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Neuroinflammatory modulators of oligodendrogenesis

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 263-273页

作者： Ana Armada-Moreira filipa F.ribeiro Ana M.Sebastião Sara Xapelli Instituto de Farmacologia e Neurociências Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal

Oligodendrocytes are key neural cells that are responsible for producing myelin sheaths that wrap around neuronal axons in the central nervous *** is essential to insulate neurons and maintain a fast and saltatory propagation of action potentials along the ***,oligodendrocytes are very susceptible to damage,and thus demyelination may arise from a brain lesion or a neurodegenerative ***,demyelination produces a loss of axonal insulation leading to sensory or motor neuron *** adulthood,there are two main sources of oligodendrocytes:parenchymal oligodendrocyte precursor cells(OPCs)and subventricular zone derived *** this review,we will discuss oligodendrogenesis derived from these two sources,and also highlight their main extrinsic and intrinsic *** addition,the neuroinflammatory mediators of oligodendrogenesis will also be assessed.

关键词： Demyelination inflammation neural stem cells oligodendrocyte remyelination

The neurosphere assay:an effective in vitro technique to study neural stem cells

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Neural Regeneration Research 2021年第11期16卷 2229-2231页

作者： Rita Soares filipa F.ribeiro Diogo M.Lourenço Rui S.Rodrigues João B.Moreira Ana M.Sebastião Vanessa A.Morais Sara Xapelli Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Instituto de Farmacologia e Neurociências Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Instituto de Biologia Molecular Faculdade de MedicinaUniversidade de LisboaLisboaPortugal

Neural stem cells(NSCs)are known to be present in the adult mammalian brain where they constitutively differentiate into the neuronal,astroglial,and oligodendroglial lineages,in defined processes termed neurogenesis,ast rogl iogenesis and oligodendrogenesis,respectively(reviewed in Braun and Jessberger,2014).During brain development,NSCs are present throughout the brain,becoming progressively restricted to defined brain *** the adult brain,NSCs are mainly present in areas classically known as neurogenic niches,*** subventricular zone(SVZ),along the lateral walls of the lateral ventricles,and the subgranular zone,located in the dentate gyrus(DG)of the hippocampus.

关键词： walls neural becoming

HPV Vaccination in Young Girls from Developing Countries: What Are the Barriers for Its Implementation? A Systematic Review

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Health 2020年第6期12卷 671-693页

作者： Inês Maria Brito Gonçalves Joana Rafaela Magalhães Fernandes filipa ribeiro Adhemar Longatto-Filho School of Medicine University of Minho Braga Portugal Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/Guimar&#227 es Portugal Molecular Oncology Research Center Barretos Cancer Hospital Barretos S&#227 o Paulo Brazil Medical Laboratory of Medical Investigation (LIM) 14 Department of Pathology Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil

Cervical cancer is the second most common cancer in women living in developing countries that account high HPV incidence and mortality rates. Vaccinating girls between 9 and 14 years old is supposed to be the most cost-effective public health approach against cervical cancer. This systematic review aims to assess the application and coverage of the HPV vaccine in developing countries and identify the main challenges for the introduction of the vaccine in these settings. Eligible studies were selected according to the defined inclusion and exclusion criteria. To determine the quality of the studies was employed the STROBE checklist. This review included seven studies, encompassing the analysis of 19 countries and 112,116 girls aged from 9 to 18 years old. The coverage of HPV vaccination ranged from 13.8% to 107.4%, with most of the programs having more than 60% of coverage, which reflects a high percentage of vaccinated girls. The main challenges were lack of knowledge and worries about the vaccine, insufficient financial resources and staff workers, lack of community involvement and dissemination of important information about HPV. In developing countries that implemented the HPV vaccine, high coverage rates were achieved, despite sociocultural, economic and political challenges. In the future, studies that analyze the coverage rates after the elimination of the barriers and the repercussions on the mortality rates should be conducted, so that more developing countries have the opportunity to efficiently implement the vaccine.

