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Hyperhomocysteinemia.a.d a.socia.ed Biologica. Ma.kers in a.Congolese Popula.ion of.Type 2 Dia.etes Mellitus in Bra.za.ille

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Open Journa. of.Endocrine a.d Meta.olic Disea.es 2024年第6期14卷 123-134页

作者： V. R. Ikia.Monde a. L. M. Boumba.E. Mokondjimobe H. Poa.y G. Louba.o-Voumbi W. f. Ondongo a. G. Ma.indou Kimba.gu K. Ona.ga.f. Elilie Ma.a.Ongoth E. Boueniza.ila.C. a.dres H. G. Mona.eka Biochemistry La.ora.ory Service University Hospital Center Brazzaville Congo f.0}ulty of.Hea.th Sciences Marien NGOUABI University Brazzaville Congo Resea.ch a.ea.of.Pointe-Noire National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Congo Microbiology a.d Molecula. Biology Depa.tment Loandjili General Hospital Pointe-Noire Congo LOMO Resea.ch University Kinshasa DRC Depa.tment of.Sta.istics Health Information and Epidemiology Surveillance Departmental Directorate of Health Care and Services Brazzaville Congo Depa.tment of.Endocrinology University Hospital Center Brazzaville Congo Depa.tment of.Biochemistry a.d Molecula. Biology Bretonneau Regional University Hospital Tours France

The sea.ch f.r new bioma.kers predictive of.type 2 dia.etes currently constitutes a.resea.ch a.enue in Bioclinica.. Tota. homocysteine rema.ns a.pref.rred ta.get due to its involvement in the occurrence of.degenera.ive complica.ions in type 2 dia.etics. The a.m of.this work wa. to study hyperhomocysteinemia.a.d other biochemica. ma.kers a.socia.ed with T2D in the Congolese popula.ion. This wa. a. a.a.ytica. ca.e-control study ca.ried out between October 2022 a.d October 2023. The study popula.ion consisted of.150 subjects including 100 T2D pa.ients a.d 50 control subjects. The ma.n clinica. da.a.were collected on a.pre-esta.lished f.rm. Homocysteine determina.ion wa. ca.ried out by the sa.dwich ELISa.method. The other biochemica. ma.kers were mea.ured by colorimetric enzyma.ic methods. Hyperhomocysteinemia.wa. present in 27.3% (41/150) of.the entire study popula.ion. Type 2 dia.etics ha. a.f.equency of.hyperhomocysteinemia.of.36% (36/100) a.d control 10% (5/50) (p = 0.001). The mea. hyperhomocysteinemia.concentra.ion wa. 31.9 μmol/l with extremes ra.ging f.om 18 to 103 μmol/l. Mea.s of.biologica. ma.kers between dia.etics a.d controls showed a.sta.istica.ly signif.ca.t dif.erence (p = 0.01). The risk f.0}tors a.socia.ed with this HHcy were: sex (OR = 3.5), a.e (OR = 9.4), sedenta.y lif.style (OR = 3.4) a.d glycosyla.ed hemoglobin (OR = 12) with a.p-va.ue a. hyperhomocysteinemia.ca. be considered a. a.predictive bioma.ker in the bioclinic of.Congolese type 2 dia.etic pa.ients.

关键词： Hyperhomocysteinemia Biologica. Ma.kers T2DM Bra.za.ille

a.tempts to restore loss of.f.nction in da.a.ed a.D cells open the wa. to non-muta.iona. oncogenesis

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Genes & Disea.es 2024年第3期11卷 5-6页

作者： Vla.imir f.Niculescu 86420 Diedorf Germany Kirschenweg

This correspondence to Gene&Disea.es ca.ls a.tention to the controversy between proponents of.genetic modif.ca.ion in ca.cinogenesis a.d supporters of.non-muta.iona. *** f.om molecula. ca.cer resea.ch a.d f.ndings f.om evolutiona.y ca.cer cell biology support the la.ter cla.m a.d provide no ra.iona.e f.r the muta.iona. origin of.spora.ic *** is more conceiva.le tha. the genera. susceptibility of.a.ymmetric cell division(a.D)phenotypes to oxygen lea.s to irrepa.a.le DNa.def.cts a.d dysregula.ed def.ctive symmetric cell division(DscD)phenotypes.

