the basic concept of Chinese medicine that “the Kidney （Shen） controls the bone”. Methods： Kaempferol was isolated form Rhizoma Drynariae （Gu Sui Bu, GSB） and at several concentrations was incubated with opossum kidney （OK） cells, osteoblasts （MC3T3 El） and human fibroblasts （HF） at cell concentrations of 2 x 104/mL. Opossum kidney cell-conditioned culture media with kaempferol at 70 nmol/L （70kaθOKM） and without kaempferol （oOKM） were used to stimulate MC3T3 E1 and HF proliferation. The bone morphological protein receptors I and Ⅱ （BMPR I and Ⅱ） in OK cells were identified by immune-fluorescence staining and Western blot analysis. Results： Kaempferol was found to increase OK cell growth （P〈0.05）, but alone did not promote MC3T3 E1 or HF cell proliferation. However, although OKM by itself increased MC3T3 E1 growth by 198% （P〈0.01）, the 70kaθOKM further increased the growth of these cells by an additional 127% （P〈0.01）. It indicates that the kidney cell generates a previously unknown osteoblast growth factor （OGF） and kaempferol increases kidney cell secretion of OGF. Neither of these media had any significant effect on HF growth. Kaempferol also was found to increase the level of the BMPR Ⅱ in OK cells. Conclusions： This lends strong support to the original idea that the Kidney has a significant influence over bone-formation, as suggested by some long-standing Chinese medical beliefs, kaempferol may also serve to stimulate kidney repair and indirectly stimulate bone formation.

关键词： kaempferol renal tubular cell osteoblast growth factor Rhizoma Drynariae bone morphological protein receptor Kidney controls the bone

Bacteria may contribute to distant species recognition in ant-aphid mutualistic relationships

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Insect Science 2017年第2期24卷 278-284页

作者： Christophe Y. Fischer Claire Detrain Philippe Thonart Eric Haubruge Frederic francis Francois j. Verheggen Georges C. Lognay Laboratory of Analytical Chemistry University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Unit of Social Ecology Universite Libre de Bruxelles CP231 50 avenue F. Roosevelt B-1050 Brussels Walloon Center of Industrial Biology University of Liege B40 Sart-Tilman 4000 Liege 4Functional and Evolutionary Entomology University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Belgium

Mutualistic interactions between ant and aphid species have been the subject of considerable historical and contemporary investigations, the primary benefits being clean- ing and protection for the aphids and carbohydrate-rich honeydew for the ants. Questions remained, however, as to the volatile semiochemical factor influencing this relationship. A recent study highlighted the role of bacterial honeydew volatile compounds in ant at- traction. Here, ant＇s ability to distantly discriminate 2 aphid species was investigated based on bacterial honeydew semiochemicals emissions using a two-way olfactometer. Both the mutualistic aphid Aphis fabae L. and the nonmyrmecophilous aphid Acyrthosiphon pisum Harris were found to be attractive for the ant Lasius niger L. The level of attraction was similar in both assays （control vs. one of the aphid species）. However, when given a choice between these 2 aphid species, ants showed a significant preference for Aphis fabae. Honeydew volatiles, mostly from bacterial origins, are known to be a key element in ant attraction. Using the same olfactometry protocol, the relative attractiveness of volatiles emitted by honeydews collected from each aphid species and by bacteria isolated from each honeydew was investigated. Again, ants significantly preferred volatiles released by Aphis fabae honeydew and bacteria. This information suggests that microbial honeydew volatiles enable ants to distantly discriminate aphid species. These results strengthen the interest of studying the occurrence and potential impact of microorganisms in insect symbioses.

关键词： ant aphid bacteria honeydew mutualism recognition VOC

Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity

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世界胃肠病学杂志:英文版 2023年第33期29卷 4991-5004页

作者： Kendra L francis Kimberly M Alonge Maria Cristina Pacheco Shannon j Hu Cody A Krutzsch Gregory j Morton Michael W Schwartz jarrad M Scarlett Department of Pediatric Gastroenterology and Hepatology Seattle Children’s HospitalSeattleWA 98105United States 不详 Department of Medicinal Chemistry University of WashingtonSeattleWA 98195United States Department of Laboratory Medicine and Pathology Seattle Children's HospitalSeattleWA 98105United States

BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier *** To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced *** Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range *** weeks later,dextran sodium sulfate was given to induce *** select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis *** included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier *** In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease *** was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese *** of these effects of diabetes in diet-induced obese mice was ameliorated by restoring *** In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of ***-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis *** findings suggest that effective diabetes management may decrease the clinical severity of IBD.

关键词： Inflammatory bowel disease Type 2 diabetes Obesity Intestinal barrier Hyperglycemia Colitis in mice Tight junction proteins

Prevalence of Gender-Based Violence among Sex Workers in Bangui, Central African Republic (CAR)

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Witten's D_4 Integrable Hierarchies Conjecture

Advances in Sexual Medicine（性医学进展） 2024年第2期 13页

作者： D.Mossoro-Kpinde Hermione S.C.Diemer Henri R.Tende Nzengou Richard S.Siki francis j.D.D.Tekpa Bertrand

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 175-192页

作者： Huijun FAN Amanda francis Tyler jARVIS Evan MERRELL Yongbin RUAN School of Mathematical Sciences Peking University Department of Mathematics Brigham Young University Department of Mathematics University of Michigan Ann Arbor the Yangtz Center of Mathematics at Sichuan University

The authors prove that the total descendant potential functions of the theory of Fan-jarvis-Ruan-Witten for D4 with symmetry group j and for D4T with symmetry group Gmax, respectively, are both tau-functions of the D4 Kac-Wakimoto/Drinfeld-Sokolov hierarchy. This completes the proof, begun in the article by Fan-jarvis-Ruan（2013）, of the Witten Integrable Hierarchies Conjecture for all simple（ADE） singularities.

