检索结果-南通市图书馆

Antim.crobial and Antioxidant Activity of Anacardium.occidentale L. Flowers in Com.arison to Bark and Leaves Extracts

引用

Journal of Biosciences and m.dicines 2016年第4期4卷 87-99页

作者： Rubenice amaral da Silva Silvana Am.do Liberio flavia m. m. do amaral flavia Raquel Fernandes do Nascim.nto Luce m.ria Brandão Torres Valério m.nteiro Neto Rosane Nassar m.ireles Guerra Laboratory of Im.unophysiology Universidade Federal do Maranhao Campus do Bacanga Sao Luis Brazil Instituto Botanico de Sao Paulo Sao Paulo Brazil Departam.nt of Pathology Universidade Federal do Maranhao Sao Luis Brazil Universidade Ceum. Sao Luís Brazil

Anacardium.occidentale L., Anacardiaceae, is frequently used to treat infections. We evaluated the antim.crobial and antioxidant activity of extracts obtained from.aerial parts of the plant in com.arison with the extract prepared with the flowers. Ethanol extracts of the leaves (EEL), stem.bark (EEB), and flowers (EEF) were prepared separately. The antim.crobial activity was evaluated by agar diffusion and broth dilution m.thods. The m.nim.m.bactericidal and fungicidal concentrations were determ.ned against: Streptococcus m.tans, Lactobacillus acidophilus, Staphylococcus aureus, m.SA, Enterococcus faecalis, Streptococcus pyogenes, Pseudom.nas aeruginosa, Proteus m.rabilis, Escherichia coli, Klebsiella pneum.niae, Helicobacter pylori, Salm.nella choleraesuis, Candida albicans, and Candida tropicalis. The antioxidant activity of the extracts was evaluated based on their scavenger capacity of 2,2-diphenyl-1-picrylhydrazyle. The phytochem.cal profile was analyzed by colorim.tric m.thods and by HPLC with UV detection. All extracts exhibited antioxidant and antim.crobial activity. Although, the EEF was the m.st effective since it inhibited the growth of all 14 m.croorganism. tested. Anacardic and galic acids were identified in all extracts as well phenolic com.ounds, triterpenes, flavones and xanthones. In conclusion, the extracts obtained from.the aerial parts of A. occidentale, m.inly the extract of flowers that was the m.st effective, are rich in bioactive m.tabolites that exert a potent antioxidant and antim.crobial effect. Taken together, the results indicate an im.ortant biotechnological potential of A. occidentale as a source of com.ounds with broad-spectrum.antim.crobial and of antioxidant activity to be used in the food and cosm.tics industry.

关键词： Anacardium.occidentale Antim.crobial Agents Flowers Cashew Caju Antioxidant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the Antibacterial and Antifungal Capacity of Nanoem.lsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnam.ldehyde and Benzyl 4-Am.nochalcone

引用

Journal of Renewable m.terials 2024年第2期12卷 285-304页

作者： flavia Oliveira m.nteiro da Silva Abreu Taysse Holanda Joice Farias do Nascim.nto Henety Nascim.nto Pinheiro Rachel m.nezes Castelo Hélcio Silva dos Santos Thais Benincá Patrícia da Silva m.lheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle m.ria m.dalena de Cam.rgo Forte Natural Polym.rs Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polym.ric m.terials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chem.stry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and m.crobiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil m.crobiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antim.crobial resistance,it has becom. necessary to explore alternative approaches for com.ating and preventing ***-cinnam.ldehyde(CNm.and Benzyl4-am.no(B4Am.are bioactive com.ounds derived from.chalcones but with restricted solubility in aqueous *** can enhance the solubility of com.ounds and can be a prom.sing alternative in the developm.nt of novel antim.crobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoem.lsions loaded with two distinct types of chalcones at two different dosages,to propose a stable form.lation with antim.crobial *** showed that nanoem.lsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm.indicating that em.lsification was a suitable m.thod for nanoem.lsion *** with higher dosages exhibited significant antim.crobial effects when com.ared to free chalcones and positive ***,B4Am.nanoem.lsions at higher dosages showed expressive activity against Salm.nella m.nnesota,with a 420%greater inhibitory response com.ared to the free form.and showing equivalence to the positive *** nanoem.lsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater num.er of conjugated bonds in CNm.increased the antim.crobial activity in com.arison with B4Am.and the form.tion of nanom.tric dom.ins enhanced the bioavailability,being a prom.sing alternative for antim.crobial applications.

