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Proteomic and metabolic prediction of response to therapy in gastric cancer

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World Journal of Gastroenterology 2014年第38期20卷 13648-13657页

作者： Michaela Aichler Birgit Luber florian Lordick Axel Walch Research Unit Analytical Pathology Institute of Pathology Helmholtz Zentrum MünchenInstitute of Pathology Technische Universit t MünchenUniversity Cancer Center Leipzig University of LeipzigResearch Unit Analytical Pathology Institute of Pathology Helmholtz Zentrum München German Research Centre for Environmental Health

Several new treatment options for gastric cancer have been introduced but the prognosis of patients diagnosed with gastric cancer is still poor. Disease prognosis could be improved for high-risk individuals by implementing earlier screenings. Because many patients are asymptomatic during the early stages of gastric cancer,the diagnosis is often delayed and patients present with unresectable locally advanced or metastatic disease. Cytotoxic treatment has been shown to prolong survival in general,but not all patients are responders. The application of targeted therapies and multimodal treatment has improved prognosis for those with advanced ***,these new therapeutic strategies do not uniformly benefit all *** whether patients will respond to specific therapies would be of particular value and would allow for stratifying patients for personalized treatment *** imaging by positron emission tomography was the first technique with the potential to predict the response of esophagogastric cancer to neoadjuvant *** and validating tissue-based biomarkers are ongoing *** this review,we discuss the status of several targeted therapies for gastric cancer,as well as proteomic and metabolic methods for investigating biomarkers for therapy response prediction in gastric cancer.

关键词： Gastric cancer Therapy Response prediction Positron emission tomography Matrix-assisted laser desorption-ionization

A multi-stage triaxial testing procedure for low permeable geomaterials applied to Opalinus Clay

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 137-148页

作者： Katrin M. Wild Marco Barla Giovanni Turinetti florian Amann Engineering Geology Group Geological Institute ETH Zürich Sonneggstrasse 5 Zürich 8092 Switzerland Department of Structural Building and Geotechnical Engineering Politecnico di Torino Corso Duca degli Abruzzi 24 Torino 10129 Italy Swiss Competence Center of Energy Research Supply of Electricity (SCCER-SoE) Geological Institute ETH Zürich Sonneggstrasse 5 Zürich 8092Switzerland

In many engineering applications,it is important to determine both effective rock properties and the rock behavior which are representative for the problem’s in situ *** this purpose,rock samples are usually extracted from the ground and brought to the laboratory to perform laboratory experiments such as consolidated undrained(CU)triaxial *** low permeable geomaterials such as clay shales,core extraction,handling,storage,and specimen preparation can lead to a reduction in the degree of saturation and the effective stress state in the specimen prior to testing remains *** changes in structure and the effect of capillary pressure can alter the properties of the specimen and affect the reliability of the test results.A careful testing procedure including back-saturation,consolidation and adequate shearing of the specimen,however,can overcome these *** substantial effort has been devoted during the past decades to the establishment of a testing procedure for low permeable geomaterials,no consistent protocol can be *** a special focus on CU tests on Opalinus Clay,this study gives a review of the theoretical concepts necessary for planning and validating the results during the individual testing stages(saturation,consolidation,and shearing).The discussed tests protocol is further applied to a series of specimens of Opalinus Clay to illustrate its applicability and highlight the key aspects.

关键词： Triaxial test Saturation Consolidation Undrained Opalinus Clay Clay shale

Machine learning for exploring small polaron configurational space

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npj Computational Materials 2022年第1期8卷 1183-1191页

作者： Viktor C.Birschitzky florian Ellinger Ulrike Diebold Michele Reticcioli Cesare Franchini University of Vienna Faculty of Physics and Center for Computational Materials ScienceViennaAustria University of Vienna Vienna Doctoral School in PhysicsBoltzmanngasse 51090ViennaAustria Institute of Applied Physics Technische Universität Wien1040ViennaAustria Department of Physics and Astronomy’Augusto Righi’ Alma Mater Studiorum-Universitàdi BolognaBologna40127Italy

Polaron defects are ubiquitous in materials and play an important role in many processes involving carrier mobility,charge transfer and surface *** small polarons’spatial distributions is essential to understand materials properties and ***,the required exploration of the configurational space is computationally demanding when using first principles ***,we propose a machine-learning(ML)accelerated search that determines the ground state polaronic *** ML model is trained on databases of polaron configurations generated by density functional theory(DFT)via molecular dynamics or random *** establish a mapping between configurations and their stability,we designed descriptors modelling the interactions among polarons and charged point *** used the DFT+ML protocol to explore the polaron configurational space for two surface-systems,reduced rutile TiO_(2)(110)and Nb-doped SrTiO_(3)(001).The ML-aided search proposes additional polaronic configurations and can be utilized to determine optimal polaron distributions at any charge concentration.

