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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino rodrigues Santos Paolo Lucas rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino rodrigues Santos Paolo Lucas rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Regional validity of the parameters of a distributed runoff-erosion model in the semi-arid region of Brazil

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Science China(Technological Sciences) 2009年第11期52卷 3348-3356页

作者： SRINIVASAN Vajapeyam Srirangachar PAIVA fernanda Maria de lima Federal University of Campina Grande Post-graduate programme in Civil and Environmental Engineering Campus I 58429-900 Campina Grande PB Brazil

The present paper examines the validity of the application of a distributed rainfall-runoff-erosion model on a regional basis in a semi-arid region of Brazil. The model tested is known as WESP (Water Erosion Simulation Program) developed by Lopes (1987). The model simulates the hydrograph and the sediment graph for individual events and thus, the model when properly calibrated can serve as a predictive tool for runoff and soil erosion on an individual or a continuous basis. The possibility of the existence of regionally applicable values for the parameters of the model WESP would be very interesting from the point of view of predictability of runoff and soil erosion from ungauged basins in the region. For this purpose, data collected in several experimental units in the experimental basin of Sumé as well as in the experimental basin of So Joo de Cariri have been used. The model was calibrated and validated in each of the experimental units (consisting of erosion plots and micro-basins) and the average value from all of the units for each of the parameters was considered to be the regional value. With these average values, all the events in all the experimental units were simulated. The results show that the runoff and erosion values simulated with this single parameter set were very good in all the units, being well within the acceptable deviations.

关键词： regional parameters model WESP experimental basins semi-arid region soil erosion

Muscle strength and its association with cardiometabolic variables in adolescents:does the expression of muscle strength values matter?

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World Journal of Pediatrics 2021年第6期17卷 597-608页

作者： Tiago rodrigues de lima Xuemei Sui Luiz Rodrigo Augustemak de lima Diego Augusto Santos Silva Research Center in Kinanthropometry and Human Performance Federal University of Santa CatarinaTrinity University CampusFlorianopolisSC CEP 88010-970Brazil Department of Exercise Science Arnold School of Public HealthUniversity of South CarolinaColumbiaSCUSA Research Group On Biodynamics of Human Performance and Health Institute of Physical Education and SportFederal University of AlagoasMaceioBrazil

Background We investigate the association between different muscle strength(MS)indices with cardiometabolic variables in *** Cross-sectional study comprising 351 adolescents(male 44.4%,age 16.6±1.0 years)from *** was assessed by handgrip strength and analyzed in live difrerent ways:absolute MS and MS normalized for body weight,body mass index(BMI),height,and fat mass,*** variables investigated as outcomes were systolic and diastolic blood pressure(DBP),waist circumference(WC),high-sensitive C-reactive protein(hs-CRP),lipid and glucose metabolism *** linear regression models adjusted for confounding factors were *** Absolute MS and/or MS normalized for height was directly associated with WC[up to 32.8 *** error(SE)=4.7]and DBP(up to 8.8 mmHg,SE=0.8),and inversely associated with high-density lipoprotein cholesterol(up to-8.0 mg/***=14.1).MS normalized for body *** or fat inass was inversely associated with WC(up to-17.5 cm,SE=2.2).According tesex,MS normalized for fat mass was inversely associated with triglycerides(male:0.02 times lower,SE=0.01;female:0.05 times lower,SE=0.01)and homeostatic model assessment for insulin resistance(male:0.02 times lower,SE=0.01;female:0.06 times ***=0.01).and inversely associated with hs-CRP only among male(0.03 times lower,SE=0.01).Conclusion When normalized for body weight,BMI or fat mass,MS was superior to absolute MS or MS normalized for height in representing adequately cardiometabolic variables among adolescents.

关键词： Abdominal C-reactive protein Hand strength Insulin resistance Obesity Triglycerides

Association of sleep quality with sociodemographic factors and lifestyle in adolescents from southern Brazil

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World Journal of Pediatrics 2018年第4期14卷 383-391页

作者： Tiago rodrigues de lima Diego Augusto Santos Silva Physical Education Department Federal University of Santa CatarinaProfessor Clementino de Britto Street362 ap 334 CapoeirasFlorianópolisSanta CatarinaBrazil