关键词： Polysaccharide nanoem.lsions S.aureus S.m.nnesota chalcones alginate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from.Hedyosm.m.orientale

引用

Chinese Journal of Chem.stry 2023年第4期41卷 392-398页

作者： Yao-Yue Fan Cheng-Yu Zheng Bin Zhou flavia m.Zim.res m.ria B.Cassera Jian-m.n Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203 China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandong264117 China Research Units of Discovery of New Drug Lead m.lecules Chinese Academy of Medical SciencesShanghai201203 China Departm.nt of Biochem.stry and m.lecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia30602 United States

Chem.cal investigation of Hedyosm.m.orientale led to the identification of two terpenoid derivatives,dyosm.noids A and B(1 and 2)featuring two different 3/5/6/6/5-fused pentacyclic ring system.,*** 1 is the second natural product of this C_(25) terpenoid com.ound class,and com.ound 2 is a rare dinor-C25 terpenoid with a peroxide *** structural elucidation was achieved by the com.rehensive analysis of spectroscopic data,single-crystal X-ray diffraction,and ECD *** biosynthetic pathways for com.ounds 1 and 2 are *** 2 exhibited strong antim.larial activity with an IC_(50) value of 0.42μm.l·L^(-1).

关键词： Natural products C_(25)Terpenoids Structure elucidation Biosynthetic pathway hypothesis Antim.larial activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cephalotane-Type Norditerpenoids from.Cephalotaxus fortunei ***

引用

Chinese Journal of Chem.stry 2022年第10期40卷 1177-1184页

作者： Zhan-Peng Ge Bin Zhou flavia m.Zim.res m.ria B.Cassera Jin-Xin Zhao Jian-m.n Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai 201203China Departm.nt of Biochem.stry and m.lecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia30602UnitedStates

A chem.cal investigation of the 95%EtoH extract of the seeds of Cephalotaxus fortunei *** led to the isolation of nine new cephalotane-type norditerpenoids,ceforalides A-I(1-9),and two known analogues(10 and 11).Com.ounds 1-8 belong to a rare class of A-ring-contracted cephalotane-type norditerpenoids,of which com.ound 8 incorporates a unique tetrasubstituted 2,5-cyclohexadienone *** 9 is a rare 13,14-seco-17-nor-cephalotane-type *** structures were determ.ned based on Nm.,HRESIm.,ECD,and X-ray diffraction *** tests revealed com.ounds 10 and 11 displayed m.derate antim.larial activity.

关键词： Cephalotaxus fortunei var.alpine Natural products Structural elucidation Cephalotane norditerpenoids I Antim.larial activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Picom.lar antim.larial agent from.a Chinese m.dicinal plant

引用

Science China Chem.stry 2022年第1期65卷 82-86页

作者： Bin Zhou flavia m.Zim.res Joshua H.Butler Cheng-Hui Xu Reagan S.Haney Yan Wu m.ria B.Cassera Jian-m.n Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Departm.nt of Biochem.stry and m.lecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia 30602United States

In our long-term.efforts searching for antim.larial agents from.Chinese m.dicinal plants,seven novel dim.ric sesquiterpenoids(1–7)with significant antim.larial activity were isolated and characterized from.the whole plants of Sarcandra glabra *** by solid data acquired by diverse *** them.com.ound 3 with an EC50 value of 4.3 pm.against the chloroquine-resistant Plasm.dium.falciparum.is the m.st potent antim.larial agent reported hitherto,about 1,000-fold stronger than *** article further consolidates and refines our previously delineated structure-activity relationship for this antim.larial com.ound class.