关键词： HPV Vaccine HPV Knowledge and Education HPV-Induced Cancer Papillomavirus Vaccine Awareness Cervical Cancer Mortality HPV Incidence HPV in Developing Countries

Environmental determinants of social wasp diversity and assemblage structure in an Amazonian archipelagic landscape

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 121-129页

作者： Jose Victor Alves Ferreira Alexandre Somavilla Maíra Benchimol Ana filipa Palmeirim Carlos A.Peres Danielle Storck-Tonon Laboratório de Ecologia Aplicada àConservação Universidade Estadual de Santa CruzIlhéus 45662-900Brazil Instituto Nacional de Pesquisas da Amazônia Coordenação de BiodiversidadeManaus 69067-001Brazil CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairão 4485-661Portugal School of Environmental Sciences University of East AngliaNorwich NR47TJUK Instituto Juruá Manaus69057-060Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda Serra 78300-970Brazil

Hydropower development has become an important driver of habitat loss and fragmentation across lowland tropical *** ample evidence on the detrimental effects of insular habitat fragmentation on biodiversity,invertebrate taxa,that may be critical to ecosystem functioning,have been *** assessed the assemblage-level responses of social wasps to forest insularization induced by the Balbina Hydroelectric Dam in Central Brazilian *** Malaise trapping,we captured wasps on 27 forest islands and three continuous *** constructed Generalized Linear Models and employed a model selection approach to examine the impact of local variables(fire severity(FIRE)and basal area of pioneer tree species(PIONEER))and landscape-scale variables(amount of habitat(COVER))on patterns of species richness,composition,and body size of wasps.A total of 374 individuals(29 species)were collected across all sampling *** was the main predictor of species richness,while PIONEER was the only variable that explained variation in community composition,with a negative effect on body *** results add evidence to the pervasive impacts of large hydroelectric dams on tropical forest biodiversity,and suggest that social wasps,among other invertebrates,can be used as bioindicators in infrastructure development projects.

关键词： Habitat amount hypothesis Habitat fragmentation Habitat loss Hydroelectric dams Invertebrates

Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana filipa Palmeirim Maíra Benchimol Danielle Storck-Tonon Anderson S.Bueno Isabel L.Jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams Landbridge Local extinctions Species-area relationships Species diversity Tropical forests

Muckle-Wells syndrome: manifestations and diagnosis in four generations of a Portuguese family

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World Journal of Pediatrics 2020年第5期16卷 541-542页

作者： Soraia Raquel Loureiro Azevedo Daniela filipa Marinho Peixoto Rheumatology Department Unidade Local de Satúde Do Alto MinhoHospital Conde Bertiandos4990-041Ponte de LimaPortugal

Several medical conditions can present as fever and rash in children,including infections,hypersensitivity reactions and immune-mediated diseases[1].Cryopyrin-associated periodic syndrome(CAPS)is a group of inherited autoinflammatory disorders caused by gain-of-function mutations in the NLRP3 gene(CIAS 1).CAPS encompass a spectrum of diseases including Muckle-Wells syndrome(MWS).The A439V mutation is considered a disease-causing mutation,although clinical phenotypes can be diverse[2].MWS is characterized by recurrent episodes of fever,urticarial rash,arthralgia/arthritis,and more rarely,oral ulcers,folliculitis,or erythema nodosum[3].

关键词： diagnosis CAPS fever

Obstructive Sleep Apnea Hypopnea Syndrome and Pulmonary Embolism： Warfarin Versus Positive Airway Pressure as Determinant

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Chinese Medical Journal 2016年第2期129卷 251-252页

作者： filipa Ramalho Fernandes Dulce Apolinario Antonio M Esquinas Department of Pneumoloqv Unidade Local de Saude da Guarda EPE - Sousa Martins Hospital Guarda Portugal Department of Pneumology Centro Hospitalar de Tras-os-Montes e Alto Douro EPE - Sao Pedro de Vila Real Hospital Vila Real Portugal Intensive Care and Non Invasive Ventilatory Unit Hospital Morales Meseguer Murcia Spain

To the Editor： Xie et al, analyzed warfarin doses in pulmonary embolism （PE） and its adverse effects in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. The key findings were that OSAHS patients required a significantly higher dose of warfarin than their non-OSAHS counterparts （4.73 mg vs. 3.61 mg, P 〈 0.001） and that PE recurrence was higher in OSAHS than in non-OSAHS groups after withdrawal ofwarfarin （21.43% vs. 6.78%, P = 0.047）.