关键词： ra.iona. la.ter f.nding

Linking IL-10 signa.ing with lipid meta.olic progra.s in ma.ropha.es:dysregula.ed cera.ide homeosta.is drives colitis

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第7期9卷 2835-2836页

作者： Imke a.reya.Ma.kus f.Neura.h Depa.tment of.Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immunthera.ie(DZI) ErlangenGermany

In a.recent study published in Na.ure,York a.d coworkers identif.ed the immunometa.olic regula.ion of.mono-unsa.ura.ed f.0}ty a.id(MUf.0}pools a.d the subsequent increa.e in sphingolipid biosynthesis in TLR2-a.tiva.ed ma.ropha.es a. a. importa.t link between impa.red IL-10 signa.ing a.d the development of.intestina. inf.a.ma.ion.1 Thus,ta.geted interf.rence with the newly identif.ed IL-10/MUf.0}sphingolipid a.is a.pea.s a. a.promising stra.egy to restore immunometa.olic homeosta.is in the intestine of.pa.ients with inf.a.ma.ory bowel disea.es(IBD).

关键词： homeosta.is impa.red intestine

a.Ra.e Ca.e of.a.rtic Va.ve Endoca.ditis a.d a.ute Meningitis Due to Ha.mophilus inf.uenza.

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Ca.e Reports in Clinica. Medicine 2024年第6期13卷 207-211页

作者： Za.ha.y M. Visinoni Justin D. Tse Christopher f. Pea.e Depa.tment of.Gra.ua.e Medica. Educa.ion Interna. Medicine Residency Sutter Roseville Medical Center Roseville USA Sutter Medica. Group Roseville USA

Ha.EK orga.isms represent a.ra.e but importa.t group of.ca.sa.ive pa.hogens in endoca.ditis. These ba.teria.ha.e historica.ly been a.socia.ed with culture-nega.ive endoca.ditis;however, modern la.ora.ory techniques ha.e ma.e this less common. In this ca.e, we present a.74-yea.-old ma. who presented with a.ute onset a.tered menta.ion, f.ver, a.d sepsis. He wa. ultima.ely f.und to ha.e Ha.mophilus inf.uenza. meningitis, cerebra. empyema. a.rtic va.ve endoca.ditis, psoa. myositis, a.d L2 - L3 diskitis with osteomyelitis. a.though Ha.EK orga.isms a.e commonly f.und in the oropha.ynx a.d upper respira.ory tra.t in huma.s, our pa.ient did not report recent preceding denta. or ENT procedures. H. inf.uenza. is responsible f.r a.proxima.ely 0.16% of.a.l ca.es of.ba.teria. endoca.ditis, representing a.very limited subset. a.though genera.ly considered low virulent pa.hogens, this ca.e demonstra.es the unusua. extent of.inf.ction f.om a.Ha.EK orga.ism, H. inf.uenza., ca.sing a.rtic va.ve endoca.ditis a. well a. a.ypica. non-ca.dia. sequela., including a.ute meningitis.

关键词： Ha.EK Ha.mophilus inf.uenza. a.rtic Va.ve Endoca.ditis Ba.teria. Meningitis Cerebra. Empyema

Pa.a.eter-f.ee Shif.ed La.la.ia. Reconstruction f.r Multiple Kernel Clustering

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IEEE/Ca. Journa. of.a.toma.ica.Sinica 2024年第4期11卷 1072-1074页

作者： Xi Wu Zhenwen Ren f.Richa.d Yu the School of.Na.iona. Def.nce Science a.d Technology Southwest University of Science and TechnologyMianyang 621010China the School of.Na.iona. Def.nce Science a.d Technology Southwest University of Science and TechnologyMianyang 621010 the Gua.gxi Key La.ora.ory of.Ma.hine Vision a.d Intelligent Control Wuzhou UniversityWuzhou 543002 the Gua.gdong La.ora.ory of.a.tif.cia. Intelligence a.d Digita. Economy(SZ) Shenzhen 518060China

Dea. Editor,This letter proposes a.pa.a.eter-f.ee multiple kernel clustering(MKC)method by using shif.ed La.la.ia. *** MKC ca. ef.ectively cluster nonlinea. da.a.but it f.0}es two ma.n cha.lenges:1)a. a. unsupervised method,it is up a.a.nst pa.a.eter problems which ma.es the pa.a.eters intra.ta.le to tune a.d is unf.a.ible in rea.-lif. a.plica.ions;2)Only considers the clustering inf.rma.ion,but ignores the interf.rence of.noise within La.la.ia..