Background Good sleep quality is an essential component for growth, development, and physical and mental health of the individual, in addition to being a positive indicator of health and well-being. The objective of this study was to estimate the prevalence of poor sleep quality and to identify the association of poor sleep quality with sociodemographic factors, lifestyle, weight status, and associated aerobic fitness in adolescents. Methods This study included 1110 students aged 14–19 years from city of S?o José/SC, Brazil. Sleep quality of the subjects was assessed using a questionnaire and classified as adequate and low. Independent variables were gender, age, monthly household income, maternal education, school shift, global physical activity, proper diet, screen time, sleeping hours of full week, sleeping hours of weekdays, sleeping hours of weekends, weight status, and aerobic fitness. Binary logistic regression was used to estimate odds ratios and confidence intervals of 95%. Results Prevalence of poor sleep quality was 60.4%. More likely to have poor sleep quality were identified in female students (OR 1.68, 95% CI 1.11–2.55), whose mothers had higher levels of education (OR 1.44, 95% CI 1.20–1.73) and low aerobic fitness (OR 1.80, 95% CI 1.02–3.19). Conclusion Adolescents who were most likely to report poor sleep quality were female, those whose mothers had a higher educational level and had low aerobic fitness. Students with sedentary risk behavior were less likely of reporting poor sleep quality.

关键词： Adolescents Brazil Cross-sectional studies Demographic indicators Sleep hygiene

Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

Characterization and electrochemical performance of CeO2 and Eu-doped CeO2 films as a manganese redox flow battery component

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Journal of Rare Earths 2018年第10期36卷 1074-1083页

作者： Monica A.rodrigues Ariadne C.Catto Elson Longo Edson Nossol Renata C.lima Institute of Chemistry.Federal University of Uberlandia 38400-902UberlandiaMGBrazil Institute of Chemistry Sao Paulo State UniversityP.O.Box 35514801-907Araraquara.SPBrazil LIEC Department of ChemistryFederal University of Sao Carlos13565-905Sao CarlosSPBrazil

Hexagonal CeO2 and Eu-doped CeO2 nanoparticles were obtained using a facile microwave-hydro thermal method under mild conditions and their application towards manganese redox flow battery component were studied. The structural properties were studied by X-ray diffraction and indicate that samples present a fluorite structure. Raman spectroscopy shows Eu3＋ ions substitute Ce4＋ and generate oxygen vacancies. Electrochemical properties of pure and Eu-doped CeO2 films deposited at graphite substrates investigated by cyclic voltammetry and galvanostatic charge-discharge indicate that dopant concentration affects the electrochemical properties of CeO2. The increase in the reversibility redox of electrochemical systems observed is attributed to coexistence of Ce4＋/Ce3＋ redox couple confirmed by ***-discharge tests display coulombic and voltage efficiency values of above 80% and 90%, respectively. The obtained specific capacity for Ce（0.99）Eu（0.01）O2（372.49 mAh/g） and pure oxide（334.84 mAh/g）indicates that both samples are promising for application in Mn-batteries.

关键词： Cerium oxide Europium Nanoparticles Electrochemical properties Batteries Rare earths

Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration

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Cellular & Molecular Immunology 2019年第10期16卷 833-834页

作者： Joao Moura Joao rodrigues Marta Gonçalves Claudia Amaral Margarida lima Eugenia Carvalho Center for Neuroscience and Cell Biology(CNC) University of CoimbraCoimbraPortugal INEB-Instituto Nacional de Engenharia Biomedica University of PortoPortoPortugal I3S-Instituto de Investigaçao e Inovaçao em Saude University of PortoPortoPortugal Department of Hematology Hospital de Santo Antonio(HSA)Centro Hospitalar Universitario do Porto(CHUP)PortoPortugal Unidade Multidisciplinar de Investigaçao Biomedica(UMIB/ICBAS/UP) PortoPortugal Department of Endocrinology Hospital de Santo Antonio(HSA)Centro Hospitalar Universitário do Porto(CHUP)PortoPortugal Department of Geriatrics University of Arkansas for Medical Sciences(UAMS)and Arkansas Children’s Hospital Research Institute(ACHRI)Little RockArkansas 72202USA

Diabetes is a growing epidemic due to the systematic increase in overweight and obesity,and chronic diabetic foot ulcers(DFUs)are the most debilitating and costly complication of *** is still essential for DFU care,but early detection is limited because we do not have a good DFU ***,we report the preliminary results of a large longitudinal study to test the effectiveness of the use of T-cell phenotype and TCR repertoire diversity as DFU *** results show that the ratio of effector/naïve T-cells and the number of TCR expansions are valuable biomarkers of DFU prognosis.

关键词： diabetic chronic obesity