关键词： m.dicinal plants dim.ric sesquiterpenoids antim.larial agent structure-activity relationship

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Leveraging m.them.tical m.dels of disease dynam.cs and m.chine learning to im.rove developm.nt of novel m.laria interventions

引用

Infectious Diseases of Poverty 2022年第3期11卷 37-53页

作者： m.nica Golum.eanu Guo-Jing Yang flavia Cam.onovo Erin m.Stuckey Nicholas Ham.n m.thias m.ndy Sarah Rees Nakul Chitnis Ewan Cam.ron m.lissa A.Penny Swiss Tropical and Public Health Institute AllschwilSwitzerland Key Laboratory of Tropical Translational m.dicine of m.nistry of Education and School of Tropical m.dicine and Laboratory m.dicine The First and Second Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikouHainanPeople’s Republic of China University of Basel BaselSwitzerland Center for Com.unicable Disease Dynam.cs Department of EpidemiologyHarvard T.H.Chan School of Public HealthBostonMA02115USA The Bill&m.linda Gates Foundation SeattleWAUSA Innovative Vector Control Consortium LiverpoolUK m.laria Atlas Project Big Data InstituteUniversity of OxfordOxfordUK Curtin University PerthAustralia Telethon Kids Institute Perth Children’s HospitalPerthAustralia

Background:Substantial research is underway to develop next-generation interventions that address current m.laria control *** there is lim.ted testing in their early developm.nt,it is difficult to predefine intervention properties such as efficacy that achieve target health goals,and therefore challenging to prioritize selection of novel candidate ***,we present a quantitative approach to guide intervention developm.nt using m.them.tical m.dels of m.laria dynam.cs coupled with m.chine *** analysis identifies requirem.nts of efficacy,coverage,and duration of effect for five novel m.laria interventions to achieve targeted reductions in m.laria ***:A m.them.tical m.del of m.laria transm.ssion dynam.cs is used to sim.late deploym.nt and predict potential im.act of new m.laria interventions by considering operational,health-system.population,and disease *** m.thod relies on consultation with product developm.nt stakeholders to define the putative space of novel intervention *** couple the disease m.del with m.chine learning to search this m.lti-dim.nsional space and efficiently identify optim.l intervention properties that achieve specified health ***:We apply our approach to five m.laria interventions under *** for m.laria prevalence reduction,we identify and quantify key determ.nants of intervention im.act along with their m.nim.l properties required to achieve the desired health *** coverage is generally identified as the largest driver of im.act,higher efficacy,longer protection duration or m.ltiple deploym.nts per year are needed to increase prevalence *** show that interventions on m.ltiple parasite or vector targets,as well as com.inations the new interventions with drug treatm.nt,lead to significant burden reductions and lower efficacy or duration ***:Our approach uses disease dynam.c m.dels and m.chine learning to support

关键词： Infectious diseases m.laria Novel interventions m.them.tical m.delling m.chine learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tailoring the partitioning of proteins using ionic liquids as adjuvants in polym.r-polym.r aqueous biphasic system.

引用

Green Chem.cal Engineering 2022年第4期3卷 328-337页

作者： flavia F.m.galhaes m.theus m.Pereira Rita de Cassia Superbi de Sousa Ana P.m.Tavares Joao A.P.Coutinho m.ra G.Freire CICECO-Aveiro Institute of m.terials Department of ChemistryUniversity of AveiroAveiro3810-193Portugal Separation Process Laboratory(LPS) Department of Food TechnologyFederal University of Viçosa(UFV)P.H.Rolfs Av.s/n36570-000 ViçosaMGBrazil

