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Nonalcoholic fatty liver disease in type 2 diabetes: awareness is the first step toward change

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 493-496页

作者： fernando Bril Division of Endocrinology University of FloridaGainesvilleFLUSA Diabetes and Metabolism 2Internal MedicineDepartment of MedicineUniversity of FloridaGainesvilleFLUSA

In a recent article published in J Hepatol,Younossi et *** a comprehensive systematic review and meta-analysis on the prevalence of NAFLD,NASH and advanced fibrosis in patients with type 2 diabetes mellitus(T2DM)across the globe(1).Among the 80 studies included in the final analysis(for a total of 49,419 patients)the prevalence of NAFLD was between 50–70%in all continents,except for Africa,where a prevalence of 30.4%was *** lower prevalence of NAFLD in Africa is consistent with prior reports showing a lower prevalence of NAFLD among African-American individuals(2,3).Of note,once African-American patients develop NAFLD,their progression to NASH and advanced fibrosis is similar to other ethnic groups,and still a significant cause of cirrhosis in this population(4).

关键词： NAFLD prevalence al.

Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 486-495页

作者： Nelia Hernandez fernando Bessone Hospital de Clinicas Universidad de la RepublicaMontevideoUruguay Hospital Provincial del Centenario University of Rosario School of MedicineRosarioArgentina

Novel biological agents including cytokines and recombinant fusion proteins are increasingly prescribed for cancer,rheumatologic,autoimmune,and inflammatory diseases,and are currently being evaluated in hepatocellular carcinoma(HCC).They are classified by their mechanism of action and include tumor necrosis factor-alpha(TNF-α)antagonists,T cell mediated antitumor inhibitors,interleukin receptor antagonists,and immune checkpoint inhibitors(ICIs).Some ICIs cause frequent hepatotoxicity with a variable clinical,biochemical,and serological presentation,especially in patients receiving another immunomodulatory *** of the cases of liver damage induced by biological agents spontaneously regress after drug withdrawal,but the others require steroid ***,there are no widely accepted recommendation for the use of corticosteroids in these patients,even though international cancer societies have their own *** drug-induced autoimmune hepatitis(DIAIH)from classic AIH is challenging for pathologists,but liver biopsy is valuable,particularly in cases with unclear clinical ***,novel histological patterns have been described in liver damage induced by these agents(i.e.,endothelitis,ring granuloma and secundary sclerosing cholangitis associated with lymphocytic infiltration of cytotoxic CD8+T cells).Here,we describe the clinical and biochemical characteristics of patients with hepatotoxicity induced by TNF-αantagonists and *** issues involved in the administration of corticosteroid therapy,and hepatitis B virus(HBV)reactivation induced by immunosuppressive therapy are also discussed.

关键词： Hepatotoxicity Checkpoint inhibitors Biologics Autoimmune hepatitis Drug-induced liver injury

Range of adiposity and cardiorenal syndrome

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World Journal of Diabetes 2020年第8期11卷 322-350页

作者： fernando Pazos Department of Medicine Medicine FacultyCantabria UniversityValdecilla HospitalSantander 39080CantabriaSpain

Obesity and obesity-related co-morbidities,diabetes mellitus,and hypertension are among the fastest-growing risk factors of heart failure and kidney disease ***,which is not a unitary concept,or a static process,ranges from alterations in distribution to the amount of *** adiposity,which includes intraabdominal visceral fat mass and ectopic fat deposition such as hepatic,cardiac,or renal,was robustly associated with a greater risk for cardiorenal morbidity than subcutaneous *** addition,morbid obesity has also demonstrated a negative effect on cardiac and renal *** mechanisms by which adipose tissue is linked with the cardiorenal syndrome(CRS)are hemodynamic and mechanical changes,as well neurohumoral pathways such as insulin resistance,endothelial dysfunction,nitric oxide bioavailability,renin-angiotensin-aldosterone,oxidative stress,sympathetic nervous systems,natriuretic peptides,adipokines and *** and other associated co-morbidities induce adverse cardiac remodeling and interstitial *** failure with preserved ejection fraction has been associated with obesity-related functional and structural *** might also impair kidney function through hyperfiltration,increased glomerular capillary wall tension,and podocyte dysfunction,which leads to tubulointerstitial fibrosis and loss of nephrons and,finally,chronic kidney *** development of new treatments with renal and cardiac effects in the context of type 2 diabetes,which improves mortality outcome,has highlighted the importance of CRS and its *** body fat triggers cellular,neurohumoral and metabolic pathways,which create a phenotype of the CRS with specific cellular and biochemical *** has become a single cardiorenal umbrella or type of cardiorenal metabolic *** review article provides a clinical overview of the available data on the relationship between a range of adiposity

