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FeedEfficiencyService: An architecture for the comparison of data from multiple studies related to dairy cattle feed efficiency indices

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Information Processing in Agriculture 2022年第3期9卷 378-396页

作者： Heitor Magaldi Linhares Regina Braga Wagner Antonio Arbex Mariana Magalhaes campos fernanda campos Jose Maria N.David Victor Stroele Programa de Pos-Graduacao em Ciencia da Computacao Universidade Federal de Juiz de ForaCampus UniversitarioRua JoseLourenco Kelmers/n-Sao PedroJuiz de ForaMinas Gerais 36036-900Brasil Brazilian Agricultural Research Corporation-Embrapa Av.Eugenio do Nascimento610-AeroportoJuiz de Fora-MGMinas Gerais 36038-330Brasil

The increased demand for food worldwide,the reduced land availability for livestock pro-duction,the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more *** tackle this problem,we propose the use of computational support to help researchers compare data on feed efficiency,therefore improving economic and environ-mental *** a solution,we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency *** proposed architecture,called FeedEfficiencyService,classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference *** results obtained from a case study with researchers from the Brazilian Agri-cultural Research Corporation–Dairy Cattle(EMBRAPA)demonstrate that this architecture is a supporting tool in their daily work *** researchers highlighted the importance of the proposed architecture as it allows analyzing animal data,comparing experiments,having reliable data analyses,and standardizing and organizing data from *** novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related *** store such data,relationships,and analyses of results in an inte-grated *** solution ensures unified access to the processing history and data from diverse experiments,including those conducted at external research centers.

关键词： Dairy Cattle

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Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?

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Neural Regeneration Research 2022年第9期17卷 1945-1954页

作者： Sofia fernanda Gonçalves Zorzella-Pezavento Luiza Ayumi Nishiyama Mimura Marina Bonifácio Denadai William Danilo Fernandes de Souza Thais fernanda de campos Fraga-Silva Alexandrina Sartori Department of Chemical and Biological Sciences Institute of BiosciencesSão Paulo State University(UNESP)BotucatuSão PauloBrazil

Multiple sclerosis is an autoimmune treatable but not curable *** are a multiplicity of medications for multiple sclerosis therapy,including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease *** all patients respond well to these therapies,and minor to severe adverse effects have been *** D,called sunshine vitamin,is being studied as a possible light at the end of the *** this review,we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis,the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis ***,based on our and other groups’experimental findings,we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.

关键词： central nervous system cytokines experimental autoimmune encephalomyelitis immunomodulation immunopathogenesis inflammation multiple sclerosis neuroprotection regulatory T cells vitamin D

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Addressing inclusion,innovation,and sustainability challenges through the lens of economic geography:Introducing the hierarchical regional innovation system

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地理学与可持续性（英文） 2024年第1期5卷 1-12页

作者： Iván Tartaruga fernanda Sperotto Luís Carvalho Centre of Studies in Geography and Spatial Planning(CEGOT) Faculty of Arts and HumanitiesUniversity of PortoPorto 4150-564Portugal Centre of Studies in Geography and Spatial Planning(CEGOT) Faculty of Arts and HumanitiesUniversity of PortoPorto 4150-564Portugal School of Economics and Management University of PortoPortoPortugal

The world is facing dramatic challenges related to environmental sustainability at an accelerating *** this context,the field of economic geography(EG)has been playing an important role in understanding both the socioeconomic and technological dimensions of these challenges,as it deals with a variety of complementary notions and *** from this lens,our aim is to explore a conceptual framework that can help us to understand environmental changes relating to multi-dimensional territorial development,notably in eco-nomic contexts where inequality is high,and stratification based on hierarchies regulate social and economic *** on the territory concept,we propose the original notion of a hierarchical regional innovation system(HRIS)that emphasises the pervasive role of hierarchies(powers)in regional innovation systems and illustrate its value with evidence and case studies from extant literature on sustainability *** HRIS can help us understand and promote development paths considering the contribution of inclusive eco-innovations(another original conceptual amalgam).Through some empirical cases from other studies in low-carbon transitions,we show the application of the HRIS(and inclusive eco-innovation)*** conclusion,we provide incen-tives to explore new regional innovation systems,alongside the HRIS,adapted to different regions worldwide and centred on the inclusiveness of people and places.

关键词： Inclusive eco-innovation Inclusive innovation Hierarchical regional innovation system (HRIS) Territorial development Sustainable development Sustainability transitions

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Antarctic red algae in dye-sensitized photoelectrochemical cells for water splitting

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Advances in Polar Science 2024年第2期35卷 219-227页

作者： Florentina ARISPE María fernanda CERDÁ Laboratorio de Biomateriales IQBFacultad de CienciasUdelaRMontevideo 11400Uruguay

Phycoerythrin extracted from Antarctic red seaweeds shows promising characteristics to be applied as an anode sensitizer in water-splitting photoelectrochemical *** light irradiation and using an LED lamp,the red-colored protein shows an interesting ability to profit the incident light,as confirmed by the presence of oxygen bubbles next to the electrode surface without applying any external *** results showed that the addition of iodide is helpful to allow the regeneration of the dye;nevertheless,oxygen evolution is not *** analysis of the involved semi-reactions is also helpful to understand the observed *** exploration of Antarctic resources offers then an alternative for the development of green energies,with a particular focus on their use as sensitizers to profit from the sunlight in water-splitting as well as in photovoltaic devices.

