Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale
作者机构：State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences555 Zuchongzhi RoadShanghai201203 China Shandong Laboratory of Yantai Drug DiscoveryBohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandong264117 China Research Units of Discovery of New Drug Lead MoleculesChinese Academy of Medical SciencesShanghai201203 China Department of Biochemistry and Molecular BiologyCenter for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia30602 United States
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第4期
页 面：392-398页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：The financial support from the National Natural Science Foundation of China(Nos.82122062,81861138045,22177121) the CAMS Innovation Fund for Medical Sciences(2019-12M-5-080) the Biological Resources Program(CAS,KFJ-BRP-008) Science and Technology Commission of Shanghai Municipality(20ZR1467800) Youth Innovation Promotion Association CAS,is gratefully acknowledged
主 题：Natural products C_(25)Terpenoids Structure elucidation Biosynthetic pathway hypothesis Antimalarial activity
摘 要：Chemical investigation of Hedyosmum orientale led to the identification of two terpenoid derivatives,dyosmunoids A and B(1 and 2)featuring two different 3/5/6/6/5-fused pentacyclic ring systems,*** 1 is the second natural product of this C_(25) terpenoid compound class,and compound 2 is a rare dinor-C25 terpenoid with a peroxide *** structural elucidation was achieved by the comprehensive analysis of spectroscopic data,single-crystal X-ray diffraction,and ECD *** biosynthetic pathways for compounds 1 and 2 are *** 2 exhibited strong antimalarial activity with an IC_(50) value of 0.42μmol·L^(-1).
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