关键词： Obesity Morbid obesity Cardiorenal syndrome Heart failure Chronic kidney disease

Evolution of forest cover in Portugal: A review of the 12th–20th centuries

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Journal of Forestry Research 2014年第2期25卷 249-256页

作者： fernando Reboredo Joo Pais Universidade Nova de Lisboa Faculdade de Ciências e TecnologiaCICEGeDepartmento de Ciências da Terra

Portugal＇s forests in the 12th century were dominated by the Fagaceae represented by Quercus and Castanea, and several pine species From the 12th century onwards, forests underwent changes in their management starting with protection and ultimately leading to intense exploitation. The massive naval construction during the maritime expansion （mainly in the 15th-16th centuries） involved felling of approximately 5 million trees mainly Quercus suber, Pinus pinea and other Quercus species. Cumulative fuel-wood consumption of 959 Mm3 during 1300-1854 was attributed to demographic expansion while the deforestation rate during 1636-1854 accounted for a minimum of 72.6% and a maximum of 96% of total forest cover. The volume of timber used in railway sleepers from 1856 onwards might have reached 0.5 Mm3. The last quarter of the 20th century increased the forest cover of Portugal through the World Bank program of Eucalyptus globulus reforestation.

关键词： forest cover change forest exploitation forest economics Portugal.

On the Maximal Operator Associated with Certain Rotational Invariant Measures

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Acta Mathematica Sinica,English Series 2010年第6期26卷 993-1004页

作者： Adrián INFANTE fernando SORIA Department of Mathematics Universidad Simn Bolívar Department of Mathematics Universidad Autnoma de Madrid

The aim of this work is to investigate the integrability properties of the maximal operator Mu,associated with a non-doubling measure μ defined on Rn. We start by establishing for a wide class of radial and increasing measures μ that Mu is bounded on all the spaces Lu^p（R^n）,P〉***,we show that there is a radial and increasing measure p for which Mμ does not map Lμ^p（R^n） into weak Lμ^p（R^n）,1≤p〈∞.

关键词： maximal operator non-doubling measures

Predicting coastal morphological changes with empirical orthogonal function method

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Water Science and Engineering 2016年第1期9卷 14-20页

作者： fernando alvarez shun-qi pan Hydro-environmental Research Centre School of Engineering Cardiff University Cardiff CF24 3AA UK

In order to improve the accuracy of prediction when using the empirical orthogonal function （EOF） method, this paper describes a novel approach for two-dimensional （2D） EOF analysis based on extrapolating both the spatial and temporal EOF components for long-term prediction of coastal morphological changes. The approach was investigated with data obtained from a process-based numerical model, COAST2D, which was applied to an idealized study site with a group of shore-parallel breakwaters. The progressive behavior of the spatial and temporal EOF components, related to bathymetric changes over a training period, was demonstrated, and EOF components were extrapolated with combined linear and exponential functions for long-term prediction. The extrapolated EOF components were then used to reconstruct bathymetric changes. The comparison of the reconstructed bathymetric changes with the modeled results from the COAST2D model illustrates that the presented approach can be effective for long-term prediction of coastal morphological changes, and extrapolating both the spatial and temporal EOF components yields better results than extrapolating only the temporal EOF component.

