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Plastic ingestion and associated additives in Faroe Islands chicks of the Northern Fulmar Fulmarus glacialis

Water Biology and Security 2022年第4期1卷 68-76页

作者： france collard Simon Leconte Johannis Danielsen Claudia Halsband Dorte Herzke Mikael Harju Felix Tulatz Geir W.Gabrielsen Arnaud Tarroux Norwegian Polar Institute Fram Centre for Climate and the EnvironmentFram CentreN-9296TromsøNorway Norwegian Institute for Nature Research Fram Centre for Climate and the EnvironmentFram CentreN-9296TromsøNorway Faroe Marine Research Institute 100TorshavnFaroe Islands Akvaplan-niva Fram Centre for Climate and the EnvironmentFram CentreN-9296TromsøNorway The Norwegian Institute for Air Research Fram Centre for Climate and the EnvironmentN-9296TromsøNorway

Northern Fulmars(Fulmarus glacialis)are a pelagic seabird species distributed at northern and polar *** are often used as an indicator of plastic pollution in the North Sea region,but data are lacking from higher latitudes,especially when it comes to ***,we investigated amounts of ingested plastic and their characteristics in fulmar chicks from the Faroe *** particles(≥1 mm)in chicks of two age classes were searched using a digestion method with *** addition,to evaluate if additive tissue burden reflects plastic ingestion,we measured liver tissue concentrations of two pollutant classes associated with plastic materials:polybrominated diphenyl ethers(PBDEs)and several dechloranes,using gas chromatography with high-resolution mass *** most common shape was hard fragment(81%)and the most common polymer was polyethylene(73%).Plastic contamination did not differ between either age class,and we found no correlation between neither the amount and mass of plastic particles and the concentration of *** comparison with previous studies on adult fulmars,we do not recommend using chicks for biomonitoring adults because chicks seem to ingest more plastics than adults.

关键词： Plastic pollution PBDE Dechlorane Arctic Early life stage Monitoring Seabird

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HIV-induced membraneless organelles orchestrate post-nuclear entry steps

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Journal of Molecular Cell Biology 2022年第11期14卷 9-23页

作者： Viviana Scoca Renaud Morin Maxence collard Jean-Yves Tinevez francesca Di Nunzio Advanced Molecular Virology Unit Department of VirologyInstitut PasteurUniversitéParis Cité75015 ParisFrance Imactiv-3D 1 Place Pierre Potier31106 ToulouseFrance Image Analysis Hub/C2RT Institut PasteurUniversitéParis Cité75015 ParisFrance

HIV integration occurs in chromatin sites that favor the release of high levels of viral progeny;alternatively, the virus is alsoable to discreetly coexist with the host. The viral infection perturbs the cellular environment inducing the remodelling of thenuclear landscape. Indeed, HIV-1 triggers the nuclear clustering of the host factor CPSF6, but the underlying mechanism ispoorly understood. Our data indicate that HIV usurps a recently discovered biological phenomenon, called liquid–liquid phaseseparation, to hĳack the host cell. We observed CPSF6 clusters as part of HIV-induced membraneless organelles (HIV-1 MLOs) inmacrophages, one of the main HIV target cell types. We describe that HIV-1 MLOs follow phase-separation rules and representfunctional biomolecular condensates. We highlight HIV-1 MLOs as hubs of nuclear reverse transcription, while the double-strandedviral DNA, once formed, rapidly migrates outside these structures. Transcription-competent proviruses localize outside but nearHIV-1 MLOs in LEDGF-abundant regions, known to be active chromatin sites. Therefore, HIV-1 MLOs orchestrate viral events priorto the integration step and create a favorable environment for the viral replication. This study uncovers single functional host–viralcomplexes in their nuclear landscape, which is markedly restructured by HIV-1.

关键词： HIV nuclear condensates nuclear remodelling phase separation reverse transcription

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High-Risk Congenital Coronary Abnormalities in Patients with Bicuspid Aortic Valve

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Congenital Heart Disease 2021年第2期16卷 141-146页

作者： Félix collard Dimitrios Buklas Pascale Maragnes Fabien Labombarda Department of Cardiology CHU de CaenCaen14000France Department of Heart Surgery CHU de CaenCaen14000France

Objective:Abnormal coronary artery origin(ACAO)from the opposite sinus with inter-arterial course of the ectopic proximal vessel is associated with the greatest potential for clinical manifestations,specifically sudden *** remain limited regarding the association between bicuspid aortic valve(BAV)and this potentially dangerous coronary variant reported in up to 0.6%in the general *** investigated the frequency of this high-risk ACAO with inter-arterial course in our surgical series of BAV *** and Results:We conducted a retrospective study to identify BAV patients with ACAO and inter-arterial course who underwent elective aortic valve/root surgery between 2010 and 2019 in our tertiary center.A total of 279 consecutive patients with BAV were *** these,four patients(1.4%)had ACAO with inter-arterial *** patients had abnormal right coronary artery arising from the theoretical opposite coronary sinus with intramural *** fourth patient presented an abnormal left coronary artery from a single coronary artery arising from the theoretical right coronary sinus with a long inter-arterial ***:Our results from a single-center experience support high-risk ACAOS may be more frequently diagnosed in BAV patients,especially in surgical series,justifying a careful preoperative assessment.