关键词： Quantum cohomology Frobenius manifolds Singularity theory Integrable hierarchies

Characterization of tungiasis infection and morbidity using thermography in Kenya revealed higher disease burden during COVID-19 school closures

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Infectious Diseases of Poverty 2023年第2期12卷 120-121页

作者： Lynne Elson Abneel K.Matharu Naomi Riithi Paul Ouma francis Mutebi Hermann Feldmeier jürgen Krücken Ulrike Fillinger KEMRI-Wellcome Trust Research Programme Kilifi Kenya Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK International Centre of Insect Physiology and Ecology Human Health Theme Nairobi Kenya College of Veterinary Medicine Animal Resources and Biosecurity Makerere University Kampala Uganda Institute of Microbiology Infectious Diseases and Immunology Charité University Medicine Berlin Germany Institute for Parasitology and Tropical Veterinary Medicine Freie Universität Berlin Berlin Germany

Background Tungiasis is a neglected tropical skin disease caused by the sand flea Tunga *** fleas penetrate the skin,particularly at the feet,and cause severe *** study aimed to characterize disease burden in two highly affected regions in Kenya,to test the use of thermography to detect tungiasis-associated inflammation and to create a new two-level classification of disease severity suitable for mapping,targeting,and monitoring *** From February 2020 to April 2021,3532 pupils age 8–14 years were quasi-randomly selected in 35 public primary schools and examined for tungiasis and associated *** the infected pupils,266 were quasi-randomly selected and their households visited,where an additional 1138 family members were *** was assessed using infra-red thermography.A Clinical score was created combining the number of locations on the feet with acute and chronic symptoms and infra-red *** The overall prevalence of tungiasis among all the school pupils who were randomly selected during survey rounds 1 and 3 was 9.3%[95%confidence interval(CI):8.4–10.3].Based on mixed effects logistic models,the odds of infection with tungiasis among school pupils was three times higher in Kwale(coastal Kenya)than in Siaya[western Kenya;adjusted odds ratio(aOR)=0.36,95%CI:0.18–0.74];three times higher in males than in females(aOR=3.0,95%CI:2.32–3.91)and three times lower among pupils sleeping in a house with a concrete floor(aOR=0.32,95%CI:0.24–0.44).The odds of finding an infected person among the household population during surveys before the COVID-19 pandemic was a third(aOR=0.32,95%CI:0.19–0.53)of that when schools were closed due to COVID-19 restrictions and approximately half(aOR=0.44,95%CI:0.29–0.68)in surveys done after school re-opening(round 3).Infection intensity was positively correlated with inflammation as measured by thermography(Spearman’s rho=0.68,P<0.001)and with the clinical score(rho=0

关键词： Tungiasis Neglected tropical diseases Thermography Morbidity Child COVID-19 Kenya

16.3%Efficiency binary all-polymer solar cells enabled by a novel polymer acceptor with an asymmetrical selenophene-fused backbone

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Science China Chemistry 2022年第2期65卷 309-317页

作者： Huiting Fu Qunping Fan Wei Gao jiyeon Oh Yuxiang Li francis Lin Feng Qi Changduk Yang Tobin j.Marks Alex K.-Y.jen Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong KongChina Department of Chemistry City University of Hong KongKowloon 999077Hong KongChina Department of Energy Engineering School of Energy and Chemical EngineeringPerovtronics Research CenterLow Dimensional Carbon Materials CenterUlsan National Institute of Science and Technology(UNIST)50 UNIST-gilUlju-gunUlsan 44919Republic of Korea Department of Materials Science and Engineering University of WashingtonSeattleWashington 98195-2120USA Department of Chemistry and the Materials Research Center Northwestern UniversityEvanstonIL60208USA Institute for Advanced Studies City University of Hong KongKowloon 999077Hong KongChina

Despite the significant progress made recently in all-polymer solar cells(all-PSCs),it is still quite challenging to achieve high open-circuit voltage(V_(oc))and short-circuit current density(j_(sc))simultaneously in order to further improve their *** recent strategy of using selenophene to replace thiophene on the Y6 based polymer acceptors has resulted in significantly improved j_(sc)s of the resulting ***,such modifications have also depressed V_(oc),which compromises the overall performance of the ***,we present the design and synthesis of a novel polymer acceptor,PYT-1S1Se,created by inserting an asymmetrical selenophene-fused framework to precisely manipulate optical absorption and electronic *** with the selenium-free analog,PYT-2S,and symmetrical selenium-fused analog,PYT-2Se,the PYT-1S1Se derived all-PSCs not only deliver optimized j_(sc)(24.1 mA cm^(−2))and V_(oc)(0.926 V)metrics,but also exhibit a relatively low energy loss of 0.502 ***,these devices obtain a record-high power conversion efficiency(PCE)of 16.3%in binary *** work demonstrates an effective molecular design strategy for balancing the trade-off between V_(oc) and j_(sc) to achieve highefficiency all-PSCs.

关键词： all-polymer solar cells polymer acceptors asymmetrical selenophene-fused backbone power conversion efficiencies stability