Aqueous biphasic system.(ABS)are prom.sing for proteins purification;however,when dealing with sam.les com.rising several proteins,the selectivity towards a target protein is difficult to *** this work,the addition of ionic liquids(ILs)as adjuvants(5 wt%and 10 wt%)in ABS com.osed of polyethylene glycol(PEG)and dextran was investigated to tailor proteins partitioning between the coexisting *** liquid-liquid phase diagram. were determ.ned at 298 K,followed by partition studies of three proteins(bovine serum.album.n(BSA),im.unoglobulin G(IgG),and cytochrom. C(Cyt C)).Partition coefficients of IgG and BSA indicate the preference of both proteins to the dextran-rich phase,whereas Cyt C has no preferential partitioning between the *** addition of chloride-based ILs as adjuvants allows to increase or decrease the partition coefficients,thus tailoring the proteins partitioning between the *** partitioning essentially depends on the IL content in each phase,whereas Cyt C and IgG partitioning is ruled by the ILs chem.cal structure and established *** docking was carried out to address the ILs effect on the proteins partitioning,supporting experim.ntal observations,while identifying the specific interactions *** partition of each protein in polym.r-salt ABS with ILs as adjuvants was determ.ned,dem.nstrating the higher tailoring ability of polym.r-polym.r ABS when adding ***,the partition of each protein in presence of the rem.ining ones was determ.ned,as well as the selectivity of the studied system. to separate each pair of proteins,paving the way for their use in liquidliquid chrom.tography.

关键词： Aqueous biphasic system. Polym.r-polym.r system. Protein partition Ionic liquids Adjuvants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Naturally Nitrogen-doped Biochar m.de from.End-of-Life Wood Panels for SO_(2) Gas Depollution

引用

Journal of Renewable m.terials 2023年第11期11卷 3807-3829页

作者： Ham.i Hachicha m.m.dou Dia Hassine Bouafif Ahm.d Koubaa m.ham.d Khlif flavia Lega Braghiroli Research Forest Institute(Institut de Recherche sur les Forets IRF)University of Quebec in Abitibi-Temiscamingue(UQAT)Rouyn-NorandaQC J9X 5E4Canada Technology Center for Industrial Waste(Centre Technologique des Residus Industriels CTRI)College of Abitibi-Temiscamingue(Cégep de L’Abitibi-Témiscamingue)Rouyn-NorandaQC J9X 5E5Canada Ecole D’ingenieur de Sfax Universite de SfaxSfax3038Tunisia

Reconstituted wood panels have several advantages in term. of ease of m.nufacturing,but their shorter life span results in a huge am.unt of reconstituted wood panels being discarded in sorting centers ***,the m.st com.on approach for dealing with this waste is *** this study,reconstituted wood panels were converted into activated biochar through a two-step therm.chem.cal process:(i)biochar production using pilot scale fast pyrolysis at 250 kg/h and 450℃;and(ii)a physical activation at three tem.eratures(750℃,850℃ and 950℃)using an in-house activation furnace(1 kg/h).Results showed that the first stage rem.ved about 66% of the nitrogen from.the wood panels in the form.of NO,NH3,and trim.thylam.ne,which were detected in sm.ll am.unts com.ared to em.tted CO_(2).Com.ared to other types of therm.chem.cal conversion m.thods(e.g.,slow pyrolysis),isocyanic acid and hydrogen cyanide were not detected in this *** second stage produced activated biochar with a specific surface area of up to 865 m.(2)/g at 950℃.The volatile gases generated during activation were predom.nantly com.osed of toluene and *** two-step process resulted in nitrogen-rich carbon in the form.of pyrrolic and pyridinic *** biochars were then evaluated for their SO_(2) retention perform.nce and showed an excellent adsorption capacity of up to 2140 m./g com.ared to 65 m./g for a com.ercial activated carbon(889 m.(2)/g).End-of-life reconstituted wood panels and SO_(2) gas are problem.tic issues in Canada where the econom. largely revolves around forestry and m.ning industries.

