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Th17 cells and their associated cytokines in liver diseases

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Cellular & Molecular Immunology 2010年第4期7卷 250-254页

作者： fouad lafdil Andrew M Miller Sung Hwan Ki Bin Gao Section on Liver Biology Laboratory of Physiologic StudiesNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMDUSA INSERM U955Cre´teilFrance Faculte´de Me´decine Universite´Paris 12Cre´teilFrance

T helper 17(Th17)cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune *** functions of Th17 cells are mediated via the production of several cytokines including interleukin(IL)-17 and *** studies show that the frequency of IL-171 cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease,viral hepatitis and hepatocellular ***-17 receptor is expressed virtually on all types of liver cells,while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the ***-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines,while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation.

关键词： IL-17 IL-22 hepatitis alcoholic liver disease liver cancer

Immunopathobiology and therapeutic targets related to cytokines in liver diseases

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Cellular & Molecular Immunology 2021年第1期18卷 18-37页

作者： Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro fouad lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA Universite Paris-Est UMR-S955UPECF-94000 CreteilFrance Department of Medicine and Department of Surgery School of MedicineUniversity of CaliforniaSan DiegoCA 92093USA Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMAUSA INSERM U955F-94000 CreteilFrance Institut Universitaire de France(IUF) Paris F-75231 Cedex 05France

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular *** progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut *** the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family *** can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly *** cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described.

关键词： T helper ALD NAFLD Fibrosis Inflammation

Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners

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Cellular & Molecular Immunology 2021年第9期18卷 2165-2176页

作者： Yeni Ait Ahmed Yaojie Fu Robim M.Rodrigues Yong He Yukun Guan Adrien Guillot Ruixue Ren Dechun Feng Juan Hidalgo Cynthia Ju fouad lafdil Bin Gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMDUSA UniversitéParis-Est-Créteil CréteilFrance Universitat Autònoma de Barcelona BarcelonaSpain Department of Anesthesiology McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonHoustonTXUSA INSERM U955 Institut Mondor de Recherche BiomédicaleCréteilFrance Institut Universitaire de France(IUF) ParisFrance

Kupffer cells(KCs),which are liver-resident macrophages,originate from the fetal yolk sac and represent one of the largest macrophage populations in the ***,the current data on the origin of the cells that restore macrophages during liver injury and regeneration remain ***,we address the question of whether liver macrophage restoration results from circulating monocyte infiltration or local KC proliferation in regenerating livers after partial hepatectomy(PHx)and uncover the underlying *** using several strains of genetically modified mice and performing immunohistochemical analyses,we demonstrated that local KC proliferation mainly contributed to the restoration of liver macrophages after *** KC proliferation was impaired in Il6-knockout(KO)mice and restored after the administration of IL-6 protein,whereas KC proliferation was not affected in Il4-KO or Csf2-KO *** source of IL-6 was identified using hepatocyte-and myeloid-specific Il6-KO mice and the results revealed that both hepatocytes and myeloid cells contribute to IL-6 production after ***,peak KC proliferation was also impaired in myeloid-specific Il6 receptor-KO mice after PHx,suggesting that IL-6 signaling directly promotes KC *** using several inhibitors to block the IL-6 signaling pathway revealed that sirtuin 1(SIRT1)contributed to IL-6-mediated KC proliferation in *** deletion of the Sirt1 gene in myeloid cells,including KCs,impaired KC proliferation after *** conclusion,our data suggest that KC repopulation after PHx is mainly driven by local KC proliferation,which is dependent on IL-6 and SIRT1 activation in KCs.

关键词： IL-6 Sirtuin 1 Liver regeneration Kupffer cells Myeloid cells

Interleukin-17 mediates liver progenitor cell transformation into cancer stem cells through downregulation of miR-122

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Cancer Biology & Medicine 2018年第S1期15卷 14-15页

作者： Imène Gasmi CamiliaMachou AurélieRodrigues Julien Calderaro Benoit Rousseau Arthur Brouillet Christophe Rodriguez Vanessa Demontant Guillaume Gricourt Alain Luciani Jean-Michel Pawlotsky fouad lafdil Université Paris-Est-Créteil CréteilFrance INSERMU955 VirusesHepatology and CancersHopital Henri MondorCréteilFrance Institut Universitaire de France(IUF) ParisFrance

Objective:Cancer stem cells(CSCs)have been the focus of several studies because oftheir involvement in cancer initiation and *** were identified in 28%to 50%of hepatocellular carcinomas(HCCs).The origin of CSCs is still unclear,but it has been recently suggested that CSCs could originate from the transformation of liver progenitor cells(LPCs)during chronic liver inflammation.

关键词： Interleukin-17 mediates liver