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Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer:A meta-analysis and systematic review

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Asian Journal of Urology 2024年第2期11卷 191-207页

作者： Stefano Salciccia marco Frisenda Giulio Bevilacqua Pietro Viscuso Paolo Casale Ettore de Berardinis giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati francesco del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci department of Urology Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly department of Urology Humanitas20089 RozzanoMIItaly

Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic ***: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect ***: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.

关键词： Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyteratio Meta-analysis Radical prostatectomy Metastatic

The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti francesco Montorsi Felix K.H.Chun Shahrokh F.Shariat Alessandro Antonelli giovanni Guano Guglielmo Mantica marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada department of Urology IRCCS Policlinico San MartinoGenovaItaly department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly department of Urology University Hospital FrankfurtFrankfurt am MainGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria department of Urology Weill Cornell Medical CollegeNew YorkNYUSA department of Urology University of Texas SouthwesternDallasTXUSA department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico de Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria de Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda giovanni Bartolucci marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso francesco Pesaresi francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela de Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti giovanni Camardese Daniela Chieffo Antonio Gasbarrini giovanni Scambia Gabriele Sani department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety depression

designs andmethodologies to recreate in vitro human gutmicrobiota models

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Bio-design and Manufacturing 2023年第3期6卷 298-318页

作者： francesco Biagini Costanza Daddi marco Calvigioni Carmelo de Maria Yu Shrike Zhang Emilia Ghelardi giovanni Vozzi Research Center(E.Piaggio) University of PisaPisaItaly department of Information Engineering University of PisaPisaItaly department of Translational Research and New Technologies in Medicine and Surgery University of PisaPisaItaly Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMAUSA

The human gut microbiota is widely considered to be a metabolic organ hidden within our bodies,playing a crucial role in the host’s *** factors affect its composition,so a wide variety of microbes residing in the gut are present in the world *** excessive imbalances in microbial composition are often associated with human disorders and pathologies,and new investigative strategies to gain insight into these pathologies and define pharmaceutical therapies for their treatment are *** vitro models of the human gut microbiota are commonly used to study microbial fermentation patterns,community composition,and host-microbe *** and microfluidic devices have been designed to culture microorganisms from the human gut microbiota in a dynamic environment in the presence or absence of eukaryotic cells to interact *** this review,we will describe the overall elements required to create a functioning,reproducible,and accurate in vitro culture of the human gut *** addition,we will analyze some of the devices currently used to study fermentation processes and relationships between the human gut microbiota and host eukaryotic cells.

关键词： Gut microbiota In vitro models Bioreactors Host-microbiome Fermentation

Increased risk of postsurgical macular edema in high stage idiopathic epiretinal membranes

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Eye and Vision 2021年第1期8卷 286-294页

作者： Lorenzo Iuliano Gloria Cisa di Gresy giovanni Fogliato Eleonora Corbelli francesco Bandello marco Codenotti department of Ophthalmology Vita-Salute UniversitySan Raffaele Scientific InstituteVia Olgettina 6020132 MilanItaly

Purpose:To assess the rate of occurrence and the risk factors of postsurgical macular edema(PSME)in eyes with idiopathic epiretinal membrane(iERM)or full-thickness macular hole(FTMH).Methods:Retrospective longitudinal analysis of all subjects scheduled for vitrectomy with or without combined cataract surgery over a 6-month *** medical charts and imaging data were analyzed preoperatively and at 1,3 and 6 months after ***:From 101 patients diagnosed with iERM or FTMH,71 patients were eligible for the ***-nine eyes with iERM(69.0%)and 22 eyes with FTMH(31.0%)underwent vitrectomy either isolated(31.0%)or combined with cataract extraction(69.0%).The overall rate of PSME was 26.7%,without differences between the two groups(P=0.9479).Combined cataract extraction did not affect the overall occurrence of PSME rate in both groups(P=0.9255 in FTMH and P=0.8658 in iERM).If grouped by stage,eyes with stage 4 iERM though disclosed an increased rate of PSME(57.1%)compared to lower(1 to 3)stages(14.3%,P=0.0021),particularly when combined with cataract surgery(71.4%vs.15.4%in stages≤3,P=0.0021).The PSME odds ratio for a stage 4 iERM is 8(95%CI:1.933-33.1;P=0.0041)compared to stages 3 and ***:PSME remains a clinically relevant and frequent event after surgery for iERM and *** with stage 4 iERM have an 8-fold higher likelihood of developing PSME in a 6-month postsurgical period compared to iERM in 1-3 stages,especially when combined with cataract extraction.

