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构建生态景观，营造和谐氛围——访fleming总设计师凌铿

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景观设计 2007年第F4期 34-37页

作者： fleming（图片）苗慧珠（采访）

作为从业多年并拥有丰富经验的景观设计师，请先谈谈您个人对“景观设计”的理解。我们常说的“景观设计”用英语解释是”Landscape Design”，多指人为设计的东西，有些设计很繁复又堆砌。现在我们提出了新的概念“Landscape Planning... 详细信息

作为从业多年并拥有丰富经验的景观设计师，请先谈谈您个人对“景观设计”的理解。我们常说的“景观设计”用英语解释是”Landscape Design”，多指人为设计的东西，有些设计很繁复又堆砌。现在我们提出了新的概念“Landscape Planning”即“景观规划”。按照生态结构与原则，在尊重自然的前提下，对其进行重新整合分配。

关键词：总设计师生态景观景观设计师和谐景观规划生态结构尊重自然

Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris Marcela M.M.Bilek Anyu Zhang Behnam Akhavan Simon fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

美国关于妊娠期间使用呼吸道合胞病毒疫苗预防婴儿呼吸道合胞病毒相关下呼吸道疾病的建议

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中国疫苗和免疫 2024年第3期30卷 377-382页

作者：刘斯宇(编译) 王富珍(审校) fleming-DUTRA KE JONES JM ROPER LE 传染病溯源预警与智能决策全国重点实验室中国疾病预防控制中心北京102206 中国疾病预防控制中心免疫规划中心北京100050 不详

呼吸道合胞病毒(Respiratory syncytial virus,RSV)是导致美国婴儿住院的主要原因。尼塞韦单抗已被推荐用于预防婴儿RSV相关下呼吸道感染(Lower respiratory tract infection,LRTI)。2023年8月,美国食品药品监督管理局(Food and Drug Administration,FDA)批准将单剂量RSVpreF疫苗用于妊娠32-36周孕妇,以预防<6月龄婴儿发生RSV相关LRTI。自2021年10月起,美国免疫实践咨询委员会(Advisory Committee on Immunization Practices,ACIP)RSV疫苗母婴工作组审查了RSV流行病学和RSV母婴预防产品(包括RSVpreF疫苗)在安全性、保护效果和潜在经济影响方面的证据。2023年9月22日,ACIP和疾病控制与预防中心(Centers for Disease Control and Prevention,CDC)推荐采用季节性接种方式(在美国大陆大部分地区为9月至次年1月)为妊娠32-36周孕妇接种RSVpreF疫苗,以预防<6月龄婴儿发生RSV相关LRTI。孕妇在妊娠期间接种RSVpreF疫苗或者为婴儿使用尼塞韦单抗都是预防婴儿发生RSV相关LRTI的推荐方法,但大多数婴儿不需要同时采用两种方法。所有婴儿应通过上述某种产品获得保护,以预防RSV相关LRTI。

关键词：呼吸道合胞病毒下呼吸道疾病呼吸道合胞病毒疫苗预防接种妊娠期婴儿

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一门学科应该学习多长时间？

中学生英语 2024年第25期 4-5页

作者： Grace fleming 苗淑华

How long should you study for a test? The answer to this question is different for everyone because it’s not just about how long you study—it’s also how effectively1you study. To study effectively, you should study at aproper2time.你应该为一次考试学习多长时间呢？这个问题的答案因人而异，因为它不仅关乎你学习的时间，还关乎你学习的效率。为了有效学习，你应该在适当的时间学习。

关键词：

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董事长“先生”又回来了?

商业周刊（中文版） 2024年第7期 26-28页

作者： Zachary fleming Cam Baker Andre Tartar Raeedah Wahid 晴川(译) 不详

企业在董事长称谓上一直在稳步转向性别中立语言。但而今,对多元平等包容政策的批评又卷土重来。今年2月,芯片制造商Advanced Micro Devices Inc.(简称AMD)就在批准其CEO苏姿丰奖金方案的前一天,从公司章程中去掉了董事长英文头衔中带... 详细信息

企业在董事长称谓上一直在稳步转向性别中立语言。但而今,对多元平等包容政策的批评又卷土重来。今年2月,芯片制造商Advanced Micro Devices Inc.(简称AMD)就在批准其CEO苏姿丰奖金方案的前一天,从公司章程中去掉了董事长英文头衔中带有性别指向的部分(译注:董事长的英文为chairman,其中man指男性)。该公司在一份监管文件中称,这是“技术化、现代化、明晰化且顺应潮流的一系列变化”中的一部分。

关键词：芯片制造商明晰化公司章程董事长技术化

New insights of T cells in the pathogenesis of psoriasis

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Cellular & Molecular Immunology 2012年第4期9卷 302-309页

作者： Yihua Cai Chris fleming Jun Yan Department of Medicine and Tumor I mmunobiology Program James Graham Brown Cancer Center University of Louisville Louisville KY USA Department of Microbiology and Immunology University of Louisville School of Medicine Louisville KY USA

Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils. Although the pathogenesis of psoriasis is not fully understood, there is ample evidence suggesting that the dysregulation of immune cells in the skin, particularly T cells, plays a critical role in psoriasis development. In this review, we mainly focus on the pathogenic T cells and discuss how these T cells are activated and involved in the disease pathogenesis. Newly identified ＇professional＇ IL-17-producing dermal γδ T cells and their potential role in psoriasis will also be included. Finally, we will briefly summarize the recent progress on the T cell and its related cytokine-targeted therapy for psoriasis treatment.

