检索结果-南通市图书馆

Soil and Rhizosphere Associated Fungi in Gray Mangroves(Avicennia marina) from the Red Sea—A Metagenomic Approach

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2015年第5期13卷 310-320页

作者： Marta filipa Simoes Andr Antunes Cristiane A.Ottoni Mohammad Shoaib Amini Intikhab Alam Hanin Alzubaidy Noor-Azlin Mokhtar John A.C.Archer Vladimir B.Bajic Computational Bioscience Research Center (CBRC) ComputerElectrical and Mathematical Sciences and Engineering Division (CEMSE)King Abdullah University of Science and Technology (KAUST) Laboratório de Biotecnologia Industrial (LBI) Instituto de Pesquisas Tecnológicas do Estado de Sao Paulo (IPT)

Covering a quarter of the world＇s tropical coastlines and being one of the most threat- ened ecosystems, mangroves are among the major sources of terrestrial organic matter to oceans and harbor a wide microbial diversity. In order to protect, restore, and better understand these ecosystems, researchers have extensively studied their microbiology, yet few surveys have focused on their fungal communities, Our lack of knowledge is even more pronounced for specific fungal populations, such as the ones associated with the rhizosphere. Likewise, the Red Sea gray man- groves （Avicennia marina） remain poorly characterized, and understanding of their fungal commu- nities still relies on cultivation-dependent methods. In this study, we analyzed metagenomic datasets from gray mangrove rhizosphere and bulk soil samples collected in the Red Sea coast, to obtain a snapshot of their fungal communities. Our data indicated that Ascomycota was the dominant phylum （76%-85%）, while Basidiomycota was less abundant （14%-24~）, yet present in higher numbers than usually reported for such environments. Fungal communities were more stable within the rhizosphere than within the bulk soil, both at class and genus level. This finding is consistent with the intrinsic patchiness in soil sediments and with the selection of specific microbial commu- nities by plant roots. Our study indicates the presence of several species on this mycobiome that were not previously reported as mangrove-associated. In particular, we detected representatives of several commercially-used fungi, e.g., producers of secreted cellulases and anaerobic producers of cellulosomes. These results represent additional insights into the fungal community of the gray mangroves of the Red Sea, and show that they are significantly richer than previously reported.

关键词： Fungal diversity Ascomycota Basidiomycota Red Sea Metagenomics Bioinformatics

A Single Case of Two Synchronous Metastatic Tumours

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2019年第8期10卷 671-676页

作者： filipa Pereira Tiago Alpoim Maria Leitao Manuela Machado Medical Oncology Department IPO PortoPortoPortugal

The incidence of multiple primary tumours increases with age and due to multiple other factors as environmental and genetic predisposition. The authors describe a case of a 77-year-old female patient with diagnosis in September 2009 of colon mucinous adenocarcinoma. She was submitted to surgery, considered R1 and adjuvant chemotherapy. Six months after treatment she had abdominal recurrence on a nodular lesion in peritoneal fat. The patient was submitted to surgery and did multiple courses of systemic treatment. She underwent cytoreductive surgery with hyperthermic chemotherapy, too. In December 2014 she presented a nodular lesion on the bladder and after excision, the histology confirmed a high-grade transitional cell carcinoma and she maintains treatment with endovesical BCG instillations. After that, she had no evidence of peritoneal disease progression. Besides the bad prognosis associated to peritoneal disease, our case report describes a long survival (5 years with no disease progression) in a patient with high risk at diagnosis to peritoneal recurrence. This case shows the importance of multimodal approach and the impact of locoregional treatment in localized metastatic disease.