关键词： configuration polaron charge

In-situ preparation of robust self-lubricating composite coating from thermally sprayed ceramic template

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Journal of Advanced Ceramics 2023年第2期12卷 357-372页

作者： Zhichao WU Shuangjian LI Xiujuan FAN florian VOGEL Jie MAO Xiaohui TU Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Institute of New Materials Guangdong Academy of SciencesNational Engineering Laboratory of Modern Materials Surface Engineering TechnologyGuangzhou 510650China

The self-lubricating ceramic coatings that can control friction and wear have attracted researchers’widespread ***,the poor interfacial bonding between lubricants and ceramics and the deterioration of mechanical properties due to a tribological design limit their practical ***,a robust self-lubricating coating was fabricated by an in-situ synthesis of MoS_(2)/C within inherent defects of thermally sprayed yttria-stabilized zirconia(YSZ)*** edge-pinning by noncoherent endows hybrid coatings with excellent interfacial strength,increasing their hardness(HV)and cohesive ***,owing to the formation of a well-covered robust lubricating film at a frictional interface,a coefficient of friction(COF)can be reduced by 79.6%to 0.15,and a specific wear rate(W)drops from 1.36×10^(−3) to 6.27×10^(−7) mm^(3)·N^(−1)·m^(−1).Combining outstanding mechanical properties and tribological performance,the hybrid coating exhibits great application potential in controlling friction and ***,this strategy of introducing the target materials into the inherent defects of the raw materials to improve the relevant properties opens new avenues for the design and preparation of composite materials.

关键词： self-lubricating ceramic coatings thermal spray in-situ synthesis MoS_(2)/C friction and wear mechanical properties

Editorial for the Special Issue on Unmanned Intelligent Cluster

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Engineering 2022年第5期8卷 1-2页

作者： Jun Zhang Toshio Fukuda Defu Lin florian Holzapfel School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Flight System Dynamics Technical University of MunichGarching 85748Germany

Recent advances in networked cooperative autonomous sys-tems offer the potential to significantly improve system quality for a wide range of *** in embedded processor,sensor,communication,and networking technology in the last few decades has accelerated interest in networked cooperative autonomous systems,multirobot systems,and distributed sensor networks for applications such as manufacturing,logistics,pro-cess monitoring,enhanced situational awareness,plant safety,inspection,security,and rescue operations.

关键词： robot networks autonomous

Anisotropic Visco-Elastoplastic Modeling of Quasi-Unidirectional Flax Fiber Reinforced Epoxy Behavior:An Investigation on Low-Velocity Impact Response

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Journal of Renewable Materials 2018年第5期6卷 464-476页

作者： Marwa Abida Jamel Mars florian Gehring Alexandre Vivet Fakhreddine Dammak Normandie Univ ENSICAENUNICAENCEACNRSCIMAP14000 CaenFrance Mechanical Modeling and Manufacturing Laboratory(LA2MP) National School of Engineers of SfaxUniversity of SfaxB.P 1173-3038SfaxTunisia Laboratory of Electromechanical Systems(LASEM) National Engineering School of SfaxUniversity of SfaxB.P.1173-3038SfaxTunisia

Based on experimental test results,flax fiber reinforced polymer composites are characterized by nonlinear visco-elastoplastic *** aim of this work is to model the quasi-unidirectional flax fiber reinforced composite behavior through a three dimensional formulation with orthotropic elasticity and orthotropic plasticity using Hill *** isotropic hardening and Johnson Cook parameters are identified from unidirectional tensile tests at different strain *** adjustment of Hill’s yield criterion is developed based on yield stresses obtained in tensile tests at different *** numerical integration of the constitutive equations is implemented in a user-defined material,UMAT subroutines for the commercial finite element code *** model parameters are identified using tensile tests,the model needs to be validated by confronting it with other experimental *** is why experimental and numerical three-point bending tests are carried out in order to validate the proposed model with tests that have not served for the ***,a numerical parametric study on low velocity impact of a flax/epoxy composite circular plate is investigated.

关键词： Visco-elastoplasticity anisotropic behavior impact simulation flax fiber composites

Simulation of urban microclimate with uhiSolver:software validation using simplifed material data

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Ecological Processes 2021年第1期10卷 921-943页

作者： florian Teichmann Christina Maria Baumgartner Andras Horvath Markus Luisser Azra Korjenic Vienna University of Technology ViennaAustria. Rheologic GmbH ViennaAustria.