关键词： Psoriasis,TH1/TH17 cells Gammadelta T cells T cell-targeted theraphy

Living on the edge： Effects of body size, group density and microhabitat selection on escape behaviour of southern leopard frogs Lithobates sphenocephalus

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Current Zoology 2014年第6期60卷 712-718页

作者： Philip W. BATEMAN Patricia A. fleming Department of Environment and Agriculture Curtin University Perth Bentley WA 6845 Australial School of Veterinary and Life Sciences Murdoch University Perth Murdoch WA 6150 Australia

Models of optimal escape strategy predict that animals should move away when the costs of fleeing （metabolic and opportunity costs） are outweighed by the costs of remaining. These theoretical models predict that more vulnerable individuals should be more reactive, moving away when an approaching threat is further away. We tested whether escape behaviour （includ- ing ＇escape calling＇） ofLithobates sphenocephalus approached by a human was influenced by body size or the initial microhabi- tat that the individual was found in. Irrespective of their size, frogs in the open tended to remain immobile, enhancing their cryp- sis. Frogs in cover showed different responses according to their body size, but, contrary to our initial predictions, larger frogs showed greater responsiveness （longer flight initiation distance and distances fled） than small frogs. Small frogs tended to remain closer to water and escaped into water, while larger individuals were more likely to jump to terrestrial cover and call during escape. Density of frogs near the focal animal had no effect on escape behaviour. This study indicates a range of escape responses in this species and points to the importance of divergent escape choices for organisms which live on the edge of different environments .

关键词： Alarm call Flight initiation distance (FID) Distance fled Microhabitat selection Rana sphenocephala

Progress in creating second-order optical nonlinearity in silicate glasses and waveguides through thermal poling

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Frontiers of Optoelectronics 2010年第1期3卷 84-91页

作者： Simon fleming Honglin AN Institute of Photonics and Optical Science School of Physics University of Sydney

This paper describes progress in characterizing the distribution and localization of the second-order nonlinearity induced in thermally poled silicate glasses and optical waveguides, in particular, optical fibers. It starts by describing the basics of the poling technique,especially the most commonly used “thermal poling”technique. Then results of systematic investigation of the distribution of the second-order nonlinearity in poled glass and special fibers using second-harmonic microscopy are presented. Interesting issues such as the effectiveness of the poling technique for waveguides formed by ultrafast laser pulses are also discussed.

关键词： poling silica nonlinearity

Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids([OMIm][Br]+[HMIm][Br]+water)at different temperatures

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Chinese Journal of Chemical Engineering 2020年第1期28卷 198-207页

作者： Mohammad Barzegar-Jalali Abolghasem Jouyban fleming Martinez Hemayat Shekaari Seyyedeh Narjes Mirheydari Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy Tabriz University of Medical SciencesTabrizIran Pharmaceutical Analysis Research Center and Faculty of Pharmacy Tabriz University of Medical SciencesTabrizIran Kimia Idea Pardaz Azarbayjan(KIPA)Science-Based Company Tabriz University of Medical SciencesTabrizIran Grupo de Investigaciones Farmacéutico-Fisicoquímicas Departamento de FarmaciaFacultad de CienciasUniversidad Nacional de Colombia–Sede BogotáCra.30 No.45-03BogotáD.C.Colombia Department of Physical Chemistry Faculty of ChemistryUniversity of TabrizTabrizIran Drug Applied Research Center Tabriz University of Medical SciencesTabrizIran

Experimental mole fraction solubility of lamotrigine(LTG)in ternary aqueous mixtures of two ionic liquids(ILs),1-hexyl and 1-octyl-3-methylimidazolium bromide,[HMIm][Br]and[OMIm][Br]were reported at several temperatures T=(293.15 to 313.15)*** van’t Hoff and(Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff,e-NRTL,UNIQUAC and Wilson)models were used to correlate the solubility *** comparison of the models with temperature and solvent composition dependencies shows that the Wilson model has the minimum ARD which are relatively close to those obtained from Jouyban-Acree-van’t Hoff and E-Jouyban-Acree-van’t Hoff models and maximum ARD belonged to the UNIQUAC *** order of ARDs for these models is:Wilson b Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff b e-NRTL b ***,the apparent thermodynamic functions,Gibbs free energy,enthalpy and entropy of dissolution and mixing were calculated based on the van’t Hoff and Gibbs free energy *** strong LTG-ILs interactions and enthalpic contribution of the dissolution process resulted from the calculated thermodynamic functions.

关键词： Solubility Lamotrigine [OMIm][Br] [HMIm][Br] UNIQUAC Thermodynamic functions

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