关键词： Epiretinal membrane Macular edema Macular hole Vitrectomy Postsurgical macular edema

Photocatalytic activity of Eu-doped ZnO prepared by supercritical antisolvent precipitation route:When defects become virtues

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Journal of Materials Science & Technology 2022年第17期112卷 49-58页

作者： Olga Sacco Paola Franco Iolanda de marco Vincenzo Vaiano Emanuela Callone Riccardo Ceccato francesco Parrino department of Chemistry and Biology“A.Zambelli” University of Salernovia Giovanni Paolo II13284084 Fisciano SalernoItaly department of Industrial Engineering Univerisity of SalernoVia Giovanni Paolo II 13284084 Fisciano SalernoItaly department of Industrial Engineering University of TrentoVia Sommarive 930123 TrentoItaly

The aim of this work is to determine the structural and optical properties of Eu-doped ZnO powders prepared by supercritical antisolvent precipitation route(SAS)and to correlate the physico-chemical features with the photocatalytic activity under UV *** and EPR spectroscopy highlight the introduction of novel defects(mainly singly and doubly ionized oxygen vacancies,and oxygen interstitials)on the Eu-doped ZnO samples,which confer higher hydrophilicity to the doped samples with respect to bare ZnO,as evidenced by FT-IR ***,photoluminescence spectra show that the presence of Eu^(3+) totally quenches the visible light emission typical of bare ZnO,which mainly results from the recombination of photogenerated holes at defective *** prepared samples were tested both for the photocatalytic degradation of crystal violet dye(CV)and for the partial oxidation of ferulic acid under UV *** photocatalytic activity results evidence of a higher ability of Eu-doped photocatalysts to degrade CV and ferulic acid,while higher selectivity values towards vanillin are obtained in the presence of bare *** higher activity of Eu-doped ZnO photocatalysts is linked to the stabilization of photogenerated holes and to their higher hydrophilicity,both brought by the generation of defective sites induced by the presence of Eu^(3+) ions within the ZnO lattice.

关键词： Europium doped ZnO Supercritical antisolvent precipitation Crystal violet Vanillin Photocatalysis UV light defective sites

Surgical treatment of locally advanced anal cancer after male-to-female sex reassignment surgery

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World Journal of Gastroenterology 2009年第23期15卷 2918-2919页

作者： marco Caricato Fabio Ausania giovanni francesco Marangi Ilaria Cipollone Gerardo Flammia Paolo Persichetti Lucio Trodella Roberto Coppola department of General Surgery Campus Bio Medico University of Rome Rome 00139 Italy Plastic and Reconstructive Surgery Campus Bio Medico University of Rome Rome 00139 Italy Radiation Oncology Campus Bio Medico University of Rome Rome 00139 Italy

We present a case of a transsexual patient who underwent a partial pelvectomy and genital reconstruction for anal cancer after chemoradiation. This is the first case in literature reporting on the occurrence of anal cancer after male-to-female sex reassignment surgery. We describe the surgical approach presenting our technique to avoid postoperative complications and preserve the sexual reassignment.