关键词： sensitizers water-splitting red algae electrochemical

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Habitat and food preferences of European rabbits in core and edge populations along the invasion front PatagoniaMonte,Argentina

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Current Zoology 2024年第3期70卷 310-319页

作者： Sabrina Yasmin Bobadilla María ADacar Fabián MJaksic Ricardo AOjeda María fernanda Cuevas Ecología de Mamíferos de Tierras Secas IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Laboratorio de Filogeografía Taxonomía Integrativa y Ecología(LFTIE)IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Center of Applied Ecology and Sustainability(CAPES) Pontifcia Universidad Católica de ChileAv.Libertador Bernardo O'Higgins 340Santiago 8320000Región MetropolitanaChile

The European rabbit Oryctolagus cuniculus is an exotic herbivorous mammal undergoing an active phase of geographical expansion in the arid ecosystems of *** Adaptive Flexibility Hypothesis states that populations at the range edge(new populations)will exhibit greater fexibility in the use of resources compared with populations located in the range core(older populations).The objective of this work was to compare the rabbit’s use of spatial and trophic resources in relation to the establishment time of their *** sampling was carried out for 2 years(2017 and 2018)in sites with different establishment times for rabbit *** sampling stratifed by type of habitat was applied using 115 fxed strip transects of 1,000 m2 laid out across the study *** rabbit signs were recorded in each transect,and environmental and anthropic variables were *** results show that the individuals from the range edge are more selective in the use of habitat than those from the range *** the microhabitat level,we observed a pattern in the particular components of habitat use by rabbits mainly linked to food availability and proximity to *** a trophic perspective,rabbits could show fexible adjustment to novel conditions and environments in the range *** variability in resource use by the European rabbit confrms its ecological fexibility,pivotal for their advance toward new environments in Argentina.

关键词： Arid ecosystems invasive species novel environments range invasion spatial use trophic use

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Structural changes in the obese brain

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Neural Regeneration Research 2024年第12期19卷 2561-2562页

作者： Anna R.R.Da Conceicao Marcelo N.N.Vieira fernanda G.De Felice D’Or Institute for Research and Education Rio de JaneiroBrazil Institute of Medical Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for Neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).

关键词： diseases consequences prevalence

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C57BL/6 and DBA/1 Mice Differ in Their Response to Supplementation with 1,25D and Paricalcitol

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Biomedical and Environmental Sciences 2018年第8期31卷 613-618页

作者： Aline Parisoto Missio Thais fernanda de campos Fraga-Silva Larissa Lumi Watanabe Ishikawa Luiza Ayumi Nishiyama Mimura Thais Graziela Donega Franga Larissa Ragozo Cardoso de Oliveira Alexandrina Sartori Sofia Femanda Goncalves Zorzella-Pezavento Department of Microbiology and Immunology Sao Paulo State University(UNESP)Institute of BiosciencesBotucatuSao PauloBrazil

Active vitamin D (1,25D) is a fat-soluble vitamin that is mainly produced in the skin by the conversion of 7-dehydrocholesterol under ultraviolet light *** role in calcium homeostasis,bone growth, and prevention of ri... 详细信息

关键词： DBA BL C57BL/6 and DBA/1 Mice Differ in Their Response to Supplementation with 1,25D and Paricalcitol

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Activation of stress-response genes by retrograde signaling-mediated destabilization of nuclear importin IMPα-9 and its interactor TPR2

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Molecular Plant 2024年第6期17卷 884-899页

作者： Liping Zeng Maria fernanda Gomez Mendez Jingzhe Guo Jishan Jiang Bailong Zhang Hao Chen Brandon Le Haiyan Ke Katayoon Dehesh Department of Botany and Plant Sciences Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideRiversideCA 92521USA School of Medicine University of CaliforniaRiversideRiversideCA 92521USA

Stress-induced retrograde signal transmission from the plastids to the nucleus has long puzzled plant *** address this,we performed a suppressor screen of the ceh1 mutant,which contains elevated 2-C-methyl-d-erythritol-2,4-cyclopyrophosphate(MEcPP)levels,and identified the gain-of-function mutant impα-9,which shows reversed dwarfism and suppressed expression of stress-response genes in the ceh1 background despite heightened *** genetic and biochemical analyses established that the accumulation of MEcPP initiates an upsurge in Arabidopsis SKP1-like 1(ASK1)abundance,a pivotal component in the proteasome degradation *** increase in ASK1 prompts the degradation of IMPα-***,we uncovered a protein-protein interaction between IMPα-9 and TPR2,a transcriptional co-suppressor and found that a reduction in IMPα-9 levels coincides with a decrease in TPR2 ***,the interaction between IMPα-9 and TPR2 was disrupted in impα-9 mutants,highlighting the critical role of a single amino acid alteration in maintaining their *** of their interaction results in the reversal of MEcPP-associated *** immunoprecipitation coupled with sequencing analyses revealed that TPR2 binds globally to stress-response genes and suggested that IMPα-9 associates with the *** function together to suppress the expression of stress-response genes under normal conditions,but this suppression is alleviated in response to stress through the degradation of the suppressing *** biological relevance of our discoveries was validated under high light stress,marked by MEcPP accumulation,elevated ASK1 levels,IMPα-9 degredation,reduced TPR2 abundance,and subsequent activation of a network of stress-response *** summary,our study collectively unveils fresh insights into plant adaptive mechanisms,highlighting intricate interactions among retrograde signaling,the proteasome,and nuclear transport machinery.

关键词： plastidial retrograde signal MEcPP ASK1 impα-9 TPR2

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira Vidal Luiz Fernando Alvarenga Ribeiro Marco Antonio de Carvalho-Filho fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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