关键词： Congenital heart disease coronary artery bicuspid aortic valve

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A REMARK ON FORMAL MODELS FOR NONLINEARLY ELASTIC MEMBRANE SHELLS

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Chinese Annals of Mathematics,Series B 2001年第3期22卷 307-324页

作者： C. collard Laboratoire d’Analyse Numerique, Tour n°55, Universite Pierre et Marie Curie, 4, place Jussieu, 75005 Paris, france. Laboratoire de Mathematiques Appliquees au Calcul Scientifique, Universite de Valenciennes et du Hainaut-Cambresis, Le Mont H Labiratoire d'Analyse Numérique Tour n°55 Université Pierre et Marie Curie 4 place Jussieu 75005 Paris France Laboratoire de Mathématiques Appliquées au Calcul Scientifique Université de Valenciennes et du Hainaut-Cambresis Le Mont Houy - B.P. 311 - F 59304 Valenciennes cedex France

This paper gives all the two-dimensional membrane models obtained from formal asymptotic analysis of the three-dimensional geometrically exact nonlinear model of a thin elastic shell made with a Saint Venant-Kirchhoff material. Therefore, the other models can be quoted as flexural nonlinear ones. The author also gives the formal equations solved by the associated stress tensor and points out that only one of those models leads, by linearization, to the "classical" linear limiting membrane model, whose justification has already been established by a convergence theorem.

关键词：非线性弹性壳体渐近分析收敛定理利普希茨边界

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Impact of Self-Fulfilling Prophecies on Progress and Motivation in Fosbury-Flop

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Journal of Sports Science 2016年第1期4卷 18-31页

作者： Corinne Fantoni Lou Counil Marc Testa Luc collard Department of Sports Science and Physical Education University of Paris Descartes l rue Lacretelle 75015 Paris France

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Fear versus Taste for the Apnea at the Schelling-Point Game in the Swimming Pool

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Journal of Sports Science 2015年第3期3卷 127-133页

作者： Lue collard Corinne Fantoni Alexandre Oboeuf Elise Defrasne Ait-Said Department of Sports Science and Physical Education University of Paris Descartes rue Lacretelle 75015 France Department of Ethics University Catholic of Lille rue du Port 59000 France

We studied a pure coordination game in which swimmers had to agree on the distance that they would swim underwater up a line after diving into a swimming pool. The swimmers were not able to communicate with each other. To win the game, the swimmer had to surface at exactly the same point as his partner. This pure coordination game was played by 81 swimmers, 43 of whom then put their decisions into practice in a 25-metre pool. The results revealed the presence of two Schelling points. One point (at 12.5 metres) was that predicted by theory and corresponded to half the maximum possible distance. The other Schelling point (at 25 metres) was practical in nature and reflected a taste for underwater swimming—-even though performance (in terms of the distance swum underwater) was not relevant in this game. The results show that swimmers underestimate their water competence when they are not subjected to a competitive challenge.

关键词： underwater swimming free—diving pure coordination game schelling point game theory

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Myocardial Perfusion Abnormalities in Patients with Hereditary Hypertrophic Cardiomyopathy: A Study of Three Cases and Review of the Literature

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World Journal of Cardiovascular Diseases 2023年第6期13卷 289-296页

作者： Ngardjibem Djita Ibrahima Sory Sylla Mamadou Bassirou Bah Felix collard Sana Samoura Mamadou Aliou Baldé Souleymane Diakité Ibrahima Sory Barry Alpha Koné Elhadj Yaya Baldé Mariame Béavogui Mamadou Dadhi Baldé Philippe Chevalier Department of Cardiology Alen&ccedilon Hospital Alen&ccedilon France Department of Cardiology CHU Ignace Deen Conakry Guinea Department of Cardiology Sino-Guinean Friendship Hospital Conakry Guinea Department of Cardiology CHU Lyon Lyon France