关键词： Sex reassignment Pelvic surgery Analcancer

Role of laparoscopic and robotic liver resection compared to open surgery in elderly hepatocellular carcinoma patients: a systematic review and meta-analysis

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Hepatoma Research 2020年第6期6卷 77-91页

作者： Alberto Brolese Marta Rigoni Alessandro Vitale giovanni de Pretis Ivo Avancini CeciliaPravadelli Michela Frisinghelli Umberto Rozzanigo Giacomo Luppi francesco Dionisi Stefano Marcucci giovanni Viel Paolo Beltempo Cristina Prezzi marco Frisini marco Brolese Giandomenico Nollo francesco A.Ciarleglio department of General Surgery&HPB Unit(Chief:Alberto Brolese MD)Azienda Provinciale per i Servizi Sanitari(APSS)Santa Chiara HospitalTrento 38122Italy IRCS-Innovation and Clinical Health Research-Bruno Kessler Foundation(FBK) Trento 38123Italy department of Surgical Oncological&Gastroenterological SciencesPadua University HospitalPadua 35128Italy department of Hepatology&Gastroenterology APSSTrento 38122Italy department of Oncology Azienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy department of Radiology Azienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy Proton therapy Unit Azienda Provinciale per i Servizi Sanitari(APSS)Trento 38122Italy department of Industrial Engineering BIOtech LabUniversity of TrentoTrento 38122Italy School of Medicine Padua UniversityPadua 35128Italy

Aim:This study aimed to compare mini-invasive liver resection(MILR)(laparoscopic/robotic approach)and open liver resection(OLR)for hepatocellular carcinoma(HCC)in elderly patients with regard to clinical and oncological outcomes through a comprehensive systematic ***:The MEDLINE and Cochrane Library electronic databases were systematically searched from 2009 to december 2019 to identify relevant English written studies comparing MILR and *** main endpoints were Child-Pugh score,serum total bilirubin level,comorbidity,presence/absence of cirrhosis,minor/major resection,challenge segment approach,operative time,estimated intraoperative blood loss,liver failure rate,morbidity according to the Clavien-Dindo classification,length of hospital stay(LOS),postoperative mortality,number of lesions,tumor size,readmission rate,recurrence rate and survival at 1,3 and 5 years after ***-analyses provided pooled relative risks and mean differences for these ***-off for"elderly age"was set at 65 years ***:Eight studies that evaluated 3051 patients who underwent liver resection for HCC,with 950 undergoing MILR and 2101 OLR,were included after the screening *** loss,morbidity,and LOS showed statistical significance in favor of *** particular,with respect to OLR,MILR decreased on average blood loss by 161.43 mL(95%CI:250.24-72.61),risk of morbidity by 42%(Pderline liver *** may be considered an important treatment o

关键词： Hepatocellular carcinoma HCC mini-invasive liver resection laparoscopic liver surgery robotic liver surgery open liver surgery meta-analysis

Drug-induced liver injury due to “natural products” used for weight loss:A case report

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World Journal of Gastroenterology 2009年第19期15卷 2414-2417页

作者： giovanni Tarantino Martina Gilda Pezzullo Matteo Nicola Dario di Minno francesco Milone Luigi Sossio Pezzullo marco Milone Domenico Capone department of Clinical & Experimental Medicine Federico II University Medical SchoolVia S.Pansini5 80131 NaplesItaly department of General Surgery Federico II University Medical School5 80131 NaplesItaly department of Neuroscience Section of Clinical PharmacologyFederico II University Medical School5 80131 NaplesItaly department of General Surgery ASL BN1 of Benevento5 80131 NaplesItaly

Taking herbal-extracts to lose weight is an underestimated health ***,these products contain active agents that can cause acute liver *** this case report,a 22-year-old female patient,who presented with a feature of cholestatic syndrome,was so sure that the "natural products" were not dangerous that she did not inform her physicians that she had taken them,making their task that much more *** presentation mimicked acute cholecystitis and the patient underwent a *** was without any consequences and complications,although it did not completely cure the *** later admitted to having taken herbal remedies and this led to the correct diagnosis of phytotherapy-related hepatotoxicity and a successful therapeutic *** true incidence of phytotherapy-related hepatotoxicity and its pathogenic mechanisms are largely *** is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies.

关键词： Drug-induced liver injury Obesity Herbalremedies Cholecystitis