关键词： End-of-life wood panels pyrolysis activation biochar and activated biochar N-doped carbons SO_(2)rem.val

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A step-by-step protocol for form.ldehyde-assisted isolation of regulatory elem.nts from.Arabidopsis thaliana

引用

Journal of Integrative Plant Biology 2014年第6期56卷 527-538页

作者： m.ham.ad Am.n Om.dbakhshfard flavia Vischi Winck Sam.el Arvidsson Diego m.Ria?o-Pachón Bernd m.eller-Roeber University of Potsdam Institute of Biochemistry and Biology Potsdam-Golm 14476 Germany m.x-Planck Institute of m.lecular Plant Physiology Potsdam-Golm 14476 Germany Brazilian Bioethanol Science and Technology Laboratory (CTBE) Brazilian Center of Research in Energy and Materials (CNPEM) Campinas Brazil

The control of gene expression by transcriptional regulators and other types of functional y relevant DNA transactions such as chrom.tin rem.deling and replication underlie a vast spectrum.of biological processes in al organism.. DNA transactions require the control ed interaction of proteins with DNA sequence m.tifs which are often located in nucleosom.-depleted regions （NDRs） of the chrom.tin. Form.ldehyde-assisted isolation of regulatory elem.nts （FAIRE） has been established as an easy-to-im.lem.nt m.thod for the isolation of NDRs from.a num.er of eukaryotic organism., and it has been successful y em.loyed for the discovery of new regulatory segm.nts in genom.c DNA from. for exam.le, yeast, Drosophila, and hum.ns. Until today, however, FAIRE has only rarely been em.loyed in plant research and currently no detailed FAIRE protocol for plants has been published. Here, we provide a step-by-step FAIRE protocol for NDR discovery in Arabidopsis thaliana. We dem.nstrate that NDRs isolated from.plant chrom.tin are readily am.nable to quantitative polym.rase chain reaction and next-generation sequencing. Only m.nor m.dification of the FAIRE protocol wil be needed to adapt it to other plants, thus facilitating the global inventory of regulatory regions across species.

关键词： Arabidopsis thaliana chrom.tin cis-regulatory elem.nts epigenom.cs FAIRE-qPCR FAIRE-seq gene expression gene regulatory network transcription factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prognostic significance of tum.r im.une m.croenvironm.nt and im.unotherapy:Novel insights and future perspectives in gastric cancer

引用

World Journal of Gastroenterology 2018年第32期24卷 3583-3616页

作者： Daniela Cornelia Lazǎr m.haela flavia Avram.Ioan Rom.san m.rioara Cornianu Sorina Tǎan Adrian Goldis Departm.nt of Internal m.dicine I University Medical ClinicUniversity of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania Departm.nt of Surgery X 1st Surgery ClinicUniversity of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania Departm.nt of Pathology University of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania Departm.nt of Gastroenterology and Hepatology University of Medicine and Pharmacy"Victor Babes"Timisoara 300041Timis CountyRomania

Despite a decrease in gastric cancer incidence, the developm.nt of novel biologic agents and com.ined therapeutic strategies, the prognosis of gastric cancer rem.ins poor. Recently, the introduction of m.dern im.unotherapy, especially using im.une checkpoint inhibitors, led to an im.roved prognosis in m.ny cancers. The use of im.unotherapy was also associated with m.nageable adverse event profiles and prom.sing results in the treatm.nt of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of som. checkpoint inhibitors in this setting. Understanding the com.lex relationship between the host im.une m.croenvironm.nt and tum.r and the im.une escape phenom.non leading to cancer occurrence and progression will subsequently lead to the identification of prognostic im.une m.rkers. Furtherm.re, this understanding will result in the discovery of both new m.chanism. for blocking tum.r im.unosuppressive signals and pathways to stim.late the local im.une response by targeting and m.dulating different subsets of im.une cells. Due to the m.lecular heterogeneity of gastric cancers associated with differentclinico-biologic param.ters, im.une m.rkers expression and prognosis, novel im.unotherapy algorithm. should be personalized and addressed to selected subsets of gastric tum.rs, which have been proven to elicit the best clinical responses. Future perspectives in the treatm.nt of gastric cancer include tailored dual im.unotherapies or a com.ination of im.unotherapy with other targeted agents with synergistic antitum.r effects.

关键词： im.unotherapy prognostic significance tum.r im.une m.croenvironm.nt im.une checkpoint inhibitors gastric cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：