Introduction: Hypertrophic cardiomyopathy (HCM) belongs to the very heterogeneous group of cardiomyopathies. This study aimed to study myocardial perfusion abnormalities on scintigraphy and assess the risk of sudden death from ventricular arrhythmia in hereditary sarcomeric HCM. Patients and Methods: This is a retrospective and prospective descriptive study over 18 months (January 01, 2021, to July 31, 2022) on the records of patients over 18 with the diagnosis of hypertrophic sarcomeric cardiomyopathy with or without ventricular rhythm disorders and who have undergone myocardial scintigraphy. Results: Three patients were included. The average age of our patients was 66 years old. Dyspnea is the primary symptomatology found in our patients. One patient presented with syncope and unsustained ventricular tachycardia. His risk score for sudden death from ESC at five years is estimated at 6.45%, and the patient received an ICD in primary prevention. The average sudden death risk score of our patients was 3.78%. The mean LV wall thickness was 20 mm. The mean maximum left intraventricular gradient was 39 mmHg. Myocardial fibrosis was present in all our patients. Myocardial scintigraphy was normal in all cases. Conclusion: Hypertrophic cardiomyopathy is a very heterogeneous group of cardiomyopathies. The rhythmic risk is multifactorial and constitutes a significant prognostic factor.

关键词： Hypertrophic Cardiomyopathy Myocardial Scintigraphy Sudden Death Ven-tricular Arrhythmia

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Radiotherapy for gynecologic cancerin nonagenarian patients：a framework for new paradigms

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Chinese Journal of Cancer 2016年第7期35卷 382-384页

作者： Benoite Mery Sylvie Mengue Ndong Jean-Baptiste Guy Avi Assouline Alexander T.Falk Anais Valeille Jane-Chloc Trone Romain Rivoirard Pierre Auberdiac Alexis Vallard Sophie Espenel Guillaume Moriceau Olivier collard Claire Bosacki Jean-Philippe Jacquin Guy de Laroche Pierre Fournel Cyrus Chargari Nicolas Magne Department of Medical Oncology Lucien Neuwirth Cancer Institute42271 Saint Priest En Jarez France Department of Radiotherapy Lucien Neuwirth Cancer Institute42271 Saint Priest En Jarez France Department of Radiotherapy Porte De Saint Cloud Clinical Center92100 Boulogne-Billancourt France Department of Radiotherapy Claude Bernard Private Hospital81000 Albi France Department of Radiotherapy Val-De-Grace Military Hospital75230 Paris France Department of Radiation Oncology Antoine Lacassagne Center06100 Nice France

No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian *** retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gynecologic cancer(6 endometrial cancers,6 cervical cancers,4 vulvar cancers,and 3 vaginal cancers) who were treated with *** was performed mainly in a palliative setting(n = 12;63.2%),with a median dose of 45 Gy(range,6-76 Gy).Infrequent major acute or late toxicities were *** 19 patients,9(47.4%) experienced tumor progression,5(26.3%) experienced complete response,2(10.5%) experienced stable disease and/or partial *** last follow-up,12 patients(63.2%) had died;most deaths(n = 9) occurred because of the *** results suggest that radiotherapy is feasible in the treatment of nonagenarian patients with gynecologic cancer.

关键词：癌症患者妇科放疗放射治疗框架肿瘤患者子宫内膜癌肿瘤治疗

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Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling

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Microsystems & Nanoengineering 2016年第1期2卷 9-17页

作者： Grégoire Perret Thomas Lacornerie Fabio Manca Stefano Giordano Momoko Kumemura Nicolas Lafitte Laurent Jalabert Mehmet C.Tarhan Eric F.Lartigau Fabrizio Cleri Hiroyuki Fujita Dominique collard LIMMS/CNRS-IIS UMI 2820 Institute of Industrial ScienceThe University of Tokyo4-6-1 Komaba Meguro KuTokyo 153-8505Japan IEMN UMR8520CNRSAvenue PoincaréCitéScientifiqueBP 60069Villeneuve d’AscqCedex 59652France CNRS/IIS/COL/Lille 1 SMMiL-E project CNRS Délégation Nord-Pas de Calais et Picardie2 rue de CanonniersLilleCedex 59046France Centre Oscar Lambret Universitéde LilleDépartement Universitaire de RadiothérapieCentre Oscar LambretLille 59000France Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

The killing of tumor cells by ionizing radiation beams in cancer radiotherapy is currently based on a rather empirical understanding of the basic mechanisms and effectiveness of DNA damage by *** contrast,the mechanical behaviour of DNA encompassing sequence sensitivity and elastic transitions to plastic responses is much better understood.A novel approach is proposed here based on a micromechanical Silicon Nanotweezers *** instrument allows the detailed biomechanical characterization of a DNA bundle exposed to an ionizing radiation beam delivered here by a therapeutic linear particle accelerator(LINAC).The micromechanical device endures the harsh environment of radiation beams and still retains molecular-level detection *** this study,the first real-time observation of DNA damage by ionizing radiation is *** DNA bundle degradation is detected by the micromechanical device as a reduction of the bundle stiffness,and a theoretical model provides an interpretation of the *** first real-time observations pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.

关键词： biomechanical measurements DNA damage microfluidic radiotherapy real-time Silicon Nanotweezers

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