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Predicting outcomes after kidney transplantation: Can Pareto’s rules help us to do so?

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World Journal of Transplantation 2024年第1期14卷 9-11页

作者： fernando M gonzalez Francisca gonzalez Cohens Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile Web Intelligence Centre Faculty of Physics and Mathematical SciencesSantiago 7500922Chile

Kidney transplantation is the best option for kidney replacement therapy,even considering that most of the times the grafts do not survive as long as their *** the Khalil et al's experience,published in this issue of the Journal,they analyze their second kidney graft survival and describe those significant predictors of early *** editorial comments on the results and put in perspective that most of the times,long-term graft survival could be inadvertently jeopardized if the immunosuppressive therapy is reduced or withdrawn for any reason,and that it could happen frequently if the transplant physician intends to innovate with the clinical care without proper evidence-based data.

关键词： Kidney transplantation Graft survival Acute rejection Interstitial fibrosis and tubular atrophy Immunosuppression

Donor hepatectomy time and liver transplantation outcomes: An opportunity that cannot be dismissed

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World Journal of Transplantation 2024年第3期14卷 5-8页

作者： Francisca gonzalez Cohens fernando M gonzalez Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 7500922Chile Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

The probability of developing primary dysfunction(PD)is a function of the probability of ischemia/reperfusion(I/R)*** probability of I/R injury in turn,is a function of several donor and transplantation process variables,among which is ischemia *** et al studied the duration of a special type of warm ischemia and showed,contrary to what is known,that a longer duration is not statistically different from a shorter one in PD *** finding opens the door to the unforeseen opportunity of training fellows in performing hepatectomies,since the duration will not jeopardize liver transplant outcomes,albeit with some precautions.

关键词： Cold ischemia Warm ischemia Liver transplantation Reperfusion Primary dysfunction

Critical care specialists,the missing link in organ procurement for transplantation

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World Journal of Critical Care Medicine 2024年第2期13卷 1-6页

作者： Francisca Del Rocio gonzalez Cohens fernando M gonzalez Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile

The procurement process for organ donation begins with the identification of potential organ donors in emergency or critical care units(CCU),followed by their clinical evaluation,diagnostic procedures,and therapeutic interventions,mostly conducted in *** concludes with the request for organ donation and,if accepted,the retrieval of *** most interventions occurring in detection units,there has been a neglect of the strategic role played by critical care specialists(CCS)in managing and caring for brain-dead or near-brain-death *** arise:Are they willing to undertake this responsibility?Do they fully comprehend the nature of organ procurement?Are they aware of the specific interventions required to maintain possible organ donors in optimal physiological condition?Our objective is to examine the role of CCS in organ procurement and propose ways to enhance it,ultimately aiming to increase and enhance organ donation rates.

关键词： Organ procurement Transplantation Brain death Cardiac death Organ donation

Kidney transplantation outcomes: Is it possible to improve when good results are falling down?

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World Journal of Transplantation 2024年第3期14卷 1-4页

作者： fernando M gonzalez Francisca del Rocío gonzalez Cohens Department of Nephrology Faculty of MedicineUniversidad de ChileSantiago 7500922Chile Web Intelligence Centre Faculty of Physics and Mathematical SciencesUniversidad de ChileSantiago 8370397Chile

Famure et al describe that close to 50%of their patients needed early or very early hospital readmissions after their kidney *** they taught us the variables related to those outcomes,we describe eight teaching capsules that may go beyond what they describe in their *** two capsules talk about the ideal donors and recipients we should choose for avoiding the risk of an early *** third and fourth capsules tell us about the reality of cadaveric donors and recipients with comorbidities,and the way transplant physicians should choose them to maximize *** capsule shows that any mistake can result in an early readmission,and thus,in poorer *** capsule talks about economic losses of early readmissions,cost-effectiveness of tran-splantation,and how to improve outcomes and reduce costs by managing a risky *** capsule argues about knowing your risk behavior to better manage your portfolio;and Eighth capsule about the importance of the center experience in transplanting complex *** finish with some lessons of the importance of the transplantation process and the collaboration with other disciplines in order to prevent the conditions that lead to early readmissions.

关键词： Kidney tranplantation Hospitalization Prognostic factors Portfolio theory Transplant

Feasibility of smart intraocular lens

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1379-1380页

作者： Francisco gonzalez CIMUS University of Santiago de CompostelaSantiago de Compostela 15782Spain Service of Ophthalmology and IDIS Complejo Hospitalario Universitario de Santiago de CompostelaSantiago de Compostela 15706Spain

Dear Editor,Wearable biosensors are monitoring implantable devices that provide real-time detection of biomarkers by means of non-invasive measurements[1].There is a high demand for novel sensors that can be comfortably used by the patients for clinical monitoring of ocular *** implanted into eyes have been improved and they have the capacity to monitor parameters such as intraocular pressure(IOP),and also have the possibility of recording lactic acid,glucose or cortisol levels[2-3].

