Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids([OMIm][Br]+[HMIm][Br]+water)at different temperatures

作     者：Mohammad Barzegar-Jalali Abolghasem Jouyban Fleming Martinez Hemayat Shekaari Seyyedeh Narjes Mirheydari Mohammad Barzegar-Jalali;Abolghasem Jouyban;Fleming Martinez;Hemayat Shekaari;Seyyedeh Narjes Mirheydari

作者机构：Research Center for Pharmaceutical Nanotechnology and Faculty of PharmacyTabriz University of Medical SciencesTabrizIran Pharmaceutical Analysis Research Center and Faculty of PharmacyTabriz University of Medical SciencesTabrizIran Kimia Idea Pardaz Azarbayjan(KIPA)Science-Based CompanyTabriz University of Medical SciencesTabrizIran Grupo de Investigaciones Farmacéutico-FisicoquímicasDepartamento de FarmaciaFacultad de CienciasUniversidad Nacional de Colombia–Sede BogotáCra.30 No.45-03BogotáD.C.Colombia Department of Physical ChemistryFaculty of ChemistryUniversity of TabrizTabrizIran Drug Applied Research CenterTabriz University of Medical SciencesTabrizIran 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2020年第28卷第1期

页      面：198-207页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 10[医学] 

基　　金：a postdoctorate grant(693118)of Tabriz University of Medical Sciences Iran for supporting this work 

主　　题：Solubility Lamotrigine [OMIm][Br] [HMIm][Br] UNIQUAC Thermodynamic functions 

摘      要：Experimental mole fraction solubility of lamotrigine(LTG)in ternary aqueous mixtures of two ionic liquids(ILs),1-hexyl and 1-octyl-3-methylimidazolium bromide,[HMIm][Br]and[OMIm][Br]were reported at several temperatures T=(293.15 to 313.15)*** van’t Hoff and(Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff,e-NRTL,UNIQUAC and Wilson)models were used to correlate the solubility *** comparison of the models with temperature and solvent composition dependencies shows that the Wilson model has the minimum ARD which are relatively close to those obtained from Jouyban-Acree-van’t Hoff and E-Jouyban-Acree-van’t Hoff models and maximum ARD belonged to the UNIQUAC *** order of ARDs for these models is:Wilson b Jouyban-Acree-van’t Hoff,E-Jouyban-Acree-van’t Hoff b e-NRTL b ***,the apparent thermodynamic functions,Gibbs free energy,enthalpy and entropy of dissolution and mixing were calculated based on the van’t Hoff and Gibbs free energy *** strong LTG-ILs interactions and enthalpic contribution of the dissolution process resulted from the calculated thermodynamic functions.