关键词： Colon Cancer Bladder Cancer Multiple Primary Neoplasms Synchronous

Design and Performance of a Novel Spillway Turbine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Power and Energy Engineering 2020年第5期8卷 14-31页

作者： filipa Adzic Thorsten Stoesser Emily Morris Stefan Runge Hydro-Environmental Research Centre Cardiff University Cardiff Wales UK Department of Civil Environmental and Geomatic Engineering University College London London UK Emrgy Inc. Atlanta GA USA

The high-speed supercritical flow in steeply sloped channels contains a significant amount of hydro-kinetic energy. A novel, horizontal axis, spillway turbine as presented in this paper attempts to convert that energy into electricity. We report on the turbine’s design and experimental testing. Its intended use is in low-head, low-flow, manmade, concrete-lined channels such as chutes, spillways and other similar steeply sloped open-channels. The design lends itself from an impulse turbine runner but without a pipe or a nozzle. The spillway turbine consists of 2 main components: 1) the runner and 2) an accelerator channel that directs the water towards the runner’s blades. The runner, once fitted with Pelton-inspired “cup inserts” shows performance improvements both in terms of efficiency and specific speeds. The specific speed and the speed factors calculated confirm that this novel spillway turbine runner can be categorized as an impulse turbine. The maximum efficiency obtained during laboratory testing is 43.4% and hence competes well with standard hydrokinetic turbines.

关键词： Hydro-Turbine Spillway-Turbine Micro-Hydro Horizontal-Axis Impulse Low-Head

Algae as Functional Foods for the Elderly

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2016年第12期7卷 1122-1148页

作者： filipa Figueiredo Telma Encarnação Maria G. Campos Faculty of Pharmacy University of Coimbra Pólo das Ciências da Saúde Azinhaga de Santa Comba Coimbra Portugal Chemistry Centre of Coimbra Faculty of Science and Technology University of Coimbra Coimbra Portugal

Older people may have more difficulties in acquiring the nutrients they need from diet and they are at greater risk of chronic diseases. Hence, functional foods based on algae, might have a role in improving very important nutrients intake without an increase in calories. This is crucial for middle age people that become less active and will not dispend as much energy as they use to, which will contribute for certain diseases associated with age. Algae produce a great variety of biological active compounds which cannot be found in other organisms. Moreover, they have been reported for their potential medicinal uses. Therefore, they have high potential as a source of functional ingredients. In this review, we will give relevant information about the issue, explain above, pointing out the information related to the compounds that could be responsible for the improvement in quality of life during elderly. It will be also referred that seaweeds can be a source of new compounds for drug discovery.

关键词： Functional Foods Algae Elderly Antioxidant Inflammation Diabetes Obesity Neuroprotection

Review of the Prognosis Factors of COVID-19 Infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Infectious Diseases 2021年第2期11卷 196-215页

作者： Bruno Besteiro Daniel Coutinho filipa Gomes Miguel Almeida Jorge Almeida Internal Medicine Department Centro Hospitalar e Universitário de S&#227 o Joã o Oporto Portugal Faculty of Medicine Oporto University Centro Hospitalar e Universitário de S&#227 o Joã o Oporto Portugal Infectious Diseases Department Centro Hospitalar de Vila Nova de Gaia Espinho Vila Nova de Gaia Portugal General Surgery Department Centro Hospitalar e Universitário de S&#227 o Joã o Oporto Portugal

An epidemic of Coronavirus disease 2019 (COVID-19) outbroke in December 2019 in China, Wuhan, which is becoming a Public Health Emergency of International Concern. As this entity has become one of the worst infectious disease outbreaks of recent times, with mortality estimates in general population ranging from 1.4% to 8%, it is crucial to better understand the prognostic factors which can be associated to the outcome of this disease. However, as the pandemic is still unfortunately under progression, there are limited data with regard to the prognostic factors. Hence, this review seeks to gather and provide the existing data of the literature of all the prognosis factors of COVID-19 infection such as older age, obesity, comorbidities, lymphocytopenia, d-dimers elevation, thrombocytopenia, elevated levels of high-sensitivity cardiac troponin, C-reactive protein elevation and imaging features of COVID-19.

