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Appropriate solid waste management system in Quelimane (Mozambique):study and design of a small-scale center for plastic sorting with wastewater treatment

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Waste Disposal and Sustainable Energy 2022年第1期4卷 49-62页

作者： francesca villa Giovanni Vinti Mentore Vaccari Department of Civil and Environmental Engineering(DICA) Politecnico di MilanoVia Golgi 3920133 MilanItaly Laboratory Centre on Appropriate Technologies for Environmental Management in Resource-Limited Countries(CeTAmb LAB) University of BresciaVia BranzeBresciaItaly

Appropriate solid waste management(SWM)strategies are necessary to avoid severe environmental and sanitary impacts,especially in low-income *** strategies are most likely to succeed whether implementing actors are supported by scientific *** this paper,the results of a collaboration between local authorities and researchers are presented and discussed that are the assessment of waste generation in the city of Quelimane(Mozambique),integrating existing and field-collected data and the design of a small-scale center for plastic sorting to complement the SWM system of the *** center is expected to receive about 0.3-0.4 t/day of plastic waste(5%-7%of the overall amount of plastic waste daily produced in Quelimane).As long-term sustainability represents a typical issue,simplicity of operation was a leading principle in the design of the center;moreover,the design included a treatment plant(WWTP)for generated wastewater,whose management is usually neglected in such *** others,natural wastewater treatment(constructed wetlands)has been chosen for its ***,the so-conceived WWTP appears as a novelty in the scientific literature associated with small-scale plastic sorting *** system is designed to treat an average flow of 6 m3/day and consisted of a septic tank followed by a subsurface flow constructed ***,the COD(chemical oxygen demand)and TSS(total suspended solids)removal higher than 80%and 90%were estimated,*** on this work,both the center and the WWTP were successfully realized,which are waiting to become *** the authors’opinion,the implemented procedure could become a reference for broader investigations and surveys.

关键词： Low-income countries Wastewater treatment Plastic recycling Informal sector Waste collection

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Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino francesca Gargano Serena Boccella Carmela Belardo Andrea Maria Morace francesca Guida Sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

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Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

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Oncology research 2025年第1期33卷 45-55页

作者： Enrico Caliman Sara Fancelli Federico Scolari Adriano Pasqui Clara Manneschi Daniele Lavacchi francesca Mazzoni francesca Gensini Valeria Pasini Camilla Eva Comin Luca Voltolini Serena Pillozzi Lorenzo Antonuzzo Clinical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Medicine University of Florence Florence 50134 Italy. Department of Health Sciences University of Florence Florence 50134 Italy. Medical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Biomedical Sciences "Mario Serio" University of Florence Florence 50134 Italy. Section of Anatomic Pathology Department of Health Sciences University of Florence Florence 50139 Italy. Section of Surgery Histopathology and Molecular Pathology University of Florence Florence 50139 Italy. Thoracic Surgery Unit Careggi University Hospital Florence 50134 Italy.

Background:Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients' survival.Materials and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes-namely , , and -were performed on patient tumor samples.Results:Overall, elevated expression of genes was observed in SCLC patients compared to healthy controls. Patients with low and expression levels exhibited a better median progression-free survival (mPFS = 7.1 . 4.9 months, = 0.39 for and mPFS = 6.9 . 4.8 months, = 0.093 for ) and overall survival (mOS = 8.7 . 6.0 months, = 0.4 for and mOS = 7.2 . 6.2 months, = 0.13 for ). Genotyping analysis of five SNPs of genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the rs11615 SNP ( = 0.24 for PFS and = 0.14 for OS) and of the rs13181 and rs1799793 SNPs ( = 0.43 and = 0.26 for PFS and = 0.21 and = 0.16 for OS, respectively) compared to patients with homozygous mutant genotypes.Conclusions:The comprehensive analysis of gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： ERCC genes Nucleotide excision repair (NER) pathway Platinum-chemotherapy (CT) Single nucleotide polymorphisms (SNPs) Small cell lung cancer (SCLC)

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Obese zebrafish: A small fish for a major human health condition

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Animal Models and Experimental Medicine 2018年第4期1卷 255-265页

作者： francesca Faillaci Fabiola Milosa Rosina Maria Critelli Elena Turola Filippo Schepis Erica villa Department of Internal Medicine Gastroenterology Unit University of Modena and Reggio Emilia Women in Hepatology Group National Institute of Gastroenterology "S.de Bellis" Research Hospital Department of Internal Medicine Endocrinology UnitAOU of Parma

Obesity is becoming a silent worldwide epidemic, with a steady increase in both adults and children. To date, even though several drugs have been licensed for long-term obesity treatment, none of them are yet used in routine clinical practice. So far the only successful intervention has been behavioral therapy. A suitable and economic experimental model mimicking the human condition would therefore be extremely useful to evaluate preventive measures and novel treatments. Zebrafish are emerging as an important model system to study obesity and related metabolic disease. Remarkable similarities have been reported in lipid metabolism and the adipogenic pathway between zebrafish and mammals. Moreover, the zebrafish possesses a number of features—the relative inexpensiveness of animal husbandry, its optical transparency and the ability to produce a large number of offspring at low cost—that make it ideal for large-scale screening and for testing drugs and intervention. In this review, we summarize recent progress in using zebrafish as a model system to study obesity and obesity-related metabolic disorders. We describe several zebrafish models(in both larvae and adult animals) that develop obesity and non-alcoholic fatty liver disease(NAFLD) using different approaches, including gene manipulation, diet manipulation and modification of microbiota composition. For these models, we have outlined the specific aspects related to obesity and its development and we have summarized their advantages and limitations.