Background:Increasing urbanization as well as global warming requires an investigation of the infuence of diferent construction methods and ground surfaces on the urban heat island efect(UHI efect).The extent of the infuence of the urban structure,the building materials used and their surfaces on the UHI efect can be signifcantly reduced already in the planning phase using a designated OpenFOAM-based solver“uhiSolver”.Results:In the frst part of this research work,it is shown that inner building details and components can be neglected while still obtaining sufciently accurate *** this purpose,the building model was divided into two layers:a surface layer without mass,where the interaction with radiation takes place,and a component layer,which contains all relevant components and cavities of the building represented with mass-averaged material *** has become apparent that the three parameters—albedo,heat capacity and thermal resistance—which have a decisive infuence on the interaction,have diferent efects on the component temperatures and the surface *** the second part of this research work,dynamic 3D computational fuid dynamics(CFD)simulations are performed with uhiSolver for a residential block in *** the simulation results with measurement data collected on site,it is shown that the simplifed assumption of homogeneous material data for building bodies provides very good results for the validation case ***,the infuence of the greening measures in the courtyard of the residential block on the air temperature is found to be ***,it was observed that due to locally higher radiation density,lower air velocities and higher air humidity,the apparent temperature in the courtyard is sometimes perceived to be higher than in the adjacent streets,despite the lower air ***:Simplifying the modeling process of the uhiSolver software by reducing the model complexity helps to reduce

关键词： Urban heat island efect Urban microclimate CFD simulation Microclimate simulation Apparent temperature

The role of polysulfide-saturation in electrolytes for high power applications of real world Li-S pouch cells

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Nano Research 2023年第6期16卷 8313-8320页

作者： Tom Boenke Sebastian Kirchhoff florian SReuter florian Schmidt Christine Weller Susanne Dörfler Kai Schwedtmann Paul Härtel Thomas Abendroth Holger Althues Jan J.Weig Stefan Kaskel Technische Universität Dresden Chair of Inorganic Chemistry IBergstr.6601069 DresdenGermany Fraunhofer Institute for Material and Beam Technology(IWS) Winterbergstr.2801277 DresdenGermany Technische Universität Dresden Chair of Inorganic Molecular ChemistryMommsenstraße 401069 DresdenGermany

The lithium-sulfur(Li-S)technology is the most promising candidate for next-generation batteries due to its high theoretical specific energy and steady progress for applications requiring lightweight batteries such as aviation or heavy electric *** these applications,however,the rate capability of Li-S cells requires significant *** electrolyte formulations in Li-S batteries enable new pathways for cell development and adjustment of all ***,their rate capability at pouch cell level is often neither evaluated nor compared to state of the art(SOTA)LiTFSI/dimethoxyethane/dioxolane(LITFSI:lithium-bis(trifluoromethylsulfonyl)imide)***,the combination of the sparingly polysulfide(PS)solvating hexylmethylether/1,2-dimethoxyethane(HME/DME)electrolyte and highly conductive carbon nanotube Buckypaper(CNT-BP)with low porosity was evaluated in both coin and pouch cells and compared to dimethoxyethane/dioxolane reference *** advanced sulfur transfer melt infiltration was employed for cathode production with *** Li+ion coordination in the HME/DME electrolyte was investigated by nuclear magnetic resonance(NMR)and Raman ***,ionic conductivity and viscosity was investigated for the pristine electrolyte and a polysulfide-statured *** electrolytes,DME/DOL-1/1(DOL:1,3-dioxolane)and HME/DME-8/2,are then combined with CNT-BP and transferred to multi-layered pouch *** study reveals that the ionic conductivity of the electrolyte increases drastically over state of(dis)charge especially for DME/DOL electrolyte and lean electrolyte regime leading to a better rate capability for the sparingly polysulfide solvating *** evaluation in prototype cells is an important step towards bespoke adaption of Li-S batteries for practical applications.

关键词： lithium-sulfur pouch cell polysulfide solubility electrolyte characterization high power

Reflections about the holographic and nonholographic acquisition of surface topography: where are the limits?

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Light(Advanced Manufacturing) 2022年第2期3卷 48-57页

作者： Gerd Häusler florian Willomitzer University of Erlangen Nuremberg Institute of OpticsInformationand Photonics91058 ErlangenGermany Northwestern University Department of Electrical and Computer EngineeringEvanston 60208USA

Recording and(computational)processing of complex wave fields offer a vast realm of new methods for optical 3D *** discuss fundamental similarities and differences between holographic surface topography measurement and non-holographic principles,such as triangulation,classical interferometry,rough surface interferometry and slope measuring *** features are the physical origin of the ultimate uncertainty limit and how the topographic information is encoded and *** the theoretical insight,the discussion will help optical metrologists to determine if their measurement results could be improved or have already hit the ultimate limit of what physics allows.

关键词： Optical metrology Topography Physical limits Holography