关键词： intraocular clinical ocular

From the backyard to collective gardens in the “blue-courtyard”: Reversing the process of upgrading historic timber-framed courtyard buildings in Madrid

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Frontiers of Architectural Research 2024年第2期13卷 265-283页

作者： Esperanza gonzalez-Redondo Department of Architecture University of AlcalaMadridSpain

This paper presents an analytical framework for evaluating the impact of the two main processes identified in Madrid timber-framed courtyard buildings reinforcing the courtyard's crucial role in architectural heritage sustainability:their development caused dwellings to darken(1737–1950),and the existing challenge is to open new patios according to the listed buildings'protection *** findings in archival research and existing building assessments led to completed data collection and *** exploring construction expansion,from the house towards the collective prototype around a gradually reduced patio and dwelling darkening(1737–1786),buildings resulted in open,semiopen,underlighted and closed *** area on-site assessment uncovered the transition from the older low-rise type(1–3)floors to the modern closed model of up to(4–6)*** enlargements,consequently reducing original green areas and courtyards,call for reversing that process or formulating a new *** debates the partial demolition of listed buildings in upgrades and its agreement with the needed“blue courtyard”strategy(PGOUM),resulting from joining new rear individual patios to create a communal building block *** uncovered“in-between”type(1864),which integrates two open-air collective spaces,an inner courtyard and a back garden,appears challenging to explore.

关键词： Courtyard Sustainabledesign Architectural heritage Archives Timber-framed construction Social housing

Task Offloading in Edge Computing Using GNNs and DQN

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2649-2671页

作者： Asier Garmendia-Orbegozo Jose David Nunez-gonzalez Miguel Angel Anton Department of Applied Mathematics University of the Basque Country UPV/EHUEibar20600Spain TECNALIA Basque Research and Technology Alliance(BRTA)San Sebastian20009Spain

In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer task *** many resource-constrained devices,the computation of many types of tasks is not feasible because they cannot support such computations as they do not have enough available memory and processing *** this scenario,it is worth considering transferring these tasks to resource-rich platforms,such as Edge Data Centers or remote cloud *** different reasons,it is more exciting and appropriate to download various tasks to specific download destinations depending on the properties and state of the environment and the nature of the *** the same time,establishing an optimal offloading policy,which ensures that all tasks are executed within the required latency and avoids excessive workload on specific computing centers is not *** study presents two alternatives to solve the offloading decision paradigm by introducing two well-known algorithms,Graph Neural Networks(GNN)and Deep Q-Network(DQN).It applies the alternatives on a well-known Edge Computing simulator called PureEdgeSimand compares them with the two defaultmethods,Trade-Off and Round *** showed that variants offer a slight improvement in task success rate and workload *** terms of energy efficiency,they provided similar ***,the success rates of different computing centers are tested,and the lack of capacity of remote cloud servers to respond to applications in real-time is *** novel ways of finding a download strategy in a local networking environment are unique as they emulate the state and structure of the environment innovatively,considering the quality of its connections and constant *** download score defined in this research is a crucial feature for determining the quality of a download path

关键词： Edge computing edge offloading fog computing task offloading

Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente fernando Vazquez-Alonso Luis Javier Martinez-gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Efficient removal of the recalcitrant metamizole contaminant from drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of Environmental Sciences 2024年第2期136卷 56-67页

作者： Ernesto Valadez-Renteria Christian Perez-Carrasco Dulce Yolotzin Medina-Velazquez Vicente Rodriguez-gonzalez Jorge Oliva CONACYT-División de Materiales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

Metamizole(MZ)is a widely used anti-inflammatory *** to its common use,this contaminant is found in sewage and *** order to reduce the contamination produced by the MZ,we fabricated in this work a photocatalytic composite using recycled polyethylene(RPE)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a microplate-like morphology and sizes of 1.4–5.5μm according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a removal efficiency of 96%.When the RPE+LCCO composite was employed for the photocatalytic degradation of MZ,a maximum degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of MZ after 240 min of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RPE+LCCO composites and found that the maximum loss of degradation was 5%.Furthermore,scavenger experiments demonstrated that the super oxide and hydroxyl radicals are formed during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Raman analysis demonstrated the formation of defects(oxygen vacancies),those ones delayed the electron-hole recombination,which in turn,enhanced the degradation of the ***,the studies performed in this work proved that composites made with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharmaceutical compounds.

关键词： Photocatalysis Metamizole Pharmaceutical contaminant UV-Vis irradiation Perovskite