关键词： inflammation metabolic diseases NAFLD obesity zebrafish

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On the Regularity of Shear Thickening Viscous Fluids

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Chinese Annals of Mathematics,Series B 2009年第3期30卷 273-280页

作者： francesca CRISPO Dipartimento di Matematica Applicata "U.Dini" Università di PisaVia Buonarroti 1/c56127 PisaItaly.

The aim of this note is to improve the regularity results obtained by H. Beirao da Veiga in 2008 for a class of p-fluid flows in a cubic domain. The key idea is exploiting the better regularity of solutions in the tan... 详细信息

关键词： Non-Newtonian fluids Shear dependent viscosity Boundary regularity

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Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)

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Cellular & Molecular Immunology 2020年第1期17卷 95-107页

作者： Michela Comi Daniele Avancini francesca Santoni de Sio Matteo villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo Silvia Gregori San Raffaele Telethon Institute for Gene Therapy(SR-TIGET) San Raffaele Scientific Institute(IRCCS)MilanItaly PhD Program in Translational and Molecular Medicine(DIMET) University of Milan-BicoccaMilanItaly Division of Stem Cell Transplantation and Regenerative Medicine Department of PediatricsISCBRMStanford School of MedicineStanfordCAUSA CRS4 Technology Park PolarisPulaItaly

Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting ***-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)*** far,the absence of markers that uniquely identify DC-10 has limited in vivo *** in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for *** coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral ***14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of ***,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 ***,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic *** results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating *** findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings.

关键词： Dendritic cells IL-10 T regulatory type 1(Tr1)cells Tolerance

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Unexpected challenging case of coronary sinus lead extraction

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World Journal of Clinical Cases 2017年第2期5卷 46-49页

作者： Luca Bontempi Donatella Tempio Raffaella De Vito Manuel Cerini francesca Salghetti Niccolò Dasseni Clara villa Abdallah Raweh Lorenza Inama francesca Vassanelli Mario Luzi Antonio Curnis University of Brescia Spedali Civili Hospital University of Catania Ferrarotto Hospital University of Siena Santa Maria della Scala Hospital Cardiac Surgery L.U.de.S. University Hospital Riuniti

An 84-year-old woman implanted with cardiac resynchronization therapy defibrillator underwent transvenous lead extraction 4 mo after the implant due to pocket infection. Atrial and right ventricular leads were easily extracted, while the attempt to remove the coronary sinus(CS) lead was unsuccessful. A few weeks later a new extraction procedure was performed in our center. A stepwise approach was used. Firstly, manual traction was unsuccessfully attempted, even with proper-sized locking stylet. Secondly, mechanical dilatation was used with a single inner sheath placed close to the CS ostium. Finally, a modified sub-selector sheath was successfully advanced over the electrode until it was free of the binding tissue. The postextraction lead examination showed an unexpected fibrosis around the tip. No complications occurred during the postoperative course. Fibrous adhesions could be found in CS leads recently implanted requiring nonstandard techniques for its transvenous extraction.

关键词： Cardiac resynchronization therapy Coronary sinus lead Transvenous lead extraction Cardiac pacing Fibrosis

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Investigation of the porous drag and permeability at the porous-fluid interface: Influence of the filtering parameters on Darcy closure

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Particuology 2023年第7期78卷 122-135页

作者： Wojciech Sadowski francesca di Mare Chair of Thermal Turbomachines and Aeroengines Department of Mechanical EngineeringRuhr University BochumUniversitatsstr.15044801Germany

The porous-fluid interface encompasses a region bridging the flow inside a porous medium and a free-flowing *** the context of volume-averaged simulations,it can be described by a set of gradually changing parameters defining the porous medium,mainly porosity and *** this paper,both the permeability and the porous-induced drag force are evaluated a-priori,by explicitly filtering a set of Particle-Resolved Simulations(PRS)of the flow in the channel partially occupied by the porous *** porous matrices are considered and the influence of the geometry and filtering parameters on the macroscopic quantities is ***,the focus is placed on the requirements for the kernel type and size to perform filtering accurately,and their impact on the distribution of permeability at the *** performance of the typically used models for the permeability is compared to the explicitly filtered ***,a new model for permeability and the drag force is introduced,taking into account the information about the fltering size and non-uniformity of the velocity *** model greatly improves the prediction of velocity at the porous-fluid interface and serves as a proof of concept that a successful porous drag model should strive to include information about both parameters.

关键词： Porous-fluid interface Explicit filtering Permeability Porous drag

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Simulation of unconventional well tests with the finite volume method

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Petroleum Science 2012年第3期9卷 317-329页

作者： CANCELLIERE Michel VERGA francesca Politecnico di Torino DITAGTorino (TO) 10129 Italy

The finite volume method has been successfully applied in several engineering fields and has shown outstanding performance in fluid dynamics simulation. In this paper, the general framework for the simulation ofnear-wellbore systems using the finite volume method is described. The mathematical model and the numerical model developed by the authors are presented and discussed. A radial geometry in the vertical plane was implemented so as to thoroughly describe near-wellbore phenomena. The model was then used to simulate injection tests in an oil reservoir through a horizontal well and proved very powerful to correctly reproduce the transient pressure behavior. The reason for this is the robustness of the method, which is independent of the gridding options because the discretization is performed in the physical space. The model is able to describe the phenomena taking place in the reservoir even in complex situations, i.e. in the presence of heterogeneities and permeability barriers, demonstrating the flexibility of the finite volume method when simulating non-conventional tests. The results are presented in comparison with those obtained with the finite difference numerical approach and with analytical methods, if possible.

关键词： Finite volume method numerical methods horizontal well modeling injection testing gridding

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