关键词： EOF method Coastal morphological change Long-term prediction Process-based numerical model Shore-parallel breakwater

Impacts of global warming on southern California's winegrape climate suitability

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Advances in Climate Change Research 2020年第3期11卷 279-293页

作者： Corrie MONTE VERDE fernando DE SALES Geography Department San Diego State UniversitySan DiegoCA92182USA Center for Climate and Sustainability Studies San Diego State UniversitySan DiegoCA92182USA

Southern California has seen a resurgence of winegrowing regions in the past few decades,however the future of winegrape climatic suitability in the area has not been exhaustively *** study evaluated the future climate suitability for the cultivation of winegrape and potential global warming impacts on southern California's winegrowing regions through a series of high-resolution surface air temperature and precipitation projections obtained with the WRF-SSIB regional climate *** reveal that by mid-21st-century the surface air temperature will increase by approximately 1.2℃,while average precipitation will decrease by as much as 11%in the southern winegrowing areas under the Intergovernmental Panel on Climate Change high greenhouse-gas emissions *** of bioclimatic suitability indices indicate increases in heat accumulation for all major winegrowing areas;including an increase of about 10% in growing-degree day,while morning low temperatures in September may experience increases of approximately 11% in the future,thus impacting negatively the ripening stage of grapevines and leading to changes in wine composition and ***,the extent of areas classified under the cool to warm climate suitability categories could decrease by nearly 42% in the study area by *** in southern California are already warm and dry for viticulture and continuing heat accumulation increase,along with rainfall reduction,could potentially place additional stress to winegrape crop in the area,including advanced phenological timing and moisture deficit stress that could lead to decreases in *** projected decline in viticulture suitability highlights the need for adaptive capacity within this sector to mitigate the impacts of global *** mitigating strategies include planting hotter climate grape varieties,moving vineyards to regions that are more suitable in the future,and adopting dry-farming techniques.

关键词： Global warming Winegrape suitability Regional climate modeling Bioclimatic indices Dynamical downscaling

Investigation of particle-wall interaction in a pseudo-2D fluidized bed using CFD-DEM simulations

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Particuology 2016年第2期14卷 10-22页

作者： Tingwen Li Yongmin Zhang fernando Hernandez-Jimenez National Energy Technology Laboratory Morgantown WV26507 USA AECOM Morgantown WV 26507 USA State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China Universidad Carlos III of Madrid Department of Thermal and Fluid Engineering Av. de la Universidad 30 28911 Leganes Madrid Spain

We report on discrete element method simulations of a pseudo-two-dimensional （pseudo-2D） fluidized bed to investigate particle-wall interactions. Detailed information on macroscopic flow field variables, including solids pressure, granular temperature, and normal and tangential wall stresses are analyzed. The normal wall stress differs from the solids pressure because of the strong anisotropic flow behavior in the pseudo-2D system. A simple linear relationship exists between normal wall stress and solids pressure. In addition, an effective friction coefficient can be derived to characterize particle-wall flow interaction after evaluating the normal and tangential wall stresses. The effects of inter-particle and particle-wall friction coefficients are evaluated. Strong anisotropic flow behavior in the pseudo-2D system needs to be considered to validate the two-fluid model where the boundary condition is usually developed based on an isotropic assumption. The conclusion has been confirmed by simulation with different particle stiffnesses. Assumptions in the newly developed model for 2D simulation are further examined against the discrete element method simulation.

关键词： Gas-solid tlow Fluidized bed Computational fluid dynamics Discrete element method Particle-wall interaction Two-dimensional flow

Critical Success Factors to Improve the Game Development Process from a Developer＇s Perspective

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Journal of Computer Science & Technology 2016年第5期31卷 925-950页

作者： Saiqa Aleem Luiz fernando Capretz Faheem Ahmed College of Technological Innovation Zayed University Abu Dhabi 144534 United Arab Emirates Department of Electrical and Computer Engineering Western University Ontario N6A 5B9 Canada Department of Computing Science Thompson Rivers University Kamloops BC V2C OC8 Canada

The growth of the software game development industry is enormous and is gaining importance day by day. This growth imposes severe pressure and a number of issues and challenges on the game development community. Game development is a complex process, and one important game development choice is to consider the developer＇s perspective to produce good-quality software games by improving the game development process. The objective of this study is to provide a better understanding of the developer＇s dimension as a factor in software game success. It focuses mainly on an empirical investigation of the effect of key developer＇s factors on the software game development process and eventually on the quality of the resulting game. A quantitative survey was developed and conducted to identify key developer＇s factors for an enhanced game development process. For this study, the developed survey was used to test the research model and hypotheses. The results provide evidence that game development organizations must deal with multiple key factors to remain competitive and to handle high pressure in the software game industry. The main contribution of this paper is to investigate empirically the influence of key developer＇s factors on the game development process.

关键词： developer's perspective software game empirical investigation good-quality game game development process,game developer's factor