关键词： pa.a.eter letter Pa.a.eter

Inf.ow a.d outf.ow permea.ility tests in a.very sof. cla. under low stresses

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Journa. of.Rock Mecha.ics a.d Geotechnica. Engineering 2024年第8期16卷 3270-3283页

作者： J.W.S.Va.ga. f.a.B.Da.ziger f.R.Lopes T.Lunne f.dera. University of.Rio de Ja.eiro Rio de JaneiroBrazil Norwegia. Geotechnica. Institute OsloNorway

In situ inf.ow a.d outf.ow permea.ility tests with the Ba. probe a. Sa.a.uíII sof. cla. test site a.e presented.a.description of.the Ba. permea.ility test is provided,discussing its a.va.ta.es a.d shortcomings,especia.ly in the ca.e of.very sof. cla.s under low *** pressures were monitored during probe insta.la.ion a.d were f.und to be slightly lower tha. piezocone u2 pore pressures,consistent with the position of.the *** role of.f.lter tip sa.ura.ion wa. investiga.ed a.ter the usua. sa.ura.ion procedure provided a. unsa.isf.0}tory pore pressure response during probe *** show tha. the va.uum sa.ura.ion procedure provides a.equa.e response during insta.la.ion a.d increa.es the relia.ility of.the coef.icient of.permea.ility determina.ion in ea.ly *** inf.ow a.d outf.ow tests yielded simila. results,indica.ing tha. ca.ef.l execution of.the test ca. lea. to good test repea.a.ility rega.dless of.the loa.ing *** sequences of.a.terna.ed inf.ow a.d outf.ow tests ha.e yielded simila. results,indica.ing tha. soil reconsolida.ion a.d f.lter clogging were negligible in the tests *** a.e presented concerning the rela.ionship between index pa.a.eters a.d the in situ coef.icient of.permea.ility f.r Sa.a.uíII cla.,which plot outside the ra.ge of.existing da.a.a.es.

关键词： Permea.ility test Sof. cla. Ba. probe Inf.ow a.d outf.ow tests

Optimiza.ion of.Stea.thwa.ch Network Security System f.r the Detection a.d Mitiga.ion of.Distributed Denia. of.Service (DDoS) a.ta.k: a.plica.ion to Sma.t Grid System

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Communica.ions a.d Network 2024年第3期16卷 108-134页

作者： Emma.uel S. Kola.ole Penrose S. Cof.e John H. f.ller Ca.eta. M. a.ujuobi Emma.uel a. Da.a.Justin f. f.rema. Pa.ela.H. Obiomon Electrica. a.d Computer Engineering Depa.tment Prairie View A&M University Prairie View TX USA

The Sma.t Grid is a. enha.cement of.the tra.itiona. grid system a.d employs new technologies a.d sophistica.ed communica.ion techniques f.r electrica. power tra.smission a.d distribution. The Sma.t Grid’s communica.ion network sha.es inf.rma.ion a.out sta.us of.its severa. integra.ed IEDs (Intelligent Electronic Devices). However, the IEDs connected throughout the Sma.t Grid, open opportunities f.r a.ta.kers to interf.re with the communica.ions a.d utilities resources or ta.e clients’ priva.e da.a. This development ha. introduced new cyber-security cha.lenges f.r the Sma.t Grid a.d is a.very concerning issue beca.se of.emerging cyber-threa.s a.d security incidents tha. ha.e occurred recently a.l over the world. The purpose of.this resea.ch is to detect a.d mitiga.e Distributed Denia. of.Service [DDoS] with a.plica.ion to the Electrica. Sma.t Grid System by deploying a. optimized Stea.thwa.ch Secure Network a.a.ytics tool. In this pa.er, the DDoS a.ta.k in the Sma.t Grid communica.ion networks wa. modeled using Stea.thwa.ch tool. The simula.ed network consisted of.Secure Network a.a.ytic tools virtua. ma.hines (VMs), electrica. Grid network communica.ion topology, a.ta.kers a.d Ta.get VMs. f.na.ly, the experiments a.d simula.ions were perf.rmed, a.d the resea.ch results showed tha. Stea.thwa.ch a.a.ytic tool is very ef.ective in detecting a.d mitiga.ing DDoS a.ta.ks in the Sma.t Grid System without ca.sing a.y bla.kout or shutdown of.a.y interna. systems a. compa.ed to other tools such a. GNS3, NeSSi2, NISST f.a.ework, OMNeT++, INET f.a.ework, Rea.E, NS2, NS3, M5 Simula.or, OPNET, PLC & TIa.Porta. ma.a.ement Sof.wa.e which do not ha.e the ca.a.ility to do so. a.so, using Stea.thwa.ch tool to crea.e a.security ba.eline f.r Sma.t Grid environment, contributes to risk mitiga.ion a.d sound security hygiene.

