Th17 cells and their associated cytokines in liver diseases

作     者：Fouad Lafdil Andrew M Miller Sung Hwan Ki Bin Gao 

作者机构：Section on Liver BiologyLaboratory of Physiologic StudiesNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMDUSA INSERMU955Cre´teilFrance Faculte´de Me´decineUniversite´Paris 12Cre´teilFrance 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2010年第7卷第4期

页      面：250-254页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the intramural program of NIAAA NIH 

主　　题：IL-17 IL-22 hepatitis alcoholic liver disease liver cancer 

摘      要：T helper 17(Th17)cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune *** functions of Th17 cells are mediated via the production of several cytokines including interleukin(IL)-17 and *** studies show that the frequency of IL-171 cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease,viral hepatitis and hepatocellular ***-17 receptor is expressed virtually on all types of liver cells,while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the ***-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines,while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation.