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Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers

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Nano Research 2024年第7期17卷 6376-6385页

作者： Fangjun Cao Hui feng Jiaxin Yao xiang Hou Tiezhi jin Junfeng Hui Shaanxi Key Laboratory of Qinling Ecological Security Shaanxi Institute of ZoologyXi’an 710072China Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing Ministry of EducationSchool of Chemical EngineeringNorthwest UniversityXi'an 710069China Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi'an 710069China

The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species,which cause a vicious circle of long-term *** the therapeutic research of metal nanoenzymes for healing diabetic ulcers,it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic ***,ultrasmall oxygen-deficient MoO_(3−X)quantum dots were fabricated and employed as nanoenzymes for healing fiabetic *** PEGylation,PEGylated MoO_(3−X)quantum dots(MoO_(3−X)/PEG)with oxygen vacancies exhibits excellent photothermal,peroxidase/catalase-like *** addition,these MoO_(3−X)/PEG showed superior properties in scavenging H_(2)O_(2)and effectively inhibiting the scavenging of reactive oxygen *** importantly,such an oxygen-defected MoO_(3−X)/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers,inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds,which shows great application potential for promoting wound *** work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidaselike and catalase-like activities show great application potential for healing diabetes wound.

关键词： oxygen-defected molybdenum-based nanoenzymes antioxidant anti-inflammatory diabetes ulcer wounds

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Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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Genes & Diseases 2024年第5期11卷 163-182页

作者： jin Tang Mingxuan feng Dong Wang Liang Zhang Ke Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China Department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

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A novel fracture-cavity reservoir outcrop geological knowledge base construction method considering parameter collection and processing, mutual transformation of data-knowledge, application and update

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Petroleum Science 2024年第4期21卷 2184-2202页

作者： Qi-Qiang Ren jin-Liang Gao Peng Zhu Meng-Ping Li Jian-Wei feng Qiang jin San Zhang Institute of Sedimentary Geology Chengdu University of Technology PetroChina Research Institute of Petroleum Exploration and Development School of Energy Chengdu University of Technology School of Resources and Geosciences China University of Mining and Technology School of Geosciences China University of Petroleum (East China) School of Geosciences Yangtze University

This study endeavors to formulate a comprehensive methodology for establishing a Geological Knowledge Base(GKB) tailored to fracture-cavity reservoir outcrops within the North Tarim Basin. The acquisition of quantitative geological parameters was accomplished through diverse means such as outcrop observations, thin section studies, unmanned aerial vehicle scanning, and high-resolution cameras. Subsequently, a three-dimensional digital outcrop model was generated, and the parameters were standardized. An assessment of traditional geological knowledge was conducted to delineate the knowledge framework, content, and system of the GKB. The basic parameter knowledge was extracted using multiscale fine characterization techniques, including core statistics, field observations, and microscopic thin section analysis. Key mechanism knowledge was identified by integrating trace elements from filling, isotope geochemical tests, and water-rock simulation experiments. Significant representational knowledge was then extracted by employing various methods such as multiple linear regression, neural network technology, and discriminant classification. Subsequently, an analogy study was performed on the karst fracture-cavity system(KFCS) in both outcrop and underground reservoir settings. The results underscored several key findings:(1) Utilization of a diverse range of techniques,including outcrop observations, core statistics, unmanned aerial vehicle scanning, high-resolution cameras, thin section analysis, and electron scanning imaging, enabled the acquisition and standardization of data. This facilitated effective management and integration of geological parameter data from multiple sources and scales.(2) The GKB for fracture-cavity reservoir outcrops, encompassing basic parameter knowledge, key mechanism knowledge, and significant representational knowledge, provides robust data support and systematic geological insights for the intricate and in-depth examination of the genetic

关键词： Geological knowledge base Karst fracture-cavity system Mutual transformation of data-knowledge Knowledge base content and application Tarim basin

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A real-time intelligent lithology identification method based on a dynamic felling strategy weighted random forest algorithm

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Petroleum Science 2024年第2期21卷 1135-1148页

作者： Tie Yan Rui Xu Shi-Hui Sun Zhao-Kai Hou jin-Yu feng School of Petroleum Engineering Northeast Petroleum UniversityDaqing163318HeilongjiangChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya572025HainanChina

Real-time intelligent lithology identification while drilling is vital to realizing downhole closed-loop drilling. The complex and changeable geological environment in the drilling makes lithology identification face many challenges. This paper studies the problems of difficult feature information extraction,low precision of thin-layer identification and limited applicability of the model in intelligent lithologic identification. The author tries to improve the comprehensive performance of the lithology identification model from three aspects: data feature extraction, class balance, and model design. A new real-time intelligent lithology identification model of dynamic felling strategy weighted random forest algorithm(DFW-RF) is proposed. According to the feature selection results, gamma ray and 2 MHz phase resistivity are the logging while drilling(LWD) parameters that significantly influence lithology identification. The comprehensive performance of the DFW-RF lithology identification model has been verified in the application of 3 wells in different areas. By comparing the prediction results of five typical lithology identification algorithms, the DFW-RF model has a higher lithology identification accuracy rate and F1 score. This model improves the identification accuracy of thin-layer lithology and is effective and feasible in different geological environments. The DFW-RF model plays a truly efficient role in the realtime intelligent identification of lithologic information in closed-loop drilling and has greater applicability, which is worthy of being widely used in logging interpretation.

关键词： Intelligent drilling Closed-loop drilling Lithology identification Random forest algorithm Feature extraction

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Efficacy and safety of carrimycin in ten patients with severe pneumonia following solid organ transplantation

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World Journal of Clinical Cases 2024年第15期12卷 2542-2550页

作者： xian-Quan Cui Lu-Wei Zhang Peng Zhao jing-jing feng Department of Organ Transplantation Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Blood Purification Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND The number of patients undergoing solid organ transplantation has increased ***,infections in solid organ transplant recipients can have a severe effect on patient survival owing to the continued use of *** is a novel macrolide antibiotic produced by genetically engineered streptomyces spiramyceticus harboring a 4’’-O-isovaleryltransferase gene(ist)from streptomyces *** has good antibacterial and antiviral ***,no relevant studies have been conducted on the efficacy and safety of carrimycin in patients with severe pneumonia(SP)after solid organ *** To explore the efficacy and safety of carrimycin in patients with SP after solid organ transplantation to provide a medication reference for clinical *** In March 2022,ten patients with SP following solid-organ transplantation were treated at our hospital between January 2021 and March *** the condition was critical and difficult to control with other drugs,carrimycin was *** ten patients'clinical features and treatment protocols were retrospectively analyzed,and the efficacy and safety of carrimycin for treating SP following solid organ transplantation were *** All ten patients were included in the *** etiological agent detection,there were three cases of fungal pneumonia,two cases of bacterial pneumonia,two cases of Pneumocystis pneumonia,and three cases of mixed *** treatment with carrimycin,the disease in seven patients significantly improved,the course of the disease was significantly shortened,fever was quickly controlled,chest computed tomography was significantly improved,and oxygenation was significantly ***,the patients were discharged after *** patient died of acute respiratory distress syndrome,and two patients discontinued *** Carrimycin is a safe and effective treatment modality for SP following soli

关键词： Carrimycin Organ transplantation Severe pneumonia Immunosuppressant Infection Antiviral drugs

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Efficient removal of U(VI) from wastewater by a sponge-like 3D porous architecture with hybrid electrospun nanofibers

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Water Science and Engineering 2024年第2期17卷 150-156页

作者： Lin Hu Lin Chen xian-kun Wu Rui Luo Rong-guan Lv Zheng-hao Fei feng Yang School of Chemistry and Environmental Engineering Yancheng Teachers UniversityYancheng 224051China Jiangsu Province Engineering Research Center of Agriculural Breeding Pollution Control and Resource Yancheng 224051China Jiangsu Nanda Huaxing Science and Technology of Environmental Protection Co.Ltd. Yancheng 224001China

Removal of uranium(VI)from nuclear wastewater is urgent due to the global nuclear energy *** study synthesized novel sponge-like 3D porous materials for enhanced uranium adsorption by combining electrospinning and fibrous freeze-shaping *** materials possessed an organic-inorganic hybrid architecture based on the electrospun fibers of polyacrylonitrile(PAN)and SiO_(2).As a sup-porting material,the surface of fibrous SiO_(2) could be further functionalized by cyano groups via(3-cyanopropyl)*** the cyano groups were turned into amidoxime(AO)groups to obtain a amidoxime-functionalized sponge(PAO/SiO_(2)-AO)through the subsequent ami-doximation *** proposed sponge exhibited enhanced uranium adsorption performance with a high removal capacity of 367.12 mg/g,a large adsorption coefficient of 4.0×10^(4)mL/g,and a high removal efficiency of 97.59%.The UO_(2)^(2+)adsorption kinetics perfectly conformed to the pseudo-second-order *** sorbent also exhibited an excellent selectivity for UO_(2)^(2+) with other interfering metal ions.2023 Hohai *** and hosting by Elsevier B.V.

关键词： Uranium removal Sponge Amidoximation Organic-inorganic hybrid structure Electrospinning

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Tau truncation in the pathogenesis of Alzheimer's disease:a narrative review

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Neural Regeneration Research 2024年第6期19卷 1221-1232页

作者： Dandan Chu Xingyue Yang jing Wang Yan Zhou jin-Hua Gu jin Miao feng Wu Fei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCoinnovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Department of Biochemistry and Molecular Biology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Clinical Pharmacy Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong UniversityNantongJiangsu ProvinceChina Laboratory of Animal Center Nantong UniversityNantongJiangsu ProvinceChina Department of Neurochemistry Inge Grundke-Iqbal Research FloorNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandNYUSA

Alzheimer's disease is characterized by two major neuropathological hallmarks—the extracellularβ-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau *** studies suggest that dysregulation of the microtubuleassociated protein Tau,especially specific proteolysis,could be a driving force for Alzheimer's disease *** physiologically promotes the assembly and stabilization of microtubules,whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers,resulting in them gaining prion-like *** addition,Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent *** review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments,investigates the role of specific truncations in physiological and pathological states of Alzheimer's disease,and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer's disease.

关键词： Alzheimer's disease cleavage site diagnosis marker neurofibrillary tangles phosphorylation Tau Tau aggregation therapy truncation

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ZnO Additive Boosts Charging Speed and Cycling Stability of Electrolytic Zn–Mn Batteries

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Nano-Micro Letters 2024年第4期16卷 293-304页

作者： jin Wu Yang Tang Haohang Xu Guandie Ma jinhong Jiang Changpeng xian Maowen Xu Shu‑Juan Bao Hao Chen Institute for Clean Energy&Advanced Materials School of Materials and EnergySouthwest UniversityChongqing 400715People’s Republic of China

Electrolytic aqueous zinc-manganese(Zn–Mn) batteries have the advantage of high discharge voltage and high capacity due to two-electron reactions. However, the pitfall of electrolytic Zn–Mn batteries is the sluggish deposition reaction kinetics of manganese oxide during the charge process and short cycle life. We show that, incorporating ZnO electrolyte additive can form a neutral and highly viscous gel-like electrolyte and render a new form of electrolytic Zn–Mn batteries with significantly improved charging capabilities. Specifically, the ZnO gel-like electrolyte activates the zinc sulfate hydroxide hydrate assisted Mn^(2+) deposition reaction and induces phase and structure change of the deposited manganese oxide(Zn_(2)Mn_(3)O_8·H_(2)O nanorods array), resulting in a significant enhancement of the charge capability and discharge efficiency. The charge capacity increases to 2.5 mAh cm^(-2) after 1 h constant-voltage charging at 2.0 V vs. Zn/Zn^(2+), and the capacity can retain for up to 2000 cycles with negligible attenuation. This research lays the foundation for the advancement of electrolytic Zn–Mn batteries with enhanced charging capability.

关键词： Electrolytic aqueous zinc-manganese batteries Electrolyte pH value ZnO electrolyte additive Fast constant-voltage charging ability

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Heterostructure Cu_(3)P-Ni_(2)P/CP catalyst assembled membrane electrode for high-efficiency electrocatalytic nitrate to ammonia

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Nano Research 2024年第6期17卷 4872-4881页

作者： Meng jin Jiafang Liu xian Zhang Shengbo Zhang Wenyi Li Dianding Sun Yunxia Zhang Guozhong Wang Haimin Zhang Laboratory of Materials Physics Centre for Environmental and Energy NanomaterialsAnhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Anhui Contango New Energy Technology Co. Ltd.Hefei 230031China

Electrochemical nitrate reduction reaction(NO_(3)RR)is a promising means for generating the energy carrier ***,we report the synthesis of heterostructure copper-nickel phosphide electrocatalysts via a simple vapor-phase hydrothermal *** resultant catalysts were evaluated for electrocatalytic nitrate reduction to ammonia(NH_(3))in three-type electrochemical *** detail,the regulation mechanism of the heterogeneous Cu_(3)P-Ni_(2)P/CP-x for NO_(3)RR performance was systematically studied through the H-type cell,rotating disk electrode setup,and membrane-electrode-assemblies(MEA)*** a result,the Cu_(3)P-Ni_(2)P/CP-0.5 displays the practicability in an MEA system with an anion exchange membrane,affording the largest ammonia yield rate(RNH_(3))of 1.9 mmol·h^(−1)·cm^(−2),exceeding most of the electrocatalytic nitrate reduction electrocatalysts reported to *** theoretical calculations and in-situ spectroscopy characterizations uncover that the formed heterointerface in Cu_(3)P-Ni_(2)P/CP is beneficial for promoting nitrate adsorption,activation,and conversion to ammonia through the successive hydrodeoxygenation pathway.

关键词： electrocatalytic nitrate reduction to ammonia three-type reactors membrane-electrode-assemblies system operando ATR-IRRAS successive hydrodeoxygenation pathway

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Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第2期89卷 266-303,I0007页

作者： Nanping Deng Xiaofan feng Yongbing jin Zhaozhao Peng Yang feng Ying Tian Yong Liu Lu Gao Weimin Kang Bowen Cheng State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage *** widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,*** various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li *** many novel array structured materials are applied to battery for tackling thorny problems mentioned *** this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are ***,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery ***,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are *** hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB.

关键词： Array structured materials Preparation methods and structural designs Action mechanism analyses Advanced Li-S batteries Excellent electrochemical performances and safety

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