关键词： analyzed warfarin pulmonary embolism great interest

Helicobacter pylori infection- recent developments in diagnosis

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World Journal of Gastroenterology 2014年第28期20卷 9299-9313页

作者： Ana Isabel Lopes filipa F Vale Mónica Oleastro Centro Académico de Medicina de Lisboa Faculdade de Medicina da Universidade de Lisboa Centro de Patogénese Molecular Unidade dos Retrovírus e Infec??es AssociadasInstituto de Medicina Molecular e Instituto de Investiga??o do MedicamentoFaculdade de FarmáciaUniversidade de Lisboa Laboratório Nacional de Referência das Infe??es Gastrintestinais Departamento de Doen?as InfeciosasInstituto Nacional de Saúde Dr Ricardo Jorge

Considering the recommended indications for Helicobacter pylori(***)eradication therapy and the broad spectrum of available diagnostic methods,a reliable diagnosis is mandatory both before and after eradication *** highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circumstances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the *** review concerns some of the most recent developments in diagnostic methods of *** infection,namely the contribution of novel endoscopic evaluation methodologies for the diagnosis of *** infection,such as magnifying endoscopy techniques and *** addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient *** studies recommend enhancing the number of biopsy fragments for the rapid urease *** culture from the gastric biopsy is the gold standard technique,and is recommended for antibiotic susceptibility *** is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while molecular methods have gained attention mostly for detecting antibiotic resistance.

关键词： Helicobacter pylori Diagnosis Endoscopy Histology Culture Urea breath test Stool antigen test Serology Molecular methods

Microwave ablation of solitary T1N0M0 papillary thyroid carcinoma:A case report

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World Journal of Clinical Cases 2023年第20期11卷 4883-4889页

作者： Teresa Dionísio Leando Lajut filipa Sousa Liliana Violante Pedro Sousa Department of Radiology Centro Hospitalar de Vila Nova de Gaia e EspinhoVila Nova de Gaia 4430-000Portugal Department of Sugery Centro Hospitalar de Tras-os-Montes e Alto DouroVila Real 5000-508Portugal Department of Radiology CHVNGEVila Nova de Gaia 4430-000Portugal Department of Nuclear Medicine Instituto Portugues de Oncologia do Porto Francisco GentilPorto 4200-072Portugal

BACKGROUND The gold standard treatment for papillary thyroid carcinoma is total thyroidectomy and indications for microwave thermal ablation for primary thyroid cancers have not yet been clearly established However,some patients refuse surgery and others have no indication for it,for example patients under palliative care as in this case,or cannot undergo surgery,based on their *** indications are described in the most recent Korean,North American and European *** ablation,radiofrequency ablation,and microwave ablation are similarly safe and effective,so the choice should be based on the specific competences and resources of the pertaining *** indications are Percutaneous minimally-invasive techniques;they can be useful to stop disease progression and as an alternative to surgery in patients with contraindication or who refuse *** present a case of a thyroid papillary carcinoma with 17 mm effectively treated with microwave thermal ablation and without recurrence after one year of follow *** SUMMARY The authors present a case of a 71-years-old patient with a left lobe papillary thyroid carcinoma with 13 mm×17 mm×13 mm,with no indication for thyroid surgery given the context of another cancer in palliative *** thermoablation was performed on December *** months later he repeated computed tomography(CT)scan,which showed that the tumor had *** months after ablation he underwent a positron emission tomography/CT-fluorodeoxyglucose scan,which didn’t show any evidence of hypermetabolic tumor *** This case shows microwave thermoablation can be a safe and effective alternative to surgery in patients with no conditions to undergo surgery or when they refuse *** treating the tumor,with this minimally invasive technique,we are stopping its growth and avoiding disease progression.

关键词： Thyroid carcinoma Microwave ablation Thyroid nodules Papillary thyroid cancer Thyroid