关键词： Sma.t Grid System Distributed Denia. of.Service (DDoS) a.ta.k Intrusion Detection a.d Prevention Systems Detection Mitiga.ion a.d Stea.thwa.ch

Python Server Pa.e Perf.rma.ce a.a.ysis a.d Modeling

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Communica.ions a.d Network 2024年第1期16卷 1-30页

作者： Ra.a.indra.be Ma.ola.y a.ix Ra.dria.omenja.a.a.y La.a.f.rdina.d Ra.a.a.ta.a.tsoa.f.nta.ne Ma.a.ody Thoma. f. a.gelo Ra.erinirina University of.f.a.a.a.tsoa Fianarantsoa Madagascar

Toda., in the f.eld of.computer networks, new services ha.e been developed on the Internet or intra.ets, including the ma.l server, da.a.a.e ma.a.ement, sounds, videos a.d the web server itself.a.a.he. The number of.solutions f.r this server is theref.re growing continuously, these services a.e becoming more a.d more complex a.d expensive, without being a.le to f.lf.ll the needs of.the users. The a.sence of.benchma.ks f.r websites with dyna.ic content is the ma.or obsta.le to resea.ch in this a.ea. These users pla.e high dema.ds on the speed of.a.cess to inf.rma.ion on the Internet. This is why the perf.rma.ce of.the web server is critica.ly importa.t. Severa. f.0}tors inf.uence perf.rma.ce, such a. server execution speed, network sa.ura.ion on the internet or intra.et, increa.ed response time, a.d throughputs. By mea.uring these f.0}tors, we propose a.perf.rma.ce eva.ua.ion stra.egy f.r servers tha. a.lows us to determine the a.tua. perf.rma.ce of.dif.erent servers in terms of.user sa.isf.0}tion. f.rthermore, we identif.ed perf.rma.ce cha.a.teristics such a. throughput, resource utiliza.ion, a.d response time of.a.system through mea.urement a.d modeling by simula.ion. f.na.ly, we present a.simple queue model of.a. a.a.he web server, which rea.ona.ly represents the beha.ior of.a.sa.ura.ed web server using the Simulink model in Ma.la. (Ma.rix La.ora.ory) a.d a.so incorpora.es spora.ic incoming tra.f.c. We obta.n server perf.rma.ce metrics such a. a.era.e response time a.d throughput through simula.ions. Compa.ed to other models, our model is conceptua.ly stra.ghtf.rwa.d. The model ha. been va.ida.ed through mea.urements a.d simula.ions during the tests tha. we conducted.

关键词： Perf.rma.ce a.a.ysis Queue Perf.rma.ce Model Web Server Internet World Wide Web Web Server Perf.rma.ce

Endopla.mic reticulum stress,a.topha.y,neuroinf.a.ma.ion,a.d sigma.1 receptors a. contributors to depression a.d its trea.ment

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2202-2211页

作者： Chika.f.jii Cha.les f.Zorumski Yukitoshi Izumi Depa.tment of.Psychia.ry Washington University School of MedicineSt.LouisMOUSA Ta.lor f.0}ily Institute f.r Innova.ive Psychia.ric Resea.ch Washington University School of MedicineSt.LouisMOUSA

The etiologica. f.0}tors contributing to depression a.d other neuropsychia.ric disorders a.e la.gely undef.ned. Endopla.mic reticulum stress pa.hwa.s a.d a.topha.y a.e well-def.ned mecha.isms tha. pla. critica. f.nctions in recognizing a.d resolving cellula. stress a.d a.e possible ta.gets f.r the pa.hophysiology a.d trea.ment of.psychia.ric a.d neurologic illnesses. a. increa.ing number of.studies indica.e the involvement of.endopla.mic reticulum stress a.d a.topha.y in the control of.neuroinf.a.ma.ion, a.contributing f.0}tor to multiple neuropsychia.ric illnesses. Initia. inf.a.ma.ory triggers induce endopla.mic reticulum stress, lea.ing to neuroinf.a.ma.ory responses. Subsequently, induction of.a.topha.y by neurosteroids a.d other signa.ing pa.hwa.s tha. converge on a.topha.y induction a.e thought to pa.ticipa.e in resolving neuroinf.a.ma.ion. The a.m of.this review is to summa.ize our current understa.ding of.the molecula. mecha.isms governing the induction of.endopla.mic reticulum stress, a.topha.y, a.d neuroinf.a.ma.ion in the centra. nervous system. Studies f.cused on inna.e immune f.0}tors, including neurosteroids with a.ti-inf.a.ma.ory roles will be reviewed. In the context of.depression, a.ima. models tha. led to our current understa.ding of.molecula. mecha.isms underlying depression will be highlighted, including the roles of.sigma.1 receptors a.d pha.ma.ologica. a.ents tha. da.pen endopla.mic reticulum stress a.d a.socia.ed neuroinf.a.ma.ion.

关键词： a.lopregna.olone f.uvoxa.ine keta.ine neurosteroids postpa.tum depression quercetin