关键词： COVID-19 SARS-CoV-2 Prognosis Outcome Risk Factors

Biodiversity Assessment of Sugar Beet Species and Its Wild Relatives:Linking Ecological Data with New Genetic Approaches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2013年第8期4卷 21-34页

作者： filipa Monteiro Maria MRomeiras Dora Batista Maria Cristina Duarte Faculdade de Ciências Universidade de LisboaBioFIGCampo GrandeLisboaPortugal Instituto de Investigacao Científica Tropical JBT&CIFC/BIOTROPTravessa Conde da RibeiraLisboaPortugal Universidade do Porto CIBIOCentro de Investi-gacao em Biodiversidade&Recursos GenéticosVairaoPortugal

The value of crop wild relatives has long been acknowledged and this wild resource has been used to improve crop performance with clear economic benefits. Sugar beet (Beta vulgaris subsp. vulgaris) is the most economically valuable crop species in the order Caryophyllales, B. vulgaris subsp. maritima being the ancestor of the cultivated beets. The wild species of the genus Beta s.l. are commonly found in coastal areas of Europe and Mediterranean Region, where a rich genetic heritage still exists. Broadening the genetic base of sugar beet by introgression with wild relatives is a growing need regarding the maintenance of ecologically important traits. Since wild relatives have adapted to specific habitats, they constitute an important source of novel traits for the beet breeding pool. So, we conducted a broader research project aiming to delimit taxa and identify priority locations to establish genetic reserves of the wild Beta species occurring in Portugal (Western Iberian Peninsula). The aim of this study was: 1) to identify and characterize the main habitats of these wild Beta species;and 2) to present a review of some genetic tools available for future application in sugar beet breeding. In this review, we have focused on EcoTILLING as a molecular tool to assess DNA polymerphisms in wild populations of Beta and identify candidate genes related to drought and salt tolerance, as well as addressed some issues related to next-generation sequencing (NGS) technologies as a new molecular tool to assess adaptive genetic variation on the wild relatives of sugar beet.

关键词： Crop Wild Relatives Beta vulgaris subsp.maritima Single Nucleotide Polymorphisms(SNPs) Western Mediterranean Region EcoTILLING

Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 547-558页

作者： Elisabeth Peeters Ana filipa Tavares da Silva Maunu Toiviainen Jeroen Van Renterghem Jurgen Vercruysse Mikko Juuti Joao Almeida Lopes Thomas De Beer Chris Vervaet Jean-Paul Remon Laboratory of Pharmaceutical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium Laboratory of Pharmaceutical Process Analytical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium REQUIMTE Department of Chemical SciencesUniversity of PortoRua de Jorge Viterbo Ferreira2284050-313PortoPortugal VTT Technical Research Centre of Finland Optical Measurement TechnologiesKaitoväylä190570 OuluFinland

This study investigated whether Raman and Near Infrared(NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares(PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn’t be established. Principal component analysis(PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression(MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.

关键词： Continuous production PAT Granulation Tableting NIR Raman

Skin models of cutaneous toxicity,transdermal transport and wound repair

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês Vilela de Sousa Miguel J.S.Ferreira Luís B.Bebiano Sandra Simões Ana filipa Matos Rúben F.Pereira Pedro L.Granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal FEUP-Faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal Faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models Ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

Protected Areas, Subsistence Farming Systems and Nature Conservation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Agricultural Science and Technology(A) 2012年第3期2卷 402-411页

作者： Luis Tiberio filipa Manso Ana Marta-Costa Carlos Fonseca Aurora Monzon Department of Economics Sociology and Management University of Tr6s-os-Montes and Alto Douro Vila Real 5000-660 Portugal

The preservation of the traditional subsistence farming systems and the conservation of natural values （habitats, fauna and flora）, in articulation with local development, was the key issues in this paper. The farmers have been able to manage the systems so as to cope with adverse conditions, but their future is quite uncertain. The methodology included：（1） field observation visits and cartographic information analysis of land use; （2） structured interviews with animal production and agro-forestry specialists; and （3） meetings with the participation of stakeholders. The paper concludes that depopulation is responsible for the increasing decline of agriculture and livestock. The decrease in agricultural activity in general and the consequent practices and traditional systems of agriculture causes changes in the landscape and has negative effects on nature conservation and biodiversity. Thus, we believe that the preservation and development of traditional economic activities linked to agriculture, agro-forestry and food processing are essential to maintain the typical landscape and to preserve natural values of Montemuro Site. The paper shows that in mountain areas, particularly those classified as nature network sites, farming, economic development and nature conservation are not antagonistic objectives.

关键词： Farming systems protected areas nature conservation biodiversity local development.